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annotation rule: PRU00722

General rule information [?]

Accession PRU00722
Dates 11-JUL-2008 (Created)
21-NOV-2019 (Last updated, Version 5)
Data class Domain
Predictors PROSITE; PS51390; WAP
Names WAP; four-disulfide core (4-DSC) domain
Function The 'four-disulfide core' or WAP domain comprises 8 cysteine residues involved in disulfide bonds. Single or multiple copies occur in eukaryotic proteins, such as whey acidic protein (WAP), antileukoproteinase and elastase-inhibitor proteins.

Propagated annotation [?]


Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case


Features [?]

case <Feature:PS51390:8=C> and <Feature:PS51390:36=C> and <Feature:PS51390:18=C> and <Feature:PS51390:40=C> and <Feature:PS51390:23=C> and <Feature:PS51390:35=C> and <Feature:PS51390:29=C> and <Feature:PS51390:44=C>
From: PS51390
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     entry     exit       WAP #        
else
DOMAIN     entry     exit       WAP #; atypical        
end case

DISULFID     8     36           disulf   C-x*-C  
DISULFID     18     40           disulf   C-x*-C  
DISULFID     23     35           disulf   C-x*-C  
DISULFID     29     44           disulf   C-x*-C  

Additional information [?]

Size range 30-65 amino acids
Related rules None
Repeats 1-7
Topology Undefined
Example Q6V9X0 (SLPI_SHEEP)
Scope
Eukaryota

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]