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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00580


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00580
General rule information [?]

Accession PRU00580
Dates 18-JUL-2006 (Created)
13-APR-2021 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51233; VWFD
Name VWFD domain profile
Function Von Willebrand factor (VWF) is a large, multimeric blood glycoprotein synthesized in endothelial cells and megakaryocytes, that is required for normal hemostasis. The type D domain (VWFD) is not only required for blood clotting factor VIII binding but also for normal multimerization of VWF.
Scope(s) Eukaryota
Example(s) P04275;

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS51233; VWFD; 1-6;

Features [?]

From: PS51233
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="VWFD #"
DISULFID 3 139 disulf C-x*-C
DISULFID 25 175 disulf C-x*-C
DISULFID 34 136 disulf C-x*-C
DISULFID 49 57 disulf C-x*-C

Additional information [?]

Size range 200-230 amino acids
Related rules none
Fusion None
Repeats 1-6
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]