PROSITE entry PS51231

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General information about the entry

Entry name [info]	DAD
Accession [info]	PS51231
Entry type [info]	MATRIX
Date [info]	01-JUL-2006 CREATED; 13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51231
Associated ProRule [info]	PRU00577

Name and characterization of the entry

Description [info]

Diaphanous autoregulatory domain (DAD) profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2037032; R2=0.0063220; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2999.1406250; R2=1.0954739; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=854; H_SCORE=3935; N_SCORE=7.6; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=680; H_SCORE=3744; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-36; D=-50; I=-50; B1=-200; E1=-200; MI=-210; MD=-210; IM=-210; DM=-210;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-210; BD=-210;
/M: SY='D';  M= -58, -77,  94,  13, -84,  26, -57, -84, -56, -83, -78, -41,   0, -53, -64,  39, -54, -79, -91, -71;
/M: SY='D';  M=  -5, -79,  81,  76, -85, -67, -54, -82, -48, -79, -75,   1,  -2,   8, -57, -54, -58, -77, -88, -72;
/M: SY='T';  M=  30, -68, -56,  10, -70, -65, -61,   0, -48, -64, -60,  35, -67, -53,  51, -12,  61,  -6, -82, -66;
/I:         I=-14; MD=-58;
/M: SY='Q';  M=  -6, -99,  20, -27, -90, -91,  12, -86, -81, -91, -85, -79,  12,  21, -86, -29, -17,  -8, -98,  15; D=-14;
/I:         I=-14; MI=-58; MD=-58; IM=-58; DM=-58;
/M: SY='D';  M= -64, -82,  63,  32, -87,  11, -61, -88,  -3, -86, -79,  12, -71, -53,  30,  29, -60, -83, -91, -75; D=-14;
/I:         I=-14; DM=-58;
/M: SY='G';  M=  -4, -74,  20,  23, -81,  80, -64, -83, -61, -81, -73,  -2, -65, -58, -69,   5,   6, -76, -79, -74;
/M: SY='V';  M=  53, -68, -68,  28,  11, -69, -73,  32, -65, -49, -50, -69, -71, -63, -70, -56, -54,  59, -76, -60;
/M: SY='M';  M= -62, -70, -85, -76,  39, -80, -63,  33, -71,  -3, 120, -73, -74, -66, -70, -71, -59,  24, -69, -46;
/M: SY='D';  M= -65, -81, 106,  59, -87, -67, -53, -86, -51, -82, -80, -40, -63, -48, -60, -56, -58, -81, -96, -71;
/M: SY='D';  M= -59, -75,  81, -42, -78, -27, -55, -76,  15, -19, -69, -10, -68,  21,  29,  47, -53, -73, -86, -66;
/M: SY='L';  M= -66, -72, -85, -79, -43, -88, -73,  62, -78,  77, -30, -81, -81, -72, -77, -76, -62, -32, -72, -54;
/M: SY='L';  M= -63, -71, -85, -78, -45, -86, -74,  54, -77,  63,  36, -80, -79, -72, -76, -74, -59,  39, -75, -55;
/M: SY='E';  M= -54, -72,  14,  70, -74, -66, -57, -72,  -5, -19, -66, -51, -61, -44,  10,  52,  37, -67, -82, -68;
/M: SY='K';  M=  50, -69,  14, -51, -76,  -6, -63, -65,  52, -70, -63, -52, -65,  21, -50,  23,   9,   0, -78, -68;
/M: SY='L';  M=  12, -69, -82, -75, -45, -80, -69,  32, -75,  76,  36, -79, -79, -69, -74, -70, -61, -37, -72, -55;
/M: SY='R';  M=  -6, -77, -58, -46, -78, -70, -56, -76,  63, -73, -63, -51, -67,  59,  71, -52,  27, -70, -75, -64;
/M: SY='S';  M=  11, -67, -51,   2, -76,  -2, -57, -71, -53, -74, -66,  50, -64,  42, -59,  60,  49, -65, -83, -68;
/M: SY='G';  M=  33, -72, -64,  -2, -75,  74, -69, -62, -64, -69, -63, -57, -68,  24, -69, -50, -60,  31, -77, -72;
/M: SY='P';  M=  26, -78,  32,  33, -82,  20, -63, -77,   0, -79, -71, -56,  79, -54, -63,   6, -56, -73, -80, -75;
/I:         I=-10; MD=-41;
/M: SY='A';  M=  49, -73, -72, -66,  15, -21, -66, -58, -67, -64, -60, -68,  49,  -2, -70,   8, -57,  21, -66,  49; D=-10;
/I:         I=-10; MD=-41;
/M: SY='F';  M= -32, -76, -74, -65,  80, -78, -66,  16, -16, -53, -55, -65, -77,  50,  21, -26,  24, -18, -62, -42; D=-10;
/I:         I=-10; MD=-41;
/M: SY='R';  M=  19, -82,  -8, -12, -84,  28, -65, -86,  41, -82, -72, -59, -74, -52,  68, -59, -67, -78, -81, -73; D=-10;
/I:         I=-10; MD=-41;
/M: SY='K';  M=  33, -77,   2,  15, -82, -32, -63, -75,  39, -77, -70,  30, -71,   5,  24, -21, -12, -17, -85, -73; D=-10;
/I:         I=-10; MD=-41;
/M: SY='D';  M= -73, -87,  88, -47, -89, -77, -63, -82, -55, -84, -80, -51, -77,  22,  40, -63,   9, -20,-100, -75; D=-10;
/I:         I=-10; MI=-41; MD=-41; IM=-41; DM=-41;
/M: SY='P';  M= -67, -85, -70, -61, -76,  -3, -65, -67, -52,  -9,  24,  -3,  76,  21,  56, -65, -65, -10, -82, -72; D=-10;
/I:         I=-10; DM=-41;
/M: SY='R';  M= -13, -78, -60,   2, -79, -70, -59, -81,  40, -78, -68, -55, -71, -45,  83,  35, -11, -74, -80, -68; D=-10;
/I:         I=-10; DM=-41;
/M: SY='R';  M= -59, -78,  12,  34, -79, -67, -55, -80,  30, -77, -68, -51,  12,   8,  74,  42, -55, -74, -79, -66;
/M: SY='A';  M=  53, -68, -68, -62,   3, -13, -65,   0, -54,   2, -54, -60, -70,  -5,  45,   0,  22, -15, -74, -61;
/M: SY='R';  M= -61, -79, -59, -50, -78, -68, -54, -79,  33, -77, -65,  -1,  32,  19,  90,  28, -57, -75, -77, -65;
/M: SY='R';  M= -66, -82, -61, -49, -76, -75, -53, -82,  51, -76, -64, -54, -72, -40, 106, -60, -64, -76, -75, -63;
/M: SY='R';  M= -59, -75, -60, -53, -71, -68, -54, -70, -36,  -1, -59,  15, -72,  34,  89,  35,   8, -67, -78, -63;
/M: SY='R';  M=  47, -74,  10, -53,  -8, -66, -60, -67,  28, -11, -60, -58,  11, -51,  71, -55, -59, -35, -75, -63;
/M: SY='C';  M=  12,  42,  21, -54, -69, -26, -62,  -4,  15,   9, -57, -20,  21,  38,   9,  24, -55, -23, -79, -66;
/I:         E1=0; IE=-210; DE=-210;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.

