ProRule PRU00463

General rule information [?]

Accession PRU00463
Dates 30-JUN-2005 (Created)
21-NOV-2019 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS50998; GLA_2
Name Gla domain
Function a membrane binding motif which, in the presence of calcium ions, interacts with phospholipid membranes that include phosphatidylserine
Scope(s) Eukaryota
Example(s) P84349 (OSTCN_GORGO);

Propagated annotation [?]

Comments [?]

case <FTGroup:1> or <FTGroup:2>
PTMGamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium.
end case

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
Gamma-carboxyglutamic acid
end case
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0005509; Molecular function:calcium ion binding
end case

Cross-references [?]

PROSITE PS00011; GLA_1; 1;

Features [?]

From: PS50998
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Gla #"
MOD_RES 21 21 /note="4-carboxyglutamate" E 1
MOD_RES 24 24 /note="4-carboxyglutamate" E 2
DISULFID 18 23 disulf C-x*-C
DISULFID 23 29 disulf C-x*-C

Additional information [?]

Size range 17-45 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]