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PROSITE entry PS51390


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS51390
Entry name [info] WAP
Accession [info] PS51390
Entry type [info] MATRIX
Date [info] 01-JUL-2008 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00026
Associated ProRule [info] PRU00722

Name and characterization of the entry

Description [info] WAP-type 'four-disulfide core' domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=48;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=48;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7587812; R2=0.0052219; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1426; N_SCORE=10.2; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=774; N_SCORE=6.8; MODE=1; TEXT='R?';
/DEFAULT: M0=-49; D=-200; I=-200; B1=-300; E1=-300; MI=-105; MD=-105; IM=-105; DM=-105;

...
 
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='P';  M= -17,  22, -25,-122,   7, -33, -25, -11,  12,  -1,   2, -12,  66, -28,  16, -59,  11,  18, -25, -44;
/M: SY='K';  M=   8,   9, -59, -10, -52,  -4, -37,  -2,  34, -14,-113,   4,  18,   9,   5,  11,  20, -29,  26,  12;
/M: SY='P';  M=  24, -49, -57,  44, -47, -51, -29,-119,  -5, -36, -26,  19,  44,  15, -33,  26,  16,   8, -21, -28;
/M: SY='K';  M= -44,-149, -56, -28,  -5,-135,  54, -68,  90, -16, -36,-108,-129,  12,  34, -13, -22, -57,-146, -30;
/M: SY='P';  M=  27,-140,   4,  -7, -23, -52,-119, -25,   2, -42,-120, -23,  86,  19, -37, -11, -44,  -7, -37,  26;
/I:         I=-44; MD=-23;
/M: SY='G';  M= -24,-150, -30, -61,-151,  95,-133,-153, -18, -64,  -1, -48, -41,-125, -32, -29, -11,-144, -18,-153; D=-44;
/I:         I=-44; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='T';  M=  -4,-136, -12,   3, -15, -52, -26, -22,  24, -30,   6, -37, -16,  29,  29,  19,  31,  21,-144, -24;
/M: SY='C';  M= -47, 151,-169,-169,-143,-154,-155,-124,-157,-131,-124,-148,-154,-149,-167,-120,-120,-120,-160,-151;
/M: SY='P';  M= -66,-150,-130, -23,-154, -73, -10, -63,-119, -57,-135,-129, 129,   8,-127,  -9,-119, -51,-166,-152;
/M: SY='P';  M=  12,-143,  24,  24, -70,-131,-118, -37,  29, -39,-121,  -2,  58,  22,  32,  -8,   7, -18,   5,-137;
/I:         I=-44; MD=-23;
/M: SY='P';  M= -37,-141,  -1,   9,  10, -82, -38,   3, -14, -24, -48,   5,  64,  11,  11, -25,   0,  27,-146, -34; D=-44;
/I:         I=-44; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='P';  M= -43,-151, -44,  11, -31, -78,-137, -27, -20, -35, -17, -35,  75,-121, -16,  23,  12, -37, -10,-144; D=-44;
/I:         I=-44; DM=-23;
/M: SY='P';  M= -19,-148, -70, -22, -11, -15,-128, -18,  18, -37, -19, -58,  60,  32, -41,  18, -15, -30,-151, -13; D=-44;
/I:         I=-44; DM=-23;
/M: SY='P';  M=  -2,-139, -26,   3,-131,   0,   7,  -2,  -6, -14, -42,  -5,  61,   3,  18,  23,  -9,  -1,-150, -21;
/I:         I=-19; MD=-10;
/M: SY='P';  M=  -4,-141,  12, -13, -62,  18,-122, -18,   8,   1,  11,  16,  49,   9, -17,  -2,  -8, -22,-148, -12; D=-19;
/I:         I=-19; MD=-10;
/M: SY='P';  M= -40,-153,  16, -37,   2, -63,-138, -14, -65, -39, -39,-130,  37, -26,  -7,   8,  15, -11,-155, -10; D=-19;
/I:         I=-19; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='Q';  M= -48,-153, -13,  16, -59,  -5,-124, -21,  -5, -21, -41,  20,  10,  29, -36,   3,  -4, -44,-152,   8; D=-19;
/I:         I=-19; DM=-10;
/M: SY='C';  M=-114, 146, -60, -61,-141,-154,-151,-122,-150, -39,-121,-143,-153,-143, -59, -56, -31,-120,-160,-150; D=-19;
/I:         I=-19; DM=-10;
/M: SY='P';  M=  13,-137, -12,  21,-134, -79,-132,  18,  -8,  -9, -35, -66,  57, -48,  -8,  -7,  23,  20,-156,-141; D=-19;
/I:         I=-19; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='P';  M= -34,-170, -37, -46, -83, -37, -32, -34,  20, -40,-144,-142,  55, -49,  -6, -23, -62, -85,-169,  -8; D=-19;
/I:         I=-19; DM=-10;
/M: SY='N';  M=-130,-159,  38, -68, -69, -49,  29, -15, -38,-152,-145,  44,  29,-126,-135,  13,  18,-141,-167,  -6; D=-19;
/I:         I=-19; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='Q';  M= -40,-144, -12,  39, -18, -33,   2, -49,   3,  10, -33,  -4,  -4,  50,  25,  12, -29, -24,  17,  15;
/M: SY='C';  M=-114, 152,-171,-171,-143,-156,-156,-124,-159,-131,-124,-149,-156,-150,-168,-121,-120,-121,-161,-152;
/M: SY='H';  M= -12,-141,  -2,  18,  -8, -51,  43, -56,  26, -58,-121,  14, -49,  35,  32,  38,  26, -42,  -3, -59;
/I:         I=-61; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='S';  M= -47, -33, -10,  20, -58, -31,  11, -65,  -7, -67, -25,  28,-130,   5,  24,  53,  41,  -2, -26,   4;
/M: SY='D';  M=-133,-168, 119, -81, -46,-127,  21,-163,-116,-164,-159,  -4, -46,-110,-129,-110,-122,-157,-181,-142;
/M: SY='S';  M=  -4,-142,  23,  24,  -3, -24,-109, -50, -10, -34,-120,   9,-131,  45,  26,  46, -27, -78,  33,  30;
/M: SY='D';  M= -69,-157,  95,  27,-151, -22,   6, -80, -18,-153,-139,   1,-131,  58,-113,  -1, -37,-145,-163, -48;
/M: SY='C';  M=-114, 152,-171,-171,-143,-156,-156,-124,-159,-131,-124,-149,-156,-150,-168,-121,-120,-121,-161,-152;
/M: SY='P';  M=   9,-146, -34,  29, -37, -36,-119, -75,  32, -89, -22,-115,  93,  40,   3,  14, -55,-132,-156,-140;
/I:         I=-37; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='G';  M=   2,-149,  11,  -2, -60,  66, -32,-151, -22, -48,-134,   2, -17,  45, -50,  11, -44,-142,-154, -49; D=-37;
/I:         I=-37; MI=0; MD=-19; IM=0; DM=-19;
/M: SY='N';  M= -38,-142,  18, -21,-134,  23,  31, -24,  -4, -34, -23,  74, -30, -27, -13, -15,  22,  -3,-153, -23;
/M: SY='Q';  M= -73,-150,  13,  32,   3, -81,  12,-129,  63, -38,  43, -24,-131,  69,  14, -29, -33, -71,-140, -11;
/M: SY='K';  M= -67,-151,-123, -36,-140,-137, -23,   5, 102, -83,  10,-110,-129, -33,  46,-112,-115, -21,-152, -54;
/M: SY='C';  M=-114, 152,-171,-171,-143,-156,-156,-124,-159,-131,-124,-149,-156,-150,-168,-121,-120,-121,-161,-152;
/I:         I=-61; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='C';  M=-114, 150,-170,-170,-142,-156,-156,-119,-158,-128,-122,-149,-155,-150,-167,-122,-120, -28,-160,-151;
/I:         I=-51; MD=-27;
/M: SY='P';  M= -34,-143,  18, -28,  29, -60, -41, -78, -14, -35, -38,  19,  55,  23,  -7,  39, -32, -28, -19,  46; D=-51;
/I:         I=-51; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='N';  M= -10,-138,  39, -62,  -2,   4, -41, -79, -68, -32, -38,  61,-133, -16, -19,  26,  44, -21,  13,   1;
/M: SY='G';  M=   6,-140, -34, -69,   9,  70, -16, -71,-119, -77,  -1, -26,   4, -40,  -8,  36, -36, -29,-138,  17;
/I:         I=-56; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='C';  M=-112, 147,-160, -61,-143, -42, -31,-125,-149,-131,-124,-141,-152,-142, -61, -33, -51, -71,-160,-148;
/M: SY='G';  M= -40,-145, -41,-125, -67,  83,  -9, -40, -45,  -9,-126,   9, -25, -23, -25,  25,-116, -50,-151, -49;
/M: SY='R';  M= -23,-144, -72, -65,   6, -39,  29, -76,  36,  -8,  31,  27,-135,   7,  59,  -4,  -7, -78,  -8,  38;
/I:         I=-51; MI=0; MD=-27; IM=0; DM=-27;
/M: SY='S';  M=  -5,-132, -35,  -3,-131, -80, -42,  10,  35, -61, -26,-113, -57,   9,  23,  42,  38,  36,-149, -48;
/M: SY='C';  M=-114, 152,-171,-171,-143,-156,-156,-124,-159,-131,-124,-149,-156,-150,-168,-121,-120,-121,-161,-152;
/I:         I=-61; MD=-32;
/M: SY='M';  M= -35,-132,-138, -22,  -2,-146,-128, -34,  30,  12,  65,-128,-138, -31,  20, -25,  27,  49,-138, -30; D=-61;
/I:         I=-61; MI=-32; IM=-32; DM=-32;
/M: SY='P';  M=   7,-141,  37,   6,-134, -55, -16, -14,  -4, -77,  -8,  -5,  38,  22,   0,  25,  12,  -9,-150,  -2;
/M: SY='P';  M=  -4,-146, -73,-125, -57, -18,-136, -15, -19, -45,-129, -19, 114,-124, -68, -12, -30, -28,-164,-148;
/M: SY='V';  M=  -2, -49, -13, -12, -77, -37, -35,  23, -17, -18,-107, -25,  -9, -34, -25,  -2, -32,  51,   7, -58;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 170 in 125 different sequences
Number of true positive hits 170 in 125 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 26
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 86.73 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 4
Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] PS_Langendijk_Genevaux
Feature key [info] DOMAIN
Feature description [info] WAP
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 125 sequences 

CALU_CAVPO  (P22075), ELAF_HUMAN  (P19957), ELAF_PIG(Q29125), 

EPPI_HUMAN  (O95925), EPPI_MACMU  (Q9BDL1), EPPI_MOUSE  (Q9DA01), 
EPPI_RAT(D4A2Z2), IBP_CARCR   (P00993), KALM_CHICK  (P33005), 
KALM_COTJA  (Q90369), KALM_HUMAN  (P23352), LEV9_CAEEL  (Q22328), 
PPN_DROME   (Q868Z9), PWAPL_LOTGI (B3A0S1), PWAP_HALAI  (P86730), 
PWAP_HALLA  (P84811), SLPI_HUMAN  (P03973), SLPI_MOUSE  (P97430), 
SLPI_PIG(P22298), SLPI_SHEEP  (Q6V9X0), SPAI_PIG(P16225), 
UROL1_HUMAN (Q5DID0), UROL1_MOUSE (Q5DID3), VKT_SISCA   (A5X2X1), 
WAP1_ERYPO  (A7X4L4), WAP1_PHIOL  (A7X4K1), WAP1_PSEPL  (A7X4M1), 
WAP1_RHATT  (A7X4J4), WAP1_THRJA  (A7X4I7), WAP2_PHIOL  (A7X4K7), 
WAP3_PHIOL  (A7X4M7), WAP3_PIG(Q29126), WAPA_AUSSU  (B5KGY9), 
WAPA_CRYNI  (B5G6H1), WAPA_DEMVE  (B5L5P8), WAPA_HOPST  (B5G6H3), 
WAPA_NOTSC  (B5G6H4), WAPA_OXYMI  (P83952), WAPA_OXYSC  (B5G6G8), 
WAPA_PSEAU  (B5G6G9), WAPA_PSEPO  (B5G6H0), WAPA_PSETE  (B5L5P9), 
WAPA_TROCA  (B5G6H2), WAPB_AUSSU  (B5L5P2), WAPB_CRYNI  (B5L5N6), 
WAPB_DEMVE  (B5L5P5), WAPB_NOTSC  (B5G6H5), WAPB_OXYMI  (B5G6G7), 
WAPB_PSEAU  (B5L5N1), WAPB_PSEPO  (B5L5N2), WAPB_TROCA  (B5L5P0), 
WAPC_AUSSU  (B5L5P3), WAPC_DEMVE  (B5L5P6), WAPC_OXYMI  (B5L5M9), 
WAPC_PSEPO  (B5L5N3), WAPD_AUSSU  (B5L5P4), WAPD_DEMVE  (B5L5P7), 
WAPD_PSEPO  (B5L5N4), WAPN_NAJNG  (P60589), WAP_APIME   (A0A7M7H308), 
WAP_CAMDR   (P09837), WAP_MOUSE   (P01173), WAP_NOTEU   (Q9N0L8), 
WAP_PIG (O46655), WAP_RABIT   (P09412), WAP_RAT (P01174), 
WAP_TETBN   (P0DQZ3), WF10A_HUMAN (Q9H1F0), WF10B_HUMAN (Q8IUB3), 
WF15A_MOUSE (Q8BH89), WF15B_MOUSE (Q9JHY4), WFC6A_MOUSE (Q3UW55), 
WFC6B_MOUSE (F6ULY1), WFD12_AOTNA (A4K2W8), WFD12_CALJA (A4K2U1), 
WFD12_CHLAE (A4K2Y4), WFD12_COLGU (A4K2P8), WFD12_GORGO (A4K2R5), 
WFD12_HUMAN (Q8WWY7), WFD12_LEMCA (A4K2S4), WFD12_MACMU (A4K2T3), 
WFD12_MOUSE (Q9JHY3), WFD12_PANTR (A4K2P0), WFD12_PAPAN (A4K2M6), 
WFD12_PONAB (A4K2V4), WFD12_RAT   (Q6IE40), WFD12_SAIBB (A4K2X6), 
WFD18_BOVIN (P62811), WFD18_MOUSE (P62810), WFD18_RAT   (P14730), 
WFDC1_CHICK (Q8JG33), WFDC1_HUMAN (Q9HC57), WFDC1_MOUSE (Q9ESH5), 
WFDC1_RAT   (O70280), WFDC2_CANLF (Q28894), WFDC2_HUMAN (Q14508), 
WFDC2_MOUSE (Q9DAU7), WFDC2_PIG   (Q8MI69), WFDC2_RABIT (Q28631), 
WFDC2_RAT   (Q8CHN3), WFDC3_HUMAN (Q8IUB2), WFDC3_MOUSE (Q14AE4), 
WFDC5_AOTNA (A4K2W7), WFDC5_CALJA (A4K2U0), WFDC5_CHLAE (A4K2Y3), 
WFDC5_COLGU (A4K2P7), WFDC5_GORGO (A4K2R4), WFDC5_HUMAN (Q8TCV5), 
WFDC5_LEMCA (A4K2S3), WFDC5_MACMU (A4K2T2), WFDC5_OTOGA (A4K2Q7), 
WFDC5_PANTR (A4K2N9), WFDC5_PAPAN (A4K2M5), WFDC5_PONAB (A4K2V3), 
WFDC5_SAIBB (A4K2X5), WFDC6_HUMAN (Q9BQY6), WFDC8_HUMAN (Q8IUA0), 
WFDC8_MOUSE (Q4KUS1), WFKN1_HUMAN (Q96NZ8), WFKN1_MOUSE (Q8R0S6), 
WFKN1_RAT   (P0C5J5), WFKN2_BOVIN (Q08E66), WFKN2_HUMAN (Q8TEU8), 
WFKN2_MOUSE (Q7TQN3), WFKN_DANRE  (Q6NUX0)
» more

UniProtKB/Swiss-Prot
False negative sequences		 26 sequences 

PWAPL_MYTGA (P86855), TXE01_LYCSI (B6DD34), TXE02_LYCSI (B6DD35), 

TXE03_LYCSI (B6DD36), TXE04_LYCSI (B6DD37), TXE05_LYCSI (B6DD38), 
TXE06_LYCSI (B6DD39), TXF07_LYCSI (B6DD40), TXF08_LYCSI (B6DD41), 
TXF09_LYCSI (B6DD42), TXF10_LYCSI (B6DD43), TXF11_LYCSI (B6DD44), 
TXF12_LYCSI (B6DD45), TXF13_LYCSI (B6DD46), TXF14_LYCSI (B6DD47), 
TXF15_LYCSI (B6DD48), TXF16_LYCSI (B6DD49), TXF17_LYCSI (B6DD50), 
TXF18_LYCSI (B6DD51), TXK01_LYCSI (B6DD60), TXK02_LYCSI (B6DD61), 
TXK03_LYCSI (B6DD62), TXK04_LYCSI (B6DCY1), WFD13_HUMAN (Q8IUB5), 
WFD13_MOUSE (Q5DQQ6), WFD21_MOUSE (Q8BTE6)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

ENA2_HORSE  (P56928)


				
	

	

		PDB
[Detailed view]		
		
			8 PDB
			


			1FLE; 1UDK; 1ZLG; 2REL; 2Z7F; 3NGG; 4DOQ; 6ATU