Home  |  Contact
annotation rule: PRU00580

General rule information [?]

Accession PRU00580
Dates 18-JUL-2006 (Created)
16-DEC-2016 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51233; VWFD
Name VWFD domain profile
Function Von Willebrand factor (VWF) is a large, multimeric blood glycoprotein synthesized in endothelial cells and megakaryocytes, that is required for normal hemostasis. The type D domain (VWFD) is not only required for blood clotting factor VIII binding but also for normal multimerization of VWF.

Propagated annotation [?]


Cross-references [?]

PROSITE PS51233; VWFD; 1-6;

Keywords [?]

case <FTTag:disulf>
end case


Features [?]

From: PS51233
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       VWFD #        
DISULFID     24     32           disulf   C-x*-C  

Additional information [?]

Size range 200-230 amino acids
Related rules none
Repeats 1-6
Topology Undefined
Example P04275 (VWF_HUMAN)
Scope
Eukaryota

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]