PROSITE entry PS51125

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General information about the entry

Entry name [info]	NHL
Accession [info]	PS51125
Entry type [info]	MATRIX
Date [info]	01-JUN-2005 CREATED; 01-OCT-2013 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51125
Associated ProRule [info]	PRU00504

Name and characterization of the entry

Description [info]

NHL repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=45;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=45;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.4541223; R2=0.0205595; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=270; N_SCORE=9.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=27; N_SCORE=4.0; MODE=1; TEXT='R?';
/DEFAULT: B0=-50; E0=-50; B1=-100; E1=-100; MM=*; II=*;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=-85; E0=*; BD=-54;
/M: SY='G';  M= -1,-41, -8,  1,-44, 18,  5, -9,  3,  3,  5,-23,-38,  6,-10,  5,-14,  3,-43,-36; M0=-7;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M= -3,  8,-12,  7, 14,  1,  3, -7,  2, -7, -7,  4,-37, 12, -2,  4,  4,-38,-43, -6; M0=-5;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-20, -3,-13, -6, 14,-18,-24,  3, 11,-17,-31, -4,-38, 11, 11,  3, -2, 11,-42, -3; M0=-6;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-12,  1,-53,-46, 28,-14,-34,  1, -1, 11, -5,-41, -8,  0,-40, -3, -7,  7,-32, -9; M0=-11;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M= -8, -3,  1,-22,-17, 22, 11,-37,-12, -5, -2,-24,-13,  1,  6,  3,  4, -6,-41,-16; M0=-6;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M=-11, -4,-26,  6,-11, -1, 16, -1,  4,-21,-32, -8,-18, 11,  4, 10,  4,  7,-43, -5; M0=-4;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-20,  4,-36, -2, 20,-19,  9,  7,  9, -3,-23, -8, -2,-28, 10, -5,  0, -1,  4,  1; M0=-5;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M=-17,-41, -7,  0, -2, 30,-24,-18, -9,-13,-32, -6,  9,-19,-25, -3,-26,-37,-43,-36; M0=-12;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='C';  M=  2, 12, -7,-10,  9,  7,  7,-10,  5,-42,  4,-11,  5, 10,  7,  6, -5, -9,-43,-36; M0=-5;
/I:         MM=-1; MI=-106; MD=-40; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M=  0,-41,  4,  8, -6, 11,  5,-23, -4, -7, -3,  8,-37, -6, -1,  2,  9, -6,  1,-36; M0=-4;
/I:         MM=0; MI=-105; MD=-58; IM=-9; II=-11; DM=-22; DD=-4;
/M: SY='D';  M=  3,-40, 13, -9, -1, 10,-22,-12,  6,-12,-31,  7,  9,  6,  8,-25, -6,-37,  5, -9; M0=-6;
/I:         MM=-3; MI=-104; MD=-24; IM=-9; II=-11; DM=-24; DD=-3;
/M: SY='G';  M= -2,-38,-11, -1,-41, 24, 20,-16,  3, -6,-29, -4,-34, -5, -1, -7,-10,-16,-40, -7; M0=-8;
/I:         MM=-2; MI=-101; MD=-31; IM=-9; II=-11; DM=-37; DD=-1;
/M: SY='Q';  M=-22,-36,  5, 10,-40, -6, 25,-37, -6,-37, -3,  2,  4, 30,-19,-11, -7,-33,-38,-31; M0=-13;
/I:         MM=0; MI=-100; MD=-110; IM=-9; II=-11; DM=-1; DD=-48;
/M: SY='F';  M=-32,-30,-56,-49, 32,-48,-37,  0,-45, 22,-21, -9,-48,-41,-13,-39, -9, -6,-35,-32; M0=-23;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='N';  M= -4, 17,  1, -2,-15,-37,-23,-42, -1, -3, -1, 19,-38,  7,  2,  7,  6,-10,-43, 11; M0=-7;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Y';  M= -9, 12,-14,-11,  6,  4,  6,-18, -6,  1,  5, 10,-38,  3,  6,  3, -4,-12,  4, 16; M0=-4;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=-19,-44,-73,-72,-46,-58,-65, -9,-69,-13,-34,-63, 41,-65,-67,-52,-46,-12,-61,-59; M0=-41;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='W';  M= -3,-41,-13, -6,-44,-37, 26,-11, -8, -5,-32,  3,-37,  7, 10,  2,  8,  3, 31,-36; M0=-9;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M= -6,-44, 12,-24,  2, 31,-28,-47, -8,-46,-37,-27,-23,-24, -9,  3,-31,-42,-48,-42; M0=-19;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=-22,-44,-76,-73,-46,-75,-73, 18,-72, 16,  0,-71,-71,-69,-73,-68,-49, 29,-64,-61; M0=-43;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='C';  M= 28, 31,-52, -9,-41,-13,-42,-36,-46,-40,-33,-43,-48,-43,-46, -5, 10, -7,-45, -3; M0=-23;
