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annotation rule: PRU00463

General rule information [?]

Accession PRU00463
Dates 30-JUN-2005 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS50998; GLA_2
Name Gla domain
Function a membrane binding motif which, in the presence of calcium ions, interacts with phospholipid membranes that include phosphatidylserine

Propagated annotation [?]


Comments [?]

case <FTGroup:1> or <FTGroup:2>
Ptm Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
end case


Cross-references [?]

PROSITE PS00011; GLA_1; 1;

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0005509; Molecular function: calcium ion binding.
end case


Keywords [?]

case <FTGroup:1> or <FTGroup:2>
Calcium
Gamma-carboxyglutamic acid
end case

case <FTTag:disulf>
Disulfide bond
end case


Features [?]

From: PS50998
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Gla #        
MOD_RES     21     21       4-carboxyglutamate     E   1
MOD_RES     24     24       4-carboxyglutamate     E   2
DISULFID     18     23           disulf   C-x*-C  
DISULFID     23     29           disulf   C-x*-C  

Additional information [?]

Size range 17-45 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P84349 (OSTCN_GORGO)
Scope
Eukaryota; Gnathostomata

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]