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PROSITE entry PS51641


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General information about the entry

Entry name [info] AGENET_LIKE
Accession [info] PS51641
Entry type [info] MATRIX
Date [info] 01-MAR-2012 CREATED;
01-MAR-2012 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51641
Associated ProRule [info] PRU00973

Name and characterization of the entry

Description [info] Agenet-like domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=53;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=48;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.1074364; R2=0.0082990; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=1072; N_SCORE=12.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=301; N_SCORE=5.6; MODE=1; TEXT='RR';
/DEFAULT: M0=-100; D=-200; I=-200; B1=-1000; E1=-1000; MI=-505; MD=-505; IM=-505; DM=-505;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-505; BD=-505;
/M: SY='D';  M= -36, -81,  62, -33,-226,-234,-222, -83, -77,  33,  33, -28, -82,  10, -57, -39,-116, -99,-245, -71;
/M: SY='E';  M= -25,-238, -26,  64,-132,-234,-223,-232,  -5, -43, -48, -80, -26, -60, -11,  -7,  18, -40,-244, -73;
/M: SY='V';  M= -77,-105,-246,-240,-218,-105,-247,   6,-238, -66, -53,-241, -36, -93,-240,-113,-216,  87,-249,-226;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='E';  M=-226,-245,   8,  95,-105,-239,-219,-122, -71, -45,-234,-220, -53, -60,-106,-114,-225,-238, -33,-235; D=-11;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='V';  M=   1,-228,-239, -96,-219, -70, -80, -19,-233,-134,-207,-235,  -8,-234,-236, -89,-107,  87,-246,-225; D=-11;
/I:         I=-11; DM=-29;
/M: SY='Y';  M=-130,  -3, -52,   2,  35,-100, -64, -82,-115, -25, -61,-224,-102,-215,  53,  -5,-222,-223,-212,  78; D=-11;
/I:         I=-11; DM=-29;
/M: SY='S';  M= -70, -77,  -8,-110, -56,  25, -27,-225,-222, -25,  -4, -30,-229, -13,-226,  54,  25, -47,  24,  -8; D=-11;
/I:         I=-11; DM=-29;
/M: SY='R';  M= -36,-255,-239, -70,-247,-248,-234, -69,  18,-245,-238,-234, -14, -32,  63, -39,-236, -22,-250, -30; D=-11;
/I:         I=-11; DM=-29;
/M: SY='A';  M=  33, -59, -20, -16, -37, -52,-224, -29, -18, -37,-219,  -5, -36,   8,-221,  32,   6, -15,-239,-225; D=-11;
/I:         I=-11; DM=-29;
/M: SY='N';  M= -52,-231,  23, -62,-236,  -9,  -3, -44, -39,-237,-227,  92,-106,  -7, -72, -37, -15, -72,-249, -78; D=-11;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='D';  M= -58, -59,  43,  28, -85, -94, -59,-260,-239, -61, -40,   3, -58,-235,-246, -42,-242,-258,-273,-254; D=-11;
/I:         I=-11; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='Q';  M= -65,-251,  13, -16, -85,-242,  -8,-247,  -6, -52,-239,   0,-244,  37, -21, -12,  -5,-108,-256, -60; D=-11;
/I:         I=-11; DM=-29;
/M: SY='E';  M= -36,-256,-222,  62, -87, -75,  -3, -55, -41, -43,-240, -35,  20,-222, -68,-235,-237,-244, -32, -73; D=-11;
