ProRule PRU00623
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00623
General rule information
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| Accession | PRU00623 |
| Dates | 08-MAY-2008 (Created)
19-NOV-2022 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51292; ZF_RING_CH |
Name | Zinc finger RING-CH-type |
| Function | The RING-CH-type is an E3 ligase mainly found in proteins associated to membranes. |
| Scope(s) |
Eukaryota Viruses |
| Example(s) | Q8TCQ1; |
Propagated annotation
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Comments
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| DOMAIN | The RING-CH-type zinc finger domain is required for E3 ligase activity. |
Keywords
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| Ligase | |
| Ubl conjugation pathway | |
| Zinc-finger | |
| case (<Feature:PS51292:9=[CH]> and <Feature:PS51292:12=[CH]> and <Feature:PS51292:36=[CH]> and <Feature:PS51292:39=[CH]>) or (<Feature:PS51292:26=[CH]> and <Feature:PS51292:28=[CH]> and <Feature:PS51292:52=[CH]> and <Feature:PS51292:55=[CH]>) | |
| Zinc | |
| Metal-binding | |
| end case | |
Features
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| From: PS51292 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case (<Feature:PS51292:9=[C]> and <Feature:PS51292:12=[C]> and <Feature:PS51292:36=[H]> and <Feature:PS51292:39=[C]>) and (<Feature:PS51292:26=[C]> and <Feature:PS51292:28=[C]> and <Feature:PS51292:52=[C]> and <Feature:PS51292:55=[C]>) | ||||||||||||
| ZN_FING | from | to | /note="RING-CH-type #" | |||||||||
| else case (<Feature:PS51292:9=[CH]> and <Feature:PS51292:12=[CH]> and <Feature:PS51292:36=[CH]> and <Feature:PS51292:39=[CH]>) and (<Feature:PS51292:26=[CH]> and <Feature:PS51292:28=[CH]> and <Feature:PS51292:52=[CH]> and <Feature:PS51292:55=[CH]>) | ||||||||||||
| ZN_FING | from | to | /note="RING-CH-type #; atypical" | |||||||||
| else | ||||||||||||
| ZN_FING | from | to | /note="RING-CH-type #; degenerate" | |||||||||
| end case | ||||||||||||
| BINDING | 9 | 9 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 12 | 12 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 26 | 26 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
[CH] | 2 | |||||||
| BINDING | 28 | 28 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
[CH] | 2 | |||||||
| BINDING | 36 | 36 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 39 | 39 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#1" |
[CH] | 1 | |||||||
| BINDING | 52 | 52 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
[CH] | 2 | |||||||
| BINDING | 55 | 55 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_label="#2" |
[CH] | 2 | |||||||
Additional information
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| Size range | 50-85 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [53] Viruses [10] All [ 63 ]
- Retrieve set of proteins with 3D structure for this domain