PROSITE entry PS51292

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51292
Entry name [info]	ZF_RING_CH
Accession [info]	PS51292
Entry type [info]	MATRIX
Date [info]	01-FEB-2007 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51292
Associated ProRule [info]	PRU00623

Name and characterization of the entry

Description [info]

Zinc finger RING-CH-type profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=62;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=57;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5666564; R2=0.0068634; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=8548.0878906; R2=2.8060076; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1302; H_SCORE=12202; N_SCORE=11.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=574; H_SCORE=10159; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-22; D=-120; I=-120; B1=-300; E1=-300; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='M';  M= -12, -58, -10,  26, -10,   1,  -7, -17,   4,  -4,  35,  17, -25,  11,  -4,  29,  -9, -18, -63, -47;
/M: SY='E';  M= -10,  -3,  22,  26, -29, -17, -14, -12,  21, -34, -14,  19, -53,   6, -21,  18,  17,   1, -63,   2;
/M: SY='S';  M=   2, -58,  20,  17,  -1,   6,   0,  -7,   9, -34, -48,   6, -24,  17, -21,  36, -10,  -8, -64, -48;
/M: SY='E';  M= -20, -17,   7,  39, -21, -10, -44, -23,   9,  -5, -15,  23, -31,  25,  -8,  19,   5, -10, -65, -50;
/M: SY='E';  M=  -2, -59,  39,  45, -61,  10, -45, -58,  -6, -59, -54, -18,  -7,  10, -31,  35,  13, -16, -66, -14;
/M: SY='E';  M=  11, -58,   3,  40, -58,  32,  -2, -41,  -1, -54,  22, -14, -14, -38, -16,  14,  11,  -9, -64, -16;
/M: SY='R';  M=   8, -13,  17, -18, -58, -34,  -9,   7,  33, -18, -19,  10,  21,   9,  39, -12,  -6, -34, -65, -51;
/M: SY='I';  M= -35,  29, -15,  18,   5, -21,  -6,  41, -45, -18, -11, -47, -57,  38,  -9,  12, -29,  25, -61, -14;
/M: SY='C';  M= -47, 150, -67, -67, -57, -63, -67, -64, -63, -55, -55, -53, -78, -71, -69, -50, -47, -52, -87, -68;
/M: SY='W';  M= -54, -71, -53, -40, -53, -61, -45, -66,  35, -61, -52, -46, -60, -30,  95, -50, -54, -64, 102, -40;
/M: SY='I';  M= -51, -63, -71, -69,  19, -75, -66,  95, -64, -19,  -1, -62, -61, -62, -67, -59, -45,  10, -54,   7;
/M: SY='C';  M= -47, 150, -67, -67, -57, -63, -67, -64, -63, -55, -55, -53, -78, -71, -69, -50, -47, -52, -87, -68;
/M: SY='H';  M= -53, -62, -52, -29,  42, -18,  67, -30,   2,  19,  22, -15, -61,  17,  38, -50, -50, -47, -50,  33;
/M: SY='E';  M= -23,  46,  35,  55, -11, -10, -45, -54, -19,  -9,  -2, -28, -52,  24, -45,  12,   3, -33,  -8, -51;
/M: SY='E';  M= -16, -61,  13,  51, -65,  44, -15, -64, -15, -45, -55, -11,  16,  10, -46,  16,  19, -58, -66, -57;
/I:         I=-15; MD=-33;
/M: SY='D';  M=  -3,  11,  45,  42, -60,  11, -47, -61, -16, -32, -23, -40, -10, -40, -34,  21,   0, -44, -67,   6; D=-15;
/I:         I=-15; MD=-33;
