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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00705


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00705
General rule information [?]

Accession PRU00705
Dates 14-APR-2008 (Created)
19-NOV-2022 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51373; HIPIP
Name High potential iron-sulfur proteins family
Function High potential iron-sulfur proteins (HiPIP) are a specific class of high-redox potential 4Fe-4S ferredoxins that functions in anaerobic electron transport and which occurs commonly in purple photosynthetic bacteria and in other bacteria, such as Paracoccus denitrificans and Thiobacillus ferrooxidans.
Scope(s) Bacteria
Example(s) P59860;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name AltName: Full=High-potential iron-sulfur protein;
                 Short=HiPIP;

Comments [?]

FUNCTIONSpecific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria.
SUBCELLULAR LOCATIONPeriplasm.
SIMILARITYBelongs to the high-potential iron-sulfur protein (HiPIP) family.

Keywords [?]

4Fe-4S
Electron transport
Iron
Iron-sulfur
Metal-binding
Periplasm
Transport

Gene Ontology [?]

GO:0051539; Molecular function:4 iron, 4 sulfur cluster binding
GO:0005506; Molecular function:iron ion binding
GO:0051536; Molecular function:iron-sulfur cluster binding
GO:0046872; Molecular function:metal ion binding
GO:0006810; Biological process:transport
GO:0042597; Cellular component:periplasmic space

Features [?]

From: PS51373
Key From To Description Tag Condition FTGroup
BINDING 36 36 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 C
BINDING 39 39 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 C
BINDING 53 53 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 C
BINDING 67 67 /ligand="[4Fe-4S] cluster"
/ligand_id="ChEBI:CHEBI:49883"		 C

Additional information [?]

Size range 55-90 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]