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PROSITE entry PS51233


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General information about the entry

Entry name [info] VWFD
Accession [info] PS51233
Entry type [info] MATRIX
Date [info] 01-JUL-2006 CREATED;
29-SEP-2021 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51233
Associated ProRule [info] PRU00580

Name and characterization of the entry

Description [info] VWFD domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=176;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=171;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3314614; R2=0.0092979; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=933; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=449; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-24; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='C';  M=  41,  50, -51, -26, -77,  45, -32, -52, -61, -53, -67, -29,  16, -26,   3,  24, -15, -27, -81, -73;
/M: SY='T';  M= -19, -72, -61,  24, -33, -72, -27,  -4, -36, -22, -57, -40, -19, -14,  23,  16,  56,  21,  -5,  10;
/M: SY='C';  M=   3, 146, -80, -80, -73, -33, -81, -56, -76, -69, -69, -67, -89, -82, -69, -62, -61, -50, -98, -81;
/M: SY='S';  M=  -7, -29, -63, -17, -53, -35, -13, -23,  -5, -14,  -6, -29, -68,   1,  -8,  57,  38,   9,  30, -10;
/M: SY='V';  M=  19, -69, -77, -73, -25, -10, -75,  30, -72,  21,  27, -70, -74, -70, -74, -39,  26,  53, -79, -61;
/M: SY='W';  M= -37, -77,  18,  -4,  44, -34, -64, -44, -39, -16, -60, -10, -39, -10, -67,  23, -10,  -8, 102,  43;
/M: SY='G';  M= -35, -77, -22,   1, -80,  83, -65, -83, -13, -81, -72,  -7, -36,   6, -53,   5, -34, -44, -76, -23;
/M: SY='D';  M= -23, -76,  76,   3, -80,  25, -30, -78, -15, -51, -33,  21, -44,  18, -43,   6,  14, -74, -86, -36;
/M: SY='P';  M= -15, -77, -12, -26,   2,  18, -12, -48,   2, -34, -65, -57,  67,  13,   3,  30,   1, -69, -75, -18;
/I:         I=-38; MD=-97;
/M: SY='H';  M= -48, -90, -67, -36,  -8, -82, 125, -88, -48, -77, -66, -37, -82, -40, -33, -31, -76, -36,-101, -19; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='Y';  M= -25, -76, -80, -78,  57, -82, -59,  45, -73,  -3, -45, -76, -52, -72, -72, -70, -63,  13, -47,  90;
/M: SY='T';  M= -38, -50, -47, -31,  -5, -74,  25,  13,  11,  -4, -30,   9, -72,  -6,  24, -10,  40,  28, -77,  -4;
/M: SY='T';  M= -39, -62, -58, -61, -69, -67, -68, -61, -58, -65, -62, -48, -60, -62, -66,  16, 110, -53, -89, -67;
/M: SY='F';  M= -59, -72, -88, -84, 117, -84, -68, -49, -79,  -8, -50, -78, -87, -88, -77, -75, -68, -54,  -7,  -3;
/M: SY='D';  M= -67, -80, 112, -25, -86, -64, -53, -85, -55, -85, -82,  29, -68, -54, -64, -19, -57, -83,-101, -40;
/M: SY='G';  M= -41, -77,  -7, -17, -83,  87, -25, -88, -39, -85, -75,  44, -69, -39, -19, -42, -64, -83, -79, -76;
/M: SY='R';  M=   6, -74,  -7, -37, -11, -71,  17, -31,  22,   6, -13, -22, -72,  14,  52, -11,  13,   5, -77, -35;
/M: SY='H';  M= -29, -74, -22, -21,  -1, -70,  42, -23,  23, -13,  -8,   7, -17, -10,  19,  25,   9,   9, -73,  26;
/M: SY='Y';  M= -44, -78, -76, -76,  77, -58,  19, -45, -70, -14, -50, -73, -84, -69, -49, -69, -67, -37, -38, 105;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='T';  M=  -1, -72,  36, -37, -25, -31,  34, -71, -20, -39, -65,  35,  10, -36,  22,  28,  39, -46, -83, -18;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='F';  M= -44, -34, -81, -79,  99, -81, -35, -31, -75,   7,  15, -23, -83, -78, -73, -70, -17, -17, -47,  50;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='P';  M= -46, -80,   4, -19, -19, -61,  31, -36, -26, -18,  15,  22,  75,  47, -10,  -7,  -3, -51, -79, -44;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='G';  M= -26, -76, -14,  -7, -55,  85, -42, -84, -19, -59, -43, -29, -68, -61, -70,  22, -23, -78, -77, -74;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='N';  M= -17, -72,  18,  20, -71, -48, -20, -41,   7,  -7,  -4,  39,   1, -33,   0,  26,  38, -28, -83, -51;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='C';  M= -24, 141, -78, -52, -56,  16, -41, -77, -75, -62, -10, -65, -86, -79, -81, -43, -62, -48, -95, -79;
/M: SY='W';  M= -27, -74,  -6,  19, -30, -67,   8, -46,  -1, -69, -63,   8, -16,  30, -32,  28,  47, -42,  57,  46;
/M: SY='Y';  M= -69, -80, -48, -53,  28, -76,  57, -57, -65, -39, -52, -29, -81, -22, -63, -20, -42, -13, -40, 114;
/M: SY='V';  M= -22, -69, -78, -52, -32, -80, -33,  37, -72,  19,  13, -30, -76, -72, -75, -31,  18,  69, -81, -42;
/M: SY='L';  M= -22, -70, -85, -78,  31, -84, -70, -11, -78,  78,  14, -82, -83, -73, -76, -75, -63,   0, -69, -50;
/M: SY='A';  M=  56,  10, -74, -68, -27, -65, -26, -12, -68,  -5,  37, -66, -72, -65, -71,   4,   7,  45, -78, -24;
/M: SY='Q';  M= -12, -78, -56,   9, -78, -12,   2, -75,  49, -59, -20, -52, -67,  79,  32, -16,  11, -72, -75, -27;
/I:         I=-15; MD=-37;
/M: SY='D';  M= -29, -80,  70,  -5, -79, -26,   6, -23, -52, -58, -72,   1,   5, -21, -37,   3,  29, -17, -92, -20; D=-15;
/I:         I=-15; MD=-37;
/M: SY='C';  M= -66, 112, -22, -54, -36, -51,   2, -20, -81, -67, -74, -77, -37,  -9, -37, -61, -74, -12, -92,  24; D=-15;
/I:         I=-15; MD=-37;
/M: SY='C';  M= -63,  51, -27, -57,-101, -18,  34, -70, -70, -82, -34, -40,  15, -14, -29,  -8, -60, -75,   2, -92; D=-15;
/I:         I=-15; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='S';  M= -15, -80,  34,  12, -83, -38, -24, -54, -29, -46,  -5,   3,  17, -31, -27,  46,  16, -74, -92, -76; D=-15;
/I:         I=-15; DM=-37;
/M: SY='S';  M=  -4, -75,   3,   7, -35,   0,  -1, -47,  -7, -53,   0,  13,  16,   6, -14,  36,  12, -13, -83, -36; D=-15;
/I:         I=-15; DM=-37;
/M: SY='D';  M= -37, -79,  40,  28, -12, -13,  11, -29,  -3,  -5, -34,  21,   7,  -5, -21,  -5, -35, -30,  12,  20; D=-15;
/I:         I=-15; DM=-37;
/M: SY='P';  M= -44, -79,  18,  23, -61,  36,  34, -49, -13, -43, -36,   5,  56,   7, -13,  12, -24, -52, -82, -69;
/M: SY='D';  M= -21, -73,  43,  -9,   4, -47, -15, -72,  14, -63, -40,  19,   9,  -1,  11,  27,  43, -68, -13, -19;
/M: SY='F';  M= -73, -35, -86, -62, 102, -67, -21, -16, -76,  19, -48, -78, -85, -80, -42, -74, -68, -29,  56,  28;
/M: SY='S';  M=   7, -71, -13,  10, -47, -44, -32,  -6, -17, -11,  32,  16, -42,  -4,  27,  37,  17, -15, -25, -64;
/M: SY='V';  M= -38, -71, -53, -77, -33, -85, -81,  58, -75,  -3,  -7, -77, -78, -26, -77, -55, -55,  78, -80, -25;
/M: SY='H';  M= -61, -74, -31,   6, -57, -76,  41,  23, -40,  33,   7, -63, -30,  33, -45,  10,  15,   9, -12,   6;
