PROSITE entry PS51378

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General information about the entry

Entry name [info]	INVERT_DEFENSINS
Accession [info]	PS51378
Entry type [info]	MATRIX
Date [info]	01-MAY-2008 CREATED; 07-APR-2021 DATA UPDATE; 27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00356
Associated ProRule [info]	PRU00710

Name and characterization of the entry

Description [info]

Invertebrate defensins family profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=32;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0351765; R2=0.0051399; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3098.6945801; R2=2.0724764; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1297; H_SCORE=5787; N_SCORE=8.7; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=869; H_SCORE=4900; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-18; D=-80; I=-80; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='G';  M=-20,-53,-38,-15,-50, 45,-39, -5, -7,-30,-39, -2, -7, -5, 42,-30,-13,-42,-52,-45;
/M: SY='Y';  M= 21,-41,-42,-18, 38, 14,-35,  3,-37, -1,-22,-36,-45,-36,-15,-13, -7, 20,-30, 41;
/M: SY='T';  M= 10,-37,-33,-36,  5, 33,-36,-34,-33,-23,-31,-22,-36,-33,-39, 12, 67,-28,-43, 13;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/I:         I=-8; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='D';  M=-23,-55, 58,  9,-56,-43,-37,-43,-15,-50,-45, -6, 58, -4,-39,-32,  2, -5,-64,-48; D=-8;
/I:         I=-8; DM=-25;
/M: SY='W';  M=-30,-50,-19,-48, 23,-55,-48, 11,-44, 29,-23,-47,-54,-45, -5, -9,  4, -3, 61,-26; D=-8;
/I:         I=-8; DM=-25;
/M: SY='N';  M=-33,  4, 25,-38,  9, -6,-39,-34,-20, 28,-30, 29,-55,-12,-44,-18,-37,-38,-55,-37; D=-8;
/I:         I=-8; DM=-25;
/M: SY='S';  M=-13,-52,  4, 20,-59,  4,-36,-56,-29,-55,-47,-13,-43, 33, -3, 38,  4,-50,-60,-47; D=-8;
/I:         I=-8; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='W';  M= 16,-44,  2,-32,-33,  4,-33, -3,-33,-37,  4,-27,-41, 14,-37, 44,  4,-32, 53, 29; D=-8;
/I:         I=-8; DM=-25;
/M: SY='A';  M= 40,-42,  5, -9,-42, -7,-31,-28,  7,-15,-32, 19,-41, 33,-29, -6,-10,-18,-47,  0; D=-8;
/I:         I=-8; DM=-25;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='H';  M= 42,-39,-26, -1,-10,-20, 50,-16,  4,-22,-29, 38,-39,  0, -9, -9, -5,-16,-50,-30;
/M: SY='A';  M= 48,-39, 16,-28,  7, -9,-33,-22,-29,  0,  2,-12,-10, -2,  6, 17,-25,-27,-45,-32;
/M: SY='H';  M=-36,-49,-27, -6, -1,-42,110,-39,-27,-33,-25,  2,-43,  2, -5,-12,-33, -7,-44, 47;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='K';  M=-32,-44,-35,-29,-31,-44, 13, 30, 36, 19,-18,  9,-43, 17, 16, -2,-27, 12,-47,-30;
/M: SY='S';  M=  0,-40, -7,  5,  6,-17,  5, -4,-29,  3, 27,-26,-39, -3, -7, 48, -4,-10,-44, -6;
/M: SY='K';  M=-32,-45,-33, -8,-13,-44,-15, 34, 43,  5, 11,  8,-41,-22, 31,  2,-27, -8,-45,-30;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='G';  M=-22,-48,-30,  2,-52, 81,  2,-59,  0,-54,-43,-21,-37,-29, -4, -8,-36,-52,-45,-44;
/M: SY='Y';  M= -8, 30,-16,-30, 11,-43,-20,-36, 29,-21,-28,  1,-47,-23, 43,-31,-32,-36,-22, 75;
/M: SY='R';  M=-13, -7,-27,  6,-45,-13,-28,-42, 47,-20,-33,  9,-13,  5, 53,  6,-10,-26,-47,-36;
/M: SY='G';  M=  7,-46,-36,-40,-44, 75,-38,-24,-35,-48,-40,-24,-39, -4,-15, 11,-33,-43, 34, -7;
/M: SY='G';  M= -8,-46,-36,-46,-13, 89,-41,-58,-40,-53,-44,-22,-39,-38,-47,-20,-38,-52,-42,-44;
/M: SY='Y';  M=-29,-49,-32,-31,  7,-41, 43,-35, -6,-31,-25, 10,-47, 24, 15, -2,-31,-38,-15, 92;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/I:         I=-19; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='N';  M=-24,-51,-39,-47, 18,-28,-41,-21,-42,-46,-43, 45,-29,-43,-48, 11, 25,-23,  7, -1; D=-19;
/I:         I=-19; DM=-61;
/M: SY='F';  M= 11,-42,  3,  7, 26,-12, -5,-33,  6,  0,-28, -4, -3, 20,-29, 25, -6,-23,-40,  3;
/I:         I=-22; MD=-71;
/M: SY='K';  M=-19,-49,-14,  4,-43,-25,-26,-31, 60,-46,-36, 38,-39, 28, 25,-26,-29,-44, 42, -2; D=-22;
/I:         I=-22; MI=-71; MD=-71; IM=-71; DM=-71;
/M: SY='K';  M=  6,-43, -2,  4,-44, 28,-33,-36, 32,-10,-32, -4,-38, 22,-16,  0, 13, -8,-49,-39; D=-22;
/I:         I=-22; DM=-71;
/M: SY='T';  M=-28,-39, -9, -9,-30,-29,-37, 19,-12, -6,-21, 24,-41,-32, -6,-24, 44, 42,-51, -2;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='V';  M=-15,-41,-38,-33,-30,-45,  8, 11, 10,-17,-22,-16,-41, -3, 17,-26, 41, 43, 35, -3;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='Y';  M=-32,-46,-30, -7,  1,-21,-22,-34, -6,-34,-29, 14,-43,  2, 52, -6, 27, -8,-30, 60;
/M: SY='R';  M=-23,-53,-12,  7,-52,-44, 10,-50, 21,-29,  5, 32,-47,  0, 32,  0, -9,-48,-60,-43;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.

Total number of hits	63 in 63 different sequences
Number of true positive hits	63 in 63 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	6
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	91.30 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Version [info]	7

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

63 sequences

ASC3A_DOLGE (A0A3G5BIB4), ASC3B_DOLGE (A0A3G5BIB1), DEF1_CRAVI  (P85008),

DEF1_DERVA  (Q86QI5), DEF1_GALME  (P85213), DEF1_HOLDI  (Q7M426), 
DEF1_MESMA  (P0DQT7), DEF1_STOCA  (O16136), DEF2_APIME  (Q5MQL3), 
DEF2_GALME  (P85215), DEF2_MESMA  (P0DQT8), DEF2_ORNSA  (P0DV61), 
DEF2_STOCA  (O16137), DEF3_ANOGA  (Q5TWR9), DEF3_MESMA  (A0A384E0Y8), 
DEF4_ANDAU  (P56686), DEF4_LEIHE  (P41965), DEF4_MESMA  (P0DQT9), 
DEF5_MESMA  (P0DQU0), DEF6_MESMA  (P0DQU1), DEFA_AEDAE  (P91793), 
DEFA_ANOCP  (P83669), DEFA_MYTED  (P81610), DEFA_ZOPAT  (P80033), 
DEFB_AEDAE  (P81602), DEFB_ANOCP  (P83668), DEFB_MYTED  (P81611), 
DEFCG_CRAGI (Q4GWV4), DEFC_AEDAE  (P81603), DEFH1_CRAGI (Q20A06), 
DEFH2_CRAGI (Q20A05), DEFI_AESCY  (P80154), DEFI_ANOGA  (Q17027), 
DEFI_APICA  (Q5J8R1), DEFI_APIME  (P17722), DEFI_BOMPA  (P81462), 
DEFI_CALVI  (C0HJX7), DEFI_DROME  (P36192), DEFI_MYTGA  (P80571), 
DEFI_ORNCO  (B2D2C0), DEFI_ORYRH  (O96049), DEFI_PALPR  (P80407), 
DEFI_PHLDU  (P83404), DEFI_PROTE  (P10891), DEFI_PYRAP  (P37364), 
DEFI_RHIMP  (Q86LE4), DEFI_TENMO  (Q27023), DEFI_TRYDI  (Q10745), 
DEFL1_CENLI (Q6GU94), DEFLU_LUCSE (P86471), DEFM0_ARTOT (I1T3C7), 
DEFN_ARCDE  (P84156), DEFN_HELVI  (P81544), DEFPL_PSENR (Q53I06), 
DEFS2_PSEDA (A0A084G2W8), DEFTR_TRIIM (A0A059J5P2), DEF_COPTR   (A9XFZ7), 
DEF_FORAQ   (Q5BU36), DEF_GLOMM   (Q8WTD4), LUCFE_LUCCU (B3EWY5), 
SAPB_SARPE  (P31529), SAPC_SARPE  (P31530), SAPE_SARPE  (P18313)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

6 sequences

DEFLO_HAELO (B2MW54), DEF_MAMBR   (Q8WQZ3), DEF_TITDI   (P0CF77),

DFP6_LONON  (Q5MGC9), NOD1_MEDTR  (P93331), TX21A_ETHRU (P0DPW6)

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PDB
[Detailed view]

32 PDB

1FJN; 1I2U; 1I2V; 1ICA; 1L4V; 1OZZ; 1P00; 1P0A; 1ZFU; 2B68; 2E3E; 2E3F; 2E3G; 2LLD; 2LN4; 2LR5; 2NY8; 2NY9; 2NZ3; 3E7R; 3E7U; 5XA6; 6B9W; 6BAM; 6BB6; 6BI5; 6K50; 6K51; 6PX8; 7O76; 7OAE; 7OAG
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