PROSITE entry PS50998

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PURL: https://purl.expasy.org/prosite/signature/PS50998

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General information about the entry

Entry name [info]	GLA_2
Accession [info]	PS50998
Entry type [info]	MATRIX
Date [info]	01-JUN-2004 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00011
Associated ProRule [info]	PRU00463

Name and characterization of the entry

Description [info]

Gla domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=47;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=43;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0481772; R2=0.0159966; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2447.1208496; R2=2.4093959; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=404; H_SCORE=3421; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=279; H_SCORE=3119; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='A';  M= 31, -5,-10,-11, -5,-20,  0,-15,-15,-10,-19,-15, -1,-10, -5,-15, 24,  9, -5,-29,-20, -5;
/M: SY='N';  M=-10, 40,-20, 20,  0,-20,  0, 10,-20,  0,-30,-20, 60,-20,  0,  0, 10,  0,-30,-40,-20,  0;
/M: SY='S';  M= 10,  0,-10,  0,  0,-20,  0,-10,-20,-10,-30,-20, 10,-10,  0,-10, 40, 20,-10,-40,-20,  0;
/M: SY='F';  M=-15,-30,-20,-35,-25, 47,-30,-20,  9,-30, 29,  9,-25,-30,-31,-20,-25,-10,  5, -4, 16,-25;
/M: SY='F';  M=-12, -9,-24,-13,-11, 10,-18, -4,-10,-11, -5, -3, -5,-22, -9, -8,-11, -8,-10, -6,  6, -9;
/M: SY='L';  M=-11,-20,-21,-22,-12, 13,-22,-16,  0,-17, 14,  3,-17,-23,-16, -9,-14, -5, -1,-12,  1,-13;
/M: SY='E';  M= -2,  5,-26,  8, 27,-27, -4, -5,-28,  4,-21,-18,  3, -8,  8,  3,  3, -8,-24,-28,-20, 17;
/M: SY='E';  M=  0, -5,-25, -3, 20,-17,-19,-11,-11, -5, -8, -9, -8, -4,  3,-10, -2, -6,-12,-26,-15, 11;
/M: SY='M';  M= -5,-19,-23,-22,-15, -3,-13,-14,  0,-10,  5,  7,-14,-19,-11, -2,-12, -8, -1,-18, -5,-14;
/M: SY='R';  M= -8, -1,-27,  1,  9,-22,-14, -8,-22, 12,-17,-11, -2,-13,  6, 13, -5, -7,-16,-22,-12,  7;
/M: SY='P';  M= -3,-13,-28,-12, -1,-21,-19,-12,-14,  2,-10, -7,-12, 13,  2,  2, -8, -6,-16,-23,-15, -1;
/M: SY='G';  M=  0, -6,-23,-10,-15,-17, 24,-16,-21,-16,-20,-14,  2,-15,-15,-16,  4, -3,-14,-24,-18,-16;
/M: SY='N';  M= -8,  7,-25,  4,  0,-22,-10, -4,-19,  4,-23,-14, 14,  3, -3, -2,  1, -3,-20,-32,-17, -2;
/M: SY='L';  M= -1,-12,-19,-12,-10, -7,-19,-15,  3,-18, 12,  2,-12,-17,-11,-16, -6, -2,  1,-27,-10,-11;
/M: SY='E';  M=-10, -2,-34,  6, 32,-31,-20, -6,-25,  4,-24,-17, -7, 30, 15, -5, -4,-10,-30,-28,-22, 21;
/M: SY='R';  M=-13,-15,-26,-16, -6,-10,-22, -7,-12,  8,  2,  0,-10,-22,  1, 31,-14, -7,-10,-19, -4, -6;
/M: SY='E';  M=-10, 10,-30, 20, 60,-30,-20,  0,-30, 10,-20,-20,  0,  0, 20,  0,  0,-10,-30,-30,-20, 40;
/M: SY='C';  M= -4,-15, 50,-20,-17,-18,-21,-21,-23,-16,-17,-15,-12,-22,-16,-11, -2, -4,-11,-39,-23,-18;
/M: SY='M';  M=-10,-11,-23,-16, -9, -9,-24, -4,  2, -7,  4,  7, -7,-21,  1, -2,-11, -4, -2,-21, -1, -6;
/M: SY='E';  M= -9,  0,-28,  5, 30,-25,-18, -2,-28, 17,-20,-15, -1, -9, 13, 26, -3, -9,-23,-25,-16, 20;
