We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS51295
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PURL: https://purl.expasy.org/prosite/signature/PS51295
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General information about the entry
| Entry name [info] | CRM |
| Accession [info] | PS51295 |
| Entry type [info] | MATRIX |
| Date [info] |
01-FEB-2007 CREATED;
01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC01005 |
| Associated ProRule [info] | PRU00626 |
Name and characterization of the entry
| Description [info] | CRM domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=97; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=92; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6734837; R2=0.0058687; TEXT='NScore'; /CUT_OFF: LEVEL=0; SCORE=1164; N_SCORE=8.5; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=772; N_SCORE=6.2; MODE=1; TEXT='RR'; /DEFAULT: M0=-15; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-255; BD=-255; /M: SY='M'; M=-19,-52, 9, 34,-40,-49,-37, -1, 3, 8, 62,-18, 34,-30, -6,-10, -4,-20, 12,-39; /M: SY='M'; M=-10, 20,-37, 13,-47, 3,-40, 3, 19,-26, 35,-17, 32,-17, 18, -7, 29,-26,-55,-43; /M: SY='L'; M=-43,-47,-61,-53, 7,-61,-45, 16,-53, 70, 47,-57,-16,-47,-51,-52,-39, -3,-47,-28; /M: SY='T'; M=-13,-45, 9, 14,-50,-21,-37,-46, -8,-49,-43, 6, 21,-12,-15, 45, 59,-40,-59,-21; /M: SY='S'; M=-10,-49, 13, 17,-22, 26,-38,-21, 15,-36,-23, 20, 15,-30,-20, 27, 9,-15,-56,-44; /M: SY='K'; M= 0,-52, 7, 41,-23,-19, 9,-50, 47,-48, 5, 4, -8, 14, 5, -9,-12,-34, 13,-40; /M: SY='Q'; M=-26,-57,-13, 69,-55,-48,-30,-35, 3,-25,-18,-15,-39, 76, -8,-31,-28,-36, 13,-42; /M: SY='R'; M=-15,-50,-42,-34,-40,-31, -9, 3, 37, 17, -6,-17,-48, -5, 52,-10, 5, 2,-53,-38; /M: SY='R'; M= -5,-51,-23, -8,-46,-46, 4,-30, 48,-24,-37,-14,-45, 12, 57, -5, 17,-22,-51, -2; /M: SY='Y'; M= -5,-14, 5, 26, 20,-48, 22,-10, 7,-38, 2,-18,-47, 13, 42,-19,-38,-40,-39, 48; /M: SY='L'; M=-42,-47,-56,-21, 8,-59,-42, -6,-49, 71, 42,-54,-23,-43,-29,-30,-25,-19,-46,-14; /M: SY='R'; M=-20,-57,-18,-27,-50,-51,-32,-16, 39,-34,-38,-32,-49, 1, 90,-36,-39,-31,-52,-39; /M: SY='S'; M= 21,-47,-22,-21,-52, 15,-37,-48, 29,-49,-17, 10,-17,-17, 34, 37, 4,-23,-55,-44; /I: I=-24; MI=0; MD=-61; IM=0; DM=-61; /M: SY='L'; M=-17,-51,-42, 6,-37, -6,-15, 21, 24, 27, 23,-39,-48, 21, 18,-30,-23, 6,-52,-37; /M: SY='A'; M= 60,-44, -8,-39,-23, 48,-16,-48,-17,-39,-41,-17,-44,-37,-43, -5,-11,-39,-50, -8; /M: SY='H'; M=-21,-51,-38,-24, -6,-35, 97,-14,-34, 10, 24, 5,-49,-18, 13, -8, -2,-16,-56, 9; /M: SY='H'; M= -5,-51, 29, 5,-49,-11, 60,-48, 24,-24,-39, -2, -9, -2, 16, 4, 20,-28,-59,-18; /M: SY='L'; M=-30,-14,-28,-30,-27,-38,-41, 12,-11, 54, 46,-10,-52,-22,-13, -7, 0, -6,-52,-34; /M: SY='K'; M= -9,-53, 3, 18,-52,-44,-16,-46, 54,-28,-14, 18, 41, -5, 16,-10,-13,-20,-55,-44; /M: SY='P'; M= 4,-57,-24,-11,-53,-44,-43,-12, -8,-37,-39, -8, 94,-13, -5,-15,-18, 0,-56,-51; /M: SY='V'; M=-24,-49,-16,-27,-18,-41, 24, 33, 0, 8,-24,-39,-49, -6, 2,-11, 18, 35, 29, 1; /M: SY='V'; M=-19,-10,-58,-52, 32,-58,-52, 38,-50, 17, 30,-51,-27,-29,-51,-43, 1, 55,-49,-28; /M: SY='W'; M= -3,-50,-38,-33,-26,-44, 0, 4, 16, -6, 29, 30,-20, 39, 21, -5, 5,-14, 55,-34; /M: SY='I'; M=-27,-48,-58,-35,-17,-61,-55, 62,-51, 27, 10,-53,-22,-49,-54,-46,-14, 51,-54,-34; /M: SY='G'; M= -5,-53,-25,-47,-59, 88,-46,-64,-28,-60,-50,-28, -4,-41,-11,-26,-23,-57,-51,-53; /M: SY='K'; M=-21,-54, -3,-16,-53, -8,-33,-53, 72,-52,-42, -5, -7, 18, 41,-19,-23,-33,-50,-15; /M: SY='N'; M= 18,-48, 16, 12,-50, -4,-11,-51, 4,-41,-43, 63,-45, 12, 15, 19,-29,-47,-56, -4; /M: SY='G'; M=-27,-53,-18,-48,-57, 89,-45,-63,-41,-44,-49,-13,-45,-41, -1,-19,-25,-58,-51,-52; /I: I=-14; MD=-35; /M: SY='V'; M=-38,-48,-58,-34,-11,-62,-52, 25,-50, 43, 5,-55,-57,-18,-29,-30,-35, 55,-54,-16; D=-14; /I: I=-14; MI=0; MD=-35; IM=0; DM=-35; /M: SY='T'; M=-24,-42,-27,-40, 17,-34,-39, -1,-27, -4,-31, 9,-43,-39,-42, 16, 77,-28,-49, 21; /M: SY='D'; M=-22,-14, 55, 52,-34, -9, 8,-54,-10,-52,-46,-26, 18, 45, -6,-20,-23,-33,-59,-44; /M: SY='G'; M= 25,-45,-18,-15,-51, 42,-38,-32,-14,-31,-42, 40,-25,-22,-40, 39, 0,-24,-57,-47; /M: SY='V'; M=-19,-45,-59,-53, 4,-59,-53, 22,-51, 31, 25,-54,-55,-50,-51,-44, -9, 65, 21,-17; /M: SY='I'; M= 4,-46,-58,-52,-17,-57,-53, 52,-40, 33, 22,-52,-53,-47,-36,-43,-14, 47,-53,-34; /M: SY='E'; M= 11,-51, 18, 51,-54, -3,-34,-36, 16,-26,-41, 17, -4, 22, 1,-11,-11,-25,-56,-46; /M: SY='E'; M= 19,-51,-11, 65,-56,-13,-31,-52, -6,-49, 2, 25,-39, 38, -1, 8,-32,-47,-56,-46; /M: SY='I'; M=-18,-49,-60,-55,-14,-61,-53, 68,-52, 26, 47,-52,-52,-48,-53,-46,-17, 36,-52,-32; /M: SY='H'; M=-20,-53, 41, 28,-49,-46, 