PROSITE entry PS51325

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General information about the entry

Entry name [info]	ALPHA_BOX
Accession [info]	PS51325
Entry type [info]	MATRIX
Date [info]	01-JUL-2007 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51325
Associated ProRule [info]	PRU00655

Name and characterization of the entry

Description [info]

Alpha box DNA-binding domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=59;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=54;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.8848138; R2=0.0188497; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3052.2575684; R2=1.0101695; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=245; H_SCORE=3300; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=139; H_SCORE=3193; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: B1=*; E1=*; MM=*; II=*;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=-85; E0=*; BM=-1; BD=-38;
/M: SY='K';  M=  9,-19,-20,-15,-20,-26,-14,  4, 17,-18,-11,-16,  3,-12,-17,  3, 12, 11,-23,-18; M0=-6;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M= 17,-27,-28,-24,-44,-28,-25,-41, 26,-41,-32,-24, 15,-22,-24, 12,-21,-33,-43,-38; M0=-19;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=-36,-42,-44,-29,-51,-41,-20,-44, 32, -3,-34,-28,-40,-15, 23,-35,  4,-41,-39,-38; M0=-24;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=-40,-44,-51,-33,-55,-43,-21,-47, 34,-43,-36,-30,-42,-17, 26,-38,-36,-45,-40,-40; M0=-32;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=  2, 17,-13, -8,-29,-24,-11,-26, 13,-26,-17,-11, 22, 10,-11, 10,-13,-22,-29, 11; M0=-8;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=-35,-29,-61,-57,-28,-59,-56, 21,-56, 20,-15,-56,-55,-52,-56,-53,-34, 23,-46,-44; M0=-33;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='N';  M=-53,-51,-48,-52,-62,-50,-53,-73,-59,-69,-66, 44,-55,-56,-58,-55,-56,-66,-55,-60; M0=-53;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M= 17,-28,  6,-26,-47, 12,-30,-45,-30,-46,-37,-25,  6,-27,-34, 24,-23,-36,-48,-43; M0=-19;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-55,-45,-59,-63, 41,-58,-20,-44,-58,-37,-38,-44,-56,-45,-52,-50,-54,-46, 26, 25; M0=-43;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='M';  M=-33,-28,-60,-56,-31,-58,-55, 30,-55,-18, 36,-54,-54,-53,-56,-51,-33, 16,-48,-44; M0=-35;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 22,-21,-44,-40,-24, 20,-30,  7,-37,  8,-15,-33,-36,-33,-35,-24,-21,-14,-30,-27; M0=-17;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-55,-45,-59,-63, 42,-58,-20,-44,-58,-37,-38,-44,-56,-46,-52,-50,-54,-46,-12, 26; M0=-43;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M=-61,-54,-62,-59,-66,-53,-50,-72,-43,-67,-64,-58,-57,-51, 43,-63,-61,-69,-55,-62; M0=-55;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M=  4, 22,-40,-37,-36,-28,-32,-32,-35,-35,-27,  7,-34,-32,-36, 28,  5,  4,-39,-36; M0=-19;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Y';  M=-44,-37,-56,-56, 29,-53,-21,-30,-52,-26, 18,-43,-52,-42,-48,-45,-43,  4,-14, 39; M0=-33;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Y';  M=-51,-43,-58,-60, -8,-55,-23,-39,-55,-32, 28,-45,-55,-46,-50,-49,-51,-42,-15, 46; M0=-41;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M=  1,-17,-40,-34,-15,-33,-23,  7,-31,  8, 16,-30,-34,-27,-29, 26,-18, -9,-22,-18; M0=-14;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M=-13,-27,  6, -7,-30,-23,-10,  1,  6, -4,-18,-10,  4, 11, 22,-12, 12,-24,-29,-23; M0=-7;