/M: SY='V';  M=  28, -70, -75, -72, -44,  12, -73,  33, -43,  19,  22, -68, -21, -49, -73, -15,  -1,  36, -18, -23;
/M: SY='R';  M= -40, -79,  14,  43, -79, -31,  27, -68,  43, -57, -66,  -1, -66,  28,  54, -20,   3, -74, -81, -65;
/M: SY='N';  M= -38, -34, -25, -56, -15, -57,  15, -29,  26,  -5,   2,  78, -12,  22,  15, -24,   6, -50, -82, -63;
/I:         I=-22; MD=-55;
/M: SY='E';  M=  -2, -26,  23,  27, -81, -15, -19, -41,  -3, -61, -41, -47, -47,   3, -16,  -2, -68,   6,   4, -12; D=-22;
/I:         I=-22; MD=-55;
/M: SY='P';  M= -15, -91,  -7, -37, -51, -31,  40,  -9,  14, -81, -33,  -2,  43,  25, -30, -30, -71, -40, -91, -31; D=-22;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='C';  M= -59, 103, -94, -59, -85, -96, -62, -46, -59, -30, -80, -41,-102, -57, -12, -37, -14, -15, -17, -32; D=-22;
/I:         I=-22; DM=-55;
/M: SY='G';  M= -33, -10,   9, -36, -48,  52, -12, -88, -49, -41, -10, -11, -19, -19,  -4,   0, -52, -85, -25, -32; D=-22;
/I:         I=-22; DM=-55;
/M: SY='S';  M=   8, -82, -10, -40, -62,  14,   0, -73, -40,  -8, -41, -37,   3,  14, -14,  18,  -1, -30, -10,   0; D=-22;
/I:         I=-22; DM=-55;
/M: SY='S';  M=   3, -16,  18, -14, -74,   2, -17, -28,   8, -31, -36,  29,  21,  29, -15,  29,  14, -29, -31, -44;
/M: SY='N';  M=  -3, -31,  34,  21, -77,  20,  14, -73,  -1, -25, -66,  38,   9,  15,  -7,  14,  -9, -41, -83, -68;
/M: SY='G';  M=   8, -73,   0,  16, -68,  30, -28, -30,  17, -23,   6,   6, -30, -41,  -7,   6,   9,   5,  -4, -10;
/I:         I=-19; MD=-47;
/M: SY='N';  M=   3, -84, -15, -12, -35, -10, -49, -36,  -6, -16, -33,   9,  -1,  -4, -30,  -4, -24,   6, -87, -10; D=-19;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='T';  M=  -4, -45, -46, -25, -16, -38, -73, -26, -27, -48, -22,   2, -28, -66, -52,  45,  51,  -1, -89, -72; D=-19;
/I:         I=-19; DM=-47;
/M: SY='C';  M= -43, 109, -40,  -4, -13, -12, -44, -58, -56, -58, -71,   2, -85, -19, -41, -11, -28, -17,  44,  12; D=-19;
/I:         I=-19; DM=-47;
/M: SY='L';  M= -43, -17, -69, -22,  -8, -31, -34,  10, -50,  34,   1, -30,   5,   4,  10,  24,  14,   8, -18, -33;
/M: SY='K';  M= -17, -15, -47,  -3, -73, -39,  15, -23,  58, -49,  -1,  -5, -55,  29,  46, -12,  -1, -32,  16, -40;
/M: SY='S';  M=  28, -72, -21,  17, -26, -11,   0, -30,   8, -37, -38,  -5, -47,  17,  11,  43,  -2, -31, -79, -45;
/M: SY='V';  M= -34, -48, -38, -78,   3, -85, -81,  61, -77,  20, -40, -77, -79, -76, -79, -53, -40,  67, -78, -57;
/M: SY='T';  M=   6, -71, -40,   9, -50, -68,   1,  12,  15, -14, -21,  18, -55, -34, -12,  16,  42,  -8, -75,  21;
/M: SY='V';  M= -12, -71, -83, -77, -38, -63, -78,  54, -51,  23,  25, -76, -78, -48, -63, -54, -31,  64, -78, -31;
/M: SY='Q';  M= -35, -25, -26,  20,  13, -62, -21,   6,  22,   6,  -5, -19, -71,  29,  10,  -2,  20, -27,   3,   6;
/M: SY='L';  M= -25, -74, -30, -10,  10, -64,  24,  32, -50,  33,   8, -70, -40, -26,   1, -46, -14,  28, -13,  12;
/M: SY='G';  M= -10, -77,  26,  21, -11,  41, -18, -76,  -6, -48, -68,  21,   1,  25,  -8,   4, -47, -50, -74,  11;
/M: SY='D';  M= -10, -75,  47,  21, -80,  41, -27, -50,  -7, -78, -28,  36,   3, -26, -32,  15,  -2, -60, -84, -72;