/I:         I=-11; DM=-29;
/M: SY='P';  M= -16,-256,-242, -30,-249, -91,-246, -35,-240, -31,-236,-117,  78,-240,-249,-234,   1, -70, -32,-249; D=-11;
/I:         I=-11; DM=-29;
/M: SY='C';  M= -10,  91, -74,-147, -15,  51, -31,-234, -87, -60, -12, -83,   3,-228, -58, -20,-115,-138,   0, -46; D=-11;
/I:         I=-11; DM=-29;
/M: SY='A';  M=  55,  40, -85, -71, -37,  44,-229, -33, -73, -48,-119,-217, -76, -49,-229,  -1, -72, -85,-235,-228;
/M: SY='W';  M=-232, -38,-251,-238,  44, -83,-241, -62,-231, -80,-223, -53,-239,-232,-233, -99,-236, -61, 156,  26;
/M: SY='W';  M= -64,-158,-242,-109,  -4,-106, -77,-120,-108, -82,-221,-107, -99, -20, -54, -56,-126, -82, 146,  77;
/M: SY='P';  M=-100, -51,-222, -35,-142,-130, -61, -92,  54,  10, -66,-176,  73,  10, -23, -80, -35, -43, -33,-225;
/M: SY='A';  M=  69,  18,-225,-226,-237,  64,-229,-234,-225,-233,-226,-215,-227,-222,-230, -95,-148,-186,-234,-233;
/M: SY='F';  M=-222, -41,-224, -30,  54,-175, -38, -21,  46, -98, -69,-219,-231, -20,  45, -25, -47,   6,-222,  -5;
/M: SY='V';  M=-216,-230,-243,-239,-211,-104,-244,  66,-235,-110,-115,-236,-236,-236,-238,-228,-213,  81,-240, -72;
/M: SY='K';  M=-214,-225, -46,-208,-213, -78, -13, -73,  69,  41,-202,-210,-223,-204,  35, -42,  18,   1,-228,-213;
/M: SY='M';  M= -37, -45,  59, -23,-216,-219, -35,-208,  32,  21,  82, -17,-220,-205, -65,  18,  -9,-121,-232,-213;
/M: SY='I';  M=-212,   8,-233,-228,  54,-115,-226,  58, -72, -19,  33,-224,-229,-224, -25, -15, -99,  56,  -9,-200;
/M: SY='H';  M= -67,-229, -33,-205, -16, -17,  86,  39,  61, -67, -40, -26,-221,  10,  22, -74,-212,-210,-228, -66;
/M: SY='G';  M= -17,-226,  19,  46,-231,  68,-214,-233, -38,-231,-224,-123, -81, -70,-215,  42, -35,-227,  24,-222;
/I:         I=-39; MI=0; MD=-99; IM=0; DM=-99;
/M: SY='D';  M= -71, -29,  91,  49,-237,   8, -58,-235,-202,-231,-225,-100,-216,  64,-208, -34,-210,-231,-238,-221;
/I:         I=-48; MI=0; MD=-120; IM=0; DM=-120;
/M: SY='F';  M=-121, -25, -65, -24,  98, -14,-216,  -9,-220, -43, -31, -62,-227, -62,-222,  40, -14, -47,-206, -16;
/M: SY='Y';  M=  25,  20,-227,-224,  19,-226, -24,  29,-221,  -3,-197,-223,-230, -58,-221, -82,-210,  28,-203,  93;
/M: SY='V';  M= -11,-219,-222,-218, -15,-226,  34,  -4, -30, -23,-199,-215,-223, -53, -24, -45,  52,  71,-230, -22;
/M: SY='V';  M=-105, -14,-234,-229,-202,-236,-234,  76,-225, -76,-190,-227,-227,-226, -69,-218,-204,  88,-231,-210;
/M: SY='E';  M=  17,-224,  19,  83, -37,-219, -69, -76,   7, -48,-213, -50,-212, -50, -20, -31,  -8,   4,-229, -74;
/M: SY='Y';  M=-218,-223,-226,-225,  88,-228, -34,-196, -70, -20,-198, -64,-232,-220,-218, -26,-212,  22,-191, 101;
/M: SY='A';  M=  60,  -1,   0,  56,-220, -71,-212, -42, -41, -23,  -4,   3, -66, -20,-211, -72,  -8,  -1,-229, -58;
/M: SY='N';  M=  61,  11,  -7, -40, -58,  37, -44,-219,-210,-222,-215,  74,-220,-208,-216, -42, -94, -17,-230, -30;
/M: SY='C';  M=-211,  99,  20,-104,   2, -43,-212,-217, -81, -35,-214,  67,  11,-213, -18,  -6,  -2, -33,  70, -53;
/I:         I=-14; MD=-37;
/M: SY='D';  M=-232,-247,  76,  21,  -6, -36,  11,-241,-224, -23,-235, -88,  -8, -19,-230, -69,-227,-241,-252,-229; D=-14;
/I:         I=-14; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='W';  M=  53,-229, -68,  13,-213,-215,-225,-223, -41,-111, -59,  -6,   6,-211,-218,  -1,  -4,-220, 132, -55; D=-14;
/I:         I=-14; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='Q';  M=   3,-222, -72,  -6,-225,-215, -26, -39, -69, -91,-211,  -2, -22,  82, -40,  10,  75,-212,-231, -69; D=-14;
/I:         I=-14; DM=-37;
/M: SY='Y';  M= -85,-229,-211,  19,  16,-222,  11, -30,  -6, -95,  -1, -34,  64,   5, -75, -37, -26, -45,-202,  95;
/M: SY='N';  M=-208, -31,  25,  51,-224,-212,-204,-103, -70,-221,  -5,  82,  27,-200,-209, -25,  55, -32, -18,-219;
/M: SY='E';  M= -76,-228,  49,  79,-227,-221,  24, -33, -43, -85, -41,-200,-213, -51,  62, -10, -29,-220,-232,-215;
/M: SY='I';  M=-212,-227,-220, -55, -81,-229,-218,  86,  10,   4,-192, -62,-221,  73, -42, -74, -78, -23,  -8,-207;
/M: SY='V';  M=-206,   3, -63,-227,  32,-233,-229,  46,-224, -83, -86,-225,-228,-226,-226,-217, -60,  91,-223,  -2;
/M: SY='P';  M= -36,-224, -62,  42,-226, -24,-214,-219, -39, -70,-215, -53,  88,-205,-213,   5,  69,-215,-231,-222;
/M: SY='F';  M= -86,-223, -88,-221,  87, -81,-216,  47,  -3,  23, -33,-220, -25,-218,  21, -59, -65, -84,-206, -12;
/M: SY='E';  M= -29,-225,  15,  74, -60,  26,  70,-134, -12,-224,-217,  28,-213, -33,-205,  10,-206, -39,-232,-213;
/M: SY='R';  M= -40,-228,  48,  18,-223,-218,  -1, -32, -25,-103,-214,  15,-219,  31,  83, -12, -62, -73,-228, -17;
/M: SY='L';  M=-105,  -1,-232,-226,-196,-233,-225,  33,-225,  68,-184,-227,-229,-222,-225, -25,-206,  64,-226,-206;
/M: SY='R';  M=-217,-232,-214,-202,-223,-227, -55,-228,-175, -48,-211,-207,-225,-191, 122,-211,-215, -76, -54,-211;
/M: SY='P';  M= -35,-222,-221,-214,  35,-220,-214, -55, -82,  47,  18,-215,  60, -16,  -3,  44, -19, -71,-220,-205;
/M: SY='P';  M= -21,-227,-220, -91,-218, -72,-221, -42,   1, -16,-205,-219,  97,-214, -19, -31, -67,  55,-230,-220;
/I:         E1=0; IE=-505; DE=-505;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 38 in 19 different sequences
Number of true positive hits 38 in 19 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] Agenet-like
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
19 sequences

FMR1A_XENLA (P51113), FMR1B_XENLA (Q2KHP9), FMR1_DROME  (Q9NFU0), 
FMR1_HUMAN  (Q06787), FMR1_MOUSE  (P35922), FMR1_PONAB  (Q5R9B4), 
FMR1_RAT(Q80WE1), FMR1_XENTR  (Q6GLC9), FXR1A_XENLA (P51115), 
FXR1B_XENLA (Q7ZTQ5), FXR1_BOVIN  (Q2TBT7), FXR1_CRIGR  (O70523), 
FXR1_DANRE  (F1QLR3), FXR1_HUMAN  (P51114), FXR1_MOUSE  (Q61584), 
FXR1_RAT(Q5XI81), FXR1_XENTR  (Q5BJ56), FXR2_HUMAN  (P51116), 
FXR2_MOUSE  (Q9WVR4)
» more

PDB
[Detailed view]
7 PDB

2BKD; 3H8Z; 3KUF; 3O8V; 4OVA; 4QVZ; 4QW2