PROSITE entry PS51364
View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS51364 |
| Entry name [info] | TB |
| Accession [info] | PS51364 |
| Entry type [info] | MATRIX |
| Date [info] |
01-JAN-2008 CREATED;
10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51364 |
| Associated ProRule [info] | PRU00697 |
Name and characterization of the entry
| Description [info] | TGF-beta binding (TB) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=52; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=47; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.6936213; R2=0.0060844; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6549.1250000; R2=1.8536444; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1152; H_SCORE=8685; N_SCORE=8.7; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=790; H_SCORE=8014; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-28; D=-80; I=-80; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-105; BD=-105; /M: SY='G'; M=-34,-58, 16, 4,-62, 74,-47,-64,-17,-60, 26,-33,-50,-41,-27, 37,-42,-59,-62,-55; /M: SY='T'; M=-23,-57,-25, 15, 7,-57, -8,-10,-42, 3,-37, 6, 31,-14, 2,-40, 40, 15,-52, 40; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /M: SY='W'; M=-58,-65,-66,-63, 79,-63,-40,-40,-56,-35,-38,-62,-67,-56,-54,-56,-54,-47,109, 91; /M: SY='R'; M= -2,-55,-49,-24,-22, 0,-45,-42, -9, 34,-35,-42,-55, 23, 39, 27, 20,-41,-58,-21; /M: SY='E'; M=-10,-59, 4, 42,-60, 4, 15,-54, 22,-29,-47, 28,-50, 36, 10, 9,-17,-10,-64,-50; /M: SY='Y'; M=-46,-57,-59,-52, 25,-63, 8, 20,-50, 24, -8,-53,-60, 24,-20,-47, 22, 36, 38, 42; /I: I=-20; MD=-26; /M: SY='G'; M=-12,-58, 12, 13, -3, 22, 5,-11, 4, -8,-43, 22,-54, 2, -1, 2, -9, -1,-61,-15; D=-20; /I: I=-20; MI=0; MD=-26; IM=0; DM=-26; /M: SY='N'; M=-22,-59, 40, 34,-65, 32, -8,-65, 0,-64,-55, 58, 2, 19,-19, -9,-22,-61,-68,-55; /M: SY='G'; M= -2,-57, 13, -6,-56, 58, -6,-39,-44,-26,-49, 7, -7, 14,-31, 6, 15,-35,-60, -1; /M: SY='M'; M=-18,-58,-44, 18,-27,-24,-43,-42, 0,-34, 49,-41, 21, 39, 35, 0, 30, 6,-61,-47; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /I: I=-25; MI=0; MD=-33; IM=0; DM=-33; /M: SY='S'; M= 29,-53, 12, 13,-60,-12,-43,-32,-38,-54,-18, -9,-49, 42,-25, 58, 5,-17,-65,-51; /M: SY='N'; M=-31,-56,-41,-24,-50, 10, 41, -5, -8, 7, -8, 49,-55, 17, 11, 20,-16, 6,-65,-45; /M: SY='P'; M=-18,-64,-11, 30,-59,-24,-48, -7,-42,-29,-46, 9, 87, 20,-50,-42,-21, 8,-64,-57; /M: SY='L'; M=-28,-54,-63,-56, 2,-65,-53, 22, -9, 70,-18,-59,-63,-51,-29, -4,-43, -7,-55,-38; /M: SY='P'; M= 30,-57,-47,-43,-25, 22,-11,-50,-18,-15,-46, 1, 64, 3,-25, 18, -1,-22,-61,-52; /I: I=-24; MI=0; MD=-32; IM=0; DM=-32; /M: SY='G'; M=-41,-59,-45, -5, 21, 51, -7,-25,-22,-39,-46, 4, -1, 27, 26,-29, 15, -5,-57,-44; /M: SY='N'; M= 18,-55,-15,-41,-53, -7, 19,-47, -7, 7,-41, 60,-11, 3, 39,-13,-18,-17,-65,-48; /M: SY='V'; M=-26, 19,-55,-53,-19,-59, 22, 10,-49, -6, 22,-46,-56,-49,-15, 4, 48, 52,-62, 11; /M: SY='T'; M=-11,-48,-43,-43,-51,-50,-49,-44,-11,-13,-42,-33,-46,-42, 7, 22, 93,-37,-68,-49; /M: SY='K'; M=-48,-63,-44,-30,-16,-56,-11,-55, 70,-51, 30,-38,-52, 56, 47,-42,-45,-55, 12, 24; /M: SY='Q'; M= 30,-55, 22, 30,-61,-45,-42,-55, -7,-54, 2,-34,-48, 46, 3, 38, 25,-49,-64,-51; /M: SY='E'; M=-12,-61, 27, 70,-56,-55,-41, -6,-19,-13, 27,-40,-47, 39,-24, -4,-42, -9,-64,-50; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /M: SY='C'; M= 15,135,-60,-59,-57, 1,-60,-61,-54,-54,-52,-47,-67,-59,-18,-10,-43,-49,-76,-63; /M: SY='S'; M= 9,-51, 21,-13,-57, -7,-45,-51,-40,-27,-49,-32,-48, 2,-17, 65, 48,-32,-67,-51; /M: SY='Y'; M=-12,-58,-10,-28,-40, 13,-45, -3,-16, 15,-35, -4,-11, 28, 7,-14,-42, 32,-53, 34; /I: I=-24; MI=0; MD=-32; IM=0; DM=-32; /M: SY='G'; M=-34,-61, 7,-28,-67, 94,-52,-74,-51,-70,-60, -5,-52,-49,-59,-34,-50,-68,-60,-61; /M: SY='R'; M= 32,-57,-41, 25,-54,-30, -3,-55, 33,-28,-45,-39,-50, -9, 55,-35, 26,-48,-58, 2; /M: SY='A'; M= 67, 49,-52,-49,-14, 43,-54,-53,-48,-54,-48,-43,-53,-47,-16, -9,-23,-27,-60,-54; /M: SY='W'; M=-59,-82,-85,-64, 15,-31,-83,-56,-56,-53,-56,-77,-63,-57,-60,-65,-70,-69,171,-11; /M: SY='G'; M=-15,-57,-44,-55,-65, 87,-51,-70,-50,-68,-58, 15,-52,-46,-56, 29,-43,-63,-60,-59; /M: SY='D'; M= -1,-57, 28, 10,-24,-49, 18,-18, 1,-27, 9, 24, 19, 11, -9, 16, 7, 8,-66,-47; /M: SY='P'; M=-14,-64,-21, 11,-19, 17, 39,-58,-27,-38,-48, -5, 76, 37,-10,-25, 4,-57,-62,-50; /I: I=-14; MI=0; MD=-19; IM=0; DM=-19; /M: SY='C'; M=-46,145,-64,-62,-56,-60,-64,-62,-59,-54,-53,-52, 23,-67,-67,-48,-45,-51,-83,-66; /M: SY='E'; M= 15,-61, 8, 80,-62,-54, 9,-59,-29,-20,-48,-39,-45, 45, -1,-37,-20,-54,-63,-52; /I: I=-24; MI=0; MD=-32; IM=0; DM=-32; /M: SY='P'; M= -5,-60,-52, -5,-45,-57,-18,-14, -1, 40, 26,-53, 71, 0, 2,-47,-19,-39,-59,-48; /M: SY='C'; M=-45,149,-65,-65,-55,-61,-65,-62,-61,-53,-53,-51,-76,-69,-67,-48,-45,-50,-85,-66; /M: SY='P'; M=-34,-73,-48, -8,-69,-52,-52,-58, -5,-67,-54,-53,116,-13,-52,-28,-42,-62,-63,-65; /M: SY='P'; M= -5,-71,-17,-59,-18,-42,-66, -9,-23, -6, 3,-61, 43,-32,-65,-10, 2, -1,-75,-61; /M: SY='P'; M=-46,-80,-11, 14,-72,-70,-55,-69, -1,-71,-63,-57, 49, 17, 41,-57,-33,-26,-73, -8; /M: SY='G'; M=-26,-72, 22,-17,-78, 48,-58,-45,-57,-79,-70, 39,-26,-55,-65, 3,-54,-73,-81,-72; /M: SY='S'; M=-25,-62,-26,-33,-70,-55,-61,-66,-55,-69,-64,-44,-60,-52,-61, 60, 58,-58,-83,-65; /I: I=-23; MD=-30; /M: SY='A'; M= 30,-70, 2, 30,-74,-62,-62,-61,-33,-46,-62,-15, -9,-52,-36,-20,-14, -4,-81,-70; D=-23; /I: I=-23; MI=-30; MD=-30; IM=-30; DM=-30; /M: SY='E'; M= 18,-75, 27, 62,-80,-44,-58,-73,-49,-73,-69,-54,-61,-17,-58,-53,-58,-28,-82,-72; D=-23; /I: I=-23; DM=-30; /M: SY='F'; M=-74,-76,-79,-78, 78,-80, -3,-53,-72,-46,-50,-73,-84,-74,-69,-70,-67,-58,-36, 74; D=-23; /I: I=-23; DM=-30; /M: SY='Q'; M= 1,-74,-53, 3,-73,-32, 8,-75, 21,-72,-62,-11,-65, 44, 26, -4,-55,-70,-72,-16; /M: SY='Q'; M=-11,-72,-26, 33,-75,-41,-56,-26, 12,-68,-62,-50,-61, 38,-15, 5, 16,-62,-77,-65; /M: SY='L'; M=-65,-70,-82,-75,-42,-85, -5, 33,-76, 59, -7,-78,-79,-69,-74,-74,-61,-33,-71,-52; /M: SY='C'; M=-59,134,-79,-79,-69,-75,-80,-74,-75,-66,-67,-66,-90,-83,-82,-62,-59,-42,-99,-80; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 122 in 33 different sequences |
| Number of true positive hits | 122 in 33 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 9 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | N_Hulo |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
33 sequences
FBN1_BOVIN (P98133), FBN1_HUMAN (P35555), FBN1_MOUSE (Q61554), FBN1_PIG(Q9TV36), FBN2_HUMAN (P35556), FBN2_MOUSE (Q61555), FBN3_HUMAN (Q75N90), FSTA_DANRE (Q9YHV4), FSTL3_BOVIN (Q1LZB9), FSTL3_HUMAN (O95633), FSTL3_MOUSE (Q9EQC7), FSTL3_RAT (Q99PW7), FST_BOVIN (P50291), FST_BUBBU (A5YT95), FST_CHICK (Q90844), FST_HORSE (O62650), FST_HUMAN (P19883), FST_MOUSE (P47931), FST_PIG (P10669), FST_RAT (P21674), FST_SHEEP (P31514), FST_XENLA (P31515), LTBP1_HUMAN (Q14766), LTBP1_MOUSE (Q8CG19), LTBP1_RAT (Q00918), LTBP2_BOVIN (Q28019), LTBP2_HUMAN (Q14767), LTBP2_MOUSE (O08999), LTBP2_RAT (O35806), LTBP3_HUMAN (Q9NS15), LTBP3_MOUSE (Q61810), LTBP4_HUMAN (Q8N2S1), LTBP4_MOUSE (Q8K4G1)» more
|
| PDB [Detailed view] |
14 PDB
1APJ; 1KSQ; 1UZJ; 1UZK; 1UZP; 1UZQ; 2B0U; 2P6A; 2W86; 3B4V; 3HH2; 3SEK; 5JHW; 5MS9 » more |