PROSITE entry PS51373

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PURL: https://purl.expasy.org/prosite/signature/PS51373

Direct ScanProsite submission

General information about the entry

Entry name [info]	HIPIP
Accession [info]	PS51373
Entry type [info]	MATRIX
Date [info]	01-APR-2008 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00515
Associated ProRule [info]	PRU00705

Name and characterization of the entry

Description [info]

High potential iron-sulfur proteins family profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=75;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=70;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6121109; R2=0.0038724; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=11781.4560547; R2=2.8502581; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1650; H_SCORE=16484; N_SCORE=9.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=1004; H_SCORE=14643; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-23; D=-80; I=-80; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='A';  M=  24, -56, -17, -18, -57,   3, -52, -28, -43, -24, -46, -43, -54, -43,  -1, -10,  -7, -44, -64, -54;
/M: SY='A';  M=  37, -49, -13, -19, -49, -15, -47, -32, -42, -11,  -3, -43, -51,  20, -45, -32, -37,  10, -59, -47;
/M: SY='T';  M=  12, -49,  25, -34, -20, -14, -43, -44, -40, -27,  -7, -32,  26, -39, -47,   8,  26, -40, -60, -45;
/M: SY='W';  M=  28, -48, -12, -40, -41,   4,  20, -21, -41, -12,  22, -37,  10, -39, -45, -30,   6, -21,  54, -36;
/M: SY='P';  M=  36, -45, -29,  10, -52, -17,  10, -43, -31, -47, -39,  21,  51,  -4, -37,   3, -27, -23, -54, -44;
/M: SY='T';  M=  10, -45, -14, -12, -40, -22,  -2, -13,  -2,  -3,  14,  -8,   8,   0,  12, -26,  25, -12, -53, -37;
/M: SY='V';  M=   9,   6,   0, -40, -30, -24, -47,   9, -18,  24, -18, -41, -49, -41, -43, -35, -10,  39, -54, -36;
/M: SY='D';  M=  28, -41,  33,  16, -46,   2, -30, -40, -25, -17, -34,  -2,   8,  26, -31,  19,   2, -35, -51, -39;
/M: SY='E';  M=  15,   7,  10,  58, -47, -39, -31, -38, -21, -25, -35, -29,  40,  -1,  -6, -25,  -6,  -9, -51, -42;
/M: SY='D';  M=  10, -40,  36, -16, -43, -29, -24, -41,   2, -42, -34,  28,  -6,  35,  12,  24,  26, -36, -48,  -4;
/M: SY='D';  M=  26, -42,  69,   0, -50,   9, -26, -47,  18, -47, -41,  16, -35, -21, -25,   4, -23, -41, -55, -39;
/M: SY='P';  M=  18, -45,   9,   9, -48, -32, -30, -41,  24, -43,  -1, -25,  68,   4,  -5,  12,  -7, -37, -47, -40;
/M: SY='Q';  M=  20, -40,  10,   5, -38, -17, -29,  12, -10, -25,  36,   5, -35,  45, -27, -20,  21,   4, -48, -32;
/M: SY='A';  M=  63, -35, -10, -27, -45,   6, -35, -35, -12, -39, -32,  -7,  24, -26,  -7,   6, -22, -11, -46, -40;
/M: SY='K';  M= -18, -46, -27, -15, -43, -38,  42, -10,  52, -35, -27,   2,  -6,  52,  15, -10, -26,   5, -46, -29;
/M: SY='A';  M=  67, -33, -32, -26, -44,  -5, -35, -37,  16, -39, -32, -25, -34, -23,  -9,  21,  -3, -26, -45, -38;
/M: SY='L';  M=  -7, -39,  10, -15,   4, -46,  29,   4, -38,  48,  26, -36, -45, -33, -38, -34,  -9,  19, -45, -22;
/M: SY='G';  M=  10, -41,  21, -10, -12,  37,  11, -35,  27, -25, -32,  27, -37, -24, -24,  -9, -26,   0, -47, -33;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='Y';  M= -40, -51, -39, -42,  13, -46,  -5, -25, -34, -22, -18, -41, -52, -29, -31, -35, -34, -30,   5, 117;
/I:         I=-24; MD=-77;
/M: SY='V';  M= -45, -58, -54, -49, -49, -64,  -4,  -7,   8, -38, -37,  -9, -61, -45,  15, -49, -41,  40, -70, -48; D=-24;
/I:         I=-24; MI=-77; IM=-77; DM=-77;
/M: SY='Q';  M=   6, -46, -20,  22, -49, -15,  62, -46,  10, -41, -29,   4, -34,  74,   0,  -8, -14, -43, -48, -27;
/M: SY='D';  M=  -5, -48,  90,  23, -54, -32,   5, -52, -22, -50, -46,   8,  -5,  -3, -30, -23, -26, -47, -64, -38;
/I:         I=-10; MD=-33;
/M: SY='A';  M=  42, -53, -54, -49, -56, -45, -54, -50, -50, -53, -48, -48, -56, -12, -54, -18,  13, -25, -61,  -5; D=-10;
/I:         I=-10; MD=-33;
/M: SY='T';  M=  24, -54, -50, -49, -64, -47, -55, -57, -18, -60, -54,  -9, -55, -47, -51,   9,  29, -48, -72, -59; D=-10;
/I:         I=-10; MD=-33;
/M: SY='K';  M= -15, -65,  17,  -1, -70, -56, -49, -69,  35, -68, -60, -38, -55, -36, -13, -11, -23, -62, -71, -59; D=-10;
/I:         I=-10; MD=-33;
/M: SY='A';  M=  26, -55, -60, -56, -57, -50, -63, -34, -56, -48, -46, -53, -61, -53, -60,  15, -38,  25, -73, -58; D=-10;
/I:         I=-10; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='A';  M=  15, -60, -55, -26, -65, -55, -59, -50, -29, -56,  -6, -13, -62, -51, -57,  -5,   0, -10, -76, -62; D=-10;
/I:         I=-10; MI=0; MD=-33; IM=0; DM=-33;
/M: SY='P';  M= -20, -80, -25, -20, -81,  -8, -64, -74, -33, -78, -68, -59,  63, -57, -64, -54, -56, -72, -76, -76; D=-10;
/I:         I=-10; DM=-33;
/M: SY='S';  M=  -4, -41, -32, -26, -40, -34,   5, -37,  21,  -1, -30, -23, -39,   9,  28,  44,  17, -34, -50, -34; D=-10;
/I:         I=-10; DM=-33;
/M: SY='P';  M= -18, -55, -38, -32,  18, -41,  46, -37, -35, -38, -31, -38,  85, -34, -39, -34, -32, -41, -28,  59; D=-10;
/I:         I=-10; DM=-33;
/M: SY='Q';  M= -10, -48,   4,   8, -48, -14, -27, -40,  42, -25,  -4,   9,  17,  53,   1, -24, -14, -25, -47, -37; D=-10;
/I:         I=-10; DM=-33;
/M: SY='D';  M=  19, -42,  40,  37, -48,   8, -28, -43,   5, -44, -39,   4,  14, -19, -27,  20,  -7, -23, -51, -40;
/M: SY='G';  M=  -9, -44,  -8,  15, -50,  72,   7, -54,  -2, -51, -41,   4, -34, -25, -33,   9, -30, -48, -46, -41;
/M: SY='Q';  M= -29, -49,   9,   5, -53, -34,  11, -46,  43, -43, -31,  18, -34,  86,  -7,  -8, -27, -46, -45, -31;
/M: SY='H';  M= -18, -42, -11, -21,   9, -36,  51, -17,  27, -10, -26,  19, -37,  35,  17,   7,  20, -32, -45, -23;
/M: SY='C';  M= -59, 284, -99, -99, -80, -91, -99, -94, -91, -75, -75, -72,-121,-106,-104, -65, -59, -69,-140,-101;
/M: SY='S';  M=  33, -37,   8,   5, -42,  23,  11, -19, -28, -26, -32, -20, -34,   0, -33,  41,   0, -14, -49, -35;