/M: SY='E';  M=-10, 10,-30, 20, 60,-30,-20,  0,-30, 10,-20,-20,  0,  0, 20,  0,  0,-10,-30,-30,-20, 40;
/M: SY='V';  M= -3,-19,-19,-23,-17, -5,-26,-21, 12,-10,  6,  5,-17,-21,-15,-10, -9,  1, 16,-23, -6,-17;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E';  M= -5, 13,-23, 17, 29,-26,-12, -3,-24,  1,-23,-19,  9, -7,  8, -5, 11,  1,-21,-34,-19, 18;
/M: SY='Y';  M=-13, -9,-25, -7, -9, 10,-24, -5, -5,-13,  6, -1,-13,-23,-12,-11,-16, -8, -8, -7, 17,-11;
/M: SY='E';  M=-12, 12,-27, 12, 27,-14,-17,  5,-22,  2,-19,-16, 10,-11,  7, -3, -1, -7,-25,-21, -1, 16;
/M: SY='E';  M=-10, -2,-29,  4, 26,-20,-21, -4,-19,  1,-14,-11, -6,  6,  6, -4, -5, -9,-20,-27,-15, 15;
/M: SY='A';  M= 27, -6,-17, -9, -6,-21, -7,-18,-12,-11,-11,-11, -9,  2,-10,-19,  4, -3, -5,-24,-20, -9;
/M: SY='C';  M=-14,-15, 45,-21,-16,-16,-25,-15,-28, -3,-19,-14,-11,-30,-12, 11,-10,-10,-14,-34,-18,-16;
/M: SY='E';  M=-13, 18,-30, 29, 46,-32,-18,  0,-32,  9,-22,-22,  5, -4, 15,  3, -1,-10,-29,-32,-19, 30;
/M: SY='V';  M= -5,-14,-23,-15, -1, -9,-25, -9,  4, -9, -1,  0,-13,-17, -5, -7, -9, -8,  5,-23, -6, -5;
/M: SY='F';  M=-16,-27,-22,-32,-24, 42,-29,-10,  8,-23, 19, 13,-22,-29,-24,-17,-22,-10,  2,  2, 28,-23;
/M: SY='A';  M= 16, -3,-20, -4, 16,-23,-10, -9,-16, -1,-13, -9, -6, -8,  5, -7,  4, -5,-12,-24,-18, 11;
/M: SY='D';  M=-14, 23,-24, 27,  4,-19,-12,  2,-23, -4,-18,-15, 17,-16, -3, -5,  1, -3,-20,-31,-10,  0;
/M: SY='B';  M= -8,  6,-23,  6,  2,-22,-16,  1,-18,  1,-18,-11,  5,-11,  3,  3,  2,  2,-13,-30,-12,  2;
/M: SY='E';  M= -7, -3,-26,  0, 11,-17,-21,  5,-10, -4,-12, -7, -5,-10,  3, -8, -4, -7,-11,-22, -2,  5;
/I:         I=-6; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='G';  M= -3, -3,-28, -2, -6,-28, 26,-13,-31, -2,-25,-15,  2,-16, -6, -3, -2,-12,-23,-23,-21, -7;
/M: SY='T';  M= -8,-15,-17,-23,-19, 16,-27,-19,  4,-19,  5,  0,-12,-19,-19,-16, -2, 18,  5,-15,  7,-19;
/M: SY='Q';  M=-10,  0,-26,  0,  3,-21,-20, -7,-10,  4,-11, -3, -1,-12,  6,  2, -6, -5,-10,-26,-11,  4;
/M: SY='E';  M= 10, -1,-22, -2, 19,-24,-14, -7,-19,  3,-15,-12, -4, -8, 11, -3,  3, -4,-16,-23,-14, 15;
/M: SY='F';  M= 15,-20,-15,-30,-20, 30,-15,-19, -5,-20,  0, -5,-15,-20,-25,-20, -5, -5,  0, -5,  6,-20;
/M: SY='W';  M=-20,-29,-39,-29,-25, 21,-25, -4, -9,-15, -9, -9,-29,-30,-15,-15,-29,-19,-19, 87, 56,-20;
/M: SY='R';  M= -4, -5,-24, -8, -1,-21,-14, -5,-17,  8,-17, -8,  1,-12,  6, 15,  0, -2,-13,-24,-11,  1;
/M: SY='R';  M= -2, -8,-24,-10, -2,-20,-15, -7,-19, 15,-17, -8, -3,-15,  2, 22, -3, -3,-11,-22,-11, -2;
/M: SY='Y';  M=-20,-22,-29,-24,-22, 36,-30, 12,  2,-14,  2,  1,-20,-30,-15,-12,-20,-10, -7, 25, 70,-22;
/M: SY='Y';  M=-12,-15,-23,-19,-16, 20,-23, -4, -3,-12, -2, -3,-11,-22,-14,-11, -9, -3, -4, -3, 25,-16;
/M: SY='G';  M= -4,  6,-28, 10, -7,-29, 31,-12,-33,-10,-26,-19,  5,-17,-11,-10, -1,-14,-25,-25,-23, -9;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	122 in 122 different sequences
Number of true positive hits	122 in 122 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	5

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Feature key [info]	DOMAIN
Feature description [info]	Gla
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

122 sequences

FA101_PSETE (Q1L659), FA102_PSETE (Q1L658), FA10_BOVIN  (P00743),

FA10_CHICK  (P25155), FA10_HUMAN  (P00742), FA10_MOUSE  (O88947), 
FA10_RABIT  (O19045), FA10_RAT(Q63207), FA10_TROCA  (Q4QXT9), 
FA7_BOVIN   (P22457), FA7_HUMAN   (P08709), FA7_MOUSE   (P70375), 
FA7_PANPA   (Q2F9P4), FA7_PANTR   (Q2F9P2), FA7_RABIT   (P98139), 
FA7_RAT (Q8K3U6), FA9_BOVIN   (P00741), FA9_CANLF   (P19540), 
FA9_CHICK   (Q804X6), FA9_FELCA   (Q6SA95), FA9_HUMAN   (P00740), 
FA9_MOUSE   (P16294), FA9_PANTR   (Q95ND7), FA9_PIG (P16293), 
FA9_RAT (P16296), FAXC_OXYMI  (Q58L95), FAXC_OXYSU  (Q58L96), 
FAXC_PSETE  (Q56VR3), FAXD1_DEMVE (A6MFK7), FAXD1_NOTSC (P82807), 
FAXD2_DEMVE (A6MFK8), FAXD2_NOTSC (Q58L94), FAXD_CRYNI  (B5G6G5), 
FAXD_HOPST  (P83370), FAXD_PSEPO  (Q58L93), FAXD_TROCA  (P81428), 
GAS6_HUMAN  (Q14393), GAS6_MOUSE  (Q61592), GAS6_RAT(Q63772), 
MGP_ARGRE   (Q800Y2), MGP_BOVIN   (P07507), MGP_CHICK   (O42413), 
MGP_CHILA   (Q6QN06), MGP_GALGA   (P56620), MGP_HUMAN   (P08493), 
MGP_MOUSE   (P19788), MGP_PIG (Q8MJ39), MGP_PONAB   (Q5RDP6), 
MGP_RABIT   (P47841), MGP_RAT (P08494), OST2A_ONCMY (A0A024QYT3), 
OST2B_ONCMY (K9J977), OSTC1_DIPSG (P86867), OSTC1_SOLSE (Q1EG28), 
OSTC2_DIPSG (K7NTD0), OSTC2_MOUSE (P86547), OSTC2_SOLSE (P86863), 
OSTCN_ARGRE (Q800Y1), OSTCN_ATEGE (A2D4U1), OSTCN_BISPR (P83489), 
OSTCN_BOVIN (P02820), OSTCN_CAMBA (P86314), OSTCN_CAMDR (P86313), 
OSTCN_CANLF (P81455), OSTCN_CAPHI (P0C225), OSTCN_CHICK (P02822), 
OSTCN_CYPCA (Q7LZI4), OSTCN_DANRE (P83238), OSTCN_DRONO (P15504), 
OSTCN_FELCA (P02821), OSTCN_GORGO (P84349), OSTCN_HOMNE (P84351), 
OSTCN_HORSE (P83005), OSTCN_HUMAN (P02818), OSTCN_LAMGU (P86315), 
OSTCN_LEPMA (P28317), OSTCN_MACFA (P02819), OSTCN_MACMU (A2D670), 
OSTCN_MACNE (A2T6K4), OSTCN_MOUSE (P86546), OSTCN_NOTEU (P0C226), 
OSTCN_PANTR (P84348), OSTCN_PIG   (Q8HYY9), OSTCN_PONPY (P84350), 
OSTCN_RABIT (P39056), OSTCN_RAT   (P04640), OSTCN_SPAAU (P40148), 
OSTCN_XENLA (P40147), OSTCN_XENTR (Q6DJ00), OSTCN_XIPGL (P02823), 
OSTR_MOUSE  (P54615), PROC_BOVIN  (P00745), PROC_CANLF  (Q28278), 
PROC_HUMAN  (P04070), PROC_MOUSE  (P33587), PROC_PIG(Q9GLP2), 
PROC_RABIT  (Q28661), PROC_RAT(P31394), PROS_BOVIN  (P07224), 
PROS_HUMAN  (P07225), PROS_MACMU  (Q28520), PROS_MOUSE  (Q08761), 
PROS_RABIT  (P98118), PROS_RAT(P53813), PROZ_BOVIN  (P00744), 
PROZ_HUMAN  (P22891), PROZ_MOUSE  (Q9CQW3), THRB_BOVIN  (P00735), 
THRB_HUMAN  (P00734), THRB_MOUSE  (P19221), THRB_PIG(Q19AZ8), 
THRB_PONAB  (Q5R537), THRB_RAT(P18292), TMG1_BOVIN  (A7Z070), 
TMG1_HUMAN  (O14668), TMG1_PONAB  (Q5RCB6), TMG2_HUMAN  (O14669), 
TMG2_MOUSE  (Q8R182), TMG3_HUMAN  (Q9BZD7), TMG3_MOUSE  (Q6PAQ9), 
TMG4_HUMAN  (Q9BZD6), TMG4_MOUSE  (Q8BGN6)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
'Partial' sequences

