PROSITE entry PS51122

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51122
Entry name [info]	CALPONIN_2
Accession [info]	PS51122
Entry type [info]	MATRIX
Date [info]	01-JUN-2005 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00808
Associated ProRule [info]	PRU00474

Name and characterization of the entry

Description [info]

Calponin-like repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=26;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=24;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.1444489; R2=0.0162099; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=485; N_SCORE=9.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=300; N_SCORE=6.0; MODE=1; TEXT='RR';
/DEFAULT: M0=-8; D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='I';  M= -8,-27,-23,-35,-27,  0,-32,-21, 37,-22, 18, 29,-22,-22,-16,-22,-18, -8, 29,-22, -2,-24;
/M: SY='G';  M= -4, -9,-26, -7, -5,-25,  9,-13,-27, -4,-28,-18, -2,  8, -5,  3,  7, -4,-22,-28,-23, -7;
/M: SY='L';  M= -5,-23,-18,-23,-15,  3,-23,-18, 11,-25, 31, 11,-21,-25,-15,-18,-14, -3,  5,-25, -5,-15;
/M: SY='Q';  M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='M';  M=  8,-13,-15,-21,-13, -9,-11, -7,  4,-10,  2, 26,-11,-15, -2,-12,  0, -1,  3,-24, -9, -8;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='W';  M=-10,-15,-25,-20,-18,  6,-23,-11, -9,-12, -9, -9,-15,-20,-12,-12, -6, 14,-10, 29, 26,-15;
/M: SY='N';  M= -4, 28,-17, 14,  0,-20,  0,  4,-20, -3,-30,-20, 45,-17,  0, -3, 19,  6,-24,-40,-20,  0;
/M: SY='K';  M=-10,  0,-30,  0, 13,-33,-20, -4,-27, 38,-27, -7,  0,-10, 25, 24, -7,-10,-23,-20,-10, 19;
/M: SY='G';  M=-10,-17,-27,-20,-23, 11, 22,-11,-21,-20,-13,-10,-10,-25,-23,-18,-10,-15,-18, -1, 10,-23;
/M: SY='A';  M= 20,  2, 15, -1, -8,-25, -9,-18,-21,-12,-17,-17, -5,-17,-12,-20,  3, -5, -9,-31,-22,-10;
/M: SY='S';  M=  4, 12,-13,  6,  0,-20,  0, -4,-20, -7,-30,-20, 25,-13,  0, -7, 31, 14,-16,-40,-20,  0;
/M: SY='Q';  M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='R';  M= -6, -2,-24, -2,  7,-27,-14, -3,-25, 18,-25,-10,  3,-12, 20, 22,  7, -1,-20,-26,-13, 12;
/M: SY='G';  M= -2,-15,-28,-15,-20,-21, 47,-20,-26,-22,-11,-11, -7,-22,-20,-20, -7,-18,-21,-20,-23,-20;
/M: SY='M';  M=-10,-14,-23,-21, -8,-12,-20,  3,  8, -4,  8, 42,-14,-17, 18, -4,-14,-10, -2,-20, -3,  5;
/I:         I=-6; MD=-32;
/M: SY='T';  M=  0,  0, -7, -7, -7, -7,-14,-14, -7, -7, -7, -7,  0, -7, -7, -7, 14, 35,  0,-21, -7, -7; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='N';  M=  7, 16,-20,  3, -7,-22, 16, -4,-22, -7,-25,-17, 29,-17, -7,-10,  8, -4,-22,-30,-22, -7;
/M: SY='F';  M=-20,-27,-23,-35,-27, 67,-30,-10,  0,-25,  7,  0,-20,-30,-32,-17,-20,-10, -3, 15, 43,-27;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='T';  M= -1, -9,-13,-14,-11, -6,-18,-18, -3,-16,  3, -3, -7,-16,-11,-13, 10, 26,  1,-29, -9,-11;
/M: SY='G';  M= -7,-12,-32,-10,-10,-27, 26,-15,-33, -5,-27,-17, -5,  5,-10,  3, -5,-15,-27,-22,-25,-13;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='H';  M=-15, 20,-28, 20, 10,-30,-13, 30,-27,  0,-25,-11, 21,-15, 20,  1,  0,-10,-30,-32, -7, 14;
/M: SY='I';  M= -5,-23,-18,-28,-23,  0,-31,-25, 24,-23, 18, 11,-20,-22,-20,-21,-11,  6, 23,-25, -5,-23;
/M: SY='Y';  M=-15, -6,  6,-13,-18,  7,-23,  6,-11,-12,-11, -9, -1,-30,-12,-12,-11, -8,-15, -4, 32,-18;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	89 in 38 different sequences
Number of true positive hits	89 in 38 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	7
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	REPEAT
Feature description [info]	Calponin-like
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

38 sequences

CLIK2_CAEEL (Q09936), CLPH_ONCVO  (P37801), CNN1_BOVIN  (Q2HJ38),

CNN1_CHICK  (P26932), CNN1_HUMAN  (P51911), CNN1_MELGA  (P37803), 
CNN1_MOUSE  (Q08091), CNN1_MUSPF  (Q9GK38), CNN1_PIG(Q08092), 
CNN1_RAT(Q08290), CNN1_SHEEP  (Q7YRL2), CNN2_BOVIN  (Q3SYU6), 
CNN2_HUMAN  (Q99439), CNN2_MOUSE  (Q08093), CNN2_PIG(Q08094), 
CNN2_PONAB  (Q5RFN6), CNN3_BOVIN  (Q32L92), CNN3_HUMAN  (Q15417), 
CNN3_MOUSE  (Q9DAW9), CNN3_RAT(P37397), MP20_DROME  (P14318), 
MYPH_ECHGR  (Q24799), TAGL2_BOVIN (Q5E9F5), TAGL2_HUMAN (P37802), 
TAGL2_MOUSE (Q9WVA4), TAGL2_RAT   (Q5XFX0), TAGL3_BOVIN (Q3ZBY2), 
TAGL3_HUMAN (Q9UI15), TAGL3_MACFA (Q4R5J4), TAGL3_MOUSE (Q9R1Q8), 
TAGL3_PONAB (Q5R6R2), TAGL3_RAT   (P37805), TAGL_BOVIN  (Q9TS87), 
TAGL_CHICK  (P19966), TAGL_HUMAN  (Q01995), TAGL_MOUSE  (P37804), 
TAGL_RAT(P31232), UNC87_CAEEL (P37806)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment