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PROSITE entry PS51200


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General information about the entry

Entry name [info] SHORT_SCORPION_CHLORIDE
Accession [info] PS51200
Entry type [info] MATRIX
Date [info] 01-APR-2006 CREATED;
10-MAY-2017 DATA UPDATE;
27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51200
Associated ProRule [info] PRU00545

Name and characterization of the entry

Description [info] Scorpion short toxin chloride channel inhibitor subfamily profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=32;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=29;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.8006358; R2=0.0062994; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3376.4003906; R2=1.3626834; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=747; H_SCORE=4394; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=429; H_SCORE=3961; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-64; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='M';  M= -74, -92, -84, -78, -87,  54, -79, -80,  52, -76,  99, -74,  42, -73, -72,   3, -77, -82, -92, -82;
/M: SY='P';  M= -84,-109, -84, -73,-104, -86, -87, -91, -80,-102, -88, -91, 131, -84, -93, -81, -76, -97, -97,-101;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='F';  M= -93, -89,-106,-101, 126,-100, -85, -66, -96, -58, -68, -94,-104,-107, -93, -92, -85, -72, -58, -36;
/M: SY='T';  M= -70, -79, -75, -78, -85, -86, -85, -76, -75, -81, -77, -64, -76, -79, -83, -53, 120, -68,-106, -83;
/M: SY='T';  M= -70, -80, -75, -76, -86, -86, -85, -77,   6, -82, -78, -64, -77, -77, -78, -54, 117, -69,-104, -83;
/M: SY='D';  M= -85, -97, 113, -53,-103, -81, -69,-102, -67,-101, -97,  43, -86, -70,  23, -72, -74, -99,-116, -87;
/M: SY='P';  M= -14,-105, -81, -71,-100, -85,  67, -92, -78, -97, -84, -83, 118,  23, -85, -78, -77, -95, -99, -89;
/M: SY='Q';  M= -79, -96,  27,  10, -94, -80, -64, -93, -62, -92, -80,  73, -86, 107, -65, -67, -75, -95, -93,  20;
/M: SY='M';  M= -76, -84, -91, -86, -73, -91, -75, -59, -81, -54, 136, -79, -84, -76, -82, -74,  69, -62, -95, -71;
/M: SY='A';  M=  59, -86, -69,  58, -95, -75, -77, -89, -70, -89, -83, -71, -80,  41, -75,  52,  10, -80, -96, -87;
/M: SY='K';  M=  41, -91, -75, -65, -96, -80, -75, -93,  76, -92, -81,   9, -84,  39,  47,  -1, -73, -86, -93, -84;
/M: SY='K';  M= -81, -96,  35, -57, -98, -87, -73, -97, 100, -95, -84, -64, -82,  39,  16, -74, -76, -94, -93, -83;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='R';  M=  60, -89,  -4, -72, -86, -79, -74, -90, -59, -88, -81, -74, -88, -66,  84,  20, -74, -82, -89,  25;
/M: SY='D';  M=   8, -93,  93,  40, -99, -83, -74, -96,  27, -95, -91, -61, -81, -67, -72, -69,  34, -89,-107, -87;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='G';  M= -68, -94, -81, -89,-100, 102, -87,-107,  17,-103, -92, -67, -85, -81, -85, -67, -85,-101, -91, -94;
/M: SY='G';  M= -68, -95, -82, -90,-100, 102, -86,-107, -79,-102, -91, -68, -86, -81,  25, -68, -85,-101, -91, -93;
/M: SY='R';  M= -81, -96, -77, -70, -90,  -6, -75,  24,  64, -86, -78,  23, -88, -63,  85, -76, -78, -81, -93, -82;
/M: SY='G';  M= -70, -94, -79, -82, -99,  94, -85,-105,  57,-101, -90, -67, -84, -76, -73, -69, -83, -99, -91, -92;
/M: SY='K';  M= -80, -97, -78, -68, -80,  21, -72, -94,  84, -91, -81, -71, -86, -63,  60, -76, -79, -91, -80,  59;
/I:         I=-28; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='F';  M=  25, -89, -93, -87,  94, -91, -78, -69,  28, -67, -70, -86, -96, -86, -79, -81, -79,   2, -64,  65;
/M: SY='G';  M= -65, -92, -80, -90, -99,  99, -86,-105, -85,-102, -92, -67, -85, -81, -92,  35, -79, -98, -92, -93;
/I:         I=-30; MD=-77;
/M: SY='P';  M= -89,-112, -89, -79, -86, -91, -84, -92, -85, -99, -88, -94, 119, -87, -94, -85, -81, -97, -86,  59; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='Q';  M= -77,-102, -72, -51,-107, -85, -65, -93, -57, -88, -75, -67, -84, 136, -57, -66, -79, -95, -90, -78;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='L';  M= -84, -90,-103, -97, -61,-105, -92,  71, -96,  77, -48, -98, -98, -90, -95, -94, -79, -48, -89, -72;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         E1=0; IE=-255; DE=-255;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.


Total number of hits 20 in 20 different sequences
Number of true positive hits 20 in 20 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
20 sequences

CTX5A_MESEU (P15222), CTXI1_MESEU (P15220), CTXI3_MESEU (P60268), 
CTXI4_MESEU (P60269), CTXI5_MESEU (P60270), CTXL1_HOTTS (P15229), 
CTXL1_LEIHE (P85066), CTXL1_MESEU (P86402), CTXL1_PARSC (P60271), 
CTXL2_MESEU (F1DI80), CTXL3_HOTTA (P83400), CTXL8_LEIHE (P55966), 
CTXLB_MESMA (Q9BJW4), CTXL_ANDAU  (P86436), CTXL_ANDMA  (P01498), 
CTXL_HOTTA  (P81761), CTXL_HOTTS  (P59887), CTXL_LEIQU  (P45639), 
CTXL_MESEU  (P86401), CTXL_MESMA  (Q9UAD0)
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PDB
[Detailed view]
10 PDB

1CHL; 1SIS; 5L1C; 6ATW; 6AVA; 7SOH; 7X41; 7X43; 7X44; 7X4D