We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS51131

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PURL: https://purl.expasy.org/prosite/signature/PS51131

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General information about the entry

Entry name [info]	ZN_HOOK
Accession [info]	PS51131
Entry type [info]	MATRIX
Date [info]	01-JUN-2005 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51131
Associated ProRule [info]	PRU00471

Name and characterization of the entry

Description [info]

Rad50 zinc-hook domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=99;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=94;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1408157; R2=0.0047655; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=10870.6640625; R2=7.8042555; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1335; H_SCORE=21289; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=915; H_SCORE=18012; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-6; D=-100; I=-100; B1=-200; E1=-200; MI=-200; MD=-200; IM=-200; DM=-200;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-200; BD=-200;
/M: SY='L';  M=  -6, -21,   1,   2,   7, -15,  -4,  11,  -9,  12,   6,  -9,   3,  -7,  -6,   0,   2,   6, -21,   0;
/M: SY='E';  M=   1,  23,  11,  26, -21,  -9,  -7,  -9,   4,  -8,  -8,   5, -14,  15,  -4,   1,  -2,  -5, -29, -16;
/M: SY='D';  M=   4, -20,  25,  20, -20, -11,  -4, -21,  10, -18, -15,  11,  -2,   4,   2,  11,   7, -15, -26,  -5;
/M: SY='I';  M=  -5, -21,  -7, -12,  15, -26, -13,  22, -14,  20,  13, -13,  -9, -14, -18, -14,  -7,  16, -13,  16;
/M: SY='E';  M=  -8, -25,  27,  30, -26,  -2,  -3, -21,  14, -19, -16,  12,  -1,  10,  10,   3,  -4, -20, -30, -17;
/M: SY='E';  M=   2, -21,  23,  25, -21, -12,  -3, -17,   9, -18,  -9,  11, -12,  11,   2,   9,   3, -11, -28,  -8;
/M: SY='Y';  M=  -8, -22,   6,   9,  19, -20,  -3,  -8,  12,  -7,  -6,   2, -18,  -1,  10,  -4,   1,  -5,  -8,  25;
/M: SY='L';  M=  -9, -22,  -3,   3,  -2, -23, -11,  12,   2,  20,   7,  -6,  12,  -6,  -4, -11,  -7,   5, -20,   1;
/M: SY='D';  M=  -7, -24,  34,  30, -26, -14,  -2, -18,  15, -21, -12,  21, -11,  10,   2,  -1,   0, -16, -33, -17;
/M: SY='E';  M=  -3, -22,  18,  25, -18, -17,   6,  -7,   6,  -2,  -6,  13, -15,  10,   7,  -4,  -3,  -5, -30, -13;
/M: SY='L';  M=  -4, -18, -26, -19,   7, -27,  -3,  24, -16,  30,  18, -20, -25, -10, -18, -12,  -2,  18, -22,  -2;
/M: SY='E';  M=  -8, -24,   8,  26, -19, -17,  -2, -14,  18, -10,  -6,  11, -13,  20,  17,   1,   0, -15, -24,  -7;
/M: SY='E';  M=   0, -23,  17,  32, -26,  -9,  -4, -21,  16, -18, -14,  10, -10,  14,   7,   5,   1, -16, -28, -17;
/M: SY='E';  M=   1, -22,  12,  25, -24,  -8,  -6, -16,  19, -19, -13,   6, -11,   7,  17,   5,   5, -11, -28, -16;
/M: SY='L';  M=  -9, -23, -15,   4,  -3, -19, -14,  20,   3,  22,  13, -16, -20,  -2,   7, -15,  -9,  10, -21,  -7;
/M: SY='E';  M=  -6, -25,  25,  30, -25, -11,   7, -19,  17, -16, -14,  11, -12,  13,  10,   0,  -5, -16, -30, -15;
/M: SY='K';  M=  -1, -23,   8,  27, -24,  -9,  -5, -21,  28, -18, -13,   6, -11,  10,  15,   5,  -3, -15, -25, -16;
/M: SY='L';  M=  -2, -19, -21, -17,   6, -23,  -9,  15, -10,  27,  15,  -8, -26, -10,   4, -10,  -7,   8, -13,  15;
/M: SY='R';  M=  -5, -22,   8,  14, -22, -10,  11, -18,  18, -14, -10,  13, -14,  13,  23,   6,   7, -15, -28, -12;
