PROSITE entry PS51131
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General information about the entry
| Entry name [info] | ZN_HOOK |
| Accession [info] | PS51131 |
| Entry type [info] | MATRIX |
| Date [info] |
01-JUN-2005 CREATED;
10-MAY-2017 DATA UPDATE; 27-MAR-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51131 |
| Associated ProRule [info] | PRU00471 |
Name and characterization of the entry
| Description [info] | Rad50 zinc-hook domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=99; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=94; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1408157; R2=0.0047655; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=10870.6640625; R2=7.8042555; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1335; H_SCORE=21289; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=915; H_SCORE=18012; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-6; D=-100; I=-100; B1=-200; E1=-200; MI=-200; MD=-200; IM=-200; DM=-200; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-200; BD=-200; /M: SY='L'; M= -6, -21, 1, 2, 7, -15, -4, 11, -9, 12, 6, -9, 3, -7, -6, 0, 2, 6, -21, 0; /M: SY='E'; M= 1, 23, 11, 26, -21, -9, -7, -9, 4, -8, -8, 5, -14, 15, -4, 1, -2, -5, -29, -16; /M: SY='D'; M= 4, -20, 25, 20, -20, -11, -4, -21, 10, -18, -15, 11, -2, 4, 2, 11, 7, -15, -26, -5; /M: SY='I'; M= -5, -21, -7, -12, 15, -26, -13, 22, -14, 20, 13, -13, -9, -14, -18, -14, -7, 16, -13, 16; /M: SY='E'; M= -8, -25, 27, 30, -26, -2, -3, -21, 14, -19, -16, 12, -1, 10, 10, 3, -4, -20, -30, -17; /M: SY='E'; M= 2, -21, 23, 25, -21, -12, -3, -17, 9, -18, -9, 11, -12, 11, 2, 9, 3, -11, -28, -8; /M: SY='Y'; M= -8, -22, 6, 9, 19, -20, -3, -8, 12, -7, -6, 2, -18, -1, 10, -4, 1, -5, -8, 25; /M: SY='L'; M= -9, -22, -3, 3, -2, -23, -11, 12, 2, 20, 7, -6, 12, -6, -4, -11, -7, 5, -20, 1; /M: SY='D'; M= -7, -24, 34, 30, -26, -14, -2, -18, 15, -21, -12, 21, -11, 10, 2, -1, 0, -16, -33, -17; /M: SY='E'; M= -3, -22, 18, 25, -18, -17, 6, -7, 6, -2, -6, 13, -15, 10, 7, -4, -3, -5, -30, -13; /M: SY='L'; M= -4, -18, -26, -19, 7, -27, -3, 24, -16, 30, 18, -20, -25, -10, -18, -12, -2, 18, -22, -2; /M: SY='E'; M= -8, -24, 8, 26, -19, -17, -2, -14, 18, -10, -6, 11, -13, 20, 17, 1, 0, -15, -24, -7; /M: SY='E'; M= 0, -23, 17, 32, -26, -9, -4, -21, 16, -18, -14, 10, -10, 14, 7, 5, 1, -16, -28, -17; /M: SY='E'; M= 1, -22, 12, 25, -24, -8, -6, -16, 19, -19, -13, 6, -11, 7, 17, 5, 5, -11, -28, -16; /M: SY='L'; M= -9, -23, -15, 4, -3, -19, -14, 20, 3, 22, 13, -16, -20, -2, 7, -15, -9, 10, -21, -7; /M: SY='E'; M= -6, -25, 