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annotation rule: PRU00580 |
Accession | PRU00580 |
Dates | 18-JUL-2006 (Created) 13-APR-2021 (Last updated, Version 7) |
Data class | Domain |
Predictors | PROSITE; PS51233; VWFD |
Name | VWFD domain profile |
Function | Von Willebrand factor (VWF) is a large, multimeric blood glycoprotein synthesized in endothelial cells and megakaryocytes, that is required for normal hemostasis. The type D domain (VWFD) is not only required for blood clotting factor VIII binding but also for normal multimerization of VWF. |
PROSITE | PS51233; VWFD; 1-6; |
From: PS51233 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | VWFD # | |||||||||
DISULFID | 3 | 139 | disulf | C-x*-C | ||||||||
DISULFID | 25 | 175 | disulf | C-x*-C | ||||||||
DISULFID | 34 | 136 | disulf | C-x*-C | ||||||||
DISULFID | 49 | 57 | disulf | C-x*-C |
Size range | 200-230 amino acids |
Related rules | none |
Repeats | 1-6 |
Topology | Undefined |
Example | P04275 (VWF_HUMAN) |
Scope | Eukaryota |
Eukaryota | [85] |