/M: SY='S';  M= -53, -82,  21,  16, -13, -31, -67, -51, -63, -80, -77,  -6, -74,  -3, -69,  22,  -1, -76, -89, -72; D=-15;
/I:         I=-15; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='W';  M= -26, -67,  11,  34, -62, -26, -51, -39,   8, -18,   6,  20,  19, -25, -15,  22, -46, -31,  40, -56; D=-15;
/I:         I=-15; DM=-33;
/M: SY='D';  M= -29, -15,  39,  20, -64,  21, -11, -26, -20, -35, -10,  19,  19, -20, -28,  21,   4, -41, -72, -58; D=-15;
/I:         I=-15; DM=-33;
/M: SY='N';  M= -16,  -4,  35,  26, -59,  31,  17, -57, -31, -22, -52,  53, -19, -39,   0,   6, -42, -17, -69, -20;
/M: SY='P';  M= -28, -64,  13,   9, -58, -55,  15, -19,  19,  -3, -46,  -5,  70,   6,   3,  -2,  -1, -18, -66, -53;
/M: SY='L';  M= -51, -12, -67, -38,  35, -44, -57,  26, -38,  60,  19, -62, -66, -56, -32, -32, -26,   2,  42, -34;
/M: SY='I';  M= -34, -13, -34,  10,  19, -40, -57,  65,  -2, -10, -32, -52, -58, -22,  10, -31,  -6,  20, -58, -20;
/M: SY='H';  M= -20, -22, -41,  -7, -53, -31,  55, -30,   3,  -8,   0,  35, -55,  -1,  33,  42,   6, -37, -66, -13;
/M: SY='P';  M= -31, -73, -52, -13, -26,   1, -53, -55, -48, -45, -52, -56, 110, -50, -28, -48, -46, -28, -59,   9;
/M: SY='C';  M= -47, 150, -67, -67, -57, -63, -67, -64, -63, -55, -55, -53, -78, -71, -69, -50, -47, -52, -87, -68;
/M: SY='R';  M=  10, -13,   6, -11, -55, -30, -41, -37,  32, -13,   3,  31, -56,  25,  49,   2, -43, -52, -60,   5;
/M: SY='C';  M= -47, 150, -67, -67, -57, -63, -67, -64, -63, -55, -55, -53, -78, -71, -69, -50, -47, -52, -87, -68;
/M: SY='K';  M= -21, -59,   0, -18, -59, -51,-100, -37,  60, -45, -50, -22, -52,   4,  40,  38,  25, -31, -63, -21;
/I:         I=-31; MD=-65;
/M: SY='G';  M= -21, -63, -50, -61, -69,  94, -56,-100, -53, -72, -61,   2, -56, -52, -15, -36, -54, -70, -62, -64; D=-31;
/I:         I=-31; MI=-65; MD=-65; IM=-65; DM=-65;
/M: SY='S';  M= -35, -54,  23,  16, -62, -10,-100, -60, -43, -62, -57, -33, -14, -38, -49,  74,  49, -52, -72, -55; D=-31;
/I:         I=-31; DM=-65;
/M: SY='M';  M= -23, -14, -63, -57, -14, -65,-100,  38, -55,  42,  55,  -5, -63,  17, -27, -37, -25,  26, -62, -43; D=-31;
/I:         I=-31; DM=-65;
/M: SY='K';  M=  16, -61, -24, -23, -58,  24,-200, -60,  54, -27, -48, -24, -53,  48,  20,  -4, -34, -56, -57,   7;
/M: SY='Y';  M= -34, -64, -36, -56,  33, -62,-100,   2, -13,   8, -35, -26, -65, -14, -50, -23, -33, -17,  74,  91;
/M: SY='V';  M=  31, -10, -66, -60, -26, -61,-100,  45, -59, -19, -30, -60, -61, -59, -61, -47, -24,  73, -67, -48;
/M: SY='H';  M= -55, -67, -39, -39, -54, -57, 144, -72, -44, -54, -40, -29, -56, -33, -38, -45, -54, -72, -89, -23;
/M: SY='Q';  M= -35, -64, -38,  45, -27, -21,  11, -40,   8, -23, -46,  -3,  -2,  56,  42,   1, -24,  -8, -63, -49;
/M: SY='E';  M= -12, -62,  18,  45, -61, -12,  -4, -60,  30, -59,   2,   8, -11,  27,  16,  24, -27, -37, -63, -10;
/M: SY='C';  M= -47, 150, -67, -67, -57, -63, -67, -64, -63, -55, -55, -53, -78, -71, -69, -50, -47, -52, -87, -68;
