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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00722


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00722
General rule information [?]

Accession PRU00722
Dates 11-JUL-2008 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51390; WAP
Name WAP
Function The 'four-disulfide core' or WAP domain comprises 8 cysteine residues involved in disulfide bonds. Single or multiple copies occur in eukaryotic proteins, such as whey acidic protein (WAP), antileukoproteinase and elastase-inhibitor proteins.
Scope(s) Eukaryota
Example(s) Q6V9X0;

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Features [?]

From: PS51390
Key From To Description Tag Condition FTGroup
case <Feature:PS51390:8=C> and <Feature:PS51390:36=C> and <Feature:PS51390:18=C> and <Feature:PS51390:40=C> and <Feature:PS51390:23=C> and <Feature:PS51390:35=C> and <Feature:PS51390:29=C> and <Feature:PS51390:44=C>
DOMAIN entry exit /note="WAP #"
else
DOMAIN entry exit /note="WAP #; atypical"
end case
DISULFID 8 36 disulf C-x*-C
DISULFID 18 40 disulf C-x*-C
DISULFID 23 35 disulf C-x*-C
DISULFID 29 44 disulf C-x*-C

Additional information [?]

Size range 30-65 amino acids
Related rules None
Fusion None
Repeats 1-7
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]