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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS51323


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PURL: https://purl.expasy.org/prosite/signature/PS51323

Direct ScanProsite submission
General information about the entry

Entry name [info] IGFBP_N_2
Accession [info] PS51323
Entry type [info] MATRIX
Date [info] 01-JUL-2007 CREATED;
03-MAY-2023 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00194
Associated ProRule [info] PRU00653

Name and characterization of the entry

Description [info] Insulin-like growth factor-binding protein (IGFBP) N-terminal domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=79;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=74;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.4291053; R2=0.0052501; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1252; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=585; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-59; D=-150; I=-150; B1=-1000; E1=-1000; MI=-355; MD=-355; IM=-355; DM=-355;

...
 
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-355; BD=-355;
/M: SY='R';  M=  27,  -4,-112,   1,-111, -68,-109, -56,-101, -14, -19,-109,  19,   5,  44,  42, -33,  12,-120,  34;
/M: SY='A';  M=  49,-118,-115, -21,  -1,  10, -29, -45, -61,  14,-104, -49,  24, -29, -59,  28,  -8,   6,-124,-111;
/M: SY='W';  M=  19,-120, -20,  -3,  38, -54,-114, -13,-110,  30, -15,-114,  15,  42, -35, -29, -42,  24,  51,-100;
/M: SY='R';  M= -44,-123,  13, -34, -11,  24,  53, -56, -11, -50,-109, -62,  14, -39,  54,  26,   2,   3,-124, -16;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='P';  M=  20,-127,-111,   0,-124,   0, -32, -35, -34, -10,-111,-113, 106,-108, -61,   5,-104,-114,-125,-122;
/I:         I=-33; MD=-79;
/M: SY='P';  M=  18,-128, -15,  25,-124,   6,-113,-123,-106,-126,-117,-109,  94,  -4, -51,  25, -47,-121,  52, -17; D=-33;
/I:         I=-33; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/I:         I=-28; MD=-66;
/M: SY='D';  M=-113,-130,  77,   7,-133,   3,-110,-128,-104,-130,-125,   2, -20,   9,  22,  13,  12, -22,-141,-123; D=-28;
/I:         I=-28; MD=-66;
/M: SY='P';  M=  25,  -2, -60,  12, -23, -45,-118,-125,  -3,-128,-120,   0,  84,  15,-116, -35, -43, -47,   7,-124; D=-28;
/I:         I=-28; MD=-66;
/M: SY='E';  M=   8,-129,  10,  64,-135,  -5,-115,-133, -35,-132,-126, -37, -36,-103, -16,  30,  22,-125,-138,-127; D=-28;
/I:         I=-28; MI=0; MD=-66; IM=0; DM=-66;
/M: SY='R';  M=  12,-122,-105,  29,-119,   2, -12,-116,  27,  -3,  20,-102,-115,  40,  57,  19, -12,-113,-124,-111;
/M: SY='C';  M=-109, 129,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='P';  M=  19,-130,-108,  20,-130, -26,-112,-123, -35,-127,-116,-111, 108, -20,  27,  -7,-105,-121,-126,-124;
