We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS51378

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PURL: https://purl.expasy.org/prosite/signature/PS51378

Direct ScanProsite submission

General information about the entry

Entry name [info]	INVERT_DEFENSINS
Accession [info]	PS51378
Entry type [info]	MATRIX
Date [info]	01-MAY-2008 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00356
Associated ProRule [info]	PRU00710

Name and characterization of the entry

Description [info]

Invertebrate defensins family profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=32;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0351765; R2=0.0051399; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3098.6945801; R2=2.0724764; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1297; H_SCORE=5787; N_SCORE=8.7; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=869; H_SCORE=4900; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-18; D=-80; I=-80; B1=-500; E1=-500; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='G';  M=-20,-53,-38,-15,-50, 45,-39, -5, -7,-30,-39, -2, -7, -5, 42,-30,-13,-42,-52,-45;
/M: SY='Y';  M= 21,-41,-42,-18, 38, 14,-35,  3,-37, -1,-22,-36,-45,-36,-15,-13, -7, 20,-30, 41;
/M: SY='T';  M= 10,-37,-33,-36,  5, 33,-36,-34,-33,-23,-31,-22,-36,-33,-39, 12, 67,-28,-43, 13;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/I:         I=-8; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='D';  M=-23,-55, 58,  9,-56,-43,-37,-43,-15,-50,-45, -6, 58, -4,-39,-32,  2, -5,-64,-48; D=-8;
/I:         I=-8; DM=-25;
/M: SY='W';  M=-30,-50,-19,-48, 23,-55,-48, 11,-44, 29,-23,-47,-54,-45, -5, -9,  4, -3, 61,-26; D=-8;
/I:         I=-8; DM=-25;
/M: SY='N';  M=-33,  4, 25,-38,  9, -6,-39,-34,-20, 28,-30, 29,-55,-12,-44,-18,-37,-38,-55,-37; D=-8;
/I:         I=-8; DM=-25;
/M: SY='S';  M=-13,-52,  4, 20,-59,  4,-36,-56,-29,-55,-47,-13,-43, 33, -3, 38,  4,-50,-60,-47; D=-8;
/I:         I=-8; MI=0; MD=-25; IM=0; DM=-25;
/M: SY='W';  M= 16,-44,  2,-32,-33,  4,-33, -3,-33,-37,  4,-27,-41, 14,-37, 44,  4,-32, 53, 29; D=-8;
/I:         I=-8; DM=-25;
/M: SY='A';  M= 40,-42,  5, -9,-42, -7,-31,-28,  7,-15,-32, 19,-41, 33,-29, -6,-10,-18,-47,  0; D=-8;
/I:         I=-8; DM=-25;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='H';  M= 42,-39,-26, -1,-10,-20, 50,-16,  4,-22,-29, 38,-39,  0, -9, -9, -5,-16,-50,-30;
/M: SY='A';  M= 48,-39, 16,-28,  7, -9,-33,-22,-29,  0,  2,-12,-10, -2,  6, 17,-25,-27,-45,-32;
/M: SY='H';  M=-36,-49,-27, -6, -1,-42,110,-39,-27,-33,-25,  2,-43,  2, -5,-12,-33, -7,-44, 47;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='K';  M=-32,-44,-35,-29,-31,-44, 13, 30, 36, 19,-18,  9,-43, 17, 16, -2,-27, 12,-47,-30;
/M: SY='S';  M=  0,-40, -7,  5,  6,-17,  5, -4,-29,  3, 27,-26,-39, -3, -7, 48, -4,-10,-44, -6;
/M: SY='K';  M=-32,-45,-33, -8,-13,-44,-15, 34, 43,  5, 11,  8,-41,-22, 31,  2,-27, -8,-45,-30;
/I:         I=-24; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='G';  M=-22,-48,-30,  2,-52, 81,  2,-59,  0,-54,-43,-21,-37,-29, -4, -8,-36,-52,-45,-44;
/M: SY='Y';  M= -8, 30,-16,-30, 11,-43,-20,-36, 29,-21,-28,  1,-47,-23, 43,-31,-32,-36,-22, 75;
/M: SY='R';  M=-13, -7,-27,  6,-45,-13,-28,-42, 47,-20,-33,  9,-13,  5, 53,  6,-10,-26,-47,-36;
/M: SY='G';  M=  7,-46,-36,-40,-44, 75,-38,-24,-35,-48,-40,-24,-39, -4,-15, 11,-33,-43, 34, -7;
/M: SY='G';  M= -8,-46,-36,-46,-13, 89,-41,-58,-40,-53,-44,-22,-39,-38,-47,-20,-38,-52,-42,-44;
/M: SY='Y';  M=-29,-49,-32,-31,  7,-41, 43,-35, -6,-31,-25, 10,-47, 24, 15, -2,-31,-38,-15, 92;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/I:         I=-19; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='N';  M=-24,-51,-39,-47, 18,-28,-41,-21,-42,-46,-43, 45,-29,-43,-48, 11, 25,-23,  7, -1; D=-19;
/I:         I=-19; DM=-61;
/M: SY='F';  M= 11,-42,  3,  7, 26,-12, -5,-33,  6,  0,-28, -4, -3, 20,-29, 25, -6,-23,-40,  3;
/I:         I=-22; MD=-71;
/M: SY='K';  M=-19,-49,-14,  4,-43,-25,-26,-31, 60,-46,-36, 38,-39, 28, 25,-26,-29,-44, 42, -2; D=-22;
/I:         I=-22; MI=-71; MD=-71; IM=-71; DM=-71;
/M: SY='K';  M=  6,-43, -2,  4,-44, 28,-33,-36, 32,-10,-32, -4,-38, 22,-16,  0, 13, -8,-49,-39; D=-22;
/I:         I=-22; DM=-71;
/M: SY='T';  M=-28,-39, -9, -9,-30,-29,-37, 19,-12, -6,-21, 24,-41,-32, -6,-24, 44, 42,-51, -2;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='V';  M=-15,-41,-38,-33,-30,-45,  8, 11, 10,-17,-22,-16,-41, -3, 17,-26, 41, 43, 35, -3;
/M: SY='C';  M=-32,143,-51,-52,-42,-47,-51,-49,-47,-39,-40,-38,-62,-55,-54,-34,-32,-36,-72,-53;
/M: SY='Y';  M=-32,-46,-30, -7,  1,-21,-22,-34, -6,-34,-29, 14,-43,  2, 52, -6, 27, -8,-30, 60;
/M: SY='R';  M=-23,-53,-12,  7,-52,-44, 10,-50, 21,-29,  5, 32,-47,  0, 32,  0, -9,-48,-60,-43;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	63 in 63 different sequences
Number of true positive hits	63 in 63 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	6
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	91.30 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20
Author [info]	PS_Langendijk_Genevaux
Version [info]	7

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

63 sequences

ASC3A_DOLGE (A0A3G5BIB4), ASC3B_DOLGE (A0A3G5BIB1), DEF1_CRAVI  (P85008),

DEF1_DERVA  (Q86QI5), DEF1_GALME  (P85213), DEF1_HOLDI  (Q7M426), 
DEF1_OLIMR  (P0DQT7), DEF1_STOCA  (O16136), DEF2_APIME  (Q5MQL3), 
DEF2_GALME  (P85215), DEF2_OLIMR  (P0DQT8), DEF2_ORNSA  (P0DV61), 
DEF2_STOCA  (O16137), DEF3_ANOGA  (Q5TWR9), DEF3_OLIMR  (A0A384E0Y8), 
DEF4_ANDAU  (P56686), DEF4_LEIHE  (P41965), DEF4_OLIMR  (P0DQT9), 
DEF5_OLIMR  (P0DQU0), DEF6_OLIMR  (P0DQU1), DEFA_AEDAE  (P91793), 
DEFA_ANOCP  (P83669), DEFA_MYTED  (P81610), DEFA_ZOPAT  (P80033), 
DEFB_AEDAE  (P81602), DEFB_ANOCP  (P83668), DEFB_MYTED  (P81611), 
DEFCG_MAGGI (Q4GWV4), DEFC_AEDAE  (P81603), DEFH1_MAGGI (Q20A06), 
DEFH2_MAGGI (Q20A05), DEFI_AESCY  (P80154), DEFI_ANOGA  (Q17027), 
DEFI_APICA  (Q5J8R1), DEFI_APIME  (P17722), DEFI_BOMPA  (P81462), 
DEFI_CALVI  (C0HJX7), DEFI_DROME  (P36192), DEFI_MYTGA  (P80571), 
DEFI_ORNCO  (B2D2C0), DEFI_ORYRH  (O96049), DEFI_PALPR  (P80407), 
DEFI_PHLDU  (P83404), DEFI_PROTE  (P10891), DEFI_PYRAP  (P37364), 
DEFI_RHIMP  (Q86LE4), DEFI_TENMO  (Q27023), DEFI_TRYDI  (Q10745), 
DEFL1_CENLI (Q6GU94), DEFLU_LUCSE (P86471), DEFM0_ARTOT (I1T3C7), 
DEFN_ARCDE  (P84156), DEFN_HELVI  (P81544), DEFPL_PSENR (Q53I06), 
DEFS2_PSEDA (A0A084G2W8), DEFTR_TRIIM (A0A059J5P2), DEF_COPTR   (A9XFZ7), 
DEF_FORAQ   (Q5BU36), DEF_GLOMM   (Q8WTD4), LUCFE_LUCCU (B3EWY5), 
SAPB_SARPE  (P31529), SAPC_SARPE  (P31530), SAPE_SARPE  (P18313)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

6 sequences

DEFLO_HAELO (B2MW54), DEF_MAMBR   (Q8WQZ3), DEF_TITDI   (P0CF77),

DFP6_LONON  (Q5MGC9), NOD1_MEDTR  (P93331), TX21A_ETHRU (P0DPW6)

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PDB
[Detailed view]

37 PDB

pdb_00001fjn; pdb_00001i2u; pdb_00001i2v; pdb_00001ica; pdb_00001l4v; pdb_00001ozz; pdb_00001p00; pdb_00001p0a; pdb_00001zfu; pdb_00002b68; pdb_00002e3e; pdb_00002e3f; pdb_00002e3g; pdb_00002lld; pdb_00002ln4; pdb_00002lr5; pdb_00002ny8; pdb_00002ny9; pdb_00002nz3; pdb_00003e7r; pdb_00003e7u; pdb_00005xa6; pdb_00006b9w; pdb_00006bam; pdb_00006bb6; pdb_00006bi5; pdb_00006k50; pdb_00006k51; pdb_00006px8; pdb_00007o76; pdb_00007oae; pdb_00007oag; pdb_00009e3v; pdb_00009e3w; pdb_00009e3x; pdb_00009e3y; pdb_00009e3z
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