/M: SY='N';  M= -17, -37,  23, -24, -43,  12, -21, -37,  -7, -44, -36,  78, -37, -23, -28,   3,  30, -10, -59, -39;
/M: SY='C';  M= -59, 284, -99, -99, -80, -91, -99, -94, -91, -75, -75, -72,-121,-106,-104, -65, -59, -69,-140,-101;
/M: SY='Q';  M=  32, -39, -34, -24, -37,  -9, -29, -26, -20,   4,  18, -27, -38,  48,  28,   5,   4,  -2, -45, -32;
/M: SY='F';  M= -21, -40, -40, -34,  61, -44, -28, -15, -34,  41, -12,  17, -48,  37, -34, -34, -31, -21, -27,  10;
/M: SY='Y';  M= -41, -46, -50, -47,  72, -48, -24,   4, -40, -14,  28, -45, -51, -40, -38, -40, -36, -23,  76,  79;
/M: SY='Q';  M=   0, -45, -27,   8, -41, -14, -26,  15,   3, -16, -22,  -4, -36,  76,  -3, -21,   0,   2, -44, -31;
/M: SY='P';  M=  34, -43,   3,  -6, -49,  45, -36, -42,  -8, -45, -36, -26,  55,   0, -35, -19, -28, -20, -46, -43;
/I:         I=-13; MD=-42;
/M: SY='P';  M=   3, -50,  26,  23, -53,   9,   7, -50,  31, -50, -41,  -8,  51, -22, -24, -26, -14, -46, -52, -43; D=-13;
/I:         I=-13; MD=-42;
/M: SY='S';  M=  24, -42,   3,   6, -48, -17,   0, -37,  -3, -43, -38, -26, -11, -27, -34,  41,  -7,   2, -56, -41; D=-13;
/I:         I=-13; MD=-42;
/M: SY='G';  M=   3, -57, -43,  -5, -65,  26, -49, -62, -44, -62, -54, -37, -51,   9, -49,  19,   3, -54, -65, -57; D=-13;
/I:         I=-13; MI=0; MD=-42; IM=0; DM=-42;
/M: SY='D';  M=  -3, -58,  42, -15, -66,  12, -45, -63, -15, -63, -57, -31, -14, -13, -45,   4, -12, -57, -69, -56; D=-13;
/I:         I=-13; DM=-42;
/M: SY='D';  M=  35, -51,  36,  24, -60,  10, -40, -55, -16, -54, -49, -30, -14, -31, -40, -28, -36, -46, -60, -51; D=-13;
/I:         I=-13; DM=-42;
/M: SY='W';  M=   9,  11, -21, -44, -31, -43,   1, -46, -43, -46, -44, -44, -51, -15, -46,   2,  -7, -30, 115,  16; D=-13;
/I:         I=-13; DM=-42;
/M: SY='G';  M= -18, -53, -39, -41, -58,  67, -43, -63,  10, -59, -48, -27, -45,  -7,   1, -11, -41, -57, -51, -50; D=-13;
/I:         I=-13; DM=-42;
/M: SY='G';  M= -12,   8, -29,   2, -42,  44, -33, -41, -26, -43, -36, -23,  43, -27,   4,  22,  23, -20, -45,  -5;
/M: SY='C';  M= -59, 284, -99, -99, -80, -91, -99, -94, -91, -75, -75, -72,-121,-106,-104, -65, -59, -69,-140,-101;
/M: SY='K';  M=   5, -41, -28, -19, -45,  -8, -30, -20,  42, -40, -31, -20,  28,  39,   0,  11,  36, -32, -46, -35;
/M: SY='V';  M=   2, -38, -46, -41, -20, -47,  27,  32, -40,  36,  27, -40, -44, -37, -41, -33,   2,  41, -47, -25;
/I:         I=-22; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='F';  M= -36, -40, -54, -50,  85, -53, -40,  26, -46,  -8, -15, -45, -51, -52, -45, -40, -30,  36, -20,  19;
/I:         I=-21; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='P';  M=  30, -46,  10,  33, -51,  19, -34, -45, -27, -47, -38, -29,  74, -24, -36, -22, -27, -40, -48, -45;
/M: SY='G';  M= -19, -44,   4, -35, -48,  79, -37, -46, -14, -48, -40, -19, -37,  -5, -39,   3, -31,  -9, -45, -43;
/I:         I=-21; MD=-65;
/M: SY='K';  M= -49, -62,  -8, -29, -57, -53, -40, -62,  61, -62, -51,   5,  -7, -28,   0, -41, -42, -60, -56,  -6; D=-21;
/I:         I=-21; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='Q';  M=   7, -45, -39,  -3, -33, -43, -37, -23, -34,  34, -19, -38,  31,  36, -37, -14,   5, -12, -49, -36; D=-21;
/I:         I=-21; DM=-65;
/M: SY='V';  M= -24, -38, -52, -47, -21, -55, -54,  52, -44,  -6,  -9, -46, -46, -45, -47, -37, -21,  74, -52, -29;
/M: SY='S';  M=  34, -34, -23,  -9, -39, -21, -26, -37,  -6, -41, -34,  39, -35, -20, -28,  59, -12, -19, -46,   2;
/M: SY='P';  M=  47, -41, -32,   4, -45,   6, -36, -34, -28, -25, -32, -12,  68, -28, -13, -20, -25, -11, -46, -42;
/M: SY='N';  M=   4, -40,  40,  20, -47,  -7, -22, -46,  21, -47, -39,  61, -35, -17,  -5,   6,   3, -41, -55, -39;
/M: SY='G';  M=  -3, -44, -33, -44, -51,  89, -39, -58, -38, -54, -43, -19, -37, -35, -45, -17, -36, -51, -42, -46;
/M: SY='W';  M= -43, -66, -65, -48,  -5, -43, -52, -39, -40, -36, -37, -60, -48, -38, -42, -48, -52, -51, 160,  52;
/M: SY='C';  M= -59, 284, -99, -99, -80, -91, -99, -94, -91, -75, -75, -72,-121,-106,-104, -65, -59, -69,-140,-101;
/M: SY='S';  M=  11, -39,  12,  -8, -37, -29, -28,  -4, -21, -18,   0,  28, -37,   1,  21,  40,   5, -15,  29, -32;
/M: SY='A';  M=  51, -33, -36, -32, -33, -25, -36,  -7, -33,  11, -22, -29, -38, -28, -36,  43, -17,  11, -46, -34;
/M: SY='W';  M= -43, -54, -56, -48,  60, -46, -34, -29, -40, -24, -28, -51, -51, -41, -40, -43, -43, -37, 132,  71;
/M: SY='A';  M=  45, -33, -31,   1, -35, -29, -37,  -2, -30, -15, -24,   0, -36, -28, -35,  17,  26,  29, -50, -35;
/M: SY='P';  M=  16, -45,  -7, -20, -43, -16,  11, -35,  48, -10, -29,  -6,  59,  -1, -17, -25, -26, -15, -46, -36;
/M: SY='K';  M=   6, -44, -29, -17, -43,  -4, -26, -39,  66, -36,  38, -21, -35,  21,  35, -24, -27, -36, -42, -32;
/M: SY='A';  M=  43, -44, -37, -15, -54,   5, -42, -48,   0, -50, -43,  -8,   7, -32, -37,  20,  -7, -39, -55, -48;
/M: SY='A';  M=  -4, -96,  -9, -80,-107, -13, -91,-102, -88,-102, -96, -77, -93, -86, -95, -73, -83, -92,-106, -99;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	24 in 24 different sequences
Number of true positive hits	24 in 24 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

24 sequences

HIP1_ECTMO  (P83341), HIP1_ECTSH  (P38941), HIP1_HALHA  (P04168),

HIP1_RHOTE  (P00266), HIP2_ECTMO  (P83342), HIP2_ECTSH  (P38524), 
HIP2_HALHA  (P04169), HIP2_RHOTE  (P33678), HIP_ALLVD   (P00260), 
HIP_ALLWA   (B3EBZ3), HIP_HALH2   (P00264), HIP_HALSE   (B3EBZ6), 
HIP_ISOBU   (B3EBZ5), HIP_MARGR   (P00262), HIP_MARPU   (P59860), 
HIP_RALN1   (Q8XUU7), HIP_RHOFE   (P80882), HIP_RHOGL   (P38589), 
HIP_RUBGE   (P00265), HIP_THETI   (P80176), HIP_THIPF   (P00263), 
HIP_THIRO   (P00261), HIP_THIVI   (B3EBZ4), IRO_ACIFR   (P50500)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

28 PDB

1B0Y; 1CKU; 1EYT; 1HIP; 1HLQ; 1HPI; 1HRQ; 1HRR; 1ISU; 1IUA; 1JS2; 1NEH;
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