ProRule PRU00463
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00463 |
| Accession | PRU00463 |
| Dates | 30-JUN-2005 (Created)
21-NOV-2019 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50998; GLA_2 |
Name | Gla domain |
| Function | a membrane binding motif which, in the presence of calcium ions, interacts with phospholipid membranes that include phosphatidylserine |
| Scope(s) |
Eukaryota Gnathostomata |
| Example(s) | P84349 (OSTCN_GORGO); |
Propagated annotation
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Comments
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| case <FTGroup:1> or <FTGroup:2> | |
| PTM | Gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. |
| end case | |
Keywords
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| case <FTGroup:1> or <FTGroup:2> | |
| Calcium | |
| Gamma-carboxyglutamic acid | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| case <FTGroup:1> or <FTGroup:2> | |
| GO:0005509; Molecular function:calcium ion binding | |
| end case | |
Cross-references
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| PROSITE | PS00011; GLA_1; 1; |
Features
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| From: PS50998 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Gla #" | |||||||||
| MOD_RES | 21 | 21 | /note="4-carboxyglutamate" | E | 1 | |||||||
| MOD_RES | 24 | 24 | /note="4-carboxyglutamate" | E | 2 | |||||||
| DISULFID | 18 | 23 | disulf | C-x*-C | ||||||||
| DISULFID | 23 | 29 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 17-45 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [127] All [ 127 ]
- Retrieve set of proteins with 3D structure for this domain