PROSITE entry PS51378
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General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS51378 |
| Entry name [info] | INVERT_DEFENSINS |
| Accession [info] | PS51378 |
| Entry type [info] | MATRIX |
| Date [info] |
01-MAY-2008 CREATED;
07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00356 |
| Associated ProRule [info] | PRU00710 |
Name and characterization of the entry
| Description [info] | Invertebrate defensins family profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=35; /DISJOINT: DEFINITION=PROTECT; N1=4; N2=32; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0351765; R2=0.0051399; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3098.6945801; R2=2.0724764; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1297; H_SCORE=5787; N_SCORE=8.7; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=869; H_SCORE=4900; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-18; D=-80; I=-80; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-255; BD=-255; /M: SY='G'; M=-20,-53,-38,-15,-50, 45,-39, -5, -7,-30,-39, -2, -7, -5, 42,-30,-13,-42,-52,-45; /M: SY='Y'; M= 21,-41,-42,-18, 38, 14,-35, 3,-37, -1,-22,-36,-45,-36,-15,-13, -7, 20,-30, 41; /M: SY='T'; M= 10,-37,-33,-36, 5, 33,-36,-34,-33,-23,-31,-22,-36,-33,-39, 12, 67,-28,-43, 13; /M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53; /I: I=-8; MI=0; MD=-25; IM=0; DM=-25; /M: SY='D'; M=-23,-55, 58, 9,-56,-43,-37,-43,-15,-50,-45, -6, 58, -4,-39,-32, 2, -5,-64,-48; D=-8; /I: I=-8; DM=-25; /M: SY='W'; M=-30,-50,-19,-48, 23,-55,-48, 11,-44, 29,-23,-47,-54,-45, -5, -9, 4, -3, 61,-26; D=-8; /I: I=-8; DM=-25; /M: SY='N'; M=-33, 4, 25,-38, 9, -6,-39,-34,-20, 28,-30, 29,-55,-12,-44,-18,-37,-38,-55,-37; D=-8; /I: I=-8; DM=-25; /M: SY='S'; M=-13,-52, 4, 20,-59, 4,-36,-56,-29,-55,-47,-13,-43, 33, -3, 38, 4,-50,-60,-47; D=-8; /I: I=-8; MI=0; MD=-25; IM=0; DM=-25; /M: SY='W'; M= 16,-44, 2,-32,-33, 4,-33, -3,-33,-37, 4,-27,-41, 14,-37, 44, 4,-32, 53, 29; D=-8; /I: I=-8; DM=-25; /M: SY='A'; M= 40,-42, 5, -9,-42, -7,-31,-28, 7,-15,-32, 19,-41, 33,-29, -6,-10,-18,-47, 0; D=-8; /I: I=-8; DM=-25; /M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53; /M: SY='H'; M= 42,-39,-26, -1,-10,-20, 50,-16, 4,-22,-29, 38,-39, 0, -9, -9, -5,-16,-50,-30; /M: SY='A'; M= 48,-39, 16,-28, 7, -9,-33,-22,-29, 0, 2,-12,-10, -2, 6, 17,-25,-27,-45,-32; /M: SY='H'; M=-36,-49,-27, -6, -1,-42,110,-39,-27,-33,-25, 2,-43, 2, -5,-12,-33, -7,-44, 47; /M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53; /M: SY='K'; M=-32,-44,-35,-29,-31,-44, 13, 30, 36, 19,-18, 9,-43, 17, 16, -2,-27, 12,-47,-30; /M: SY='S'; M= 0,-40, -7, 5, 6,-17, 5, -4,-29, 3, 27,-26,-39, -3, -7, 48, -4,-10,-44, -6; /M: SY='K'; M=-32,-45,-33, -8,-13,-44,-15, 34, 43, 5, 11, 8,-41,-22, 31, 2,-27, -8,-45,-30; /I: I=-24; MI=0; MD=-77; IM=0; DM=-77; /M: SY='G'; M=-22,-48,-30, 2,-52, 81, 2,-59, 0,-54,-43,-21,-37,-29, -4, -8,-36,-52,-45,-44; /M: SY='Y'; M= -8, 30,-16,-30, 11,-43,-20,-36, 29,-21,-28, 1,-47,-23, 43,-31,-32,-36,-22, 75; /M: SY='R'; M=-13, -7,-27, 6,-45,-13,-28,-42, 47,-20,-33, 9,-13, 5, 53, 6,-10,-26,-47,-36; /M: SY='G'; M= 7,-46,-36,-40,-44, 75,-38,-24,-35,-48,-40,-24,-39, -4,-15, 11,-33,-43, 34, -7; /M: SY='G'; M= -8,-46,-36,-46,-13, 89,-41,-58,-40,-53,-44,-22,-39,-38,-47,-20,-38,-52,-42,-44; /M: SY='Y'; M=-29,-49,-32,-31, 7,-41, 43,-35, -6,-31,-25, 10,-47, 24, 15, -2,-31,-38,-15, 92; /M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53; /I: I=-19; MI=0; MD=-61; IM=0; DM=-61; /M: SY='N'; M=-24,-51,-39,-47, 18,-28,-41,-21,-42,-46,-43, 45,-29,-43,-48, 11, 25,-23, 7, -1; D=-19; /I: I=-19; DM=-61; /M: SY='F'; M= 11,-42, 3, 7, 26,-12, -5,-33, 6, 0,-28, -4, -3, 20,-29, 25, -6,-23,-40, 3; /I: I=-22; MD=-71; /M: SY='K'; M=-19,-49,-14, 4,-43,-25,-26,-31, 60,-46,-36, 38,-39, 28, 25,-26,-29,-44, 42, -2; D=-22; /I: I=-22; MI=-71; MD=-71; IM=-71; DM=-71; /M: SY='K'; M= 6,-43, -2, 4,-44, 28,-33,-36, 32,-10,-32, -4,-38, 22,-16, 0, 13, -8,-49,-39; D=-22; /I: I=-22; DM=-71; /M: SY='T'; M=-28,-39, -9, -9,-30,-29,-37, 19,-12, -6,-21, 24,-41,-32, -6,-24, 44, 42,-51, -2; /M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53; /M: SY='V'; M=-15,-41,-38,-33,-30,-45, 8, 11, 10,-17,-22,-16,-41, -3, 17,-26, 41, 43, 35, -3; /M: SY='C'; M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53; /M: SY='Y'; M=-32,-46,-30, -7, 1,-21,-22,-34, -6,-34,-29, 14,-43, 2, 52, -6, 27, -8,-30, 60; /M: SY='R'; M=-23,-53,-12, 7,-52,-44, 10,-50, 21,-29, 5, 32,-47, 0, 32, 0, -9,-48,-60,-43; /I: E1=0; IE=-255; DE=-255;» more |
Numerical results [info]
| Total number of hits | 63 in 63 different sequences |
| Number of true positive hits | 63 in 63 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 6 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 91.30 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | PS_Langendijk_Genevaux |
| Version [info] | 7 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
63 sequences
ASC3A_DOLGE (A0A3G5BIB4), ASC3B_DOLGE (A0A3G5BIB1), DEF1_CRAVI (P85008), DEF1_DERVA (Q86QI5), DEF1_GALME (P85213), DEF1_HOLDI (Q7M426), DEF1_OLIMR (P0DQT7), DEF1_STOCA (O16136), DEF2_APIME (Q5MQL3), DEF2_GALME (P85215), DEF2_OLIMR (P0DQT8), DEF2_ORNSA (P0DV61), DEF2_STOCA (O16137), DEF3_ANOGA (Q5TWR9), DEF3_OLIMR (A0A384E0Y8), DEF4_ANDAU (P56686), DEF4_LEIHE (P41965), DEF4_OLIMR (P0DQT9), DEF5_OLIMR (P0DQU0), DEF6_OLIMR (P0DQU1), DEFA_AEDAE (P91793), DEFA_ANOCP (P83669), DEFA_MYTED (P81610), DEFA_ZOPAT (P80033), DEFB_AEDAE (P81602), DEFB_ANOCP (P83668), DEFB_MYTED (P81611), DEFCG_MAGGI (Q4GWV4), DEFC_AEDAE (P81603), DEFH1_MAGGI (Q20A06), DEFH2_MAGGI (Q20A05), DEFI_AESCY (P80154), DEFI_ANOGA (Q17027), DEFI_APICA (Q5J8R1), DEFI_APIME (P17722), DEFI_BOMPA (P81462), DEFI_CALVI (C0HJX7), DEFI_DROME (P36192), DEFI_MYTGA (P80571), DEFI_ORNCO (B2D2C0), DEFI_ORYRH (O96049), DEFI_PALPR (P80407), DEFI_PHLDU (P83404), DEFI_PROTE (P10891), DEFI_PYRAP (P37364), DEFI_RHIMP (Q86LE4), DEFI_TENMO (Q27023), DEFI_TRYDI (Q10745), DEFL1_CENLI (Q6GU94), DEFLU_LUCSE (P86471), DEFM0_ARTOT (I1T3C7), DEFN_ARCDE (P84156), DEFN_HELVI (P81544), DEFPL_PSENR (Q53I06), DEFS2_PSEDA (A0A084G2W8), DEFTR_TRIIM (A0A059J5P2), DEF_COPTR (A9XFZ7), DEF_FORAQ (Q5BU36), DEF_GLOMM (Q8WTD4), LUCFE_LUCCU (B3EWY5), SAPB_SARPE (P31529), SAPC_SARPE (P31530), SAPE_SARPE (P18313)» more
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| UniProtKB/Swiss-Prot False negative sequences |
6 sequences
DEFLO_HAELO (B2MW54), DEF_MAMBR (Q8WQZ3), DEF_TITDI (P0CF77), DFP6_LONON (Q5MGC9), NOD1_MEDTR (P93331), TX21A_ETHRU (P0DPW6)» more |
| PDB [Detailed view] |
32 PDB
1FJN; 1I2U; 1I2V; 1ICA; 1L4V; 1OZZ; 1P00; 1P0A; 1ZFU; 2B68; 2E3E; 2E3F; 2E3G; 2LLD; 2LN4; 2LR5; 2NY8; 2NY9; 2NZ3; 3E7R; 3E7U; 5XA6; 6B9W; 6BAM; 6BB6; 6BI5; 6K50; 6K51; 6PX8; 7O76; 7OAE; 7OAG » more |