25, 30, -25, -11, 7, -19, 17, -16, -14, 11, -12, 13, 10, 0, -5, -16, -30, -15; /M: SY='K'; M= -1, -23, 8, 27, -24, -9, -5, -21, 28, -18, -13, 6, -11, 10, 15, 5, -3, -15, -25, -16; /M: SY='L'; M= -2, -19, -21, -17, 6, -23, -9, 15, -10, 27, 15, -8, -26, -10, 4, -10, -7, 8, -13, 15; /M: SY='R'; M= -5, -22, 8, 14, -22, -10, 11, -18, 18, -14, -10, 13, -14, 13, 23, 6, 7, -15, -28, -12; /M: SY='K'; M= 0, -22, 15, 16, -15, 0, -7, -11, 17, -15, -7, 5, -13, 15, 6, 4, 2, -7, -26, -13; /M: SY='R'; M= 3, -22, 9, 17, -14, -14, -5, -17, 18, -14, -10, 4, -14, 17, 22, 5, 2, -14, -24, -11; /M: SY='L'; M= -9, -22, -8, 0, 3, -27, 5, 15, 4, 20, 9, -14, -22, -5, 12, -14, -8, 11, -23, -4; /M: SY='G'; M= 9, -20, 2, 14, -22, 23, 3, -17, 5, -14, -12, 3, -13, 1, 6, 8, -1, -14, -26, -16; /M: SY='E'; M= 3, -21, 18, 27, -24, -11, -4, -15, 6, -19, -11, 17, 4, 8, 1, 9, 3, -10, -31, -17; /M: SY='L'; M= -10, -18, -30, -23, 9, -31, -16, 24, -19, 39, 23, -26, -28, -17, -20, -20, -6, 16, -19, 2; /M: SY='K'; M= -1, -23, 5, 22, -26, -12, -1, -24, 24, -22, -8, 19, -13, 21, 22, 4, -3, -20, -26, -15; /M: SY='W'; M= 9, -18, -9, 4, 1, 5, -8, -7, -3, -5, 8, -2, -16, 12, -8, 11, 2, -4, 14, 1; /M: SY='H'; M= 2, -22, 7, 14, -21, -8, 26, -18, 15, -13, -9, 5, -14, 8, 24, 1, 3, -15, -29, -10; /M: SY='E'; M= 0, -21, 0, 11, -14, -12, 0, 4, 11, 1, 2, -1, -15, 10, 7, 3, 2, 0, -25, -10; /M: SY='R'; M= 2, -21, -2, 6, -16, 13, -7, -11, 8, -11, -2, 4, -15, 5, 18, 3, 8, -8, -23, -5; /M: SY='E'; M= -8, -22, 5, 22, -3, -14, 5, -3, 3, 5, 5, -6, -15, 7, 2, -2, 2, -1, -22, -1; /M: SY='Y'; M= -11, -24, -22, -16, 13, -27, -4, 13, -1, 19, 9, -18, -26, -8, 8, -15, -8, 6, 20, 37; /M: SY='E'; M= -6, -25, 14, 27, -21, -18, 16, -15, 19, -10, -6, 7, -13, 16, 13, -1, -6, -13, -28, -12; /M: SY='K'; M= -1, -21, 8, 14, 4, -8, -4, -16, 17, -12, -2, 11, -15, 10, 10, 1, 0, -14, -19, 1; /M: SY='Y'; M= 8, -18, -9, -11, 17, -12, 7, -1, 2, -2, -3, 15, -21, -6, 2, -1, -2, -2, -10, 21; /M: SY='I'; M= -8, -22, -23, -9, 1, -30, -17, 30, -10, 23, 17, -20, -23, -4, -2, -16, -7, 21, -21, 0; /M: SY='E'; M= 2, -23, 9, 22, -23, -3, -7, -10, 16, -17, -9, 6, 8, 8, 11, 0, -1, -9, -27, -16; /M: SY='E'; M= 7, -20, 6, 22, -3, -14, -5, -8, 8, -3, 3, 10, -14, 8, 2, -1, -5, -8, -23, -10; /M: SY='L'; M= 2, 7, -17, -7, 1, -20, -12, 12, -11, 28, 16, -8, -23, -9, -15, -3, -5, 6, -21, 0; /I: I=-28; MD=-56; /M: SY='E'; M= -6, -24, 14, 23, -23, -17, -5, -20, 18, -22, -16, 12, -14, 6, 14, 3, -1, -13, -28, -9; D=-28; /I: I=-28; MI=-56; MD=-56; IM=-56; DM=-56; /M: SY='E'; M= -5, -24, 7, 18, -21, -18, -7, -10, 14, -8, -9, 4, -16, 