ProRule PRU00722

General rule information [?]

Accession PRU00722
Dates 11-JUL-2008 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain;
Predictors PROSITE; PS51390; WAP
Name WAP
Function The 'four-disulfide core' or WAP domain comprises 8 cysteine residues involved in disulfide bonds. Single or multiple copies occur in eukaryotic proteins, such as whey acidic protein (WAP), antileukoproteinase and elastase-inhibitor proteins.
Scope(s) Eukaryota
Example(s) Q6V9X0 (SLPI_SHEEP);

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Features [?]

From: PS51390
Key From To Description Tag Condition FTGroup
case <Feature:PS51390:8=C> and <Feature:PS51390:36=C> and <Feature:PS51390:18=C> and <Feature:PS51390:40=C> and <Feature:PS51390:23=C> and <Feature:PS51390:35=C> and <Feature:PS51390:29=C> and <Feature:PS51390:44=C>
DOMAIN entry exit /note="WAP #"
DOMAIN entry exit /note="WAP #; atypical"
end case
DISULFID 8 36 disulf C-x*-C
DISULFID 18 40 disulf C-x*-C
DISULFID 23 35 disulf C-x*-C
DISULFID 29 44 disulf C-x*-C

Additional information [?]

Size range 30-65 amino acids
Related rules None
Fusion None
Repeats 1-7
Topology Undefined


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UniProtKB rule member sequences [?]