5 sequences

FAXD_NOTSN  (P0CY52), MGP_PRIGL   (P83347), OSTCN_CAMHE (P86312),

OSTCN_HALDD (P83473), THRB_SALSA  (P84122)

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PDB
[Detailed view]

128 PDB

pdb_00001cfh; pdb_00001cfi; pdb_00001dan; pdb_00001ezq; pdb_00001f0r; pdb_00001f0s; pdb_00001fak; pdb_00001iod; pdb_00001j34; pdb_00001j35; pdb_00001ksn; pdb_00001lpg; pdb_00001lpk; pdb_00001lpz; pdb_00001lqd; pdb_00001lqv; pdb_00001mgx; pdb_00001nfu; pdb_00001nfw; pdb_00001nfx; pdb_00001nfy; pdb_00001nl0; pdb_00001nl1; pdb_00001nl2; pdb_00001o5d; pdb_00001p0s; pdb_00001pfx; pdb_00001q3m; pdb_00001q8h; pdb_00001vzm; pdb_00001w0y; pdb_00001w2k; pdb_00001whe; pdb_00001whf; pdb_00001wqv; pdb_00001wss; pdb_00001wtg; pdb_00001wun; pdb_00001wv7; pdb_00001x7a; pdb_00001z6j; pdb_00002a2q; pdb_00002aei; pdb_00002aer; pdb_00002b7d; pdb_00002b8o; pdb_00002boh; pdb_00002c4f; pdb_00002cji; pdb_00002ec9; pdb_00002f9b; pdb_00002fir; pdb_00002flb; pdb_00002flr; pdb_00002j2u; pdb_00002j34; pdb_00002j38; pdb_00002j4i; pdb_00002j94; pdb_00002j95; pdb_00002pf1; pdb_00002pf2; pdb_00002spt; pdb_00002uwl; pdb_00002uwo; pdb_00002uwp; pdb_00002vh0; pdb_00002vh6; pdb_00002wyg; pdb_00002wyj; pdb_00002y7x; pdb_00002y7z; pdb_00002y80; pdb_00002y81; pdb_00002y82; pdb_00002zp0; pdb_00002zwl; pdb_00002zzu; pdb_00003ela; pdb_00003jtc; pdb_00003th2; pdb_00003th3; pdb_00003th4; pdb_00004bxs; pdb_00004bxw; pdb_00004ibl; pdb_00004mzz; pdb_00004nzq; pdb_00004o03; pdb_00004y6d; pdb_00004y71; pdb_00004y76; pdb_00004y79; pdb_00004y7a; pdb_00004y7b; pdb_00004ylq; pdb_00004zh8; pdb_00004zha; pdb_00004zma; pdb_00005edk; pdb_00005edm; pdb_00006bjr; pdb_00006c2w; pdb_00006m3b; pdb_00006m3c; pdb_00007tpp; pdb_00008eok; pdb_00008i74; pdb_00008i75; pdb_00008i76; pdb_00008rtn; pdb_00008uf7; pdb_00008uud; pdb_00009bur; pdb_00009bux; pdb_00009bvk; pdb_00009bvl; pdb_00009bvm; pdb_00009bvp; pdb_00009bvq; pdb_00009bvr; pdb_00009cli; pdb_00009cln; pdb_00009cls; pdb_00009cm2; pdb_00009cm9; pdb_00009cmo; pdb_00009cth
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