15, 11, 4, -3, -9, -28, -15; D=-28; /I: I=-28; DM=-56; /M: SY='A'; M= 22, -15, 2, 4, -16, -8, -12, 4, -5, -2, -3, 3, -16, 0, -11, 8, 2, 5, -27, -14; /M: SY='E'; M= -9, -26, 1, 22, -15, 9, 6, -17, 17, -9, -6, 5, 7, 9, 14, -5, -9, -17, -24, -13; /I: I=-18; MD=-35; /M: SY='G'; M= 0, -27, 13, 9, -31, 29, 10, -33, -1, -28, -19, 6, -17, 9, 9, 0, -9, -27, -31, -19; D=-18; /I: I=-18; MD=-35; /M: SY='D'; M= -12, -29, 11, 9, -29, -9, -13, -22, 4, -18, -14, 7, -22, -4, -1, -1, -5, -22, -38, -23; D=-18; /I: I=-18; MI=0; MD=-35; IM=0; DM=-35; /M: SY='C'; M= -21, 54, -31, -24, -19, -36, -30, -13, 0, -20, -14, -22, -36, -21, -2, -18, -9, -7, -43, -26; D=-18; /I: I=-18; DM=-35; /M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100; /M: SY='P'; M= -83,-105, -83, -74, -85, -86, -4, -87, -79, -42, -82, -21, 118, -6, -88, -27, -76, -92, -86, 49; /M: SY='V'; M= -76, 33, -93, -1, -68,-100, -92, 11, -89, 53, -57, -92, -95, -87, -91, -84, 12, 68, -98, -77; /M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100; /M: SY='G'; M= -2, -25, 6, 11, -29, 44, 1, -30, 4, -24, -17, 2, -14, 16, -1, 5, -9, -26, -24, -18; /M: SY='R'; M= -3, -25, -7, 2, -25, -4, 13, -25, 18, -21, -11, 4, -18, 23, 45, 3, 1, -20, -26, -10; /M: SY='P'; M= -3, -24, 12, 23, -25, -9, 2, -14, 12, -21, -14, 8, 34, 4, -2, 5, 0, -11, -29, -18; /M: SY='F'; M= -15, -18, -33, -26, 40, -32, -16, 19, -25, 34, 20, -28, -31, -22, -22, -22, -11, 14, -8, 16; /M: SY='D'; M= -5, -22, 25, 17, -26, 7, 3, -24, 7, -24, -17, 14, 5, 7, 5, 9, 12, -19, -32, -16; /M: SY='D'; M= -2, -24, 23, 21, -29, 19, -7, -27, 4, -27, -20, 8, 21, 2, -4, 8, 4, -22, -30, -20; /M: SY='E'; M= -4, -24, 33, 35, -28, -8, 7, -25, 11, -24, -19, 13, -10, 8, -1, 4, 2, -19, -33, -17; /M: SY='H'; M= 1, -24, 5, 22, -21, -5, 39, -23, 14, -20, -12, 0, 9, 6, 8, 1, -1, -17, -27, -2; /M: SY='W'; M= 2, -22, -6, 14, -2, -19, 11, 3, 10, 1, 1, -7, -15, 1, 6, -1, -2, 0, 16, -5; /I: I=-22; MI=0; MD=-44; IM=0; DM=-44; /M: SY='N'; M= 3, 0, 3, 11, -25, -13, 1, -15, 10, -19, -9, 13, -17, 10, 5, 6, 3, -8, -32, -16; D=-22; /I: I=-22; DM=-44; /M: SY='E'; M= -9, 10, 25, 26, -28, -19, 3, -29, 18, -22, -19, 7, -15, 6, 13, -2, -7, -24, -33, -18; D=-22; /I: I=-22; DM=-44; /M: SY='F'; M= -12, -21, -31, -26, 30, -33, -23, 22, -18, 23, 10, -25, -29, -22, -15, -19, -6, 17, -15, 4; D=-22; /I: I=-22; DM=-44; /M: SY='I'; M= -3, -21, -15, -18, -5, -26, -19, 21, -12, 16, 14, -13, -24, -10, -9, -9, -2, 18, -28, -9; D=-22; /I: I=-22; DM=-44; /M: SY='E'; M= 2, -21, 9, 25, -25, -7, 6, -21, 20, -22, -14, 10, -11, 11, 13, 9, 3, -17, -28, -15; /M: SY='H'; M= -11, -27, 