We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS51058

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PURL: https://purl.expasy.org/prosite/signature/PS51058

Direct ScanProsite submission

General information about the entry

Entry name [info]	ZF_CXXC
Accession [info]	PS51058
Entry type [info]	MATRIX
Date [info]	01-JAN-2005 CREATED; 13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51058
Associated ProRule [info]	PRU00509

Name and characterization of the entry

Description [info]

Zinc finger CXXC-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=48;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=44;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.9837625; R2=0.0100230; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2157.0463867; R2=2.8840206; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=551; H_SCORE=3746; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=351; H_SCORE=3169; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-10; D=-20; I=-20; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='S';  M=  3, -8,-18,-11, -6,-23, -7,-12,-17, -2,-16,-11,  0,-10, -5, -3,  5, -1,-12,-30,-20, -6;
/M: SY='K';  M= -5,-13,-22,-16, -8,-16,-11,-13,-17,  3,-14, -4, -8, -8, -4, -2, -3, -8,-13,-24,-15, -7;
/M:         M= -5,-17,-19,-19, -8, -9,-20,-13, -9, -1, -4, -1,-13,-20, -6, -2, -6, -8, -7,-21, -8, -8;
/M: SY='R';  M= -7, -6,-27,-14,  3,-27,-18,  1,-28, 25,-20,-11,  0,-15,  8, 27, -3, -8,-23,-29,-16,  3;
/M: SY='R';  M= -8, -6,-28,-13,  4,-28,-18, -4,-27, 20,-19, -9,  1,-17,  8, 31, -3, -8,-24,-29,-20,  4;
/I:         I=-6; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='K';  M= -5, -8,-22,-12, -3,-22,-19,-12,-13,  7,-14, -7, -4,-16, -1,  7, -5, -1, -7,-29,-17, -4;
/M: SY='R';  M= -4, -9,-27,-13, -4,-28,  2, -9,-29,  5,-24,-14, -3,-14, -1, 16, -4,-11,-25,-27,-23, -5;
/M: SY='C';  M=  2,-29, 85,-29,-38,-20,-28,-29,-10,-29,-10,-10,-29,-29,-29,-29, -9, -9, -9,-21,-20,-29;
/M: SY='G';  M=  0, -8,-28,-10,-16,-29, 44,-16,-37,-13,-35,-26,  3,-19,-15,-11,  0,-16,-28,-23,-28,-16;
/M: SY='V';  M= -2,-11,-18,-11, -1,-19,-21,-14, -5, -3, -8, -3,-10,-16, -3, -8, -4,  0,  2,-28,-15, -2;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='E';  M= -3, -2,-28,  2, 19,-26,-16, -7,-24,  5,-23,-14, -6,-11, 10,  2, -1, -7,-17,-23,-18, 15;
/M: SY='G';  M= 11,-13,-17,-11,-13,-25, 14,-20,-19,-15,-22,-17,-11, -7,-14,-17,  1, -9,-11,-28,-24,-13;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='Q';  M= -8,-13,-20,-15,  1,-22,-24,-10,-15,  4, -6,  2, -9,-17, 17,  7, -6, -8,-11,-23,-13,  5;
/I:         I=-6; MD=-32;
/M: SY='R';  M= -4,-13,-13,-17, -5,-18,-20,-11, -9,  1, -7,  1, -8,-15,  4,  8, -6, -1, -5,-22,-13, -3; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='K';  M= -6, -8,-25, -8,  2,-29,-19,-11,-24,  9,-20,-11, -5,  4,  6,  7, -2,  1,-17,-29,-21,  3;
/I:         I=-6; MD=-32;
/M: SY='E';  M= -6,  2,-19,  7, 13,-17,-13, -7,-11, -2,-14, -9, -2, -9,  3, -7,  0, -1, -7,-21,-14,  9; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='D';  M=-18, 31,-31, 40, 18,-30, -9, -4,-30, -5,-36,-26, 20,-10,  2,-12,  2, -7,-28,-39,-26, 11;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='G';  M= -3, -6,-31, -5, -8,-30, 43,-15,-38,-14,-37,-26,  2,-18,-10,-15,  0,-17,-28,-22,-27, -9;
/M: SY='Q';  M= -8, -3,-25, -5,  5,-22,-16,  0,-17,  2,-18,-10, -2,-15,  6, -3, -3, -7,-11,-27,-12,  5;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='S';  M= -3, -3,-15, -1, -2,-21,-16, -9,-15, -4,-16,-11, -1,-11, -5,-11,  6,  6,-11,-28,-18, -3;
/M: SY='F';  M=  0,-19,-14,-20,-17,  1,-16,-14, -1,-17, -7, -5,-14,-19,-16,-20, -4, -4,  1,-18,  0,-17;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='R';  M= -9,-20,-16,-25,-10,-17,-28,-15, -9,  6,  4,  4,-13,-22,  0, 10,-11,-10,-10,-24,-15, -9;
/M: SY='D';  M=-14, 19,-26, 26,  5,-25,-10,-10,-21, -9,-24,-19, 11,-15, -4,-13, -1, -8,-21,-36,-24,  0;
/I:         I=-4; MD=-21;
/M: SY='K';  M= -7,-12,-19,-16, -4,-17,-16,-12,-13, 11, -5,  9, -7,-13,  5,  6, -2, -8,-10,-20,-15, -1; D=-4;
/I:         I=-4; MD=-21;
/M: SY='P';  M= -5,-15,-17,-16, -8,-19,-19,-15, -9,  1, -7, -2,-12,  4, -5, -3, -5, -4, -5,-25,-16, -8; D=-4;
/I:         I=-4; MI=-21; MD=-21; IM=-21; DM=-21;
/M: SY='K';  M=-11, -6,-25,-12,  1,-17,-19,  1,-22, 20,-15, -8, -4, -8,  4,  9, -5,-11,-17,-22, -9,  1; D=-4;
/I:         I=-4; DM=-21;
/M: SY='F';  M=-14,-15,-20,-17,-16, 21,-21, -6, -8,-13, -8, -5,-12,-22,-16,-15,-10,-12,-12, -7,  9,-16; D=-4;
/I:         I=-4; DM=-21;
/M: SY='G';  M= -4, -5,-27, -2, -8,-26, 29,-11,-32,-13,-33,-24, -1, -6,-11,-15, -2,-15,-24,-22,-23, -9; D=-4;
/I:         I=-4; DM=-21;
/M: SY='G';  M= -5, -6,-24, -7, -9,-23, 21,-10,-25,-10,-24,-18,  1,-17,-10, -9, -3,-13,-19,-22,-20,-10; D=-4;
/I:         I=-4; DM=-21;
/M: SY='P';  M= -2,-13,-20,-14, -6,-20,-14,-10,-19,  2,-14, -8, -9,  3, -3,  2, -2, -6,-15,-26,-16, -6; D=-4;
/I:         I=-4; DM=-21;
/M: SY='N';  M= -9,  6,-28,  2, -3,-28, 12, -2,-32, -2,-31,-21, 15,-14, -3, -5,  5,-10,-27,-29,-21, -3;
/M: SY='R';  M= -7,-12,-22,-16, -7,-21,-18,-13,-10,  3,-10, -5, -6,-19, -2,  7, -5, -4, -9,-28,-17, -6;
/I:         I=-4; MD=-21;
/M: SY='K';  M= -3,-12,-17,-14, -7,-17,-12,-11,-15,  3,-11, -4, -7, -9, -4, -6,  3, -4,-11,-18,-14, -6; D=-4;
/I:         I=-4; MD=-21;
/M: SY='K';  M=-11, -6,-26,-11,  2,-17,-13,  3,-26, 16,-21,-12, -2,-16,  2,  9, -4,-11,-22,-15, -8,  1; D=-4;
/I:         I=-4; MD=-21;
/M: SY='Q';  M= -5, -4,-16, -6,  8,-25,-17, -4,-24,  9,-16, -3, -3,-11, 27, 10, -1, -8,-17,-20,-12, 15; D=-4;
/I:         I=-4; MD=-21;
/M: SY='K';  M=  2,-11, -4,-13, -7,-14,-14,-14, -6,  3, -5, -1, -8,-12, -5, -5,  2, -2, -3,-21,-13, -6; D=-4;
/I:         I=-4; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M: SY='K';  M= -5,-15,-20,-17, -5,-18,-25,-16, -4,  4, -2,  1,-14,-18, -3,  0, -9, -8, -1,-28,-16, -5;
/M: SY='K';  M=-12,-15,-23,-18, -4,-10,-25,-11,-14,  5, -4,  4,-12,-20,  5,  2, -9,-11,-12,-13, -7, -2;
/M: SY='R';  M=-10, -9,-30,-19,  1,-30,-20, -1,-30, 22,-20,-10,  0,-19, 10, 48, -9,-10,-29,-30,-20,  1;
/M: SY='R';  M=-10, -8,-28,-14,  4,-25,-20, -4,-27, 18,-18, -7, -2,-17, 16, 28, -6, -8,-23,-25,-16,  6;
/M: SY='C';  M=  0,-30, 90,-30,-40,-20,-30,-30,-10,-30,-10,-10,-30,-30,-30,-30,-10,-10,-10,-20,-20,-30;
/M:         M= -9,-16,-20,-14, -7,-15,-26,-17, -3,-11,  0, -1,-12, -9, -6,-15, -8, -5, -3,-27,-15, -8;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	47 in 43 different sequences
Number of true positive hits	47 in 43 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	97.92 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	3
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	N_Hulo
Feature key [info]	ZN_FING
Feature description [info]	CXXC-type
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

