PROSITE entry PS51137

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51137
Entry name [info]	VM
Accession [info]	PS51137
Entry type [info]	MATRIX
Date [info]	01-JUN-2005 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51137
Associated ProRule [info]	PRU00483

Name and characterization of the entry

Description [info]

VM domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=38;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=35;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.8932132; R2=0.0075220; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3012.3496094; R2=3.5786853; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=879; H_SCORE=6158; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=613; H_SCORE=5206; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-200; E1=-200; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='G';  M=  6, -4,-19, -4, -9,-24, 31,-14,-29,-14,-30,-20,  6,-14, -9,-14, 22,  2,-19,-31,-24, -9;
/M: SY='Y';  M=-14,-26,-30,-31,-26, 13,-36, -8, 28,-21, 11, 11,-20,-24,-16,-21,-20,-10, 12,  2, 36,-26;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='A';  M= 38, -7,-10,-14, -7,-20,  0,-17,-13,-10,-16,-13, -4,-10, -7,-17, 19,  6, -3,-26,-20, -7;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='K';  M= -6,  0,-21, -4,  1,-21,-20,-14,-21, 23,-21,-10,  0,-10,  1, 12,  3, 17,-11,-24,-10,  1;
/M: SY='N';  M=-10, 40,-20, 20,  0,-20,  0, 10,-20,  0,-30,-20, 60,-20,  0,  0, 10,  0,-30,-40,-20,  0;
/M: SY='Y';  M=-20,-20,-30,-20,-20, 30,-30, 20,  0,-10,  0,  0,-20,-30,-10,-10,-20,-10,-10, 30, 80,-20;
/M: SY='L';  M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='F';  M=-20,-30,-20,-40,-30, 80,-30,-20,  0,-30, 10,  0,-20,-30,-40,-20,-20,-10,  0, 10, 30,-30;
/M: SY='S';  M= 10,  0,-10,  0,  0,-20,  0,-10,-20,-10,-30,-20, 10,-10,  0,-10, 40, 20,-10,-40,-20,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q';  M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='N';  M= -4, 28,-17, 14,  0,-20,  0,  4,-20, -3,-30,-20, 46,-17,  0, -3, 19,  6,-24,-40,-20,  0;
/M: SY='L';  M=-10,-30,-20,-30,-20, 10,-30,-20, 20,-30, 50, 20,-30,-30,-20,-20,-30,-10, 10,-20,  0,-20;
/M: SY='A';  M= 33, -7,-16,-14, -1,-26, -6,-11,-13, -4,-13, -7, -7,-10, 10,-11,  7, -3, -9,-20,-17,  4;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='V';  M= 22,-21,-10,-26,-21, -9,-17,-26, 12,-16,  1,  1,-21,-21,-21,-20, -1,  0, 28,-26,-14,-21;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='A';  M= 28, -4,-10, -9, -4,-20,  0,-14,-16,-10,-21,-16,  1,-10, -4,-14, 27, 11, -6,-31,-20, -4;
/M: SY='A';  M= 23, -6,-19,-11,  3,-29, -9, -7,-14, -1,-14, -6, -6,-10, 21, -7,  6, -4,-13,-20,-16, 12;
/M: SY='P';  M=-10, -7,-36,  3, 27,-30,-20,-11,-24, -1,-26,-20,-11, 50,  3,-11, -6,-10,-30,-30,-26, 12;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='P';  M=-10,-14,-37, -7,  6,-33,-20,-11,-20, -4,-27,-14,-14, 61, 10,-11, -7,-10,-30,-27,-24,  4;
/M: SY='A';  M= 28, -4,-10, -9, -4,-20,  0,-14,-16,-10,-21,-16,  1,-10, -4,-14, 27, 11, -6,-31,-20, -4;
/M: SY='Y';  M=-20,-20,-30,-20,-20, 30,-30, 20,  0,-10,  0,  0,-20,-30,-10,-10,-20,-10,-10, 30, 80,-20;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='S';  M= 10,  0,-10,  0,  0,-20,  0,-10,-20,-10,-30,-20, 10,-10,  0,-10, 40, 20,-10,-40,-20,  0;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='G';  M= -5,-10,-30,-10,-15,-28, 48,-15,-38, -8,-28,-18,  0,-20,-13,  2, -2,-18,-28,-20,-25,-15;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='Y';  M=-20,-20,-30,-20,-20, 30,-30, 20,  0,-10,  0,  0,-20,-30,-10,-10,-20,-10,-10, 30, 80,-20;
/M: SY='T';  M=  6,  0,-10, -4, -4,-16, -9,-14,-16,-10,-21,-16,  6,-10, -4,-10, 31, 33, -6,-36,-16, -4;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	15 in 15 different sequences
Number of true positive hits	15 in 15 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	3
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	83.33 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	VM
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

15 sequences

VTU1_DROME  (P11449), VTU2_DROME  (P13238), VTU3_DROME  (Q06521),

VTU4_DROAN  (B3MMW0), VTU4_DROER  (B3N4J9), VTU4_DROMA  (A4UM12), 
VTU4_DROME  (Q9VKI3), VTU4_DROPE  (B4G9V0), VTU4_DROPS  (Q29M30), 
VTU4_DROSE  (A4UM15), VTU4_DROSI  (A4UM14), VTU4_DROSN  (A4UM16), 
VTU4_DROTE  (A4UM19), VTU4_DROYA  (B4P184), VTUL_DROME  (A8JUV4)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

3 sequences

V15A1_AEDAE (Q16KE2), V15A2_AEDAE (P19425), V15A3_AEDAE (Q16G12)