General rule information
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Accession |
PRU00722 |
Dates |
11-JUL-2008 (Created) 21-NOV-2019 (Last updated, Version 5) |
Names |
WAP; four-disulfide core (4-DSC) domain |
Function |
The 'four-disulfide core' or WAP domain comprises 8 cysteine residues involved in disulfide bonds. Single or multiple copies occur in eukaryotic proteins, such as whey acidic protein (WAP), antileukoproteinase and elastase-inhibitor proteins. |
Propagated annotation
[?]
case <FTTag:disulf>
end case
case <Feature:PS51390:8=C> and <Feature:PS51390:36=C> and <Feature:PS51390:18=C> and <Feature:PS51390:40=C> and <Feature:PS51390:23=C> and <Feature:PS51390:35=C> and <Feature:PS51390:29=C> and <Feature:PS51390:44=C>
From: PS51390 |
Key
|
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From
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|
To
|
|
Description
|
|
Tag
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|
Condition
|
|
FTGroup
|
DOMAIN
|
|
entry
|
|
exit
|
|
WAP #
|
|
|
|
|
|
|
else
DOMAIN
|
|
entry
|
|
exit
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|
WAP #; atypical
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|
|
|
|
|
|
end case
DISULFID
|
|
8
|
|
36
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
18
|
|
40
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
23
|
|
35
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
DISULFID
|
|
29
|
|
44
|
|
|
|
disulf
|
|
C-x*-C
|
|
|
Additional information
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Size range |
30-65 amino acids |
Related rules |
None |
Repeats |
1-7 |
Topology |
Undefined |
Example |
Q6V9X0 (SLPI_SHEEP) |
Scope |
Eukaryota |
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(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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