/M: SY='P';  M=  33,-125,   4,   8,-124,   3,-114, -53, -55, -62, -34,-109,  93, -11,-115,  10, -21,-116,  48,-118;
/I:         I=-18; MD=-42;
/M: SY='P';  M= -15,-135,-127,   0,-125, -54,-129,  -3,-125,  13, -14, -74,  45,  -5,-130,   8,  -5,   2,-141,-127; D=-18;
/I:         I=-18; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='P';  M=  -3,-140, -12,-112,-139, -36,-123,-132, -62,-137,-126,-120, 103,-117,  15,  -5, -32,-131,-137,-134; D=-18;
/I:         I=-18; DM=-42;
/M: SY='P';  M=  -4,-128, -23,   1,-123, -10,-116,-112,   2,   1, -57,-113,  86,-109,   8, -25,   4,  -7,-129,-121; D=-18;
/I:         I=-18; DM=-42;
/M: SY='P';  M= -39,-124,  28, -37,-124,  36, -15,-124, -42,-125,-116,  14,  53,   3,  47,  27,  15, -77,-126, -17;
/M: SY='C';  M=-109, 129,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='P';  M=  31,-122,-106,  44, -21, -69,-112,-110,   6,  -2,-108,-110,  81, -31,-109,   1,  -1, -17,-124,-116;
/I:         I=-33; MD=-79;
/M: SY='P';  M=  31,-127,-107,  57, -29,  15,-114,-117,-109,  -4,-112,-114,  58, -29,-116, -50, -41, -44,-123,  13; D=-33;
/I:         I=-33; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='G';  M= -29,-122,-115,-120,-116,  89,-117, -13,-114,  21,-107,-103,-118,-112, -12,  11,-110, -63,  -4,-116;
/M: SY='V';  M=-103,-117, -52,  17,-106,-123,-115,   5, -33, -28, -98,-110, -28, -27,  10,  12,  45,  69,-125,  14;
/M: SY='R';  M=   5,-118,-114,-109,-113, -53,-113, -55, -34, -70,-104,-108,  36,-105,  59,  21,  41,  52,-126,  -5;
/M: SY='P';  M=  30,-121,-109,  39,-111,-117,-110,-103,   0,  42,  19,-113,  48, -14,  26, -22,-106, -31,-123,-112;
/I:         I=-36; MI=0; MD=-85; IM=0; DM=-85;
/M: SY='D';  M= -16,-129, 105, -11,-132, -18,-107,-128,-106, -48,-124, -92,  56,-105,-115,-104, -21,-125,-141,-121; D=-36;
/I:         I=-36; DM=-85;
/M: SY='G';  M=  18,-124,  -9, -21,-124,  78, -14, -39, -37, -19,-113,-104,  11, -41,   6,-101,-111, -23,-125,-120; D=-36;
/I:         I=-36; DM=-85;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='G';  M= -23,-123, -14, -34,-129,  98,-114,-134,-111,-131,-121,  -2,-115, -14, -43, -30, -28,-127,-123,-123;
/M: SY='C';  M=-109, 157,-123,   4,-120,-124,-126,-126,-121,-117,-117,-114,-136,-126,-128,-111,-109,-114,-147,-129;
/M: SY='C';  M=  -6, 157,-128,-127,-119,-122,-128,-125,-123,-116,-116,-114,-137,-130,-130,-109,-108,-112,-147,-129;
/M: SY='P';  M=  -7,-126, -43,  15, -58, -19,-109,-113,  17,  10,  -3,-110,  76,  -2,  33,  -3,-107,-114,  32,  12;
/M: SY='V';  M=-102,-116,-120, -29,-106,  -5,-121,  -3,-113, -46,  45,-115,-120,  19, -33,-107,  35,  86,-131,-109;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='A';  M=  94,-112,-117,-110, -29,  -7,-116,-109,-111,   2,-105,-111,   5,-108, -29, -93,-102,-101,-122,-115;
/M: SY='R';  M=  37,-121,-112,-103,-115,  -8,-107,-110,  35,  25,-102, -15,-119,  11,  73, -24,-106, -42,-122,-111;
