ProRule PRU00580

General rule information [?]

Accession PRU00580
Dates 18-JUL-2006 (Created)
13-APR-2021 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51233; VWFD
Name VWFD domain profile
Function Von Willebrand factor (VWF) is a large, multimeric blood glycoprotein synthesized in endothelial cells and megakaryocytes, that is required for normal hemostasis. The type D domain (VWFD) is not only required for blood clotting factor VIII binding but also for normal multimerization of VWF.
Scope(s) Eukaryota
Example(s) P04275 (VWF_HUMAN);

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS51233; VWFD; 1-6;

Features [?]

From: PS51233
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="VWFD #"
DISULFID 3 139 disulf C-x*-C
DISULFID 25 175 disulf C-x*-C
DISULFID 34 136 disulf C-x*-C
DISULFID 49 57 disulf C-x*-C

Additional information [?]

Size range 200-230 amino acids
Related rules none
Fusion None
Repeats 1-6
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]