ProRule PRU00580
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00580 |
| Accession | PRU00580 |
| Dates | 18-JUL-2006 (Created)
13-APR-2021 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51233; VWFD |
Name | VWFD domain profile |
| Function | Von Willebrand factor (VWF) is a large, multimeric blood glycoprotein synthesized in endothelial cells and megakaryocytes, that is required for normal hemostasis. The type D domain (VWFD) is not only required for blood clotting factor VIII binding but also for normal multimerization of VWF. |
| Scope(s) |
Eukaryota |
| Example(s) | P04275 (VWF_HUMAN); |
Propagated annotation
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Keywords
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| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Cross-references
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| PROSITE | PS51233; VWFD; 1-6; |
Features
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| From: PS51233 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="VWFD #" | |||||||||
| DISULFID | 3 | 139 | disulf | C-x*-C | ||||||||
| DISULFID | 25 | 175 | disulf | C-x*-C | ||||||||
| DISULFID | 34 | 136 | disulf | C-x*-C | ||||||||
| DISULFID | 49 | 57 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 200-230 amino acids |
| Related rules |
none |
| Fusion | None |
| Repeats | 1-6 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [85] All [ 85 ]
- Retrieve set of proteins with 3D structure for this domain