/M: SY='L';  M=  -4, -55, -69, -62, -12, -68, -57,  19, -62,  75,  -1, -66, -67, -57, -61, -58, -47,   9, -58, -40;
/M: SY='E';  M= -14, -62,  13,  42,  -4, -55, -42,  -6,  40, -40,  21,  16, -52,  40,   7, -14, -28, -21, -61, -18;
/M: SY='R';  M=   0, -60, -15,  26, -57, -54,  29, -54,  35, -27,  28,  -1, -52,  27,  42,  -9,  15, -33, -63, -17;
/M: SY='W';  M= -59, -83, -32, -10, -29, -60, -75, -59, -53, -40, -57, -72, -63,  10, -57, -63, -68, -71, 167,   6;
/M: SY='I';  M= -34,  22, -68, -62,  37, -70, -59,  62, -55,  28,  21, -60, -64, -23,   7, -56, -29,  19, -55, -36;
/M: SY='N';  M= -26, -58, -10,  13, -25, -27, -19,  16,  -5,  -4, -19,  39, -55, -13,  27,  27,  13,  -9, -64, -18;
/I:         I=-36; MD=-77;
/M: SY='T';  M= -13, -12, -20,  15, -21, -42,  12,  -9,  -4, -15,  28,  -6, -55,  27,   7,  16,  29,  11, -63,  -5; D=-36;
/I:         I=-36; MI=-77; IM=-77; DM=-77;
/M: SY='K';  M= -26, -59, -20, -16, -64, -10, -42, -63,  53, -62, -52,  22, -52,  40,  37,  43,   6, -58, -64, -52;
/I:         I=-16; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='G';  M=  -9, -62,  18, -15, -30,  42,  18, -62,  20, -39, -52,  20, -27,  33,  32,  -5, -29, -41, -64, -51;
/M: SY='N';  M= -44, -28,  -5,  16,  -8, -28,  -6,  -2,  15, -41, -49,  54, -18,   1,  20,  28,  22, -37, -66, -49;
/M: SY='T';  M=   5, -56, -49, -31, -45, -55, -48,  20,  10,   8,  19,  26, -28, -21,  10,   2,  33,   5,   1,   1;
/M: SY='K';  M=  -5,   0, -20, -12, -36, -55,  37, -13,  41, -44,  -8, -12, -54,  26,  38,   1,  24, -21, -61,   5;
/M: SY='C';  M= -47, 150, -67, -67, -57, -63, -67, -64, -63, -55, -55, -53, -78, -71, -69, -50, -47, -52, -87, -68;
/M: SY='E';  M= -22, -66,  22,  84, -68, -58, -42, -38,  11, -61, -56, -40,  22,   5,   5, -22, -18, -59, -66, -57;
/M: SY='I';  M= -47, -60, -61, -37,  -1, -66, -57,  68, -54,  23,  18, -27, -60,  36, -56,  -4, -27,  22, -59, -41;
/M: SY='C';  M= -47, 150, -67, -67, -57, -63, -67, -64, -63, -55, -55, -53, -78, -71, -69, -50, -47, -52, -87, -68;
/M: SY='H';  M= -44, -63, -40, -21, -62,  37,  51, -65,  44, -38, -50,  33, -54,  49,  14,   4, -45, -62, -63, -23;
/M: SY='T';  M=   6,  -5, -14,  14,  25, -31,  42, -46, -12, -47, -21, -41, -54,  20, -29,   7,  43,   4, -55,  31;
/M: SY='P';  M= -13, -61, -24,  29, -30, -55, -48, -29,  33, -51,   1, -26,  51,  22,   2,  -3,  20,  15, -64, -52;
/M: SY='Y';  M=  -4, -13, -62, -61,  71, -63, -35, -38, -56, -21, -36, -59, -69, -55, -54, -52, -50, -17, -22, 103;
/M: SY='Q';  M= -34, -60, -15,   4, -58, -52, -12, -25,  21, -14, -45,  39, -34,  48,  45,  18,   7, -14, -66, -50;
/M: SY='M';  M= -49, -23, -57, -57,  29, -61, -51,  34, -30,  26,  58,  37,   0, -52, -33, -38,  -7,  16,   3, -15;
/M: SY='E';  M=  -3, -59,  -1,  34, -55, -38,   9,   9,  29, -25, -44,  17, -22, -11,   6,  -2,   4,  19, -67, -51;
/I:         E1=0; IE=-255; DE=-255;

