We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00545
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00545
General rule information
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| Accession | PRU00545 |
| Dates | 02-JUN-2006 (Created)
03-JUN-2021 (Last updated, Version 11) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51200; SHORT_SCORPION_CHLORIDE |
Name | Scorpion short toxin chloride channel inhibitor subfamily |
| Function | Short scorpion toxin chloride channel inhibitors are short-chain neurotoxins (SCNs), which block small-conductance chloride channels. They are 30-40-residue long and contain four intramolecular disulfide bridges, which have been assigned as C1-C4, C2-C6, C3-C7 and C5-C8. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P15229; |
Propagated annotation
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Comments
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| FUNCTION | Probable chloride channel ligand, which blocks small- conductance chloride channels. |
| SUBCELLULAR LOCATION | Secreted. |
| SIMILARITY | Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family. |
Keywords
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| Secreted | |
| Voltage-gated chloride channel impairing toxin | |
| Chloride channel impairing toxin | |
| Ion channel impairing toxin | |
| Neurotoxin | |
| Toxin | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Gene Ontology
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| GO:0019869; Molecular function:chloride channel inhibitor activity |
| GO:0008200; Molecular function:ion channel inhibitor activity |
Features
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| From: PS51200 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DISULFID | 1 | 18 | disulf | C-x*-C | ||||||||
| DISULFID | 4 | 25 | disulf | C-x*-C | ||||||||
| DISULFID | 15 | 30 | disulf | C-x*-C | ||||||||
| DISULFID | 19 | 32 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 20-35 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
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UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [20] All [ 20 ]
- Retrieve set of proteins with 3D structure for this domain