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annotation rule: PRU00577

General rule information [?]

Accession PRU00577
Dates 14-JUL-2006 (Created)
16-DEC-2016 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51231; DAD
Names Diaphanous autoregulatory domain (DAD); DRF autoregulatory domain; Diaphanous autoinhibitory domain
Function The DAD domain is a ~32 amino acid autoinhibitory domain in diaphanous-related formins (DRF), which inhibits the activity of the DRF catalytical formin homology 2 (FH2) domain to nucleate and elongate nonbranched actin filaments.

Propagated annotation [?]

Features [?]

From: PS51231
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       DAD #        

Additional information [?]

Size range 20-40 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q9Z207 (DIAP3_MOUSE)


PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.

UniProtKB rule member sequences [?]