/M: SY='Q';  M=  -9, -73,  21,  -4, -12,  -9,  31, -18, -10, -18, -25, -13, -34,  37, -60,  30,  26, -18, -76,  12;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='E';  M= -80, -95,   4,  16, -28, -61, -49,  -6,  -6, -42, -77, -10, -51,   9, -18, -31,  -6,  -8, -26, -41; D=-18;
/I:         I=-18; DM=-45;
/M: SY='I';  M= -20, -79, -17, -43, -39, -84, -14,  31,   2,  17,  22, -73, -43, -15, -41, -19,  -8,  29, -85, -43; D=-18;
/I:         I=-18; DM=-45;
/M: SY='V';  M= -32, -74,  -4,   8,  -4, -65,  -1,  41,  -2, -13, -50, -28, -21, -33,   3, -31,   2,  44, -75,  11;
/M: SY='V';  M= -34, -73, -29,  -2,  -7, -35,  22,  21,   2,  16,  12, -34,  -6,  16, -18, -18,  15,  30, -77, -36;
/M: SY='L';  M= -42, -73,  -3, -10,   9, -44, -64,  11,   0,  31,   8,  -6, -30,   9,   5, -15,  19,   6, -11, -11;
/M: SY='H';  M=   3, -12,  12, -24, -14, -26,  23, -12,  17,   4,   4,   2, -25,  23,  10,   2,  -1,   1, -78, -39;
/M: SY='S';  M=  -9, -14,  14,  -2, -12,  13, -14, -52,  10, -34, -44,  21,   3,   2,   2,  29,  -4, -24, -19,   5;
/M: SY='D';  M=   1, -46,  45,  -2, -62,  33,   4, -59,   1, -52, -36,  38,  -8,   2,   5,  -2, -23, -34, -83, -47;
/M: SY='G';  M= -36, -53,   7,  -8, -26,  36,  31, -21,   4, -10,   9,   4, -26,  -5,  23, -29, -24,   2,   9, -22;
/M: SY='E';  M= -20, -31, -18,  36, -60,  -8,  -9, -44,  32, -35, -31,   4, -27,  30,   2,   7,  29, -11, -80, -35;
/M: SY='V';  M= -14, -33, -82, -58, -24, -52, -80,  27, -74,  11,  -1, -77, -46, -38, -56, -67, -38,  80, -81, -27;
/M: SY='T';  M= -22, -72, -50,  -7, -26, -67, -33,  -8,  28,  26,   9, -39, -40, -16,   1,  -6,  40,  11, -12,  -4;
/M: SY='V';  M= -35, -71, -46, -23,  -5, -38, -31,  18, -33,   7,   4, -31, -35,  -1, -55, -51, -26,  72, -26, -34;
/M: SY='N';  M= -47, -73,  58, -16, -48, -10, -51, -79,   0, -72, -73,  92, -55, -52, -22,   3, -17, -78, -92, -71;
/I:         I=-29; MD=-75;
/M: SY='G';  M= -49, -38,  20, -22, -80,  72, -65, -78, -31, -57, -72,  18, -16,   0, -15,   3, -15, -21, -81, -58; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='Q';  M= -27, -78,  10,  33, -33, -33, -15,  -8,  -7, -22, -12,   2,  15,  63,   3, -12, -18,  -8, -48, -14;
/M: SY='R';  M= -31, -75,   9,   6, -14, -20, -25,  -8,   2,  -8,  -5,  -6,  14,   4,  24,   7,  -1,  20, -77, -10;
/M: SY='V';  M= -25, -72, -21,   0,  -7, -50, -11,  19,  -2,   5,  11, -49, -47, -32, -58, -30,  -8,  63, -32, -35;
/M: SY='S';  M=   6, -74,   4,  22, -34, -35,  18, -45,  16, -31, -63,  18,   4,  24, -20,  26,  11, -20,   9, -13;
/M: SY='L';  M= -55, -28, -78, -41,   9, -25, -69,  28, -41,  56,  -7, -35, -13, -11, -56, -54, -21,  20, -70,   7;
/I:         I=-19; MD=-49;
/M: SY='P';  M= -67, -91, -24, -10, -86, -53, -44, -79, -26, -86, -74, -32, 109,  -9, -44,  -1, -33, -81, -83, -35; D=-19;
/I:         I=-19; MD=-49;
/M: SY='Y';  M= -17, -43,  -7, -21,  43, -50,  27, -41, -27, -24, -39, -46, -24,   8, -24, -36, -33,   4,   6,  66; D=-19;
/I:         I=-19; MD=-49;
/M: SY='W';  M= -28, -79, -28, -39,   6, -75, -10,  -3,  10, -25, -45,  -7, -53,  10, -39,  31,  19,   4,  32,   8; D=-19;
/I:         I=-19; MD=-49;
/M: SY='S';  M= -22, -81,  -9,   0, -79, -20,  18, -47,   9, -18, -44,  -6,  13, -13,  -5,  34,   9, -43, -88, -32; D=-19;
/I:         I=-19; MD=-49;