/M: SY='Q';  M=  19,-125,-108,   1,-123,  41,-107, -52, -96,  -5,-107,-104,  24,  79,  45, -27,-108, -70,-122,-114;
/M: SY='E';  M=-110,-126, -94,  92,-115,-125,-106, -39, -15,  36, -50,-110,  33, -92,  22,-110,-109,-110,-125,-114;
/M: SY='G';  M= -99,-123, -13,-118,-129, 101,-114,-135,-113,-132,-122,  32,-116,-111, -44, -66, -43,-130,  -1,-123;
/M: SY='E';  M=  17,-126,  19,  92,-130, -45,  11,-126, -93,-120,   8,-101,-108,  67,-100,-101,-108,-120,-127,-116;
/M: SY='P';  M=  25,-119, -21,  -3,   3,-111,-110, -21,-105,   1,-106, -21,  57,  -5,  -2,  52,  -1, -37,-122, -16;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='G';  M= -99,-122,  30, -47,-124,  93,-112,-131,-112,-129,-121, -25,-115,-110,-119,  11,   5,-126,-122,   6;
/M: SY='V';  M=-103,-121, -58,  31,-115,  56,  19, -65, -15, -13,-104, -17, -44, -35,   7, -26,-106,  56,-128,-113;
/M: SY='Y';  M=  25,-121,  -1,-110,  23, -10,-104,-105,-108,  -8, -16,-110,  39,   4,   3,-104,  24, -21,-105,  80;
/M: SY='T';  M=  -8,-119,  -2,  14,   9, -21,  21, -64,-104, -28,-106, -46,  12,  10, -12, -31,  73, -12,  47,  -1;
/M: SY='P';  M=   9,-123,  -4,  16,-123,  34,-112, -34, -27, -42,-111,  17,  76,  -7,-113,   4, -50,   4,-127,-120;
/I:         I=-24; MD=-56;
/M: SY='R';  M= -28,-134, -16,-114,-127,   3, -37, -30, -31,  -4,-116,  16,  14, -28,  71, -25,-117, -45,-135,-122; D=-24;
/I:         I=-24; MI=0; MD=-56; IM=0; DM=-56;
/M: SY='C';  M=-109, 159,-128,-129,-117,-124,-127,-125,-124,-116,-116,-115,-139,-132,-131,-111,-109,-113,-146, -36;
/M: SY='A';  M=  64,-119,  62, -44,-128,  59,   4,-124,-108,-123,-117, -98,-115,   6,-114, -57,-106, -70,-128,-118;
/M: SY='P';  M= -38,-129, -12,  53, -18, -63,   6,-122, -60,-123,-115,-106,  90,  27,  21,  19, -45, -57,-126,-116;
/I:         I=-42; MI=0; MD=-99; IM=0; DM=-99;
/M: SY='G';  M= -98,-124,   6,-116,-127, 101,-115,-135,-113,-131,-121, -97,-116, -10, -56, -16, -61,-129,-121, -20;
/M: SY='L';  M=-115,-117,-132,-124,   4,-133,-115, -80,-125,  95,  26,-130,-131,-118,-122,-124,-111, -88,-117, -98;
/M: SY='R';  M= -19,-125,-105,  42, -11,-120,-103,-111,  -8,-113,-107,-106,-117,  55,  69,  -6, -44,  15,  35,  43;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='Q';  M=  -5,-122,  34, -55,-106, -47,  34, -32,-102,  -5,-100, -15,-121,  56,  27, -45,-105,  49,-120,  44;
/M: SY='P';  M=   3,-125,-115,-107,  32,-117,-111, -11,  12, -45,-106, -17,  86, -28,  29, -23, -27,   0,-116,  12;
/I:         I=-17; MD=-41;
/M: SY='P';  M= -39,-124, -12, -63,-117,  19,  -3,-115, -58,  10,-108,  13,  59, -44,  50,  37, -40, -56,-125, -14; D=-17;
/I:         I=-17; MD=-41;
/M: SY='P';  M=  31,-122, -22,  -9,  11,  13,-113,-116,  -6, -63,-112, -37,  66, -17,  13,  13,   7, -29,-124,-114; D=-17;
/I:         I=-17; MD=-41;
/M: SY='G';  M= -18,-125,  48,   2,-131,  75,-111,-132,   4,-131,-122,  -3,  28,-105, -42,   1,-108,-127,-128,-123; D=-17;
