General rule information
[?]
Accession |
PRU00545 |
Dates |
2-JUN-2006 (Created) 3-JUN-2021 (Last updated, Version 10) |
Predictors |
PROSITE; PS51200; SHORT_SCORPION_CHLORIDE
|
Name |
Scorpion short toxin chloride channel inhibitor subfamily |
Function |
Short scorpion toxin chloride channel inhibitors are short-chain neurotoxins (SCNs), which block small-conductance chloride channels. They are 30-40-residue long and contain four intramolecular disulfide bridges, which have been assigned as C1-C4, C2-C6, C3-C7 and C5-C8. |
Propagated annotation
[?]
Function |
Probable chloride channel ligand, which blocks small-conductance chloride channels. |
Subcellular location |
Secreted. |
Similarity |
Belongs to the short scorpion toxin superfamily. Chloride channel inhibitor family. |
GO:0019869; Molecular function: chloride channel inhibitor activity.
GO:0008200; Molecular function: ion channel inhibitor activity.
case <FTTag:disulf>
end case
From: PS51200 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DISULFID
|
|
1
|
|
18
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
4
|
|
25
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
15
|
|
30
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
19
|
|
32
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
Additional information
[?]
Size range |
20-35 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P15229 (CTXL1_HOTTS) |
Scope |
Eukaryota; Metazoa; Arachnida; Scorpiones |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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