28, 30, -27, -18, 36, -30, 21, -24, -16, 5, -11, 12, 17, -2, -4, -25, -32, -9; /M: SY='Y'; M= -5, 26, -10, -11, 7, -15, 10, 8, -13, 17, 7, -14, -25, -2, -9, -11, -6, 4, -9, 27; /M: SY='R'; M= -8, -24, 2, 20, -16, -6, 13, -15, 20, -18, -10, 9, -13, 19, 21, 2, 2, -15, -25, -10; /M: SY='E'; M= 1, -19, 21, 21, -20, -12, 9, -13, 4, -8, -10, 10, -12, 3, -2, 11, 8, -8, -32, -13; /M: SY='E'; M= -7, -26, 11, 32, -23, -20, 7, -23, 26, -17, -2, -1, -10, 16, 21, -4, -4, -19, -24, -8; /M: SY='C'; M= -2, 21, -21, -16, -1, -25, -17, 19, -3, 20, 11, -14, -21, -12, -7, -8, 8, 14, -22, -1; /M: SY='D'; M= -2, -22, 21, 20, -22, -6, -3, -15, 16, -11, -11, 17, -14, 11, 10, 4, -3, -15, -29, -15; /I: I=-18; MI=0; MD=-35; IM=0; DM=-35; /M: SY='R'; M= -3, -22, 3, 11, -22, -2, -6, -16, 14, -13, -11, 11, -17, 8, 17, 10, -2, -11, -29, -15; D=-18; /I: I=-18; DM=-35; /M: SY='L'; M= -10, -20, -28, -22, 23, -30, -20, 21, -11, 28, 13, -22, -27, -18, -17, -15, -4, 13, -16, 2; D=-18; /I: I=-18; DM=-35; /M: SY='P'; M= -2, -28, 17, 29, -27, -9, -4, -26, 8, -25, -17, 3, 39, 14, 8, 0, -6, -23, -26, -13; /M: SY='E'; M= 3, -21, 20, 22, -24, -7, -5, -18, 19, -16, -13, 11, -12, 6, 7, 8, 3, -15, -28, -16; /M: SY='E'; M= -3, -24, 19, 33, -26, -17, 6, -24, 16, -18, -14, 6, -10, 20, 14, 1, 3, -19, -29, -15; /M: SY='L'; M= -9, -21, -19, -7, 2, -27, -12, 21, -5, 26, 19, -12, -23, -2, -1, -12, -7, 12, -19, 1; /M: SY='E'; M= 9, -21, 13, 27, -23, -13, -4, -23, 22, -22, -14, 9, -11, 10, 13, 1, 0, -16, -24, -8; /M: SY='E'; M= -3, -24, 26, 28, -22, -16, 5, -19, 14, -20, -15, 5, -12, 10, 14, 3, 2, -14, -27, -7; /M: SY='L'; M= 0, -16, -21, -14, 5, -24, -19, 20, -13, 25, 12, -15, -20, -14, -18, -5, 11, 15, -23, -5; /M: SY='E'; M= -2, -23, 19, 28, -16, -18, -4, -12, 14, -4, -8, 4, -13, 9, 8, -2, -3, -10, -24, -6; /M: SY='E'; M= 0, -20, 12, 14, -18, -13, -6, -7, 14, -7, -8, 14, -14, 6, 10, 6, 4, -5, -29, -14; /M: SY='E'; M= -4, -25, 21, 35, -23, -19, 7, -17, 14, -11, -11, 2, -10, 14, 10, -3, -1, -13, -29, -14; /M: SY='I'; M= -5, 4, -14, 6, -1, -26, -4, 18, -4, 17, 10, -16, -21, -1, -3, -10, -7, 13, -19, 5; /M: SY='K'; M= 2, -21, 7, 17, -26, -10, -3, -23, 26, -22, -9, 14, -13, 17, 19, 10, -1, -19, -26, -14; /M: SY='K'; M= 0, -21, 11, 19, -23, -13, -3, -17, 21, -12, -10, 17, -13, 17, 9, 4, 2, -13, -27, -15; /M: SY='L'; M= -4, -21, -15, -12, 7, -25, -9, 16, -6, 24, 15, -18, -24, -9, -1, -11, -8, 10, -11, 21; /M: SY='R'; M= -3, -23, 11, 19, -19, -9, -5, -14, 18, -5, -8, 8, -15, 8, 21, -1, -1, -13, -26, -14; /M: SY='K'; M= 7, -21, 6, 11, -21, -7, 8, -6, 18, -14, -6, 7, -14, 14, 11, 