/M: SY='G';  M=   9, -43, -12, -15, -53,  17,  11, -44,  -7, -47, -72,   5,   9,  17, -47,   5, -19, -54, -23,  10; D=-19;
/I:         I=-19; MD=-49;
/M: SY='N';  M= -52, -95,   7,  -6, -36, -26, -36, -27, -38, -43, -45,  24, -51,   4, -58,  -2,  -4, -51, -20, -51; D=-19;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='G';  M= -15, -76, -20,   4, -19,  49,  26,  -6,  -5, -20,   1,  -1, -25,   9,  -7,  -3,  -9, -38, -76, -10;
/M: SY='Y';  M= -43, -73, -77, -57,  30, -81, -41,  32, -69,  32,  -1, -48, -78,  -5, -24, -24,  16,  32, -65,  40;
/M: SY='H';  M= -50, -76, -27,  12, -24, -44,  43,  16,   7,   1, -55,  14, -40,  25,  11,  25, -16,  -8, -21,  -3;
/M: SY='I';  M= -22, -73, -81, -57,  14, -83, -28,  69, -74,  17, -10, -74, -77, -19, -58, -32, -19,  43, -73, -17;
/M: SY='W';  M= -38, -78,   1,  32, -31, -49,  40, -41,   4, -35,  -5,   4, -40,  13,  28,   6,   7, -29,  52,  33;
/M: SY='Q';  M= -16, -78,   6, -17, -71, -40, -11, -19,  22,  -2, -38, -25,  24,  54,  31,  -5,   3, -41,  33, -32;
/M: SY='S';  M=   1, -25,   0,  -2, -33, -33, -38, -34, -14,  -8, -17,  18, -42,  12,  -2,  52,  13, -13, -36,  -5;
/M: SY='G';  M=   0, -42,  17, -10, -56,  75, -66, -57, -23, -80, -35, -11, -34, -41, -41,  18, -28, -66, -78, -48;
/M: SY='S';  M= -10, -74,  19,   7,   2,  -2, -10,   1, -29, -22, -10,  23, -56,  15,   5,  30, -12,  -8, -76,  -2;
/M: SY='Y';  M= -43, -76, -20, -40,  30,   1,  50, -37, -29, -18,  12,   6, -75, -24,   0,   8,   7, -24,  21,  66;
/M: SY='V';  M= -35, -71, -59, -51,   6, -81, -49,  42, -57,  28,  11, -46, -77, -70, -73, -18,  21,  45, -71,  29;
/M: SY='V';  M= -11, -72, -71, -26, -28, -39, -20,  30,   0,   7,  21, -65, -73,  18, -20,  15,  -3,  43, -77, -16;
/M: SY='V';  M= -16, -71, -80, -55,  -6, -64, -30,  24, -72,  46,   3, -44, -80, -41, -15, -69, -33,  59, -78, -57;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='E';  M= -18, -37,  18,  29,  -8, -52,   7, -17,   0, -33, -62,   1, -38,  -2,  12,  25,  21, -11, -75,  21;
/M: SY='T';  M=  10, -28, -65, -18,  17, -30,  -9,   9, -63, -10, -31, -46, -69, -28, -68,  45,  59, -43,   3,  -3;
/M: SY='P';  M= -42, -80,  34,  -1, -80,  14, -13, -66,  27, -59, -54,   5,  64, -12,  17,  -8,   4, -66, -29, -47;
/I:         I=-9; MD=-23;
/M: SY='F';  M=  16, -76, -35,   1,  41,  -2, -34,   2, -25,   7, -58, -23, -29,  -3, -21,   9, -29, -37, -70,   2; D=-9;
/I:         I=-9; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='G';  M= -10, -79,   4,  12, -32,  65,  23, -17, -41, -22, -31,  -9, -73, -22, -26, -58, -66, -15, -80, -40; D=-9;
/I:         I=-9; DM=-23;
/M: SY='L';  M= -44, -37, -16, -15,   8, -28, -49,  30,  -9,  51,  16, -70, -77, -54, -24, -21, -18,  11, -22, -56;
/M: SY='Q';  M= -24, -72, -34, -13, -27, -73, -24,  15, -24,  -2, -52, -48, -71,  52,  -4,  13,  31,  40, -78, -20;
/M: SY='V';  M= -39, -28, -38, -24, -17, -63, -76,  35, -38,  26, -18, -35, -52, -70, -55, -15,   4,  63, -81, -60;
/M: SY='Q';  M=  -7,  -5,  -8, -34,  -3, -58, -64,  -6,   9,   9,  31, -63, -74,  32,  28,  -2, -13,  20,  28, -17;
/M: SY='W';  M= -19, -80, -41, -24,  39, -34, -67, -12, -47,  -1, -25, -23, -46,  -8, -51, -41, -13, -19, 121,  57;
/M: SY='D';  M= -36, -76,  74,  -8,   4, -17, -25, -37, -36, -20, -24,  35, -27, -43, -28,  14, -21, -28,  -9,   7;