/I:         MM=-9; MI=-89; MD=-11; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I';  M=-11,-10,-32,-26,-10,-26,-16, 22,-23, 14, -2,-23,-27,-20,-22,  7, 11, -1,-16,-12; M0=-10;
/I:         MM=-13; MI=-79; MD=-8; IM=-9; II=-11; DM=-31; DD=-2;
/M: SY='N';  M= -7,-15, -2, -3,-25,-13, -9,-24, -7,-25,-17, 27, 26, -6,-11, -7, -9,-19,-26,-20; M0=-9;
/I:         MM=0; MI=-67; MD=-77; IM=-9; II=-11; DM=-1; DD=-43;
/M: SY='I';  M=-35,-31,-60,-54, 11,-55,-45, 24,-52, 15, 18,-52,-51,-44,-49,-48,-34, 18,-36,-36; M0=-29;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-15,-17,-24,-19, 26,  1,-15,-13,  3,  6, -9,  6,-29,-15,-19,  1,-14,-12,-21, 20; M0=-7;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='N';  M=  2,-29,-12,  5,-32, 14,-10,-30,  7,-29,-20, 15, 13, -6,-12, 10,-14,-25,-31,-24; M0=-8;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=-13,-28,-12,  5,-31,  9,-10,  1, -6,-28,-19,  7,  3, 23,  6,  3,-13,  0,-30,-23; M0=-6;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='W';  M=-19,-17,-42, 10, 10,-34,-23, 19,-32, 16, -6,-31,-34,-28,-30,-25,-18,  7, 24,-18; M0=-14;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M=  1,-30,-17,-11,-34,-27, 25,-31,  8,-30,-22,-13, 23, -8,  7,-16, 18,-27,-32,-26; M0=-12;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=-38,-42,-40,-39,-38,-43,-35,-40,-28,-34, 18,-38,-47, 44,-28,-40,-40,-42,-42,-38; M0=-33;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M= 10,-31,-16,-10,-35,-26,-12,-32, 25,-31,-22,  9,-27, 10, 14,-16,  4,-27,-32,-26; M0=-12;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='E';  M=-13,-28,  5, 23,-31,-23, 16,-29,  7,-28,-19, -9,-24, 11,-11,  2,-13,  1,-30,  9; M0=-9;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M=-33,-35,-46,-31,-35,-41,-21,  4, 15, 22,-23,-30,-40,-18, 22,-34,-30,-29,-35,-33; M0=-20;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M=-32,-37,-52,-55,-57,-39,-51,-61,-57,-61,-54,-46,-46,-53,-54, 37,-37,-50,-55,-57; M0=-44;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='T';  M=  9,-28,-12, -6,-31, -1,-10,-29,  6,-28,-19,  8,  4, -5,  7, 10, 17,-24,-30,-23; M0=-7;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I';  M=-16,-14,-39,-33,  9,-31,-20, 22,  1, 16, -6,-28,-32,-25,-27,-22,  4, -8,-19, 12; M0=-12;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='M';  M=-44,-38,-68,-63,-19,-67,-53, 25,-61, 24, 27,-64,-56,-48,-55,-61,-43,-20,-38,-40; M0=-38;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M= 12,-25,-33,-29,-44, 12,-29,-41,-27,-43,-34,-26,-33,-26, 21, 17, 14,-33,-45,-41; M0=-18;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=  2,-18,-20, 11,  7,-27,-14,  4, 12, -1,-10,-16,-27, 17,-17,-16,-14, 10,-22,-18; M0=-6;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='M';  M=-16,-14,-38,  2,  8,-31, 15, -9,-28, 18, 26,-27,-31,-24,-26,-22,-15,  5,-18, 11; M0=-12;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='W';  M=-70,-55,-65,-69,-51,-56,-56,-76,-69,-69,-69,-67,-60,-68,-64,-74,-71,-74, 63,-48; M0=-65;
/I:         MM=-1; MI=-37; MD=-99; IM=-2; II=-33; DM=-7; DD=-14;
/M: SY='Q';  M=  1,-28,-12, 13,-31, -1, 17,-29,  6,-28,-19,  8,-24, 17,-10,  2, 12,-24,-30,-23; M0=-8;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M= 10,-27,-13, -7,-30,-24, 24,-28,  7, -4,-18, 20,-24, 10,  6,-13,-13,  0,-29,-23; M0=-7;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M=-34,-55, 33, 23,-56,-31, 17,-56,-30,-54,-49,-17,-37,-23,-41,-30,-35,-51,-56,-45; M0=-31;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=-21,-34,-19,-14,-39,-30, 17,-36, 15,-34,-26,-16, 29, 19, -9,  1,-21,-32,-35,-30; M0=-16;
/I:         MM=-1; MI=-37; MD=-99; IM=-2; II=-33; DM=-7; DD=-14;
/M: SY='F';  M=-15,-15,-33,-27, 26,-30, 26,-10,-24,-13, 18, 20,-31,-21,-24,-21,  5,  5,-19,-15; M0=-12;
/I:         MM=-28; MI=-89; MD=-2; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=-10,-16, -4, -3,-18,-14, -5,-18,  0,-18,-13, -5,-18, 36, -1, -9,-10,-16,-18,-13; M0=-9;
/I:         MM=0; MI=-61; MD=-72; IM=-9; II=-11; DM=-1; DD=-45;
/M: SY='H';  M=-38,-44,-47,-30,-53,-42, 37,-45, 30,-41,-35,-29,-41, 10, 10,-36,-34,-43,-39,-39; M0=-29;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M= 13,-28,-12,  5,-31,  1,-10,-29, 13,-28,-19,  8,-24, -5,-11,  9, 13,-24,-30,-23; M0=-8;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=  2,-23,-15,  5,-25,-24,-11, 11, 17, -3,-15,  7,-25, -7,-13,  3,  4,  1,-26,-21; M0=-5;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='W';  M=-56,-46,-60,-63, -8,-57,-22,-46,-59,-39,-40,-46,-57,-47,-53,-52,-55,-48, 61, 17; M0=-46;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M=  8,-32, 15, 13,-35,-25,-13,-33,  6,-32,-23,  8,-27, -8,-15, 19,-16,-28,-34,-27; M0=-12;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-16,-14,-39,-32, 17,-31,-20, 13,-28, 16, -5,-27,-31,  7,  3,-22,-15,  6,-18, 13; M0=-11;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='M';  M=-34,-31,-57,-52, 20,-52,-37, 15,-48, 15, 33,-48,-48,-40,-45,-43,-33,-19,-30, 21; M0=-27;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 29, 22,-52,-54,-50,-28,-44,-48,-51,-51,-41,-36,-36,-45,-47,  3, 20,-36,-53,-52; M0=-31;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=-17,-31,-16,  5,-35,-26,-12,  1, 22,-31,-22,-13,-27, 23, 15,  2,-16,-27,-32,-26; M0=-12;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 17,-27,-13, 12,-29,-24, 15,-26, -7,-27,-18,-11,-25, 11,-12,  2,-13, 15,-29,-23; M0=-9;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Y';  M=-56,-45,-59,-63, -6,-58,-21,-45,-58,-38,-39,-45,-57,-46,-52,-51,-54,-47, 43, 44; M0=-45;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='N';  M=-20,-27,-34,-37,-51,-28,-39,-49,-41,-51,-42, 31,-36,-37,-42, 21, 21,-37,-52,-50; M0=-28;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='C';  M=-15, 19,-35,-29, 18,-30, 16,  6,-25,  0, -6,  5,-31,-22,  4,  9,  5,  5,-18,-15; M0=-8;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I';  M=  1,-16, 12,-21,-16,-29,-17, 28,-19,-14, 16,-21,-29,  8,-21,-19,-14,-10,-20, 11; M0=-10;
/I:         MM=0; MI=-89; MD=-99; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M= 10,-32,-29,-23,-39,-33,-20,-35,-10, -3,-28, 17,-35,-16, 33,-25,-24,-31,-36,-33; M0=-17;
/I:         B0=*; E1=-10;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	21 in 21 different sequences
Number of true positive hits	21 in 21 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DNA_BIND
Feature description [info]	Alpha box
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

21 sequences

FMR1_PODAS  (P35692), HMAL1_YEAST (P0CY07), MAT1_ALTAL  (O94160),

MAT1_COCC2  (O13402), MAT1_COCCY  (Q9Y8D1), MAT1_COCEL  (Q9Y8C7), 
MAT1_COCHE  (Q02990), MAT1_COCSA  (Q9P446), MAT1_CURKU  (Q9Y8D3), 
MAT1_FUSOX  (O59851), MATA_NEUAF  (Q02292), MATA_NEUCR  (P19392), 
MTA1_SOREQ  (O13595), MTA1_SORFI  (O13596), MTA1_SORMK  (O42837), 
MTAL1_CANAL (Q9UW19), MTAL1_CANGA (Q874P0), MTAL1_KLULA (Q08398), 
MTAL1_NAKDE (Q874N0), MTAL1_PICAN (Q707Y7), MTAL1_YEAST (P0CY06)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment