PROSITE entry PS51113

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51113
Entry name [info]	ZF_BTK
Accession [info]	PS51113
Entry type [info]	MATRIX
Date [info]	01-APR-2005 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51113
Associated ProRule [info]	PRU00432

Name and characterization of the entry

Description [info]

Zinc finger Btk-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=37;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=34;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4293971; R2=0.0121034; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2214.9492188; R2=2.0891609; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=543; H_SCORE=3349; N_SCORE=9.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=337; H_SCORE=2919; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='N';  M=-10, 40,-20, 20,  0,-20,  0, 10,-20,  0,-30,-20, 60,-20,  0,  0, 10,  0,-30,-40,-20,  0;
/M: SY='T';  M= -2,  0,-21, -3,  0,-22,-13,-10,-17, -6,-23,-15,  4, 12,  3, -9, 14, 15,-17,-32,-18,  0;
/M: SY='N';  M=-11, 13,-28,  9, -4,-23, -1,  7,-18, -9,-23,-14, 20, -4, -5,-10, -1, -9,-23,-32,-15, -6;
/M: SY='R';  M=-12,-18,-26,-19, -9, -8,-26,-14, -1,  4, 10,  5,-14,-22, -5, 13,-19,-10, -2,-20, -5, -9;
/M: SY='L';  M= -6,-24,-17,-26,-19,  2,-24,-15, 16,-21, 27, 23,-23,-25,-14,-16,-16, -5, 13,-24, -4,-16;
/M: SY='Q';  M=  1,-12,-23,-14, -9,-15, -7, -8, -5,-10,-11, -3, -8,-18,  4,-11,  0, -5, -5,-17, -3, -3;
/M: SY='K';  M= -4, -9,-24,-11, -4, -5,-17, -8,-19, 14,-18, -9, -5,-16, -2, 13, -3, -4,-13,-13,  3, -4;
/M: SY='Y';  M=-19,-21,-12,-24,-22, 30,-30, 10, -3,-15, -1, -2,-20,-31,-16,-13,-19,-10, -9, 19, 62,-22;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='P';  M= -8,-18,-36, -9,  0,-29,-18,-19,-20,-10,-30,-20,-16, 78, -9,-19, -4, -6,-28,-31,-29, -9;
/M: SY='G';  M=  0, -8, -5, -9,-13,-26, 30,-18,-33,-11,-29,-19,  0,-19,-13,-13,  7, -8,-21,-29,-25,-13;
/M: SY='F';  M=  3,-25,-15,-31,-24, 26,-23,-23,  8,-23, 11,  3,-22,-25,-28,-20,-12, -5, 15,-12,  4,-24;
/M: SY='W';  M=-20,-32,-32,-37,-29, 48,-26,-19, -7,-24, -2, -7,-27,-30,-29,-19,-27,-17,-12, 65, 36,-25;
/M: SY='V';  M= -6,-18,-19,-20,-15, -8,-24,-17,  5, -7,  1,  1,-12,-21,-11,  4, -4,  3, 11,-26, -9,-15;
/M: SY='D';  M= -6, 21,-24, 25,  2,-30, 16, -7,-33, -8,-30,-24, 17,-14, -6,-11, 11, -5,-25,-34,-23, -2;
/M: SY='G';  M=  1,  0,-28,  2, -9,-30, 39,-16,-35, -7,-28,-19,  2,-16,-12,-12,  0,-15,-25,-23,-25,-11;
/M: SY='K';  M=-10,  0,-25, -3,  3,-15,-16, -5,-23, 20,-23,-10,  6,-15,  8, 18, -2, -5,-19,-21, -8,  6;
/M: SY='W';  M=-20,-32,-39,-33,-26, 26,-25,-11,-10,-18, -9,-10,-30,-30,-19,-16,-30,-20,-19, 89, 48,-21;
