PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00653


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00653
General rule information [?]

Accession PRU00653
Dates 05-DEC-2007 (Created)
23-JAN-2023 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51323; IGFBP_N_2
Name Insulin-like growth factor binding protein N-terminal domain
Function The IGFBP N-terminal domain participates in binding to IGFs.
Scope(s) Eukaryota
Metazoa
Example(s) P48745;

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS00222; IGFBP_N_1; 1;

Features [?]

From: PS51323
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="IGFBP N-terminal #"
case <Feature:PS51323:31-32=C-C>
DISULFID 5 29 disulf C-x*-C
DISULFID 8 31 disulf C-x*-C
DISULFID 13 32 disulf C-x*-C
DISULFID 20 35 disulf C-x*-C
DISULFID 43 56 disulf C-x*-C
DISULFID 50 76 disulf C-x*-C
else
DISULFID 5 8 disulf C-x*-C
DISULFID 13 20 disulf C-x*-C
DISULFID 29 35 disulf C-x*-C
DISULFID 43 56 disulf C-x*-C
DISULFID 50 76 disulf C-x*-C
end case

Additional information [?]

Size range 60-100 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]