69,-29, 31,-16,-37, 18,-44, -5, 15,-25,-35,-13,-62,-36; /M: SY='E'; M=-17,-52, 31, 36,-26, -4, -2,-36, 20, -6, -1, 10,-44, 9, 32,-12,-13,-28,-56,-40; /M: SY='H'; M= 45,-20,-38, -9,-47,-39, 56,-41, -4, 1, 2,-32,-45, 50, 3, -5, 1,-37,-55,-36; /M: SY='W'; M=-47,-54,-67,-56, 28,-58,-54, 14,-53, 55, -5,-62,-58,-49,-52,-55,-46,-25,122,-16; /M: SY='E'; M= -5,-52, 15, 53,-52,-36,-33,-50, 45,-14,-41, 10,-40, 10, 17, -8, -5,-46,-55,-44; /M: SY='K'; M= 18,-48, 22,-13,-23,-43, 22,-28, 43,-32,-37,-21,-44,-13, 11, 2, 19, 12,-55,-17; /M: SY='H'; M=-22, 12, 2, -8,-50,-20, 93,-58, 2,-50,-39, 19,-47,-23, 54, 10,-24,-53,-64,-31; /I: I=-30; MI=0; MD=-77; IM=0; DM=-77; /M: SY='E'; M=-25,-56, -6, 89,-57,-19,-32,-56, 2,-26,-45,-33,-17, 1, -7,-12,-36,-50,-56,-48; /M: SY='L'; M=-20,-45,-59,-53,-22,-60,-49, 28,-53, 66, -9,-56,-57,-48,-52,-48,-10, 31,-51,-32; /M: SY='V'; M= 16, -8,-58,-53,-30,-56,-58, 59,-51, 4,-18,-52,-52,-50,-54,-41,-31, 61,-56,-37; /M: SY='K'; M=-39,-54,-33,-20,-54,-33,-34,-38, 90,-51,-14,-26,-41, -2, 33,-34,-24,-49,-49,-41; /M: SY='V'; M=-35,-17,-61,-56,-27,-47,-59, 62,-53, 16, -2,-54,-54,-52,-55,-46,-32, 65,-56,-35; /M: SY='K'; M= -1, -7, 11,-16,-32,-44,-19,-15, 65,-37,-40, 6,-44,-22, 44, -4, -9,-43,-53,-41; /M: SY='C'; M=-20, 62,-59,-55, 33,-58,-54, 44,-51, 10, 23,-50,-55,-52,-53,-31,-12, 43, 15,-29; /M: SY='L'; M=-15,-49, -7, -4,-18, -9, 32,-32, 32, 34, -7, 14,-21, -2, -2,-14,-18,-16,-53,-35; /I: I=-22; MD=-57; /M: SY='Q'; M=-12,-55, 6, 14,-55, 29, -3, -5, 15,-49,-41, 3,-12, 42, 33, -8,-26,-32,-55,-44; D=-22; /I: I=-22; MI=0; MD=-57; IM=0; DM=-57; /M: SY='N'; M= 8,-48, 16, 6,-12,-14,-38,-13, 0, 1,-10, 26, 12,-33,-15, 13, -1, 12,-55,-18; /M: SY='E'; M= -4, 34, 29, 36,-32,-13,-37,-32, -6,-15,-40,-22, 23, 16,-17, 21, 2,-27,-56,-17; /M: SY='R'; M=-13,-12,-16, 10, -8, 17,-35,-32, 11,-19, 6, 22, 21,-28, 49, -8,-12,-32,-53,-41; /M: SY='E'; M= -7,-50, 26, 42,-44, 0,-11, -3, -3, 2, 27,-31,-42,-28, -3, 10, 8,-13,-56,-30; /M: SY='D'; M=-21,-13, 71, 29,-34,-29,-32,-39,-16,-45,-27, 36, -1, 3,-10,-21, 18,-39,-65,-45; /M: SY='R'; M=-31, -4,-44,-36,-21,-50,-36, 4, 23, -7, 52, -6, 7,-29, 57,-11,-17, 5,-50, -1; /M: SY='K'; M= 2,-53, 33, 34,-32,-45, 1,-31, 52,-28,-40,-19,-42, 24, 22,-24,-16,-33,-55,-41; /M: SY='E'; M= 10,-52, 0, 56,-52,-25, -2,-37, 19,-34,-23, 3,-29, 19, 