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annotation rule: PRU00623

General rule information [?]

Accession PRU00623
Dates 8-MAY-2008 (Created)
16-MAR-2021 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51292; ZF_RING_CH
Name Zinc finger RING-CH-type
Function The RING-CH-type is an E3 ligase mainly found in proteins associated to membranes.

Propagated annotation [?]


Comments [?]

Domain The RING-CH-type zinc finger domain is required for E3 ligase activity.

Keywords [?]

case (<Feature:PS51292:9=[CH]> and <Feature:PS51292:12=[CH]> and <Feature:PS51292:36=[CH]> and <Feature:PS51292:39=[CH]>) or (<Feature:PS51292:26=[CH]> and <Feature:PS51292:28=[CH]> and <Feature:PS51292:52=[CH]> and <Feature:PS51292:55=[CH]>)
end case


Features [?]

case (<Feature:PS51292:9=[C]> and <Feature:PS51292:12=[C]> and <Feature:PS51292:36=[H]> and <Feature:PS51292:39=[C]>) and (<Feature:PS51292:26=[C]> and <Feature:PS51292:28=[C]> and <Feature:PS51292:52=[C]> and <Feature:PS51292:55=[C]>)
From: PS51292
Key     From     To       Description   Tag   Condition   FTGroup
ZN_FING     from     to       RING-CH-type #        
else case (<Feature:PS51292:9=[CH]> and <Feature:PS51292:12=[CH]> and <Feature:PS51292:36=[CH]> and <Feature:PS51292:39=[CH]>) and (<Feature:PS51292:26=[CH]> and <Feature:PS51292:28=[CH]> and <Feature:PS51292:52=[CH]> and <Feature:PS51292:55=[CH]>)
ZN_FING     from     to       RING-CH-type #; atypical        
else
ZN_FING     from     to       RING-CH-type #; degenerate        
end case

METAL     9     9       Zinc #1     [CH]   1
METAL     12     12       Zinc #1     [CH]   1
METAL     26     26       Zinc #2     [CH]   2
METAL     28     28       Zinc #2     [CH]   2
METAL     36     36       Zinc #1     [CH]   1
METAL     39     39       Zinc #1     [CH]   1
METAL     52     52       Zinc #2     [CH]   2
METAL     55     55       Zinc #2     [CH]   2

Additional information [?]

Size range 50-85 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q8TCQ1 (MARH1_HUMAN)
Scope
Eukaryota
Viruses

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]