/M: SY='K';  M=   0, -22,  15,  16, -15,   0,  -7, -11,  17, -15,  -7,   5, -13,  15,   6,   4,   2,  -7, -26, -13;
/M: SY='R';  M=   3, -22,   9,  17, -14, -14,  -5, -17,  18, -14, -10,   4, -14,  17,  22,   5,   2, -14, -24, -11;
/M: SY='L';  M=  -9, -22,  -8,   0,   3, -27,   5,  15,   4,  20,   9, -14, -22,  -5,  12, -14,  -8,  11, -23,  -4;
/M: SY='G';  M=   9, -20,   2,  14, -22,  23,   3, -17,   5, -14, -12,   3, -13,   1,   6,   8,  -1, -14, -26, -16;
/M: SY='E';  M=   3, -21,  18,  27, -24, -11,  -4, -15,   6, -19, -11,  17,   4,   8,   1,   9,   3, -10, -31, -17;
/M: SY='L';  M= -10, -18, -30, -23,   9, -31, -16,  24, -19,  39,  23, -26, -28, -17, -20, -20,  -6,  16, -19,   2;
/M: SY='K';  M=  -1, -23,   5,  22, -26, -12,  -1, -24,  24, -22,  -8,  19, -13,  21,  22,   4,  -3, -20, -26, -15;
/M: SY='W';  M=   9, -18,  -9,   4,   1,   5,  -8,  -7,  -3,  -5,   8,  -2, -16,  12,  -8,  11,   2,  -4,  14,   1;
/M: SY='H';  M=   2, -22,   7,  14, -21,  -8,  26, -18,  15, -13,  -9,   5, -14,   8,  24,   1,   3, -15, -29, -10;
/M: SY='E';  M=   0, -21,   0,  11, -14, -12,   0,   4,  11,   1,   2,  -1, -15,  10,   7,   3,   2,   0, -25, -10;
/M: SY='R';  M=   2, -21,  -2,   6, -16,  13,  -7, -11,   8, -11,  -2,   4, -15,   5,  18,   3,   8,  -8, -23,  -5;
/M: SY='E';  M=  -8, -22,   5,  22,  -3, -14,   5,  -3,   3,   5,   5,  -6, -15,   7,   2,  -2,   2,  -1, -22,  -1;
/M: SY='Y';  M= -11, -24, -22, -16,  13, -27,  -4,  13,  -1,  19,   9, -18, -26,  -8,   8, -15,  -8,   6,  20,  37;
/M: SY='E';  M=  -6, -25,  14,  27, -21, -18,  16, -15,  19, -10,  -6,   7, -13,  16,  13,  -1,  -6, -13, -28, -12;
/M: SY='K';  M=  -1, -21,   8,  14,   4,  -8,  -4, -16,  17, -12,  -2,  11, -15,  10,  10,   1,   0, -14, -19,   1;
/M: SY='Y';  M=   8, -18,  -9, -11,  17, -12,   7,  -1,   2,  -2,  -3,  15, -21,  -6,   2,  -1,  -2,  -2, -10,  21;
/M: SY='I';  M=  -8, -22, -23,  -9,   1, -30, -17,  30, -10,  23,  17, -20, -23,  -4,  -2, -16,  -7,  21, -21,   0;
/M: SY='E';  M=   2, -23,   9,  22, -23,  -3,  -7, -10,  16, -17,  -9,   6,   8,   8,  11,   0,  -1,  -9, -27, -16;
/M: SY='E';  M=   7, -20,   6,  22,  -3, -14,  -5,  -8,   8,  -3,   3,  10, -14,   8,   2,  -1,  -5,  -8, -23, -10;
/M: SY='L';  M=   2,   7, -17,  -7,   1, -20, -12,  12, -11,  28,  16,  -8, -23,  -9, -15,  -3,  -5,   6, -21,   0;
/I:         I=-28; MD=-56;
/M: SY='E';  M=  -6, -24,  14,  23, -23, -17,  -5, -20,  18, -22, -16,  12, -14,   6,  14,   3,  -1, -13, -28,  -9; D=-28;
/I:         I=-28; MI=-56; MD=-56; IM=-56; DM=-56;
/M: SY='E';  M=  -5, -24,   7,  18, -21, -18,  -7, -10,  14,  -8,  -9,   4, -16,  15,  11,   4,  -3,  -9, -28, -15; D=-28;
/I:         I=-28; DM=-56;
/M: SY='A';  M=  22, -15,   2,   4, -16,  -8, -12,   4,  -5,  -2,  -3,   3, -16,   0, -11,   8,   2,   5, -27, -14;
/M: SY='E';  M=  -9, -26,   1,  22, -15,   9,   6, -17,  17,  -9,  -6,   5,   7,   9,  14,  -5,  -9, -17, -24, -13;
/I:         I=-18; MD=-35;
/M: SY='G';  M=   0, -27,  13,   9, -31,  29,  10, -33,  -1, -28, -19,   6, -17,   9,   9,   0,  -9, -27, -31, -19; D=-18;
/I:         I=-18; MD=-35;
/M: SY='D';  M= -12, -29,  11,   9, -29,  -9, -13, -22,   4, -18, -14,   7, -22,  -4,  -1,  -1,  -5, -22, -38, -23; D=-18;
/I:         I=-18; MI=0; MD=-35; IM=0; DM=-35;
/M: SY='C';  M= -21,  54, -31, -24, -19, -36, -30, -13,   0, -20, -14, -22, -36, -21,  -2, -18,  -9,  -7, -43, -26; D=-18;
/I:         I=-18; DM=-35;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='P';  M= -83,-105, -83, -74, -85, -86,  -4, -87, -79, -42, -82, -21, 118,  -6, -88, -27, -76, -92, -86,  49;
/M: SY='V';  M= -76,  33, -93,  -1, -68,-100, -92,  11, -89,  53, -57, -92, -95, -87, -91, -84,  12,  68, -98, -77;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G';  M=  -2, -25,   6,  11, -29,  44,   1, -30,   4, -24, -17,   2, -14,  16,  -1,   5,  -9, -26, -24, -18;
/M: SY='R';  M=  -3, -25,  -7,   2, -25,  -4,  13, -25,  18, -21, -11,   4, -18,  23,  45,   3,   1, -20, -26, -10;
/M: SY='P';  M=  -3, -24,  12,  23, -25,  -9,   2, -14,  12, -21, -14,   8,  34,   4,  -2,   5,   0, -11, -29, -18;
/M: SY='F';  M= -15, -18, -33, -26,  40, -32, -16,  19, -25,  34,  20, -28, -31, -22, -22, -22, -11,  14,  -8,  16;
/M: SY='D';  M=  -5, -22,  25,  17, -26,   7,   3, -24,   7, -24, -17,  14,   5,   7,   5,   9,  12, -19, -32, -16;
/M: SY='D';  M=  -2, -24,  23,  21, -29,  19,  -7, -27,   4, -27, -20,   8,  21,   2,  -4,   8,   4, -22, -30, -20;
/M: SY='E';  M=  -4, -24,  33,  35, -28,  -8,   7, -25,  11, -24, -19,  13, -10,   8,  -1,   4,   2, -19, -33, -17;
/M: SY='H';  M=   1, -24,   5,  22, -21,  -5,  39, -23,  14, -20, -12,   0,   9,   6,   8,   1,  -1, -17, -27,  -2;
/M: SY='W';  M=   2, -22,  -6,  14,  -2, -19,  11,   3,  10,   1,   1,  -7, -15,   1,   6,  -1,  -2,   0,  16,  -5;
/I:         I=-22; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='N';  M=   3,   0,   3,  11, -25, -13,   1, -15,  10, -19,  -9,  13, -17,  10,   5,   6,   3,  -8, -32, -16; D=-22;
/I:         I=-22; DM=-44;
/M: SY='E';  M=  -9,  10,  25,  26, -28, -19,   3, -29,  18, -22, -19,   7, -15,   6,  13,  -2,  -7, -24, -33, -18; D=-22;
/I:         I=-22; DM=-44;
/M: SY='F';  M= -12, -21, -31, -26,  30, -33, -23,  22, -18,  23,  10, -25, -29, -22, -15, -19,  -6,  17, -15,   4; D=-22;
/I:         I=-22; DM=-44;
/M: SY='I';  M=  -3, -21, -15, -18,  -5, -26, -19,  21, -12,  16,  14, -13, -24, -10,  -9,  -9,  -2,  18, -28,  -9; D=-22;
/I:         I=-22; DM=-44;
/M: SY='E';  M=   2, -21,   9,  25, -25,  -7,   6, -21,  20, -22, -14,  10, -11,  11,  13,   9,   3, -17, -28, -15;
/M: SY='H';  M= -11, -27,  28,  30, -27, -18,  36, -30,  21, -24, -16,   5, -11,  12,  17,  -2,  -4, -25, -32,  -9;
/M: SY='Y';  M=  -5,  26, -10, -11,   7, -15,  10,   8, -13,  17,   7, -14, -25,  -2,  -9, -11,  -6,   4,  -9,  27;
/M: SY='R';  M=  -8, -24,   2,  20, -16,  -6,  13, -15,  20, -18, -10,   9, -13,  19,  21,   2,   2, -15, -25, -10;
/M: SY='E';  M=   1, -19,  21,  21, -20, -12,   9, -13,   4,  -8, -10,  10, -12,   3,  -2,  11,   8,  -8, -32, -13;
/M: SY='E';  M=  -7, -26,  11,  32, -23, -20,   7, -23,  26, -17,  -2,  -1, -10,  16,  21,  -4,  -4, -19, -24,  -8;
/M: SY='C';  M=  -2,  21, -21, -16,  -1, -25, -17,  19,  -3,  20,  11, -14, -21, -12,  -7,  -8,   8,  14, -22,  -1;
/M: SY='D';  M=  -2, -22,  21,  20, -22,  -6,  -3, -15,  16, -11, -11,  17, -14,  11,  10,   4,  -3, -15, -29, -15;
/I:         I=-18; MI=0; MD=-35; IM=0; DM=-35;
/M: SY='R';  M=  -3, -22,   3,  11, -22,  -2,  -6, -16,  14, -13, -11,  11, -17,   8,  17,  10,  -2, -11, -29, -15; D=-18;
/I:         I=-18; DM=-35;
/M: SY='L';  M= -10, -20, -28, -22,  23, -30, -20,  21, -11,  28,  13, -22, -27, -18, -17, -15,  -4,  13, -16,   2; D=-18;
/I:         I=-18; DM=-35;
/M: SY='P';  M=  -2, -28,  17,  29, -27,  -9,  -4, -26,   8, -25, -17,   3,  39,  14,   8,   0,  -6, -23, -26, -13;
/M: SY='E';  M=   3, -21,  20,  22, -24,  -7,  -5, -18,  19, -16, -13,  11, -12,   6,   7,   8,   3, -15, -28, -16;
/M: SY='E';  M=  -3, -24,  19,  33, -26, -17,   6, -24,  16, -18, -14,   6, -10,  20,  14,   1,   3, -19, -29, -15;
/M: SY='L';  M=  -9, -21, -19,  -7,   2, -27, -12,  21,  -5,  26,  19, -12, -23,  -2,  -1, -12,  -7,  12, -19,   1;
/M: SY='E';  M=   9, -21,  13,  27, -23, -13,  -4, -23,  22, -22, -14,   9, -11,  10,  13,   1,   0, -16, -24,  -8;
/M: SY='E';  M=  -3, -24,  26,  28, -22, -16,   5, -19,  14, -20, -15,   5, -12,  10,  14,   3,   2, -14, -27,  -7;
/M: SY='L';  M=   0, -16, -21, -14,   5, -24, -19,  20, -13,  25,  12, -15, -20, -14, -18,  -5,  11,  15, -23,  -5;
/M: SY='E';  M=  -2, -23,  19,  28, -16, -18,  -4, -12,  14,  -4,  -8,   4, -13,   9,   8,  -2,  -3, -10, -24,  -6;
/M: SY='E';  M=   0, -20,  12,  14, -18, -13,  -6,  -7,  14,  -7,  -8,  14, -14,   6,  10,   6,   4,  -5, -29, -14;
/M: SY='E';  M=  -4, -25,  21,  35, -23, -19,   7, -17,  14, -11, -11,   2, -10,  14,  10,  -3,  -1, -13, -29, -14;
/M: SY='I';  M=  -5,   4, -14,   6,  -1, -26,  -4,  18,  -4,  17,  10, -16, -21,  -1,  -3, -10,  -7,  13, -19,   5;
/M: SY='K';  M=   2, -21,   7,  17, -26, -10,  -3, -23,  26, -22,  -9,  14, -13,  17,  19,  10,  -1, -19, -26, -14;
/M: SY='K';  M=   0, -21,  11,  19, -23, -13,  -3, -17,  21, -12, -10,  17, -13,  17,   9,   4,   2, -13, -27, -15;
/M: SY='L';  M=  -4, -21, -15, -12,   7, -25,  -9,  16,  -6,  24,  15, -18, -24,  -9,  -1, -11,  -8,  10, -11,  21;
/M: SY='R';  M=  -3, -23,  11,  19, -19,  -9,  -5, -14,  18,  -5,  -8,   8, -15,   8,  21,  -1,  -1, -13, -26, -14;
/M: SY='K';  M=   7, -21,   6,  11, -21,  -7,   8,  -6,  18, -14,  -6,   7, -14,  14,  11,   3,  -3,  -5, -26, -12;
/M: SY='E';  M=  -6, -23,  17,  24, -13, -16,   8, -19,  20, -13, -12,  10, -13,  11,  16,   2,  -1, -15, -27, -11;
/M: SY='L';  M= -11, -21, -24, -12,  24, -30, -13,  19,  -7,  25,  14, -21, -26, -13,   0, -17,  -9,  14, -11,  15;
/M: SY='R';  M=  -8, -24,  19,  19, -25,  -8,  -3, -17,  18, -20, -14,  13, -15,  13,  28,   2,  -2, -13, -29, -15;
/M: SY='R';  M=   1, -22,   5,  17, -23, -13,   5, -18,  21, -15, -10,  11, -14,  17,  22,   6,   0, -15, -26, -13;
/M: SY='L';  M=  -6,   0, -29, -23,  12, -19, -17,  23, -22,  33,  19, -24, -28, -13, -21, -18,  -8,  18, -17,   7;
/M: SY='E';  M=  -5, -24,  14,  27, -17, -18,  -4,  -7,  14,  -6,  -7,   8, -13,  13,   9,   0,  -4,  -7, -25,  -8;
/M: SY='K';  M=   1, -23,  11,  17, -26,   1,  -6, -21,  25, -22, -11,   4,  -2,  15,  13,   8,  -3, -18, -25, -15;
/M: SY='L';  M=   1, -20,   7,   8,   1, -21,  -1,   5,   0,  16,   7, -10, -19,  -4,  -4,  -7,  -3,   3, -19,   5;
/M: SY='K';  M= -10, -21,  -6,   2,  -6, -24, -10,  10,  17,  13,   8,  -4, -19,  -1,  14,  -8,  -3,   8, -22,  -4;
/M: SY='P';  M=   1, -24,   5,  11, -20,  10,  -8, -17,  11, -13, -11,   7,  27,   1,  10,   1,  -2, -16, -24, -11;
/I:         E1=0; IE=-200; DE=-200;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	33 in 33 different sequences
Number of true positive hits	33 in 33 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	12
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	73.33 %

Comments [info]

Taxonomic range [info]	Archaea, Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	N_Hulo
Feature key [info]	DOMAIN
Feature description [info]	Zinc-hook
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

33 sequences

BPS2_ACIAM  (P32985), RA50L_XENLA (A0A1L8GXM0), RA50S_XENLA (A0A1L8GVF0),

RAD50_AERPE (Q9YFZ1), RAD50_AQUAE (O67124), RAD50_ARATH (Q9SL02), 
RAD50_ARCFU (O29230), RAD50_CAEEL (O44199), RAD50_DICDI (Q54CS9), 
RAD50_DROME (Q9W252), RAD50_HALSA (Q9HRW3), RAD50_HALVD (D4GUK1), 
RAD50_HUMAN (Q92878), RAD50_METAC (Q8TRL1), RAD50_METJA (Q58718), 
RAD50_METKA (Q8TXI4), RAD50_METMA (Q8PUY4), RAD50_METMP (P62134), 
RAD50_METTH (O26640), RAD50_MOUSE (P70388), RAD50_PYRAB (Q9UZC8), 
RAD50_PYRFU (P58301), RAD50_PYRHO (O58687), RAD50_RAT   (Q9JIL8), 
RAD50_SACS2 (Q97WH0), RAD50_SCHPO (Q9UTJ8), RAD50_SULAC (O33600), 
RAD50_SULTO (Q96YR5), RAD50_THEAC (Q9HLR8), RAD50_THEKO (Q5JHN1), 
RAD50_THEMA (Q9X1X1), RAD50_THEVO (P58302), RAD50_YEAST (P12753)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

12 sequences

RAD50_CHATD (G0SHW7), RAD50_ENCCU (Q8SRK6), RAD50_NANEQ (P62135),

RAD50_PLAF7 (C6KSQ6), SMC1_ARATH  (Q6Q1P4), SMC21_ARATH (Q9C5Y4), 
SMC22_ARATH (Q9SN90), SMC3_ARATH  (Q56YN8), SMC4_ARATH  (Q9FJL0), 
SMC5_ARATH  (Q9LFS8), SMC6A_ARATH (Q9FLR5), SMC6B_ARATH (Q9FII7)

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PDB
[Detailed view]

6 PDB

pdb_00001l8d; pdb_00005gox; pdb_00006zff; pdb_00007zqy; pdb_00007zr1; pdb_00009bi4