We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

ProRule PRU00710

View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00710

General rule information [?]

Accession	PRU00710
Dates	22-MAY-2008 (Created) 21-NOV-2019 (Last updated, Version 6)
Data class	Domain;
Predictors	PROSITE; PS51378; INVERT_DEFENSINS
Name	Invertebrate defensins family
Function	Invertebrate defensins are a family of cysteine-rich antimicrobial peptides, primarily active against Gram-positive bacteria.
Scope(s)	Eukaryota Fungi Metazoa
Example(s)	P91793;

Propagated annotation [?]

Comments [?]

FUNCTION	Antibacterial peptide mostly active against Gram-positive bacteria.
case <AnyFeature:Signal>
SUBCELLULAR LOCATION	Secreted.
end case
SIMILARITY	Belongs to the invertebrate defensin family.

Keywords [?]

Antibiotic
Antimicrobial
Defensin
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0006952; Biological process:defense response

Features [?]

From: PS51378

Key

From

Description

Tag

Condition

FTGroup

DISULFID

disulf

C-x*-C

DISULFID

disulf

C-x*-C

DISULFID

disulf

C-x*-C

Additional information [?]

Size range	25-50 amino acids
Related rules	None
Fusion	None
Repeats	1
Topology	Undefined

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota	[69]
All	[ 69 ]

Retrieve set of proteins with 3D structure for this domain