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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00577


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00577
General rule information [?]

Accession PRU00577
Dates 14-JUL-2006 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51231; DAD
Name Diaphanous autoregulatory domain (DAD)
Function The DAD domain is a ~32 amino acid autoinhibitory domain in diaphanous-related formins (DRF), which inhibits the activity of the DRF catalytical formin homology 2 (FH2) domain to nucleate and elongate nonbranched actin filaments.
Scope(s) Eukaryota
Example(s) Q9Z207;

Propagated annotation [?]

Features [?]

From: PS51231
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="DAD #"

Additional information [?]

Size range 20-40 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]