ProRule PRU00545
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00545 |
| Accession | PRU00545 |
| Dates | 2-JUN-2006 (Created)
3-JUN-2021 (Last updated, Version 10) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51200; SHORT_SCORPION_CHLORIDE |
Name | Scorpion short toxin chloride channel inhibitor subfamily |
| Function | Short scorpion toxin chloride channel inhibitors are short-chain neurotoxins (SCNs), which block small-conductance chloride channels. They are 30-40-residue long and contain four intramolecular disulfide bridges, which have been assigned as C1-C4, C2-C6, C3-C7 and C5-C8. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P15229 (CTXL1_HOTTS); |
Propagated annotation
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Comments
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| FUNCTION | Probable chloride channel ligand, which blocks small- conductance chloride channels. |
| SUBCELLULAR LOCATION | Secreted. |
| SIMILARITY | Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family. |
Keywords
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| Secreted | |
| Voltage-gated chloride channel impairing toxin | |
| Chloride channel impairing toxin | |
| Ion channel impairing toxin | |
| Neurotoxin | |
| Toxin | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0019869; Molecular function:chloride channel inhibitor activity |
| GO:0008200; Molecular function:ion channel inhibitor activity |
Features
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| From: PS51200 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 1 | 18 | disulf | C-x*-C | ||||||||
| DISULFID | 4 | 25 | disulf | C-x*-C | ||||||||
| DISULFID | 15 | 30 | disulf | C-x*-C | ||||||||
| DISULFID | 19 | 32 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 20-35 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [20] All [ 20 ]
- Retrieve set of proteins with 3D structure for this domain