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ProRule PRU00545


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PURL: https://purl.expasy.org/prosite/rule/PRU00545
General rule information [?]

Accession PRU00545
Dates 02-JUN-2006 (Created)
03-JUN-2021 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51200; SHORT_SCORPION_CHLORIDE
Name Scorpion short toxin chloride channel inhibitor subfamily
Function Short scorpion toxin chloride channel inhibitors are short-chain neurotoxins (SCNs), which block small-conductance chloride channels. They are 30-40-residue long and contain four intramolecular disulfide bridges, which have been assigned as C1-C4, C2-C6, C3-C7 and C5-C8.
Scope(s) Eukaryota
Metazoa
Example(s) P15229 (CTXL1_HOTTS);

Propagated annotation [?]

Comments [?]

FUNCTIONProbable chloride channel ligand, which blocks small- conductance chloride channels.
SUBCELLULAR LOCATIONSecreted.
SIMILARITYBelongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.

Keywords [?]

Secreted
Voltage-gated chloride channel impairing toxin
Chloride channel impairing toxin
Ion channel impairing toxin
Neurotoxin
Toxin
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0019869; Molecular function:chloride channel inhibitor activity
GO:0008200; Molecular function:ion channel inhibitor activity

Features [?]

From: PS51200
Key From To Description Tag Condition FTGroup
DISULFID 1 18 disulf C-x*-C
DISULFID 4 25 disulf C-x*-C
DISULFID 15 30 disulf C-x*-C
DISULFID 19 32 disulf C-x*-C

Additional information [?]

Size range 20-35 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]