Total number of hits	28 in 28 different sequences
Number of true positive hits	28 in 28 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	12
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	70.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	DOMAIN
Feature description [info]	DAD
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

28 sequences

BNI1_CANAL  (Q5AL52), BNI1_YEAST  (P41832), BNR1_YEAST  (P40450),

DAA1A_XENLA (B0DOB5), DAAM1_HUMAN (Q9Y4D1), DAAM1_MOUSE (Q8BPM0), 
DAAM2_CHICK (A0A1D5P556), DAAM2_HUMAN (Q86T65), DAAM2_MOUSE (Q80U19), 
DIAP1_HUMAN (O60610), DIAP1_MOUSE (O08808), DIAP1_RAT   (F1M775), 
DIAP2_HUMAN (O60879), DIAP2_MOUSE (O70566), DIAP3_HUMAN (Q9NSV4), 
DIAP3_MOUSE (Q9Z207), DIAP3_RAT   (F1LVW7), DIA_DROME   (P48608), 
FHOD3_HUMAN (Q2V2M9), FHOD3_MOUSE (Q76LL6), FMNL1_HUMAN (O95466), 
FMNL1_MOUSE (Q9JL26), FMNL2_HUMAN (Q96PY5), FMNL3_DANRE (Q6NXC0), 
FORA_DICDI  (Q54WH2), FORB_DICDI  (Q54SP2), FRL_DROME   (Q9VUC6), 
SEPA_EMENI  (P78621)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

12 sequences

FHOD1_HUMAN (Q9Y613), FHOD1_MOUSE (Q6P9Q4), FMNL2_MOUSE (A2APV2),

FMNL3_HUMAN (Q8IVF7), FMNL3_MOUSE (Q6ZPF4), FORC_DICDI  (Q54KF1), 
FORD_DICDI  (Q5TJ55), FORE_DICDI  (Q5TJ57), FORF_DICDI  (Q5TJ56), 
FORG_DICDI  (Q1ZXK2), FORH_DICDI  (Q54N00), FORJ_DICDI  (Q54ER5)

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PDB
[Detailed view]

7 PDB

2BAP; 2F31; 2J1D; 3O4X; 3OBV; 8FG1; 8RU2