31,-11, -5,-36,-54,-21; /M: SY='M'; M= 12,-46,-54,-49, -5,-52,-47, 51,-47, 17, 57,-21,-49,-27,-49,-38, 15, 23, -9,-14; /M: SY='A'; M= 55, 27,-46,-42,-29, 8, 33, 20,-32,-16, -6,-38,-47,-18,-27, -6,-26,-15, 6,-11; /M: SY='E'; M= 19,-50, 21, 56,-31,-42, -7,-45, 17,-28,-20, 5,-40,-12, -7, 8,-15, -9, 8,-42; /M: SY='Q'; M= -2,-51, -5, 31, -8,-36, 0, 6, 31,-14, -7,-15,-43, 37, 14,-16, 4,-11,-51,-23; /M: SY='L'; M=-40,-47,-61,-55,-22,-62,-51, 52,-54, 59, 14,-56,-56,-48,-53,-30,-36, 26,-51,-32; /M: SY='C'; M= 35, 60,-32, 43,-51,-42,-39,-34, 25,-26,-17,-35,-27, 6, 4, -8,-11,-18,-56,-46; /I: I=-19; MD=-47; /M: SY='E'; M= 1,-51, 30, 47,-24, -6,-19,-31, 3,-33,-41, -5,-42, 12, 10, -8, 17,-13,-56,-21; D=-19; /I: I=-19; MD=-47; /M: SY='K'; M= 14,-50,-23, 16,-43,-37,-16, -9, 44, 6, 8, 7,-46, -7, 16,-11,-19,-23,-52,-14; D=-19; /I: I=-19; MI=0; MD=-47; IM=0; DM=-47; /M: SY='T'; M=-14,-14,-39,-19,-38,-25,-42,-11,-17, 12,-29, -6,-44,-22,-20, 32, 60, 18,-58,-24; /M: SY='G'; M=-32,-53, 11,-26,-24, 62,-38,-55, 3,-28,-45, 23, 16, 7, 12, 3,-37,-53,-53,-46; /M: SY='G'; M= 43, 42,-41,-25,-32, 45, -5,-23,-41,-29,-40,-32,-45,-13,-45, 34,-30,-16,-54,-45; /M: SY='E'; M= -6,-49, -5, 43,-19,-49,-19, 12, 1, 1,-30,-36,-44, 12,-10, 6, 8, 24,-54,-23; /M: SY='L'; M=-32,-48,-55,-39, -9,-46,-11, 26,-46, 48, -2,-52, 22,-46,-10,-34,-27, 41,-52,-34; /M: SY='V'; M= -2,-46,-56,-52,-31,-34,-57, 56,-48,-10, -3,-49,-52,-48,-29,-13,-16, 65,-57,-37; /M: SY='Q'; M=-26,-55, 20, 2,-27, -8, 20,-49,-26,-21,-39, 1,-45, 76, 0, 25,-16,-49, 60,-17; /M: SY='V'; M=-15,-48,-47,-40, 26,-51, 18, 15, -2,-19, 2,-39,-50, 4, 36, 6, 4, 41,-51,-30; /M: SY='I'; M=-39,-53, 6, 2,-37,-53, -8, 59, 3, -5, 0, 5,-47,-14, 32, -5,-19, -7,-54,-37; /I: I=-24; MI=0; MD=-61; IM=0; DM=-61; /M: SY='G'; M=-13,-52,-17,-28,-54, 82,-42,-42, -9,-57,-48, 16,-23,-39,-46,-15,-40,-36,-51,-17; /M: SY='N'; M=-25,-52,-11, 18, 2,-12, 34,-30, 30,-48,-40, 43,-45,-15, 43, 5,-14,-47,-50, 7; /M: SY='T'; M=-16,-45,-22,-39,-20,-48,-43, 26, 0, -6, 7, -4,-45, 8,-16, 9, 50, 28,-55,-16; /M: SY='I'; M= 16,-48,-55,-50, 18,-27,-16, 52,-29, 28, -1,-49,-52,-33,-49,-41,-25, 24,-45, 6; /M: SY='V'; M=-35,-46,-11,-49, -3,-59,-54, 44,-30, 29,-17,-49,-53,-49,-50,-30, 1, 59,-55,-34; /M: SY='L'; M=-33,-48,-60,-54, 27,-62,-47, 46,-52, 54, 7,-55,-57,-21,-51,-50,-37, 18,-42, 