/M: SY='G';  M= -31, -80,  44, -21, -53,  53,  23, -83,   0, -70, -72,   8,  22,  -1,  10, -13, -63, -80,  49, -34;
/M: SY='G';  M= -44, -76,  15, -11,  -4,  29,  -2,  -6,  13,  -8, -60,  24, -72,   0,  16,  10, -22, -15, -76,  -3;
/M: SY='M';  M= -38, -48,   1,   8, -23,   9,  25, -49,   1,  -3,  44,  14, -26, -13, -27,  16,  33, -31, -23, -14;
/M: SY='Q';  M=  -4, -73, -43, -22,  19, -14,  23, -34, -11, -19, -59,  -3, -71,  37,  26,  27,  25,  -6, -74, -12;
/M: SY='V';  M=  17,  -4, -80, -73,   2, -62, -76,  34, -25,  35, -44, -74, -52, -44, -35, -24, -58,  48,  24, -38;
/M: SY='Y';  M= -19, -74, -35,  -5,  14, -72,   5,  -9,   3,  -2,  30, -61, -61,  18,   7,  27,   1,   2, -66,  45;
/M: SY='V';  M= -45, -73, -27, -57,   0, -84, -77,  58, -57,  21, -16, -48, -78, -38, -22, -41, -38,  60, -77, -38;
/M: SY='T';  M= -25, -73, -47,  14, -26, -41,  11,  -5,  24,  -4,  -2, -20, -68,  31,  10,  21,  35, -17, -23, -35;
/M: SY='L';  M=   4, -71, -79, -47, -33, -79,  -3,  20, -73,  48,  11, -53,  22, -70, -75, -47, -30,  47, -79, -60;
/M: SY='P';  M= -10, -76,  39, -23,  -9,  -3, -21, -72, -39, -60, -69, -18,  65, -39, -42,  49,  -3, -35, -79,  -4;
/M: SY='P';  M= -12, -77,  20,   2, -50,   7,  20, -57, -15, -63, -68,   0,  56,   8,  -8,  34,   7, -55,   6, -16;
/M: SY='W';  M=   6, -75,  -1,  13,  -7, -38,  14, -69,  25, -24, -10,  -7, -24,  15,  13,  22,  12, -37,  60, -59;
/M: SY='Y';  M= -58, -78, -37, -71,  54, -58,  32, -56, -66,  -9,  34, -43, -80, -16, -19, -25, -11, -39,  53,  93;
/M: SY='Q';  M=   2, -77, -47, -47,  28, -38,   5, -37,  30, -22,  12, -32, -45,  51,  45, -18, -26, -48,  12,  18;
/I:         I=-33; MD=-84;
/M: SY='N';  M= -34, -76,  -6, -13, -80,  65, -30, -84, -39, -85, -74,  78, -72, -34, -16, -40, -19, -81, -84, -31; D=-33;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='Q';  M= -22, -12, -25, -36, -76, -42,  27, -76,  53, -31, -64,  10, -55,  63,  31,   2, -24, -74, -10, -11; D=-33;
/I:         I=-33; DM=-84;
/M: SY='T';  M= -56, -66, -69, -68, -37, -52, -72, -16, -66,  13,   2, -60, -69, -30, -71, -36,  87,  44, -85, -63;
/M: SY='C';  M= -25, 117, -46,   1, -69, -44,  11, -71, -10, -29, -38, -62, -53,  10,  30, -27, -40, -21, -85,  -2;
/M: SY='G';  M= -50, -78, -66, -78, -84, 102, -72, -92, -71, -88, -77, -52, -70, -69, -79, -51, -70, -86, -75, -79;
/M: SY='L';  M= -52, -71, -85, -76, -34, -86, -70,   5, -77,  84,  -9, -83, -84, -12, -75, -77, -64, -21, -73, -55;
/M: SY='C';  M= -63, 147, -83, -82, -33, -79, -81, -72, -79,  -4, -64, -70, -93, -85, -84, -67, -63, -64, -97, -78;
/M: SY='G';  M= -44, -78, -66, -77, -84, 102, -72, -92, -71, -88, -77, -52, -70, -69, -79, -51, -70, -85, -75, -79;
/M: SY='N';  M= -49, -70,   9, -58, -32, -61,   7,  -6, -12, -47, -64,  94, -31, -55,  -9, -31,  39, -22, -90, -67;
/M: SY='Y';  M= -28,  55, -75, -77,  80, -49, -57, -46, -71, -31, -10,  24, -84, -73, -71, -67, -65, -61,  53,  80;
/M: SY='N';  M= -51, -73,  79, -33, -82, -58, -50, -80, -53, -84, -76,  95, -71, -53, -61, -11,   0, -79, -99, -72;
/M: SY='G';  M= -22, -76,  23,  -4, -56,  69, -17, -46, -19, -50, -33,  40, -69,  -1, -21,  -7, -43, -76,  -8, -71;
