Home  |  Contact
annotation rule: PRU00722

General rule information [?]

Accession PRU00722
Dates 11-JUL-2008 (Created)
19-DEC-2016 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51390; WAP
Names WAP; four-disulfide core (4-DSC) domain
Function The 'four-disulfide core' or WAP domain comprises 8 cysteine residues involved in disulfide bonds. Single or multiple copies occur in eukaryotic proteins, such as whey acidic protein (WAP), antileukoproteinase and elastase-inhibitor proteins.

Propagated annotation [?]


Keywords [?]

case <FTTag:disulf>
end case


Features [?]

case <Feature:PS51390:8=C> and <Feature:PS51390:36=C> and <Feature:PS51390:18=C> and <Feature:PS51390:40=C> and <Feature:PS51390:23=C> and <Feature:PS51390:35=C> and <Feature:PS51390:29=C> and <Feature:PS51390:44=C>
From: PS51390
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     entry     exit       WAP #        
else
DOMAIN     entry     exit       WAP #; atypical        
end case

DISULFID     8     36           disulf   C-x*-C  
DISULFID     18     40           disulf   C-x*-C  
DISULFID     23     35           disulf   C-x*-C  
DISULFID     29     44           disulf   C-x*-C  

Additional information [?]

Size range 30-65 amino acids
Related rules None
Repeats 1-7
Topology Undefined
Example Q6V9X0 (SLPI_SHEEP)
Scope
Eukaryota

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]