/I:         MM=0; MI=-106; MD=-58; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=  9,  2,-53,-47, -3,-45,-34, 10,-43,  2,  8,-42,-46,-39,-41,-36, -7, 28,-33, -5; M0=-20;
/I:         MM=0; MI=-105; MD=-116; IM=-9; II=-11; DM=-4; DD=-20;
/M: SY='D';  M=-16,  8, 25,-17,-38,-19, -6,-17,-22,-10,-28, 16,-39,-21,-26,  9, 17, -8,-40,-34; M0=-12;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=  0,  3,  5, -4,-45,-13,-23,-42,  2,-42,-32,  6, 19,-18,  6, 17, -1,-18, 11,-36; M0=-10;
/I:         MM=-3; MI=-23; MD=-116; IM=-6; II=-15; DM=-7; DD=-14;
/M: SY='Q';  M= -4,-41, 16, -1,-45,-17,  4,-42,  9, -9, -3,  9,-37, 17, -3,  3, 12,-38,-43,-37; M0=-10;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M=-29,  5,-20,-12,-47, 32, -2,-44,-21,-22,-35, 15,-40, -9, -6,-18,-29,-40,-46,-39; M0=-20;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M= -3,-41,  7,  8,-45,-10, 22,-42,-11,-12,-32, 17,-37, 13, 12, -1,  6,-38,-43,-37; M0=-11;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I';  M=-50,-45,-76,-71,  3,-73,-64, 28,-70,  5,-30,-69,-69,-65,-69,-66,-50, 25,-56,  2; M0=-41;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Y';  M= -5, 11,-53,-47, -2,-15,-34, 21,-42,  7,-20,-41,-45,-39,-40,-36,-29, 17, 14, 23; M0=-19;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=-48,-43,-75,-72,-51,-73,-76, 11,-72,-38,-38,-70,-71,-72,-74,-67,-15, 37,-69,-64; M0=-50;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='T';  M= 21,  2,-62,-60,-44, -9,-48,-40,-56, -1,-36,-49,-50,-51,-53,  8, 24,  5,-49,-46; M0=-25;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M=-51,-72, 40,  6,-73,-48,  5,-73,-47,-72,-66,-34,-54,-40,-58,-17,-52,-68,-74,-62; M0=-44;
/I:         MM=-26; MI=-106; MD=-3; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M=-11,-26, -6, 10,-29, 10, 31,-26, -2,-26,-17, 15,-21, -2, 12,-10,-11,-22,-27,-21; M0=-9;
/I:         MM=-3; MI=-24; MD=-90; IM=-28; II=-2; DM=0; DD=-60;
/M: SY='C';  M=  5, 15, -5,-21,  6,-11,  3,-39, -5,-39,-31,  6,-38,-20, 14, 14,  5,  1,  3,  7; M0=-8;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M= -1, 12,  7,  9,-45, 11, 15,-42,  3,-42, -3, 12,-10,-18,  3,  3,-13,-38,  7,  3; M0=-9;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='N';  M=  2,-41,  4,-20,-44, -4,-23,-41, -7,-13,-32, 34,-38,-19, -5, -3, -3,-14,-43, -7; M0=-12;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M=-27,  9,-13,-20, -7,  7, 38,-42, -4,-42, -1, 13, -9,  7,  5, -4, -7,-38,-43, -4; M0=-12;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M= -6, 29,-25, -9,-44,-37,-23,-42, -6,-41,-32, -5,-38,  7, 30,  8, -5,-10,  8,-36; M0=-16;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I';  M=-49,-44,-75,-29, -8,-74,-71, 27,-71,  7,-33,-70,-70,-69,-72,-67,-49, 27,-63,-60; M0=-42;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=-29,  2,-52,-45,  5,-45,  5, -8, 20, -6, -5,-41,-45, 25,-40, -3, -3,  6, 22, -5; M0=-15;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=-19, 23,-52,-46,-27,-45, -1, 17, 10,  0,-20,-41,-45,  2,-40,-36,-17, 25,-32,-29; M0=-19;
/I:         MM=0; MI=-106; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-21,-49,-74,-70, 40,-69,-48,-12,-67,  8,-26,-64,-66,-58,-63,-61,-52,-18,-40, 19; M0=-40;
/I:         MM=0; MI=-105; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M= -1,-41, 21, -4,-44, -2, -4,-42,  1,-41,-32, 14,-11, -4, -8, 12, 11,-38,-43,-36; M0=-12;
/I:         MM=0; MI=-105; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=  6,-38,-27,-21, -6, -7,-24,-37,  8,-11,  0, -2, 16, 12, -7,  7, -2,  1,-41, 11; M0=-6;
/I:         MM=0; MI=-105; MD=-116; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M=-26,-41, 21, 13, -2,  3, 10,-42, -1,-18, -3,  9, -8, -7,-17,  7, -7,-37,-43, -4; M0=-9;
/I:         B0=*; E1=-10;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	244 in 49 different sequences
Number of true positive hits	244 in 49 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	17
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	93.49 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	6
Feature key [info]	REPEAT
Feature description [info]	NHL
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

