We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00463
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00463
General rule information
[?]
| Accession | PRU00463 |
| Dates | 30-JUN-2005 (Created)
21-NOV-2019 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50998; GLA_2 |
Name | Gla domain |
| Function | a membrane binding motif which, in the presence of calcium ions, interacts with phospholipid membranes that include phosphatidylserine |
| Scope(s) |
Eukaryota Gnathostomata |
| Example(s) | P84349; |
Propagated annotation
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Comments
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| case <FTGroup:1> or <FTGroup:2> | |
| PTM | Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. |
| end case | |
Keywords
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| case <FTGroup:1> or <FTGroup:2> | |
| Calcium | |
| Gamma-carboxyglutamic acid | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| case <FTGroup:1> or <FTGroup:2> | |
| GO:0005509; Molecular function:calcium ion binding | |
| end case | |
Cross-references
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| PROSITE | PS00011; GLA_1; 1; |
Features
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| From: PS50998 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Gla #" | |||||||||
| MOD_RES | 21 | 21 | /note="4-carboxyglutamate" | E | 1 | |||||||
| MOD_RES | 24 | 24 | /note="4-carboxyglutamate" | E | 2 | |||||||
| DISULFID | 18 | 23 | disulf | C-x*-C | ||||||||
| DISULFID | 23 | 29 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 17-45 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [127] All [ 127 ]
- Retrieve set of proteins with 3D structure for this domain