PROSITE entry PS51364
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General information about the entry
| Entry name [info] | TB |
| Accession [info] | PS51364 |
| Entry type [info] | MATRIX |
| Date [info] |
01-JAN-2008 CREATED;
10-MAY-2017 DATA UPDATE; 08-NOV-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51364 |
| Associated ProRule [info] | PRU00697 |
Name and characterization of the entry
| Description [info] | TGF-beta binding (TB) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=52; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=47; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6936213; R2=0.0060844; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6549.1250000; R2=1.8536444; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1152; H_SCORE=8685; N_SCORE=8.7; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=790; H_SCORE=8014; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-28; D=-80; I=-80; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-105; BD=-105; /M: SY='G'; M=-34,-58, 16, 4,-62, 74,-47,-64,-17,-60, 26,-33,-50,-41,-27, 37,-42,-59,-62,-55; /M: SY='T'; M=-23,-57,-25, 15, 7,-57, -8,-10,-42, 3,-37, 6, 31,-14, 2,-40, 40, 15,-52, 40; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /M: SY='W'; M=-58,-65,-66,-63, 79,-63,-40,-40,-56,-35,-38,-62,-67,-56,-54,-56,-54,-47,109, 91; /M: SY='R'; M= -2,-55,-49,-24,-22, 0,-45,-42, -9, 34,-35,-42,-55, 23, 39, 27, 20,-41,-58,-21; /M: SY='E'; M=-10,-59, 4, 42,-60, 4, 15,-54, 22,-29,-47, 28,-50, 36, 10, 9,-17,-10,-64,-50; /M: SY='Y'; M=-46,-57,-59,-52, 25,-63, 8, 20,-50, 24, -8,-53,-60, 24,-20,-47, 22, 36, 38, 42; /I: I=-20; MD=-26; /M: SY='G'; M=-12,-58, 12, 13, -3, 22, 5,-11, 4, -8,-43, 22,-54, 2, -1, 2, -9, -1,-61,-15; D=-20; /I: I=-20; MI=0; MD=-26; IM=0; DM=-26; /M: SY='N'; M=-22,-59, 40, 34,-65, 32, -8,-65, 0,-64,-55, 58, 2, 19,-19, -9,-22,-61,-68,-55; /M: SY='G'; M= -2,-57, 13, -6,-56, 58, -6,-39,-44,-26,-49, 7, -7, 14,-31, 6, 15,-35,-60, -1; /M: SY='M'; M=-18,-58,-44, 18,-27,-24,-43,-42, 0,-34, 49,-41, 21, 39, 35, 0, 30, 6,-61,-47; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /I: I=-25; MI=0; MD=-33; IM=0; DM=-33; /M: SY='S'; M= 29,-53, 12, 13,-60,-12,-43,-32,-38,-54,-18, -9,-49, 42,-25, 58, 5,-17,-65,-51; /M: SY='N'; M=-31,-56,-41,-24,-50, 10, 41, -5, -8, 7, -8, 49,-55, 17, 11, 20,-16, 6,-65,-45; /M: SY='P'; M=-18,-64,-11, 30,-59,-24,-48, -7,-42,-29,-46, 9, 87, 20,-50,-42,-21, 8,-64,-57; /M: SY='L'; M=-28,-54,-63,-56, 2,-65,-53, 22, -9, 70,-18,-59,-63,-51,-29, -4,-43, -7,-55,-38; /M: SY='P'; M= 30,-57,-47,-43,-25, 22,-11,-50,-18,-15,-46, 1, 64, 3,-25, 18, -1,-22,-61,-52; /I: I=-24; MI=0; MD=-32; IM=0; DM=-32; /M: SY='G'; M=-41,-59,-45, -5, 21, 51, -7,-25,-22,-39,-46, 4, -1, 27, 26,-29, 15, -5,-57,-44; /M: SY='N'; M= 18,-55,-15,-41,-53, -7, 19,-47, -7, 7,-41, 60,-11, 3, 39,-13,-18,-17,-65,-48; /M: SY='V'; M=-26, 19,-55,-53,-19,-59, 22, 10,-49, -6, 22,-46,-56,-49,-15, 4, 48, 52,-62, 11; /M: SY='T'; M=-11,-48,-43,-43,-51,-50,-49,-44,-11,-13,-42,-33,-46,-42, 7, 22, 93,-37,-68,-49; /M: SY='K'; M=-48,-63,-44,-30,-16,-56,-11,-55, 70,-51, 30,-38,-52, 56, 47,-42,-45,-55, 12, 24; /M: SY='Q'; M= 30,-55, 22, 30,-61,-45,-42,-55, -7,-54, 2,-34,-48, 46, 3, 38, 25,-49,-64,-51; /M: SY='E'; M=-12,-61, 27, 70,-56,-55,-41, -6,-19,-13, 27,-40,-47, 39,-24, -4,-42, -9,-64,-50; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /M: SY='C'; M= 15,135,-60,-59,-57, 1,-60,-61,-54,-54,-52,-47,-67,-59,-18,-10,-43,-49,-76,-63; /M: SY='S'; M= 9,-51, 21,-13,-57, -7,-45,-51,-40,-27,-49,-32,-48, 2,-17, 65, 48,-32,-67,-51; /M: SY='Y'; M=-12,-58,-10,-28,-40, 13,-45, -3,-16, 15,-35, -4,-11, 28, 7,-14,-42, 32,-53, 34; /I: I=-24; MI=0; MD=-32; IM=0; DM=-32; /M: SY='G'; M=-34,-61, 7,-28,-67, 94,-52,-74,-51,-70,-60, -5,-52,-49,-59,-34,-50,-68,-60,-61; /M: SY='R'; M= 32,-57,-41, 25,-54,-30, -3,-55, 33,-28,-45,-39,-50, -9, 55,-35, 26,-48,-58, 2; /M: SY='A'; M= 67, 49,-52,-49,-14, 43,-54,-53,-48,-54,-48,-43,-53,-47,-16, -9,-23,-27,-60,-54; /M: SY='W'; M=-59,-82,-85,-64, 15,-31,-83,-56,-56,-53,-56,-77,-63,-57,-60,-65,-70,-69,171,-11; /M: SY='G'; M=-15,-57,-44,-55,-65, 87,-51,-70,-50,-68,-58, 15,-52,-46,-56, 29,-43,-63,-60,-59; /M: SY='D'; M= -1,-57, 28, 10,-24,-49, 18,-18, 1,-27, 9, 24, 19, 11, -9, 16, 7, 8,-66,-47; /M: SY='P'; M=-14,-64,-21, 11,-19, 17, 39,-58,-27,-38,-48, -5, 76, 37,-10,-25, 4,-57,-62,-50; /I: I=-14; MI=0; MD=-19; IM=0; DM=-19; /M: SY='C'; M=-46,145,-64,-62,-56,-60,-64,-62,-59,-54,-53,-52, 23,-67,-67,-48,-45,-51,-83,-66; /M: SY='E'; M= 15,-61, 8, 80,-62,-54, 9,-59,-29,-20,-48,-39,-45, 45, -1,-37,-20,-54,-63,-52; /I: I=-24; MI=0; MD=-32; IM=0; DM=-32; /M: SY='P'; M= -5,-60,-52, -5,-45,-57,-18,-14, -1, 40, 26,-53, 71, 0, 2,-47,-19,-39,-59,-48; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /M: SY='P'; M=-34,-73,-48, -8,-69,-52,-52,-58, -5,-67,-54,-53,116,-13,-52,-28,-42,-62,-63,-65; /M: SY='P'; M= -5,-71,-17,-59,-18,-42,-66, -9,-23, -6, 3,-61, 43,-32,-65,-10, 2, -1,-75,-61; /M: SY='P'; M=-46,-80,-11, 14,-72,-70,-55,-69, -1,-71,-63,-57, 49, 17, 41,-57,-33,-26,-73, -8; /M: SY='G'; M=-26,-72, 22,-17,-78, 48,-58,-45,-57,-79,-70, 39,-26,-55,-65, 3,-54,-73,-81,-72; /M: SY='S'; M=-25,-62,-26,-33,-70,-55,-61,-66,-55,-69,-64,-44,-60,-52,-61, 60, 58,-58,-83,-65; /I: I=-23; MD=-30; /M: SY='A'; M= 30,-70, 2, 30,-74,-62,-62,-61,-33,-46,-62,-15, -9,-52,-36,-20,-14, -4,-81,-70; D=-23; /I: I=-23; MI=-30; MD=-30; IM=-30; DM=-30; /M: SY='E'; M= 18,-75, 27, 62,-80,-44,-58,-73,-49,-73,-69,-54,-61,-17,-58,-53,-58,-28,-82,-72; D=-23; /I: I=-23; DM=-30; /M: SY='F'; M=-74,-76,-79,-78, 78,-80, -3,-53,-72,-46,-50,-73,-84,-74,-69,-70,-67,-58,-36, 74; D=-23; /I: I=-23; DM=-30; /M: SY='Q'; M= 1,-74,-53, 3,-73,-32, 8,-75, 21,-72,-62,-11,-65, 44, 26, -4,-55,-70,-72,-16; /M: SY='Q'; M=-11,-72,-26, 33,-75,-41,-56,-26, 12,-68,-62,-50,-61, 38,-15, 5, 16,-62,-77,-65; /M: SY='L'; M=-65,-70,-82,-75,-42,-85, -5, 33,-76, 59, -7,-78,-79,-69,-74,-74,-61,-33,-71,-52; /M: SY='C'; M=-59,134,-79,-79,-69,-75,-80,-74,-75,-66,-67,-66,-90,-83,-82,-62,-59,-42,-99,-80; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 122 in 33 different sequences |
| Number of true positive hits | 122 in 33 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | N_Hulo |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 9 |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
33 sequences
FBN1_BOVIN (P98133), FBN1_HUMAN (P35555), FBN1_MOUSE (Q61554), FBN1_PIG(Q9TV36), FBN2_HUMAN (P35556), FBN2_MOUSE (Q61555), FBN3_HUMAN (Q75N90), FSTA_DANRE (Q9YHV4), FSTL3_BOVIN (Q1LZB9), FSTL3_HUMAN (O95633), FSTL3_MOUSE (Q9EQC7), FSTL3_RAT (Q99PW7), FST_BOVIN (P50291), FST_BUBBU (A5YT95), FST_CHICK (Q90844), FST_HORSE (O62650), FST_HUMAN (P19883), FST_MOUSE (P47931), FST_PIG (P10669), FST_RAT (P21674), FST_SHEEP (P31514), FST_XENLA (P31515), LTBP1_HUMAN (Q14766), LTBP1_MOUSE (Q8CG19), LTBP1_RAT (Q00918), LTBP2_BOVIN (Q28019), LTBP2_HUMAN (Q14767), LTBP2_MOUSE (O08999), LTBP2_RAT (O35806), LTBP3_HUMAN (Q9NS15), LTBP3_MOUSE (Q61810), LTBP4_HUMAN (Q8N2S1), LTBP4_MOUSE (Q8K4G1)» more
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| PDB [Detailed view] |
14 PDB
1APJ; 1KSQ; 1UZJ; 1UZK; 1UZP; 1UZQ; 2B0U; 2P6A; 2W86; 3B4V; 3HH2; 3SEK; 5JHW; 5MS9 » more |