43 sequences

CXXC1_BOVIN (Q5EA28), CXXC1_DROME (Q9W352), CXXC1_HUMAN (Q9P0U4),

CXXC1_MOUSE (Q9CWW7), CXXC4_HUMAN (Q9H2H0), CXXC4_MOUSE (Q6NXI8), 
CXXC4_RAT   (Q9EQC9), CXXC4_XENLA (Q800L6), CXXC4_XENTR (Q0VFP6), 
CXXC5_BOVIN (Q32LB3), CXXC5_HUMAN (Q7LFL8), CXXC5_MOUSE (Q91WA4), 
CXXC5_PONAB (Q5R7N4), CXXC5_RAT   (Q5XIQ3), DNMT1_BOVIN (Q24K09), 
DNMT1_CHICK (Q92072), DNMT1_HUMAN (P26358), DNMT1_MOUSE (P13864), 
DNMT1_PARLI (Q27746), DNMT1_RAT   (Q9Z330), FXL19_HUMAN (Q6PCT2), 
FXL19_MOUSE (Q6PB97), JHD1_DROME  (Q9VHH9), KDM2A_HUMAN (Q9Y2K7), 
KDM2A_MOUSE (P59997), KDM2A_XENTR (Q5U263), KDM2B_HUMAN (Q8NHM5), 
KDM2B_MOUSE (Q6P1G2), KDM2B_XENLA (Q640I9), KMT2A_HUMAN (Q03164), 
KMT2A_MOUSE (P55200), KMT2B_HUMAN (Q9UMN6), KMT2B_MOUSE (O08550), 
MBD1_HUMAN  (Q9UIS9), MBD1_MOUSE  (Q9Z2E2), TET1_HUMAN  (Q8NFU7), 
TET1_MOUSE  (Q3URK3), TET3A_XENLA (A0A1L8GSA2), TET3B_XENLA (K9JHZ4), 
TET3_HUMAN  (O43151), TET3_MOUSE  (Q8BG87), TET3_XENTR  (A0JP82), 
TET_DROME   (M9NEY8)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

1 sequence

CFP1_CAEEL  (Q9XUE7)

PDB
[Detailed view]

36 PDB

pdb_00002j2s; pdb_00002jyi; pdb_00002kkf; pdb_00003av4; pdb_00003av5; pdb_00003av6; pdb_00003pt6; pdb_00003pta; pdb_00003qmb; pdb_00003qmc; pdb_00003qmd; pdb_00003qmg; pdb_00003qmh; pdb_00003qmi; pdb_00003swr; pdb_00004bbq; pdb_00004d4w; pdb_00004hp1; pdb_00004hp3; pdb_00004nw3; pdb_00004o64; pdb_00004pzi; pdb_00004wxx; pdb_00004yoc; pdb_00004z3c; pdb_00005exh; pdb_00005vc9; pdb_00005w9q; pdb_00005w9s; pdb_00005wy1; pdb_00006asb; pdb_00006asd; pdb_00007uv9; pdb_00007xi9; pdb_00007xib; pdb_00008xqc
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