PROSITE

Home | Contact

	Home ScanProsite ProRule Documents Downloads Links Funding
	Entry: PS51150

General information about the entry

Entry name [info]

AGOUTI_2

Accession [info]

PS51150

Entry type [info]

MATRIX

Date [info]

01-OCT-2005 CREATED;
10-MAY-2017 DATA UPDATE;
10-FEB-2021 INFO UPDATE.

PROSITE Doc. [info]

PDOC60024

Associated ProRule [info]

PRU00494

Name and characterization of the entry

Description [info]

Agouti domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=40;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=36;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7000277; R2=0.0052378; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2728.9633789; R2=3.2879581; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1108; H_SCORE=6372; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=726; H_SCORE=5116; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-11; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='V';  M=  0,-30,-10,-30,-30,  0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10,  0, 50,-30,-10,-30;
/M: SY='A';  M= 28,-10,-16,-17, -7,-20, -6,-14,-16,  3,-13,-10, -7,-13, -4,  8,  4, -3, -6,-20,-17, -7;
/M: SY='T';  M= -4, -5,-14,-13,-12, -5,-21,-16, -2,-15,  7, -2, -2,-17,-12,-12,  3, 25,  0,-28, -8,-12;
/M: SY='R';  M=-17,-16,-27,-16, -6,-11,-23, -6,-14, 11,  2, -1, -9,-23,  1, 42,-16,-10,-11,-20, -7, -6;
/M: SY='D';  M=-15, 35,-28, 43, 28,-32,-11,  2,-32,  3,-27,-25, 23, -9,  6, -5,  2, -8,-30,-37,-20, 17;
/M: SY='S';  M= 10,  0,-10,  0,  0,-20,  0,-10,-20,-10,-30,-20, 10,-10,  0,-10, 40, 20,-10,-40,-20,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='K';  M=-10, -9,-27, -9,  1,-17,-23,-13,-14, 25, -5, -1, -9,-16,  1, 14,-16,-10,-11,-20, -7,  1;
/M: SY='P';  M= -4,-14,-32, -8, -6,-28, 11,-18,-26,-13,-30,-20, -9, 40,-12,-18,  1, -9,-27,-28,-28,-12;
/M: SY='P';  M=-13,-14,-37, -7,  0,-27,-20, 18,-23,-10,-27,-14,-11, 55, -4,-14,-10,-13,-30,-30,-14, -7;
/M: SY='A';  M= 31, -7,-16,-14, -1,-26, -6,-11,-13, -4,-13, -7, -7,-10, 12,-11,  7, -3, -9,-20,-17,  6;
/M: SY='P';  M=-10,-24,-35,-22,-12,-16,-27,-23,  7,-19, -5, -3,-21, 41,-14,-23,-15,-10, -6,-26,-17,-17;
/M: SY='A';  M= 31,-13,-19,-17, -7,-23, -6,-20,-13,-10,-16,-13,-13, 22,-10,-20,  4, -3, -9,-23,-23,-10;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='D';  M=-19, 49,-29, 64, 18,-38, -9,  1,-38,  0,-30,-29, 25,-11,  0, -9,  1, -9,-30,-40,-20,  9;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='S';  M=  2, -5,-12,-10, -8,  0,-11,-15,-13,-13,-17,-13,  2,-13,-10,-12, 24, 24, -5,-28, -8, -8;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q';  M=-13, -6,-30, -6,  7,-18,-23, 13,-14,  4,-14,  0, -6,-16, 38,  4, -6,-10,-24, -4, 18, 21;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='F';  M=-20,-30,-20,-40,-30, 80,-30,-20,  0,-30, 10,  0,-20,-30,-40,-20,-20,-10,  0, 10, 30,-30;
/M: SY='F';  M=-20,-30,-20,-40,-30, 80,-30,-20,  0,-30, 10,  0,-20,-30,-40,-20,-20,-10,  0, 10, 30,-30;
/M: SY='R';  M=-14,  6,-27, -1, -3,-22,  1,  0,-28, 13,-25,-15, 19,-20,  2, 33, -2, -8,-25,-26,-16, -3;
/M: SY='S';  M= 23, -3,-10, -6, -3,-20,  0,-13,-17,-10,-24,-17,  4,-10, -3,-13, 31, 14, -7,-34,-20, -3;
/M: SY='A';  M= 26,-16,-13,-25,-16, 12, -9,-19, -7,-16, -5, -7,-12,-16,-19,-19,  2, -2, -1,-12, -4,-16;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='T';  M= -3, -6,-16, -9, -9, -1,-16, -4,-11,-10,-14,-11, -3,-16, -6,-10, 15, 20, -7,-15, 15, -9;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='R';  M=-20,-10,-30,-10,  0,-20,-20,  0,-30, 30,-20,-10,  0,-20, 10, 70,-10,-10,-20,-20,-10,  0;
/M: SY='V';  M= -3,-21,-16,-21,-17, -9,-27,-24, 11,  2, -3,  4,-21,-24,-17, -4,-10, -3, 28,-27,-10,-17;
/M: SY='L';  M=-10,-30,-23,-33,-23,  7,-33,-23, 29,-30, 41, 20,-27,-27,-20,-23,-27,-10, 16,-20,  0,-23;
/M: SY='N';  M=  2, 16,-14,  7, -1,-19, -1, -3,-19, -6,-29,-19, 29,-14, -1, -6, 27, 14,-17,-39,-19, -1;
/M: SY='P';  M= -8,-14,-28,-11, -5,-20,-21,-19,-15, -9,-17,-13,-13, 42, -9,-11, -2,  9,-17,-29,-20,-10;
/M: SY='T';  M= -3,  9,-14, -2, -6,-14,-14,-11,-15, -5,-17,-13, 15,-13, -5, -2, 17, 31, -9,-32,-13, -6;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/I:         E1=0; IE=-105; DE=-105;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2021_01 which contains 564'277 sequence entries.