/I:         I=-17; MD=-41;
/M: SY='E';  M= -23,-125,  -8,  54, -22,   5,-111,-112,-102, -13,-111,  11,  43,-102,  28,  12, -58,  14,-128,-116; D=-17;
/I:         I=-17; MD=-41;
/M: SY='P';  M=   3,-127,  30,  53,-131,   0,-107,-128, -25,-128,-120,  41,  56, -10,  15, -17, -21,-124,-132,-122; D=-17;
/I:         I=-17; MD=-41;
/M: SY='R';  M=  29,-124,  14,-107, -14,  13,-111, -28,  25,  13, -29, -19,  13, -40,  41,-107,-109, -39,-122,  -2; D=-17;
/I:         I=-17; MD=-41;
/M: SY='P';  M=-109,-129, -15,  -5,  -7,  12,  11,-120,   1, -46,   0,-108,  86, -29, -28,  31, -32,-121,-122,  11; D=-17;
/I:         I=-17; MD=-41;
/M: SY='L';  M=  14,-127, -34,  11, -21,  17,-119,-112, -27,  44,-106, -21, -63, -19, -25,   1, -55,-113,-130,-118; D=-17;
/I:         I=-17; MD=-41;
/M: SY='H';  M=   7,-134,  -3, -16,-127,   5,  54, -27, -45, -35,-118,-114, -29,  14,  28,-113,  11, -38,-136,  -5; D=-17;
/I:         I=-17; MD=-41;
/M: SY='A';  M=  47,-130,-123,   5,-127, -36,-127,-116, -28, -28,-118, -21,   1, -41, -60,-111,  16,  13,-137, -10; D=-17;
/I:         I=-17; MD=-41;
/M: SY='W';  M= -39,  23,-136,  -3,  -6, -45,-130,-113,-126,  45,-109,-137, -55, -40,  10,-132,-128, -36,  55,  -5; D=-17;
/I:         I=-17; MD=-41;
/M: SY='Y';  M= -39,-139,-142,-136,-115, -45,-130, -22,-129,  30,  -5,-137, -18,-131,  10,-130,  -1,  13,-134,  32; D=-17;
/I:         I=-17; MD=-41;
/M: SY='H';  M= -39,-149, -37,  23, -58, -45,  37, -38,-117, -14, -61, -42, -15,  14,  34,-129, -66,-135,-149,-131; D=-17;
/I:         I=-17; MD=-41;
/M: SY='G';  M= -17,-153, -46, -68, -24,  63,-146,-159,-143,-155,-148,-131,-146, -17,-149,-128,-143,-154,  34,-142; D=-17;
/I:         I=-17; MI=0; MD=-41; IM=0; DM=-41;
/M: SY='Q';  M= -11,-128,  -7, -16,-124,-126,-117,  -2,  17, -23,-110, -51,-123,  54,  26, -34,  30,  18,-134,-118; D=-17;
/I:         I=-17; DM=-41;
/M: SY='G';  M= -16,-123,-111, -38,-130, 103,-117,-135,-115,-131,-121, -99, -16,-112,-122, -24, -46,-128,-122,-124;
/M: SY='V';  M= -15,-117, -43,-115, -41,-124,-118,  29,-106,  13,  -5, -43,-121,-111,  41, -33,  46,  60,-127,-107;
/M: SY='C';  M=-109, 159,-129,-129,-119,-124,-129,-126,-124,-116,-117,-115,-139,-132,-131,-111,-109,-113,-149,-130;
/M: SY='V';  M=  19,-119,-110,  33,-114,  10,-112, -96,  -3, -13,  43,-109,-116,  33,  15,-103,   5,  50,-126,-112;
/M: SY='C';  M=   3, 105,  23,   1,-119,-117,-110,-115,  16, -55,-111,  21,   5,   1,  33,-105, -70,   0,-131, -20;
/M: SY='A';  M=  44,  22,-107,  22,-117,-113, -44, -38,  36,   5,-105,  13,  27,  -8,  19, -30, -69,  -3,-126,-114;
/I:         E1=0; IE=-355; DE=-355;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 98 in 98 different sequences
Number of true positive hits 98 in 98 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] IGFBP N-terminal
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 98 sequences 