49 sequences

AMDA_XENLA  (P08478), AMDB_XENLA  (P12890), AMDL_CAEEL  (P83388),

AMD_BOVIN   (P10731), AMD_HUMAN   (P19021), AMD_MOUSE   (P97467), 
AMD_RAT (P14925), BRAT_DROME  (Q8MQJ9), LIN41_BOVIN (E1BJS7), 
LIN41_CAEEL (Q9U489), LIN41_CHICK (Q1PRL4), LIN41_DANRE (E7FAM5), 
LIN41_HUMAN (Q2Q1W2), LIN41_MOUSE (Q1PSW8), LIN41_RAT   (D3ZVM4), 
LIN41_XENTR (F6QEU4), NCL1_CAEEL  (P34611), NHL1_CAEEL  (Q03601), 
NHLC1_HUMAN (Q6VVB1), NHLC1_MOUSE (Q8BR37), NHLC1_RAT   (Q6IMG5), 
NHLC2_BOVIN (A4IF69), NHLC2_CHICK (Q5ZI67), NHLC2_HUMAN (Q8NBF2), 
NHLC3_HUMAN (Q5JS37), NHLC3_MOUSE (Q8CCH2), NHLC3_PONAB (Q5R9V0), 
NHLC4_HUMAN (P0CG21), NHLC4_MOUSE (Q3UP44), PAL1_DROME  (Q9V5E1), 
PAL2_DROME  (Q9W1L5), PG17_MYCTU  (Q79FU2), PG18_MYCTU  (Q79FU0), 
PGAL_CAEEL  (P91268), PKND_MYCTO  (P9WI78), PKND_MYCTU  (P9WI79), 
TEN1_CAEEL  (G5EGQ6), TRI32_HUMAN (Q13049), TRI32_MOUSE (Q8CH72), 
TRIM2_AILME (D2GXS7), TRIM2_BOVIN (A4IF63), TRIM2_CALJA (F7H9X2), 
TRIM2_HUMAN (Q9C040), TRIM2_MOUSE (Q9ESN6), TRIM2_RAT   (D3ZQG6), 
TRIM3_HUMAN (O75382), TRIM3_MOUSE (Q9R1R2), TRIM3_RAT   (O70277), 
WECH_DROME  (Q9V4M2)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

17 sequences

NHLC2_MOUSE (Q8BZW8), SOQ1_ARATH  (Q8VZ10), TEN1_CHICK  (Q9W6V6),

TEN1_HUMAN  (Q9UKZ4), TEN1_MOUSE  (Q9WTS4), TEN2_CHICK  (Q9DER5), 
TEN2_HUMAN  (Q9NT68), TEN2_MOUSE  (Q9WTS5), TEN2_RAT(Q9R1K2), 
TEN3_DANRE  (Q9W7R4), TEN3_HUMAN  (Q9P273), TEN3_MOUSE  (Q9WTS6), 
TEN4_DANRE  (Q9W7R3), TEN4_HUMAN  (Q6N022), TEN4_MOUSE  (Q3UHK6), 
TENA_DROME  (Q9VYN8), TENM_DROME  (O61307)

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PDB
[Detailed view]

32 PDB

1Q7F; 1RWI; 1RWL; 3FVZ; 3FW0; 4ZLR; 5EX7; 5WM0; 6CMX; 6FAY; 6FB3; 6FPT; 6FQ3; 6FQL; 6G7W; 6GC1; 6SKA; 6SKE; 6VHH; 7B2R; 7B96; 7BAM; 7BAN; 7BAO; 7DJJ; 7DJK; 7DJL; 7DJM; 7QRV; 7QRW; 7QRX; 8FIA
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