Total number of hits

48 in 48 different sequences

Number of true positive hits

48 in 48 different sequences

Number of 'unknown' hits

Number of false positive hits

Number of false negative sequences

Number of 'partial' sequences

Precision (true positives / (true positives + false positives))

100.00 %

Recall (true positives / (true positives + false negatives))

82.76 %

Comments [info]

Matrix type [info]

protein_domain

Scaling database [info]

reversed

Author [info]

CJA_Sigrist

Taxonomic range [info]

Eukaryotes

Maximum number of repetitions [info]

Feature key [info]

DOMAIN

Feature description [info]

Agouti

Version [info]

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

48 sequences

AGRP_BOVIN  (P56413    ), AGRP_HUMAN  (O00253    ), AGRP_MOUSE  (P56473    ),

AGRP_PIG    (Q9TU18    ), ASIP_BOVIN  (Q29414    ), ASIP_CALGE  (A1YL78    ), 
ASIP_CALGO  (A1YL80    ), ASIP_CALJA  (A1YL77    ), ASIP_CALPY  (A1YL79    ), 
ASIP_CANLF  (Q5UK76    ), ASIP_CERMI  (Q1XGU9    ), ASIP_CHLAE  (Q1XGV1    ), 
ASIP_COLPO  (Q1XGU5    ), ASIP_ERYPA  (Q1XGV0    ), ASIP_FELCA  (Q865F0    ), 
ASIP_GORGO  (Q1XGV5    ), ASIP_HORSE  (Q95MP2    ), ASIP_HUMAN  (P42127    ), 
ASIP_LEOCY  (A1YL81    ), ASIP_LEORO  (A1YL82    ), ASIP_MACAR  (A8CEM9    ), 
ASIP_MACAS  (A8CEN3    ), ASIP_MACCY  (A8CEM1    ), ASIP_MACFA  (Q1XGV3    ), 
ASIP_MACFU  (A8CEM0    ), ASIP_MACHE  (A8CEM5    ), ASIP_MACMR  (A8CEM4    ), 
ASIP_MACMU  (A1YL67    ), ASIP_MACNE  (A1YL69    ), ASIP_MACNG  (A1YL68    ), 
ASIP_MACNR  (A8CEM7    ), ASIP_MACRA  (Q1XGV2    ), ASIP_MACSI  (A8CEN1    ), 
ASIP_MACSL  (A8CEM8    ), ASIP_MACSY  (A1YL66    ), ASIP_MOUSE  (Q03288    ), 
ASIP_PANPA  (Q1XGV6    ), ASIP_PANTR  (Q1XGV7    ), ASIP_PAPAN  (A1YL70    ), 
ASIP_PIG    (Q6ZYM3    ), ASIP_PONPY  (Q1XGV4    ), ASIP_RAT    (Q99JA2    ), 
ASIP_SEMEN  (Q1XGU8    ), ASIP_TRAAU  (A1YL72    ), ASIP_TRACR  (Q1XGU6    ), 
ASIP_TRAFR  (A1YL74    ), ASIP_TRAOB  (Q1XGU7    ), ASIP_VULVU  (P79407    )

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

10 sequences

TXD01_LYCSI (B6DD19    ), TXD02_LYCSI (B6DD20    ), TXD03_LYCSI (B6DD21    ),

TXD04_LYCSI (B6DD22    ), TXD05_LYCSI (B6DD23    ), TXD06_LYCSI (B6DD24    ), 
TXD07_LYCSI (B6DD25    ), TXD08_LYCSI (B6DD26    ), TXD09_LYCSI (B6DD27    ), 
TXD10_LYCSI (B6DD28    )

» more

PDB
[Detailed view]

6 PDB

1HYK; 1MR0; 1Y7J; 1Y7K; 2KZA; 2L1J

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission