PROSITE documentation PDOC51137
VM domain profile


In Drosophila melanogaster the vitelline membrane (VM) is the first layer of the eggshell produced by the follicular epithelium. It is composed of at least four different proteins. VM proteins are similarly organized with a central highly conserved 38-amino acid domain which is flanked by unrelated regions. Since the surrounding regions have diverged significantly, it is possible that the VM domain is of key importance in VM protein structure [1,2].

The profile we developed covers the entire VM domain.

Last update:

June 2005 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

VM, PS51137; VM domain profile  (MATRIX)


1AuthorsScherer L.J. Harris D.H. Petri W.H.
TitleDrosophila vitelline membrane genes contain a 114 base pair region of highly conserved coding sequence.
SourceDev. Biol. 130:786-788(1988).
PubMed ID3143615

2AuthorsScherer L.J. Harris D.H. White M.K. Steel L.F. Jin J. Petri W.H.
TitleComparative analysis of the sequence and structure of two Drosophila melanogaster genes encoding vitelline membrane proteins.
SourceGene 136:121-127(1993).
PubMed ID8293994

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