3, -3, -5, -26, -12; /M: SY='E'; M= -6, -23, 17, 24, -13, -16, 8, -19, 20, -13, -12, 10, -13, 11, 16, 2, -1, -15, -27, -11; /M: SY='L'; M= -11, -21, -24, -12, 24, -30, -13, 19, -7, 25, 14, -21, -26, -13, 0, -17, -9, 14, -11, 15; /M: SY='R'; M= -8, -24, 19, 19, -25, -8, -3, -17, 18, -20, -14, 13, -15, 13, 28, 2, -2, -13, -29, -15; /M: SY='R'; M= 1, -22, 5, 17, -23, -13, 5, -18, 21, -15, -10, 11, -14, 17, 22, 6, 0, -15, -26, -13; /M: SY='L'; M= -6, 0, -29, -23, 12, -19, -17, 23, -22, 33, 19, -24, -28, -13, -21, -18, -8, 18, -17, 7; /M: SY='E'; M= -5, -24, 14, 27, -17, -18, -4, -7, 14, -6, -7, 8, -13, 13, 9, 0, -4, -7, -25, -8; /M: SY='K'; M= 1, -23, 11, 17, -26, 1, -6, -21, 25, -22, -11, 4, -2, 15, 13, 8, -3, -18, -25, -15; /M: SY='L'; M= 1, -20, 7, 8, 1, -21, -1, 5, 0, 16, 7, -10, -19, -4, -4, -7, -3, 3, -19, 5; /M: SY='K'; M= -10, -21, -6, 2, -6, -24, -10, 10, 17, 13, 8, -4, -19, -1, 14, -8, -3, 8, -22, -4; /M: SY='P'; M= 1, -24, 5, 11, -20, 10, -8, -17, 11, -13, -11, 7, 27, 1, 10, 1, -2, -16, -24, -11; /I: E1=0; IE=-200; DE=-200;» more |
Numerical results [info]
| Total number of hits | 31 in 31 different sequences |
| Number of true positive hits | 31 in 31 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 11 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 73.81 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | N_Hulo |
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | DOMAIN |
| Feature description [info] | Zinc-hook |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
31 sequences
BPS2_ACIAM (P32985), RAD50_AERPE (Q9YFZ1), RAD50_AQUAE (O67124), RAD50_ARATH (Q9SL02), RAD50_ARCFU (O29230), RAD50_CAEEL (O44199), RAD50_DICDI (Q54CS9), RAD50_DROME (Q9W252), RAD50_HALSA (Q9HRW3), RAD50_HALVD (D4GUK1), RAD50_HUMAN (Q92878), RAD50_METAC (Q8TRL1), RAD50_METJA (Q58718), RAD50_METKA (Q8TXI4), RAD50_METMA (Q8PUY4), RAD50_METMP (P62134), RAD50_METTH (O26640), RAD50_MOUSE (P70388), RAD50_PYRAB (Q9UZC8), RAD50_PYRFU (P58301), RAD50_PYRHO (O58687), RAD50_RAT (Q9JIL8), RAD50_SACS2 (Q97WH0), RAD50_SCHPO (Q9UTJ8), RAD50_SULAC (O33600), RAD50_SULTO (Q96YR5), RAD50_THEAC (Q9HLR8), RAD50_THEKO (Q5JHN1), RAD50_THEMA (Q9X1X1), RAD50_THEVO (P58302), RAD50_YEAST (P12753)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
11 sequences
RAD50_ENCCU (Q8SRK6), RAD50_NANEQ (P62135), RAD50_PLAF7 (C6KSQ6), SMC1_ARATH (Q6Q1P4), SMC21_ARATH (Q9C5Y4), SMC22_ARATH (Q9SN90), SMC3_ARATH (Q56YN8), SMC4_ARATH (Q9FJL0), SMC5_ARATH (Q9LFS8), SMC6A_ARATH (Q9FLR5), SMC6B_ARATH (Q9FII7)» more |
| PDB [Detailed view] |
3 PDB
1L8D; 5GOX; 6ZFF |