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PROSITE entry PS51364


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General information about the entry

Entry name [info] TB
Accession [info] PS51364
Entry type [info] MATRIX
Date [info] 01-JAN-2008 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51364
Associated ProRule [info] PRU00697

Name and characterization of the entry

Description [info] TGF-beta binding (TB) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=52;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=47;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6936213; R2=0.0060844; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6549.1250000; R2=1.8536444; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1152; H_SCORE=8685; N_SCORE=8.7; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=790; H_SCORE=8014; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-28; D=-80; I=-80; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='G';  M=-34,-58, 16,  4,-62, 74,-47,-64,-17,-60, 26,-33,-50,-41,-27, 37,-42,-59,-62,-55;
/M: SY='T';  M=-23,-57,-25, 15,  7,-57, -8,-10,-42,  3,-37,  6, 31,-14,  2,-40, 40, 15,-52, 40;
/M: SY='C';  M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66;
/M: SY='W';  M=-58,-65,-66,-63, 79,-63,-40,-40,-56,-35,-38,-62,-67,-56,-54,-56,-54,-47,109, 91;
/M: SY='R';  M= -2,-55,-49,-24,-22,  0,-45,-42, -9, 34,-35,-42,-55, 23, 39, 27, 20,-41,-58,-21;
/M: SY='E';  M=-10,-59,  4, 42,-60,  4, 15,-54, 22,-29,-47, 28,-50, 36, 10,  9,-17,-10,-64,-50;
/M: SY='Y';  M=-46,-57,-59,-52, 25,-63,  8, 20,-50, 24, -8,-53,-60, 24,-20,-47, 22, 36, 38, 42;
/I:         I=-20; MD=-26;
/M: SY='G';  M=-12,-58, 12, 13, -3, 22,  5,-11,  4, -8,-43, 22,-54,  2, -1,  2, -9, -1,-61,-15; D=-20;
/I:         I=-20; MI=0; MD=-26; IM=0; DM=-26;
/M: SY='N';  M=-22,-59, 40, 34,-65, 32, -8,-65,  0,-64,-55, 58,  2, 19,-19, -9,-22,-61,-68,-55;
/M: SY='G';  M= -2,-57, 13, -6,-56, 58, -6,-39,-44,-26,-49,  7, -7, 14,-31,  6, 15,-35,-60, -1;
/M: SY='M';  M=-18,-58,-44, 18,-27,-24,-43,-42,  0,-34, 49,-41, 21, 39, 35,  0, 30,  6,-61,-47;
/M: SY='C';  M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66;
/I:         I=-25; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='S';  M= 29,-53, 12, 13,-60,-12,-43,-32,-38,-54,-18, -9,-49, 42,-25, 58,  5,-17,-65,-51;
/M: SY='N';  M=-31,-56,-41,-24,-50, 10, 41, -5, -8,  7, -8, 49,-55, 17, 11, 20,-16,  6,-65,-45;
/M: SY='P';  M=-18,-64,-11, 30,-59,-24,-48, -7,-42,-29,-46,  9, 87, 20,-50,-42,-21,  8,-64,-57;
/M: SY='L';  M=-28,-54,-63,-56,  2,-65,-53, 22, -9, 70,-18,-59,-63,-51,-29, -4,-43, -7,-55,-38;
/M: SY='P';  M= 30,-57,-47,-43,-25, 22,-11,-50,-18,-15,-46,  1, 64,  3,-25, 18, -1,-22,-61,-52;
/I:         I=-24; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='G';  M=-41,-59,-45, -5, 21, 51, -7,-25,-22,-39,-46,  4, -1, 27, 26,-29, 15, -5,-57,-44;
/M: SY='N';  M= 18,-55,-15,-41,-53, -7, 19,-47, -7,  7,-41, 60,-11,  3, 39,-13,-18,-17,-65,-48;
/M: SY='V';  M=-26, 19,-55,-53,-19,-59, 22, 10,-49, -6, 22,-46,-56,-49,-15,  4, 48, 52,-62, 11;
/M: SY='T';  M=-11,-48,-43,-43,-51,-50,-49,-44,-11,-13,-42,-33,-46,-42,  7, 22, 93,-37,-68,-49;
/M: SY='K';  M=-48,-63,-44,-30,-16,-56,-11,-55, 70,-51, 30,-38,-52, 56, 47,-42,-45,-55, 12, 24;
/M: SY='Q';  M= 30,-55, 22, 30,-61,-45,-42,-55, -7,-54,  2,-34,-48, 46,  3, 38, 25,-49,-64,-51;
/M: SY='E';  M=-12,-61, 27, 70,-56,-55,-41, -6,-19,-13, 27,-40,-47, 39,-24, -4,-42, -9,-64,-50;
/M: SY='C';  M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66;
/M: SY='C';  M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66;
/M: SY='C';  M= 15,135,-60,-59,-57,  1,-60,-61,-54,-54,-52,-47,-67,-59,-18,-10,-43,-49,-76,-63;
/M: SY='S';  M=  9,-51, 21,-13,-57, -7,-45,-51,-40,-27,-49,-32,-48,  2,-17, 65, 48,-32,-67,-51;
/M: SY='Y';  M=-12,-58,-10,-28,-40, 13,-45, -3,-16, 15,-35, -4,-11, 28,  7,-14,-42, 32,-53, 34;
/I:         I=-24; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='G';  M=-34,-61,  7,-28,-67, 94,-52,-74,-51,-70,-60, -5,-52,-49,-59,-34,-50,-68,-60,-61;
/M: SY='R';  M= 32,-57,-41, 25,-54,-30, -3,-55, 33,-28,-45,-39,-50, -9, 55,-35, 26,-48,-58,  2;
/M: SY='A';  M= 67, 49,-52,-49,-14, 43,-54,-53,-48,-54,-48,-43,-53,-47,-16, -9,-23,-27,-60,-54;
/M: SY='W';  M=-59,-82,-85,-64, 15,-31,-83,-56,-56,-53,-56,-77,-63,-57,-60,-65,-70,-69,171,-11;
/M: SY='G';  M=-15,-57,-44,-55,-65, 87,-51,-70,-50,-68,-58, 15,-52,-46,-56, 29,-43,-63,-60,-59;
/M: SY='D';  M= -1,-57, 28, 10,-24,-49, 18,-18,  1,-27,  9, 24, 19, 11, -9, 16,  7,  8,-66,-47;
/M: SY='P';  M=-14,-64,-21, 11,-19, 17, 39,-58,-27,-38,-48, -5, 76, 37,-10,-25,  4,-57,-62,-50;
/I:         I=-14; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='C';  M=-46,145,-64,-62,-56,-60,-64,-62,-59,-54,-53,-52, 23,-67,-67,-48,-45,-51,-83,-66;
/M: SY='E';  M= 15,-61,  8, 80,-62,-54,  9,-59,-29,-20,-48,-39,-45, 45, -1,-37,-20,-54,-63,-52;
/I:         I=-24; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='P';  M= -5,-60,-52, -5,-45,-57,-18,-14, -1, 40, 26,-53, 71,  0,  2,-47,-19,-39,-59,-48;
/M: SY='C';  M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66;
/M: SY='P';  M=-34,-73,-48, -8,-69,-52,-52,-58, -5,-67,-54,-53,116,-13,-52,-28,-42,-62,-63,-65;
/M: SY='P';  M= -5,-71,-17,-59,-18,-42,-66, -9,-23, -6,  3,-61, 43,-32,-65,-10,  2, -1,-75,-61;
/M: SY='P';  M=-46,-80,-11, 14,-72,-70,-55,-69, -1,-71,-63,-57, 49, 17, 41,-57,-33,-26,-73, -8;
/M: SY='G';  M=-26,-72, 22,-17,-78, 48,-58,-45,-57,-79,-70, 39,-26,-55,-65,  3,-54,-73,-81,-72;
/M: SY='S';  M=-25,-62,-26,-33,-70,-55,-61,-66,-55,-69,-64,-44,-60,-52,-61, 60, 58,-58,-83,-65;
/I:         I=-23; MD=-30;
/M: SY='A';  M= 30,-70,  2, 30,-74,-62,-62,-61,-33,-46,-62,-15, -9,-52,-36,-20,-14, -4,-81,-70; D=-23;
/I:         I=-23; MI=-30; MD=-30; IM=-30; DM=-30;
/M: SY='E';  M= 18,-75, 27, 62,-80,-44,-58,-73,-49,-73,-69,-54,-61,-17,-58,-53,-58,-28,-82,-72; D=-23;
/I:         I=-23; DM=-30;
/M: SY='F';  M=-74,-76,-79,-78, 78,-80, -3,-53,-72,-46,-50,-73,-84,-74,-69,-70,-67,-58,-36, 74; D=-23;
/I:         I=-23; DM=-30;
/M: SY='Q';  M=  1,-74,-53,  3,-73,-32,  8,-75, 21,-72,-62,-11,-65, 44, 26, -4,-55,-70,-72,-16;
/M: SY='Q';  M=-11,-72,-26, 33,-75,-41,-56,-26, 12,-68,-62,-50,-61, 38,-15,  5, 16,-62,-77,-65;
/M: SY='L';  M=-65,-70,-82,-75,-42,-85, -5, 33,-76, 59, -7,-78,-79,-69,-74,-74,-61,-33,-71,-52;
/M: SY='C';  M=-59,134,-79,-79,-69,-75,-80,-74,-75,-66,-67,-66,-90,-83,-82,-62,-59,-42,-99,-80;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 122 in 33 different sequences
Number of true positive hits 122 in 33 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 9
Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] N_Hulo
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
33 sequences

FBN1_BOVIN  (P98133), FBN1_HUMAN  (P35555), FBN1_MOUSE  (Q61554), 
FBN1_PIG(Q9TV36), FBN2_HUMAN  (P35556), FBN2_MOUSE  (Q61555), 
FBN3_HUMAN  (Q75N90), FSTA_DANRE  (Q9YHV4), FSTL3_BOVIN (Q1LZB9), 
FSTL3_HUMAN (O95633), FSTL3_MOUSE (Q9EQC7), FSTL3_RAT   (Q99PW7), 
FST_BOVIN   (P50291), FST_BUBBU   (A5YT95), FST_CHICK   (Q90844), 
FST_HORSE   (O62650), FST_HUMAN   (P19883), FST_MOUSE   (P47931), 
FST_PIG (P10669), FST_RAT (P21674), FST_SHEEP   (P31514), 
FST_XENLA   (P31515), LTBP1_HUMAN (Q14766), LTBP1_MOUSE (Q8CG19), 
LTBP1_RAT   (Q00918), LTBP2_BOVIN (Q28019), LTBP2_HUMAN (Q14767), 
LTBP2_MOUSE (O08999), LTBP2_RAT   (O35806), LTBP3_HUMAN (Q9NS15), 
LTBP3_MOUSE (Q61810), LTBP4_HUMAN (Q8N2S1), LTBP4_MOUSE (Q8K4G1)
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PDB
[Detailed view]
14 PDB

1APJ; 1KSQ; 1UZJ; 1UZK; 1UZP; 1UZQ; 2B0U; 2P6A; 2W86; 3B4V; 3HH2; 3SEK; 5JHW; 5MS9
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