/M: SY='N';  M= -65, -25,  59,  47, -27, -67, -21, -24,  -8, -39, -22,  66, -69,  -8,  -7, -42, -34, -47, -34, -21;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='P';  M=   2, -38, -31, -11, -75, -40, -65, -14,   3, -37,  -8, -46,  75,  36,  -7,  12,   8, -29, -29, -37;
/M: SY='E';  M=  11, -74,   8,  34, -35, -19,  -9, -37,   6, -36, -47,  13, -67,   8,  21,  24,  19, -42, -23, -14;
/M: SY='D';  M= -66, -77,  94, -28, -84, -61, -23, -82, -32, -83, -77,  72, -70,   9, -60, -33,  -6, -80, -98, -53;
/M: SY='D';  M= -67, -82, 106,  53, -56, -68, -55, -87, -53, -83, -82, -41, -65, -50, -62, -57, -60, -83, -97, -72;
/M: SY='F';  M= -53,   6, -84, -80,  98, -82, -52, -28, -75,  25,  22, -27, -85, -52, -35, -64, -66, -39,  -5,  19;
/M: SY='M';  M= -32, -10, -70, -34, -42, -77,   8,  -8, -22,  22,  52, -24, -74,  -9,  42, -50,  38,  19, -78, -10;
/M: SY='T';  M= -23, -69,  -4, -11, -47, -24, -64, -30, -17,  11,  62, -56, -67, -31,  -9,  13,  70, -39, -81, -63;
/M: SY='P';  M= -11, -83, -18, -24, -80, -55,  13, -57, -21, -35, -66, -63,  96,   6,  25,  19, -58, -48, -81, -72;
/M: SY='N';  M= -20, -74,  53,  13, -78,   3, -36, -39, -12, -77,  -9,  60, -68,  17, -23,  36, -44, -60, -86, -30;
/M: SY='G';  M= -23, -76, -11, -28, -80,  82,  -9, -70, -30, -51, -51,  42, -70, -22, -31, -37, -52, -59, -79, -51;
/M: SY='C';  M= -18,  48, -12,  -6, -67, -27, -20,  -9,  20,  -9,  13, -27, -70,  17,  11,  17,  35, -21, -79,  -7;
/M: SY='V';  M= -30,   2, -59,  -4, -11, -68, -27,  16, -53,  35, -17, -73,  18,  -9, -72, -34, -11,  50, -76,  -5;
/I:         I=-17; MD=-42;
/M: SY='A';  M=  44, -36, -65,  30, -39, -71, -71,   5, -26,  -4, -15, -66, -71, -62, -55, -45,  44,   8, -82, -39; D=-17;
/I:         I=-17; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='S';  M=  -9, -78,  23,  20, -46, -13, -21, -75,   2, -60,  10,   5,  12,  -7,   9,  27,  22, -44, -86, -71; D=-17;
/I:         I=-17; DM=-42;
/M: SY='D';  M= -47,  -6,  62, -26, -76, -36, -36, -21,  -1, -30, -38,  51, -70, -37, -53,  39,  29, -68, -91, -70; D=-17;
/I:         I=-17; DM=-42;
/M: SY='P';  M=  28,  14, -32,   1, -24, -30,   1,  14, -60, -20, -58, -42,  56, -41, -72,  -1, -30,  15,  11, -11; D=-17;
/I:         I=-17; DM=-42;
/M: SY='E';  M=  11, -76, -15,  41, -16, -36, -10, -28,  -2,  -4, -14, -10,  -6,  16,  -8,  -5,  -9,   5, -77,  -3; D=-17;
/I:         I=-17; DM=-42;
/M: SY='E';  M=  13, -76,  27,  54, -31, -38,  -7, -38, -14,   5, -15, -35, -20,   1, -31, -12,   0, -10, -82, -67; D=-17;
/I:         I=-17; DM=-42;
/M: SY='F';  M= -45, -35, -87, -83, 107, -84, -36, -49, -79,   9,   3, -78, -87, -84, -77, -74, -41, -42, -12,  23; D=-17;
/I:         I=-17; DM=-42;
/M: SY='G';  M=  49, -71, -47, -71, -56,  60, -10,   5, -69, -27, -13, -61, -71, -66, -58, -23, -45,  15, -78, -70;
/M: SY='N';  M=  10, -73,  12,  12, -50, -25,  45, -58, -11, -28, -19,  78, -71,  12,   1, -10, -42, -72, -87, -66;
/M: SY='S';  M=   2, -27, -23,  -4, -36, -37, -10, -71,  -9, -33, -14, -35, -66, -40, -61,  86,  12, -65, -82, -66;
/M: SY='W';  M= -75, -96, -91, -75, -15, -75, -47, -71, -69, -69, -69, -49, -33,  11, -72, -77, -82, -83, 164,  58;
/M: SY='K';  M=  12, -76, -59,  14, -47, -44, -32, -16,  55, -16, -35, -40, -68,  45,  38, -27,  -2, -32, -76, -65;
/M: SY='V';  M=   4, -71, -24,  -4, -54, -78, -72,  23, -36,  38,  30, -71, -50, -66, -71, -38,   5,  47, -38, -20;