13; /M: SY='Y'; M=-26,-57,-50,-17, 53,-54, -7,-18,-43,-24,-29,-50,-57,-15,-42,-44,-44,-37, 81,100; /M: SY='R'; M=-42,-57,-19,-26,-52,-52,-31,-54, 42,-38,-40,-31,-49,-18, 94,-36,-22,-33,-52,-40; /M: SY='G'; M= 0,-23,-38, 4,-27, 52,-41,-12, 12,-50,-42,-16, 46, 7, 19,-31,-38,-31,-51,-47; /M: SY='N'; M= 7,-47,-16,-22,-33,-15, 16,-48, 31,-50,-17, 45,-45,-25, 30, 44,-27,-23, 6,-40; /M: SY='P'; M=-18, -5, 33, 27,-52,-14,-33,-28, 4,-39,-44, 38, 47, -4, 11, 7,-32,-29,-58,-16; /M: SY='Y'; M= -9,-53, 10, 27, 2, -7,-30,-44, 28,-43,-38, 7,-17, -4, -6,-13, -7,-19, 14, 61; /M: SY='W'; M= -2, -4, 11, 11,-45,-15,-36,-33, 33,-16,-39, 16, 18, 11, 20,-11,-12,-22, 39, -1; /M: SY='P'; M=-29,-21, 5, 22,-45,-23,-35,-42, 8, 2,-37, 14, 51, 3, 25, 6,-10,-22,-53, -2; /M: SY='P'; M= -5,-52,-34, 11,-47,-44, 4, -2, 33,-37,-37, 11, 49, 12, 15, -2, 12,-17,-53, -5; /M: SY='I'; M= 1,-13,-25, 11, -8,-11,-39, 27, 12,-10,-31,-23, -4, 26, 8, 3, -4, -8,-47, 11; /M: SY='K'; M=-30,-49,-10,-15,-22, -5, 17,-23, 39, 21,-29, 1,-47, 8, 14, 2, 4, 6,-54,-37; /M: SY='P'; M=-21,-50,-22, -8,-24,-38,-40, 12, 4, 20, 18,-21, 36, 0, 11, 24, -4, -2,-53,-39; /M: SY='P'; M= -9, -3, -5, 1,-30,-43, -4, 0, 1, 0,-15, 15, 40, 12, 13, 25,-11,-29, 10,-40; /I: E1=0; IE=-255; DE=-255;» more |
Numerical results [info]
| Total number of hits | 55 in 28 different sequences |
| Number of true positive hits | 55 in 28 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 4 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | CRM |
| Version [info] | 4 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
28 sequences
CAF1M_ARATH (Q8VYD9), CAF1M_ORYSJ (Q6Z4U2), CAF1P_ARATH (Q9SL79), CAF1P_MAIZE (Q84N49), CAF1P_ORYSJ (Q5VMQ5), CAF2M_ARATH (Q9FFU1), CAF2M_ORYSJ (Q0J7J7), CAF2P_ARATH (Q9LDA9), CAF2P_MAIZE (Q84N48), CAF2P_ORYSJ (Q657G7), CFM2_ARATH (Q8L7C2), CFM3A_ARATH (F4J2U9), CFM3B_ARATH (F4JVH1), CFM3_MAIZE (A7XN92), CFM3_ORYSJ (Q2R1U8), CFM9_ARATH (Q9LT57), CRS1_ARATH (Q9LF10), CRS1_MAIZE (Q9FYT6), CRS1_ORYSJ (Q6YYA3), Y1333_HAEIN (P71376), Y3544_ARATH (Q67XL4), Y4753_PSEAE (P95453), Y652_METJA (Q58068), YHBY_ECO57 (P0AGK6), YHBY_ECOL6 (P0AGK5), YHBY_ECOLI (P0AGK4), YHBY_SHIFL (P0AGK7), YQEI_BACSU (P54454)» more
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| PDB [Detailed view] |
2 PDB
pdb_00001jo0; pdb_00001ln4 |