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annotation rule: PRU00509

General rule information [?]

Accession PRU00509
Dates 23-NOV-2005 (Created)
30-MAR-2021 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51058; ZF_CXXC
Name CXXC-type zinc finger
Function it binds specifically to non-methylated CpG

Propagated annotation [?]

Gene Ontology [?]

case (<Feature:PS51058:8=[CH]> and <Feature:PS51058:11=[CH]> and <Feature:PS51058:14=[CH]> and <Feature:PS51058:42=[CH]>) or (<Feature:PS51058:20=[CH]> and <Feature:PS51058:23=[CH]> and <Feature:PS51058:26=[CH]> and <Feature:PS51058:42=[CH]>)
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

Features [?]

case (<Feature:PS51058:8=[C]> and <Feature:PS51058:11=[C]> and <Feature:PS51058:14=[C]> and <Feature:PS51058:47=[C]>) and (<Feature:PS51058:20=[C]> and <Feature:PS51058:23=[C]> and <Feature:PS51058:26=[C]> and <Feature:PS51058:42=[C]>)
From: PS51058
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     from     to       CXXC-type #        
else case (<Feature:PS51058:8=[CH]> and <Feature:PS51058:11=[CH]> and <Feature:PS51058:14=[CH]> and <Feature:PS51058:47=[CH]>) and (<Feature:PS51058:20=[CH]> and <Feature:PS51058:23=[CH]> and <Feature:PS51058:26=[CH]> and <Feature:PS51058:42=[CH]>)
ZN_FING     from     to       CXXC-type #; atypical        
ZN_FING     from     to       CXXC-type #; degenerate        
end case

METAL     8     8       Zinc #1     [CH]   1
METAL     11     11       Zinc #1     [CH]   1
METAL     14     14       Zinc #1     [CH]   1
METAL     20     20       Zinc #2     [CH]   1
METAL     23     23       Zinc #2     [CH]   2
METAL     26     26       Zinc #2     [CH]   2
METAL     42     42       Zinc #2     [CH]   2
METAL     47     47       Zinc #1     [CH]   2

Additional information [?]

Size range 6-48 amino acids
Related rules None
Repeats 1-3
Topology Undefined
Example Q6PCT2 (FXL19_HUMAN)
Eukaryota; Metazoa


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]