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Post-processing [info]

COMPETES_HIT_WITH

PS50089

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.

Total number of hits	59 in 59 different sequences
Number of true positive hits	59 in 59 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	4
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	93.65 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	N_Hulo
Feature key [info]	ZN_FING
Feature description [info]	RING-CH-type
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

59 sequences

DOA10_SCHPO (O60103), DOA10_YEAST (P40318), LAP_LSDVN   (Q91T40),

LAP_MYXVL   (Q997C2), LAP_RFVKA   (Q9Q8T2), LAP_SWPVK   (P32225), 
LAP_YLDV(Q9DHV7), LAP_YMTV5   (Q6TV02), MARC3_CAEEL (Q93227), 
MARH1_HUMAN (Q8TCQ1), MARH1_MOUSE (Q6NZQ8), MARH2_BOVIN (Q32L65), 
MARH2_DANRE (Q1LVZ2), MARH2_HUMAN (Q9P0N8), MARH2_MOUSE (Q99M02), 
MARH2_RAT   (Q5I0I2), MARH2_XENLA (Q5PQ35), MARH2_XENTR (Q28EX7), 
MARH3_BOVIN (A0JN69), MARH3_HUMAN (Q86UD3), MARH3_MOUSE (Q8BRX9), 
MARH3_RAT   (Q5XIE5), MARH3_XENLA (Q0IH10), MARH3_XENTR (Q68FA7), 
MARH4_DANRE (Q0P496), MARH4_HUMAN (Q9P2E8), MARH4_MOUSE (Q80TE3), 
MARH5_BOVIN (Q3ZC24), MARH5_CHICK (Q5ZJ41), MARH5_CHLAE (Q0X0A5), 
MARH5_DANRE (Q6NYK8), MARH5_HUMAN (Q9NX47), MARH5_MOUSE (Q3KNM2), 
MARH5_XENLA (Q6GM44), MARH6_HUMAN (O60337), MARH6_MOUSE (Q6ZQ89), 
MARH6_PONAB (Q5R9W1), MARH7_HUMAN (Q9H992), MARH7_MOUSE (Q9WV66), 
MARH7_PONAB (Q5R9W2), MARH7_RAT   (Q5XI50), MARH8_BOVIN (Q0VD59), 
MARH8_HUMAN (Q5T0T0), MARH8_MOUSE (Q9DBD2), MARH8_XENLA (Q5XH39), 
MARH8_XENTR (Q28IK8), MARH9_HUMAN (Q86YJ5), MARH9_MOUSE (Q3TZ87), 
MARHA_HUMAN (Q8NA82), MARHA_RAT   (Q5XIV2), MARHB_HUMAN (A6NNE9), 
MARHB_MOUSE (Q8CBH7), MARHB_RAT   (A6P320), MIR1_HHV8P  (P90495), 
MIR1_MHV68  (O41933), MIR2_HHV8P  (P90489), SUD1_ARATH  (F4JKK0), 
VIE1_BHV4D  (P27426), YG87_SCHPO  (O74371)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

4 sequences

FANCL_DROME (Q8T913), ORTH2_ARATH (Q8VYZ0), ORTH4_ARATH (Q9C8E1),

ORTH5_ARATH (Q680I0)

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PDB
[Detailed view]

7 PDB

1VYX; 2D8S; 2M6M; 3K1L; 8PD0; 8PDA; 8TQM