PROSITE logo
Due to maintenance work, this service will be unavailable from Mon Nov 11 17:30 until Tue Nov 12 09:00 CET. Apologies for the inconvenience.

ProRule PRU00509


General rule information [?]

Accession PRU00509
Dates 23-NOV-2005 (Created)
19-NOV-2022 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51058; ZF_CXXC
Name CXXC-type zinc finger
Function it binds specifically to non-methylated CpG
Scope(s) Eukaryota
Metazoa
Example(s) Q6PCT2 (FXL19_HUMAN);

Propagated annotation [?]

Keywords [?]

Metal-binding
Zinc
end case
Zinc-finger

Gene Ontology [?]

case (<Feature:PS51058:8=[CH]> and <Feature:PS51058:11=[CH]> and <Feature:PS51058:14=[CH]> and <Feature:PS51058:42=[CH]>) or (<Feature:PS51058:20=[CH]> and <Feature:PS51058:23=[CH]> and <Feature:PS51058:26=[CH]> and <Feature:PS51058:42=[CH]>)
GO:0046872; Molecular function:metal ion binding

Features [?]

From: PS51058
Key From To Description Tag Condition FTGroup
case (<Feature:PS51058:8=[C]> and <Feature:PS51058:11=[C]> and <Feature:PS51058:14=[C]> and <Feature:PS51058:47=[C]>) and (<Feature:PS51058:20=[C]> and <Feature:PS51058:23=[C]> and <Feature:PS51058:26=[C]> and <Feature:PS51058:42=[C]>)
ZN_FING from to /note="CXXC-type #"
else case (<Feature:PS51058:8=[CH]> and <Feature:PS51058:11=[CH]> and <Feature:PS51058:14=[CH]> and <Feature:PS51058:47=[CH]>) and (<Feature:PS51058:20=[CH]> and <Feature:PS51058:23=[CH]> and <Feature:PS51058:26=[CH]> and <Feature:PS51058:42=[CH]>)
ZN_FING from to /note="CXXC-type #; atypical"
else
ZN_FING from to /note="CXXC-type #; degenerate"
end case
BINDING 8 8 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 11 11 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 14 14 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 20 20 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 1
BINDING 23 23 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 26 26 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 42 42 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#2"		 [CH] 2
BINDING 47 47 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 2

Additional information [?]

Size range 6-48 amino acids
Related rules None
Fusion None
Repeats 1-3
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



View rule in raw text format (no links)

UniProtKB rule member sequences [?]