CCN1_CHICK  (P19336), CCN1_HUMAN  (O00622), CCN1_MOUSE  (P18406), 

CCN1_PANTR  (A5A6L1), CCN1_RAT(Q9ES72), CCN2_BOVIN  (O18739), 
CCN2_HUMAN  (P29279), CCN2_MOUSE  (P29268), CCN2_PIG(O19113), 
CCN2_RAT(Q9R1E9), CCN3_CHICK  (P28686), CCN3_COTJA  (P42642), 
CCN3_HUMAN  (P48745), CCN3_MOUSE  (Q64299), CCN3_RAT(Q9QZQ5), 
CCN3_XENLA  (P51609), CCN4_HUMAN  (O95388), CCN4_MOUSE  (O54775), 
CCN4_RAT(Q99PP0), CCN5_HUMAN  (O76076), CCN5_MOUSE  (Q9Z0G4), 
CCN5_RAT(Q9JHC6), CCN6_HUMAN  (O95389), CCN6_MOUSE  (D3Z5L9), 
CRIM1_CHICK (Q8AWW5), CRIM1_DANRE (Q7T3Q2), CRIM1_HUMAN (Q9NZV1), 
CRIM1_MOUSE (Q9JLL0), ESM1_HUMAN  (Q9NQ30), ESM1_MOUSE  (Q9QYY7), 
ESM1_RAT(P97682), HTR1A_DANRE (Q6GMI0), HTR1B_DANRE (A9JRB3), 
HTRA1_BOVIN (F1N152), HTRA1_HUMAN (Q92743), HTRA1_MOUSE (Q9R118), 
HTRA1_RAT   (Q9QZK5), HTRA1_XENLA (A6YFB5), HTRA1_XENTR (A4IHA1), 
HTRA3_HUMAN (P83110), HTRA3_MOUSE (Q9D236), HTRA3_RAT   (D3ZA76), 
HTRA4_BOVIN (E1BJW1), HTRA4_HUMAN (P83105), HTRA4_MOUSE (A2RT60), 
HTRA4_RAT   (D3ZKF5), IBP1_BOVIN  (P24591), IBP1_HUMAN  (P08833), 
IBP1_ICTTR  (Q6Q484), IBP1_MOUSE  (P47876), IBP1_PIG(Q75ZP3), 
IBP1_RAT(P21743), IBP2A_DANRE (Q9PTH3), IBP2B_DANRE (B3F211), 
IBP2_BOVIN  (P13384), IBP2_CHICK  (P49705), IBP2_HUMAN  (P18065), 
IBP2_MOUSE  (P47877), IBP2_PIG(P24853), IBP2_RAT(P12843), 
IBP2_SHEEP  (Q29400), IBP2_XENLA  (Q5XHC5), IBP2_XENTR  (A4IIA2), 
IBP3_BOVIN  (P20959), IBP3_HUMAN  (P17936), IBP3_MOUSE  (P47878), 
IBP3_PIG(P16611), IBP3_RAT(P15473), IBP4_BOVIN  (Q05716), 
IBP4_HUMAN  (P22692), IBP4_MOUSE  (P47879), IBP4_PIG(P24854), 
IBP4_RAT(P21744), IBP4_SHEEP  (Q28893), IBP5_BOVIN  (Q05717), 
IBP5_HUMAN  (P24593), IBP5_MOUSE  (Q07079), IBP5_PIG(Q28985), 
IBP5_RAT(P24594), IBP5_XENLA  (Q90WV8), IBP6_BOVIN  (Q05718), 
IBP6_HUMAN  (P24592), IBP6_MOUSE  (P47880), IBP6_RAT(P35572), 
IBP7_HUMAN  (Q16270), IBP7_MOUSE  (Q61581), IBPL1_BOVIN (A5PKD8), 
IBPL1_HUMAN (Q8WX77), IBPL1_MOUSE (Q80W15), IGFBP_CUPSA (G4V4G1), 
KAZD1_HUMAN (Q96I82), KAZD1_MOUSE (Q8BJ66), PLSLP_LOTGI (B3A0Q9), 
PLS_HALLA   (P82595), SIBD1_CUPSA (G4V4F9), SIBD2_CUPSA (G4V4G0), 
VP302_LYCMC (P0CJ14), VP59_LYCMC  (P0CJ12)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

IBP2_ONCTS  (P83628)


				
	

	

		PDB
[Detailed view]		
		
			13 PDB
			


			pdb_00001boe; pdb_00001h59; pdb_00001wqj; pdb_00002dsp; pdb_00002dsq; pdb_00002dsr; pdb_00002jm2; pdb_00003tjq; pdb_00003zxb; pdb_00003zxc; pdb_00007ufg; pdb_00007wrq; 
			
				pdb_00008ivd
			
			

			» more