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annotation rule: PRU00580

General rule information [?]

Accession PRU00580
Dates 18-JUL-2006 (Created)
13-APR-2021 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS51233; VWFD
Name VWFD domain profile
Function Von Willebrand factor (VWF) is a large, multimeric blood glycoprotein synthesized in endothelial cells and megakaryocytes, that is required for normal hemostasis. The type D domain (VWFD) is not only required for blood clotting factor VIII binding but also for normal multimerization of VWF.

Propagated annotation [?]

Cross-references [?]

PROSITE PS51233; VWFD; 1-6;

Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS51233
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       VWFD #        
DISULFID     3     139           disulf   C-x*-C  
DISULFID     25     175           disulf   C-x*-C  
DISULFID     34     136           disulf   C-x*-C  
DISULFID     49     57           disulf   C-x*-C  

Additional information [?]

Size range 200-230 amino acids
Related rules none
Repeats 1-6
Topology Undefined
Example P04275 (VWF_HUMAN)


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]