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annotation rule: PRU00545

General rule information [?]

Accession PRU00545
Dates 2-JUN-2006 (Created)
3-JUN-2021 (Last updated, Version 10)
Data class Domain
Predictors PROSITE; PS51200; SHORT_SCORPION_CHLORIDE
Name Scorpion short toxin chloride channel inhibitor subfamily
Function Short scorpion toxin chloride channel inhibitors are short-chain neurotoxins (SCNs), which block small-conductance chloride channels. They are 30-40-residue long and contain four intramolecular disulfide bridges, which have been assigned as C1-C4, C2-C6, C3-C7 and C5-C8.

Propagated annotation [?]


Comments [?]

Function Probable chloride channel ligand, which blocks small-conductance chloride channels.
Subcellular location Secreted.
Similarity Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family.

Gene Ontology [?]

GO:0019869; Molecular function: chloride channel inhibitor activity.
GO:0008200; Molecular function: ion channel inhibitor activity.

Keywords [?]

Secreted
Voltage-gated chloride channel impairing toxin
Chloride channel impairing toxin
Ion channel impairing toxin
Neurotoxin
Toxin
case <FTTag:disulf>
Disulfide bond
end case


Features [?]

From: PS51200
Key     From     To       Description   Tag   Condition   FTGroup
DISULFID     1     18           disulf   C-x*-C  
DISULFID     4     25           disulf   C-x*-C  
DISULFID     15     30           disulf   C-x*-C  
DISULFID     19     32           disulf   C-x*-C  

Additional information [?]

Size range 20-35 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P15229 (CTXL1_HOTTS)
Scope
Eukaryota; Metazoa; Arachnida; Scorpiones

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]