/M: SY='T';  M= -1,-11,-16,-13, -7,-10,-16,-13, -4,-15,  4, -1, -7,-18, -2,-12,  7,  9, -3,-29,-10, -4;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q';  M= -9, -6,-26, -6,  2,-24, -8, 10,-22,  4,-16, -5, -1,-16, 14,  8, -2, -9,-20,-24, -8,  7;
/M: SY='Q';  M=-10, -1,-30,  0, 18,-35, -8,  4,-25,  9,-21, -6,  0,-11, 39, 12, -1,-11,-29,-21,-14, 27;
/M: SY='T';  M=  5, -5,-14,-10, -6,-14,-14,-16,-11, -4,-10, -9, -3,-13, -6, -7, 13, 21, -4,-29,-12, -6;
/M: SY='E';  M=  1,  5, -7,  8, 17,-27, -3,-10,-29, -5,-22,-20,  0,-11,  0,-11,  5, -6,-21,-32,-22,  8;
/M: SY='K';  M=-12,  0,-30,  3, 20,-28,-20, -5,-30, 35,-25,-12,  0,-10, 12, 32, -8,-10,-22,-22,-12, 15;
/M: SY='N';  M=  2, 11,-15, -1, -6,-14, -9, -7,-12, -8,-13,-12, 19,-16, -6, -9, 12, 15,-11,-33,-15, -6;
/M: SY='A';  M= 25, -6,-13,-14,-10,-19,  5,-19,-16,-11,-15,-13, -4,-11,-10,-16, 15, 12, -6,-25,-19,-10;
/M: SY='P';  M= -5,-19,-27,-19, -7, -7,-20,-13, -6,-12, -4,  2,-17, 19, -4,-14,-11, -9,-12,-20,-10, -7;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='K';  M= -9,  7,-25, 10, 13,-28,-16, -5,-27, 16,-24,-14,  4,-10, 13, 14,  3,  1,-20,-27,-14, 12;
/M: SY='K';  M= -3,-13,-27,-14, -4,-19,-21,-15, -9, 12,-10, -4,-10, -2, -3,  8,-11, -9, -8,-21,-11, -5;
/M: SY='T';  M= -1,-18, -2,-24,-20, -2,-22,-19, -4,-18, -1, -5,-18,-24,-17,-18, -7,  6,  1, -1,  2,-19;
/M: SY='E';  M= -4,  1,-23, -2, 10,-18,-16,  5,-18,  0,-10, -9,  3,-14,  3,  4, -1, -1,-16,-27,-10,  5;
/M: SY='S';  M=  8,  6,-17,  3, -2,-19, -7,  4,-17,-10,-15,-12,  8,-15, -3,-11, 10,  0,-13,-32,-13, -3;
/M: SY='R';  M= -8,-16,-29,-18,-12, -2, -9,-10,-21,  4,-16,-10,-11,-21, -8, 12,-13,-13,-17, 11,  7,-11;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	23 in 23 different sequences
Number of true positive hits	23 in 23 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	ZN_FING
Feature description [info]	Btk-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

23 sequences

BMX_HUMAN   (P51813), BMX_MOUSE   (P97504), BTKL_DROME  (P08630),

BTK_CHICK   (Q8JH64), BTK_HUMAN   (Q06187), BTK_MOUSE   (P35991), 
GAP1_DROME  (P48423), ITK_HUMAN   (Q08881), ITK_MOUSE   (Q03526), 
RAS4B_HUMAN (C9J798), RASA2_HUMAN (Q15283), RASA2_MOUSE (P58069), 
RASA2_RAT   (Q63713), RASA3_BOVIN (Q28013), RASA3_HUMAN (Q14644), 
RASA3_MOUSE (Q60790), RASA3_RAT   (Q9QYJ2), RASL1_HUMAN (O95294), 
RASL1_MOUSE (Q9Z268), RASL2_HUMAN (O43374), RASL2_MOUSE (Q6PFQ7), 
TEC_HUMAN   (P42680), TEC_MOUSE   (P24604)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

16 PDB

1B55; 1BTK; 1BWN; 2E6I; 2LUL; 2YS2; 2Z0P; 6TSE; 6TT2; 6TUH; 6TVN; 6YYF; 6YYG; 6YYK; 8GMB; 8S93
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