/I:         I=-45; MD=-115;
/M: SY='P';  M= -22,  -7,   8,  10, -34,  -8, -18, -55,   9, -35, -22,  31,  42,  28, -28,  23,   7, -42, -82, -46; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='D';  M=   5, -76,  37,  16, -81,  27, -24, -59,  -6, -71, -70,  20,  26,  22, -15,  24, -17, -33, -83, -71;
/M: SY='E';  M=  -9,  20,  23,  42, -48, -11, -62, -39, -28, -34, -11, -28,  41,   8, -27,  25,  17, -51, -24, -51;
/I:         I=-23; MD=-58;
/M: SY='E';  M= -61, -85,  18,  28, -14,   2, -42, -45, -28, -37, -76,  18,   1,   9, -17,  26, -11, -79, -89, -75; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='C';  M= -46, 145, -50, -54, -73, -75, -50, -77, -74, -50, -69, -43, -88, -34, -80,  -1, -38, -54, -99, -80;
/M: SY='P';  M= -11, -76,  -4,  13, -13, -14,  -6, -36, -22,  -5, -16,  16,  40,  34,   0,  13,  -3, -22,  12, -35;
/I:         E1=0; IE=-380; DE=-380;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 185 in 85 different sequences
Number of true positive hits 185 in 85 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 13
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] VWFD
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
85 sequences

APLP_DROME  (Q9V496), APLP_GALME  (Q68YP1), APLP_LOCMI  (Q9U943), 
APLP_MANSE  (Q25490), BMPER_HUMAN (Q8N8U9), BMPER_MOUSE (Q8CJ69), 
CLOT_PENMO  (Q9U572), FCGBP_HUMAN (Q9Y6R7), HMCT_BOMMO  (P98092), 
KCP_HUMAN   (Q6ZWJ8), KCP_MOUSE   (Q3U492), KCP_XENLA   (Q9IBG7), 
LUCI_VARHI  (P17554), MESH_BOMMO  (H9JIQ1), MESH_DROME  (Q0KHY3), 
MLP_ACRMI   (B3EWY9), MUC19_BOVIN (P98091), MUC19_HUMAN (Q7Z5P9), 
MUC19_MOUSE (Q6PZE0), MUC2L_RAT   (P98089), MUC2_HUMAN  (Q02817), 
MUC2_MOUSE  (Q80Z19), MUC2_RAT(Q62635), MUC4_HUMAN  (Q99102), 
MUC4_MOUSE  (Q8JZM8), MUC4_RAT(Q63661), MUC5A_HUMAN (P98088), 
MUC5B_CHICK (Q98UI9), MUC5B_HUMAN (Q9HC84), MUC6_CHICK  (F1NBL0), 
MUC6_HUMAN  (Q6W4X9), MUC6_MOUSE  (Q80T03), OTOGL_HUMAN (Q3ZCN5), 
OTOGL_MOUSE (F7A4A7), OTOGL_PONAB (Q5RCW9), OTOG_HUMAN  (Q6ZRI0), 
OTOG_MOUSE  (O55225), SSPO_BOVIN  (P98167), SSPO_CHICK  (Q2PC93), 
SSPO_HUMAN  (A2VEC9), SSPO_MOUSE  (Q8CG65), SSPO_RAT(Q700K0), 
SUSD2_HUMAN (Q9UGT4), SUSD2_MOUSE (Q9DBX3), TECTA_CHICK (Q9YH85), 
TECTA_HUMAN (O75443), TECTA_MOUSE (O08523), VIT1_AEDAE  (Q16927), 
VIT1_CAEEL  (P55155), VIT1_CHICK  (P87498), VIT1_FUNHE  (Q90508), 
VIT1_PERAM  (Q9U8M0), VIT1_SOLIN  (Q7Z1M0), VIT2_CAEEL  (P05690), 
VIT2_CHICK  (P02845), VIT2_FUNHE  (Q98893), VIT2_PERAM  (Q9BPS0), 
VIT2_SOLIN  (Q2VQM6), VIT3_CAEEL  (Q9N4J2), VIT3_SOLIN  (Q2VQM5), 
VIT4_CAEEL  (P18947), VIT5_CAEEL  (P06125), VIT6_CAEEL  (P18948), 
VIT6_OSCTI  (Q94637), VITA2_XENLA (P18709), VIT_ACITR   (Q90243), 
VIT_ANTGR   (Q05808), VIT_APIME   (Q868N5), VIT_BOMMO   (Q27309), 
VIT_ICHUN   (Q91062), VIT_ONCMY   (Q92093), VIT_PENME   (Q6RG02), 
VIT_TAKPA   (A0A292G9J6), VWDE_HUMAN  (Q8N2E2), VWDE_MOUSE  (Q6DFV8), 
VWF_BOVIN   (P80012), VWF_CANLF   (Q28295), VWF_HUMAN   (P04275), 
VWF_MOUSE   (Q8CIZ8), VWF_PIG (Q28833), YMS5_CAEEL  (P34501), 
ZAN_HUMAN   (Q9Y493), ZAN_MOUSE   (O88799), ZAN_PIG (Q28983), 
ZAN_RABIT   (P57999)
» more

PDB
[Detailed view]
17 PDB

1LSH; 6N29; 6RBF; 6TM2; 7A5O; 7KWO; 7PMV; 7PNF; 7POV; 7PP6; 7PRL; 7QCL; 7QCN; 7QCU; 7ZWH; 8D3C; 8D3D
» more