PROSITE entry PS51657
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General information about the entry
| Entry name [info] | PSRV_HELICASE |
| Accession [info] | PS51657 |
| Entry type [info] | MATRIX |
| Date [info] |
01-OCT-2012 CREATED;
07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51657 |
| Associated ProRule [info] | PRU00990 |
Name and characterization of the entry
| Description [info] | (+)RNA virus helicase core domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=291; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=286; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.9624734; R2=0.0079194; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=55473.0000000; R2=0.0000000; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1457; H_SCORE=55473; N_SCORE=14.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=447; H_SCORE=55473; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-63; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='C'; M= -4, 40, 34, -28, -29, -37,-204, -11, -11, -14, -27, 16, -21, 5, -55, -43, -32, -29,-222, -51; /M: SY='Q'; M= -71,-215, -4, -53,-210, 14,-206, -15, -10, -9, -39, 12, -63, 21, -17, 2, 0, 16,-223,-208; /M: SY='M'; M= -42, -21, -47, -19, 16, -61, -31, -11, -28, -79, 61, 2, 27, -12, -14, -37, 31, -65,-212, 6; /M: SY='C'; M= -30, 59, 1, -10,-207, -78, 8, -39, -21, -84,-204, 32,-211, 5, 2, 11, 20, -59, 13, 9; /M: SY='P'; M= -87, -24, 17, -41, -3, -47, -25, -20, 5, 15,-194, 15, 18, -39, -46, -4, -60, 11,-217, -54; /M: SY='M'; M= 2, 6, -23,-201, 10, 0, -30,-192, 23, 22, 55, -22, -44, -54, -16, -42, -28, -29,-212,-196; /M: SY='E'; M= -14, -38, 0, 30, -14,-205,-197, -2, -9, -73, -22, 22, -26, 16, -38, 11, 17, -13,-212, 6; /M: SY='T'; M= -1, -23, -5, -4,-209, -34, -21, -40, -70, -56, 1, 43, 8, -17, 16, 1, 44,-201, 27,-203; /M: SY='W'; M= -2, 58, -58, -14, -65, -17, -20, -25, -16, 28, 32, 28, -28,-198, -61, -55,-196, -13, 58, -51; /M: SY='I'; M= -29,-211, -28, -5, 23, -84,-200, 37, 23, 6, 2, -6,-209, 18, 13, -74, -55, 0,-208,-192; /M: SY='L'; M= 12, -26, 0, -36, -54, -21,-200, -4, -69, 25, -4, -1, -4, 21, -24, -26, -14, 1,-212, -13; /M: SY='L'; M= 15,-207,-209,-205, -7,-209,-203, 33, -8, 47,-180, -15,-212, -39, -54, -3, -31, -34, 19, 8; /M: SY='Q'; M= -14, -29, 5, 18, -41, -44, -19, -42, -13, 14,-191, 9, -15, 25, 22, -7, -64, -3,-213, -40; /M: SY='Q'; M= -29,-213, -35, 39,-214, -9, 36, -67, 43, -92, 0, 23, -52, 61, -25, -20, -62,-208,-215,-201; /M: SY='L'; M= 6, -38,-207, -33, -16, -40, -14, -34, -57, 47, -4, -19, -56,-200, -70, -8, -38, 13,-204, 37; /M: SY='L'; M= 7, 20, 18, -26, 13,-211,-203, -14,-203, 44, 8, -48,-213,-202, -25, -39, -65, 24,-210, -38; /M: SY='N'; M= -29,-210, 24, -37,-209, -11, -17, -70, 18, -37,-200, 39, 13, -16, 19, 20, 16, -42,-217, -44; /I: I=-19; MD=-47; /M: SY='T'; M= 10, -15, -10, -29, -9, -28,-202, -43, 32, -51, 3, -5,-207,-195, -29, -31, 36, 9, 24, -8; D=-19; /I: I=-19; MD=-47; /M: SY='Y'; M= -53,-216, -43, -17,-200, -15,-197, -7, 9, -40, -24, 33, 16, 22, 2, -22, -26, -40, 28, 40; D=-19; /I: I=-19; MD=-47; /M: SY='P'; M= 18, 1, 10, 23, -3,-208, -31,-208, 13, -85, 8, -18, 34, -39, -10, -30, -15, -41,-219,-205; D=-19; /I: I=-19; MD=-47; /M: SY='P'; M= -20, 14,-212, -17, 18, -28, -25, -70, -66, -19, -27,-209, 48, -47, -70, -64, 17, 19,-218, -46; D=-19; /I: I=-19; MD=-47; /M: SY='R'; M= -32,-222,-210, 1,-210, -30, -5, -27, -6, 1, -24, -18, -17, -39, 9, -71, -2, -2,-224, -11; D=-19; /I: I=-19; MD=-47; /M: SY='P'; M= -73,-229, -62, -14, 2, -21,-213,-214, 12,-217, -26, -37, 32,-209, 10,-210, -2, -11,-221, 11; D=-19; /I: I=-19; MD=-47; /M: SY='S'; M= -2, -13, -54, -61, -50, -45,-221,-217, -35, -37, -33, -50, 7, -42, -30, 32, -57, -24,-235,-222; D=-19; /I: I=-19; MI=0; MD=-47; IM=0; DM=-47; /M: SY='S'; M= -27,-208, 8, -5, -48, -47, -29, -39, 29, -16,-196, -19, 9, -3, -70, 41, 20, -12,-214, -28; /M: SY='V'; M= -3, 16,-206, -50, 26, -44,-205, -3, -19, -1,-187, -18, -51, -12, -21, 8, -13, 45,-210, -36; /M: SY='H'; M= -21, -1, 1, 2,-208, -27, 40,-208, 38, -23,-199, 23, -22, -51, 31, 14, -19, -70,-217, -42; /M: SY='V'; M= -9,-209,-211,-206, -9, -82,-207, 41, -64, 7, -24,-206, 27, -41, -22, -7, -11, 41,-208, 6; /M: SY='T'; M= -36, 17, -49, 16,-200, -4, -14, 33, -14, -7,-190, -15,-205, -20, -10, -42, 50, -26,-215, -36; /M: SY='V'; M= -25, -15,-215,-211, 30, -40, 23, 17,-208, 23, 25,-207,-214,-207,-209,-201, 2, 41, 34, 25; /M: SY='I'; M= -73,-210,-219,-215, -25,-221,-214, 70,-209, -85, -18,-213,-213,-210, -35,-205, -66, 68, 39, 24; /M: SY='H'; M= -8, 6, 54, -14, -21,-205, 91, -38, -57, -22, -15, -13,-206, 7,-196, -35, -8, -35,-221, -34; /M: SY='G'; M= -3, -28,-201,-210,-218, 97,-207,-222, -61,-218, -23,-188,-205,-202,-210, -34,-201,-215,-211,-213; /M: SY='V'; M= 23, -33,-212,-205, 32, -66,-212,-175,-206, -78,-189,-209, 61,-209,-211,-196, -18, 71,-212,-195; /M: SY='P'; M= 45,-215,-204,-197, -13, 21,-207,-208,-201,-213,-204,-203, 102,-202,-210,-191, -59,-206,-212,-210; /M: SY='G'; M=-186,-213,-201,-213,-220, 105,-208,-228,-206,-223,-212,-187,-205,-204,-214,-186,-205,-221,-210,-215; /M: SY='C'; M= 19, 99,-201,-201,-210, -38,-204,-208,-200,-208,-204,-190,-207,-197,-205, 78, 14, -69,-223,-208; /M: SY='G'; M=-186,-213,-201,-213,-220, 105,-208,-228,-206,-223,-212,-187,-205,-204,-214,-186,-205,-221,-210,-215; /M: SY='K'; M=-199,-214,-192,-178,-216,-206,-195,-216, 114,-215,-203,-184,-200,-176,-160,-194,-194,-211,-209,-202; /M: SY='S'; M=-182,-199,-193,-195,-208,-193,-199,-203,-194,-207,-202,-182,-198,-190,-200, 89, 84,-195,-222,-203; /M: SY='T'; M= -45,-205,-196,-195, -7, -68, 62,-202, -36,-201,-196,-187,-202, -4, 11, 7, 87,-197, -13, 22; /M: SY='W'; M= 26, -23,-204, 1, 9,-206, 3, -16, -36, 28, -3, -51, 0,-196, -12, -12, 6,-190, 58, -14; /M: SY='I'; M= -40, 8,-221,-217, -13,-222,-216, 82,-214, 38,-173,-214,-214,-211,-216,-208,-195, 18,-210,-192; /M: SY='Q'; M= -72,-212, -61, -27,-200,-210,-194, 4, 42, 8, 25,-195,-206, 70, 32, -41, -67, 6,-209, -28; /M: SY='K'; M= -3,-209, 8, 16,-215, -43, 15,-213, 52,-212,-202, 52, -38, 36, -24, 9, -13,-208,-217,-202; /M: SY='W'; M= 2,-207, -57, -53, 20,-209, -23, -5,-198, 44, -23, -7,-211, -43, 16, -41, 14, 2, 55,-188; /I: I=-22; MD=-55; /M: SY='F'; M= 19, 7,-216,-209, 49, -72,-205, -14,-209, 45, 27,-210,-215, -10,-209,-201, -54, 16,-202, -4; D=-22; /I: I=-22; MD=-55; /M: SY='R'; M= -27, 7, 27, 10,-208,-208, -28, -16, 20, -10,-196, 22,-209, 14, 42, -61, -60, -4,-220,-203; D=-22; /I: I=-22; MD=-55; /M: SY='Y'; M= -23,-222, -7, -4,-209, -75, -25, -5, 19, -56,-207, -28, -51, -47, 3, 9, 4,-208,-218, 32; D=-22; /I: I=-22; MD=-55; /M: SY='D'; M= -42, -23, 12, -59, -6, -36,-214, -32, -19, -14,-211, 11, -30, -18, -60, -3, -12, -71,-229, -39; D=-22; /I: I=-22; MI=0; MD=-55; IM=0; DM=-55; /M: SY='P'; M= -8,-222, -22, -33, 18, 7, -24,-212, -5, -39,-209, -49, 44, -51, -61, -8, -24, -41, -5,-207; D=-22; /I: I=-22; DM=-55; /M: SY='K'; M= -32, -38, 24, 8, 11, -26,-197, -58, 26, -54, 0, -3,-207, 22, 13, 24, -64, -23,-214,-198; D=-22; /I: I=-22; DM=-55; /M: SY='N'; M= -25,-209, 9, -20,-210, 7, 26,-206, 4,-209,-202, 42, 18,-188, 26, 26, 10, -12, 14,-201; /M: SY='D'; M= 1, 2, 63, -30, 43, -61,-200, 22, -36, -70,-194,-190,-207, -42, 4, -4, -28, 1,-210,-191; /M: SY='M'; M= -65, 3, -44, -18, -40,-213,-202, -17, -76, 41, 43, -56,-209,-198, 9,-196, 43, 38,-212, -38; /M: SY='V'; M= -5, 23,-213, -53, 1,-214,-210, 45,-205, -14, -19,-208,-211,-206, -45,-198, -23, 74,-209, -5; /M: SY='V'; M= -34,-205,-213,-209, -18,-215, 5, 38,-207, 34,-174,-209,-213,-204,-207, -42,-191, 62,-199, 58; /M: SY='C'; M= -24, 86,-200, -55,-199, -40,-204, -68,-199, -3,-191,-191,-204,-199,-204, 37, 75, 12,-220,-201; /M: SY='P'; M= 37,-211,-200, -32, -21, -20,-201,-200,-195, -31,-197,-200, 98, -53, -28, -1, -36, -47,-209, -37; /M: SY='T'; M= -72, 23,-191,-196, -18, 30,-196,-202, -58, -56,-198, 51, 16,-193, 23, -51, 78,-198,-215,-201; /M: SY='R'; M= -84,-207, -24,-189, -52, -75, 31, -36, 43, -70,-194, 16, -19,-185, 60, -2, 37, 12,-215,-196; /M: SY='E'; M= 8,-209,-185, 59, -50, -64, 57,-200, -3, -52, -27, 10, 21, -16, 6, 6, -63, -1,-215,-197; /M: SY='L'; M= 19,-202, -9, -27,-191, -70,-196,-183, -67, 58, -19, 1, -20, -41, -18, 35, -9, -57,-211,-195; /M: SY='M'; M= 34, 3, -48,-188,-195,-198,-190, -64, 6, 11, 67, -47, -36, 4, 66, -12, 9, -71,-206, -41; /M: SY='D'; M= -20,-204, 56, 42, -40, -43, 0, -13, -34, 20, -20, 22, -22, -15, -5, -15, -16, -9,-211,-193; /M: SY='D'; M= -29,-206, 93, 63, -43, -61, -18, -53,-182,-202, 12, -20,-194, -45, -61, 18,-185, -30,-217,-196; /M: SY='W'; M= -24, -25, -44,-204, 13, -43,-204, 62,-200, 20, 5, -51,-206, -33, -51, -34,-193, -1, 120, 9; /M: SY='R'; M= -13,-203, -50, -33, -53,-199, 27, 22, 29, 3, 25, 18,-200, 17, 51, 28,-185, -2,-207,-189; /M: SY='R'; M= 5, 28, 10, 26, 8, 15, 12, -53, 11, -76, 4, 44,-199,-181, 49, -33, 1,-197,-208,-192; /M: SY='K'; M= 24,-203, -6, 13, -55, -68,-189, -36, 60, -22, -14, -52,-197, 19, 54, -10, -8, -39,-206,-193; /M: SY='L'; M= -23,-202,-205, -64, 12, 10,-198, 11, -13, 56, 31,-200, 15, -40, -5, -53,-190, 16, -3, -41; /M: SY='K'; M= 6, -30, -14, -16, -9, 14,-195, 12, 45, -76, -39, 5, 45,-186, -26, -2, 17, -3,-206,-195; /M: SY='K'; M= 18, 23, -7, -31, -23, -27, -31, -73, 35, -9, -15, 2, 9, 17, 19, 26, -15, -8, -3,-192; /M: SY='H'; M= 6, 24, 16, -18, -20, -18, 46, -64, 41, -12, -7, 22, 11, -10, 14, -17, -14, -71,-206, -10; /M: SY='P'; M= 3,-205, 26, 8, -28, 33, 16,-200, -1,-202,-196, 6, 47,-185, 13, 2, 14, -16, -3, 0; /M: SY='F'; M= -6, -24, -11, -59, 59, -70,-194, -4, -7, -7,-184, -5, 51, -55, 4, 20, -63, 13,-197, -5; /M: SY='D'; M=-187, 20, 48, 5, -50, 7,-190, -37, -17, -20, -27, 12, 15, 19, -25, 36, 30, -16,-211, -46; /M: SY='R'; M= -51, 7, -58, -13, -54, 1, 15, -13, 24, -19, -33, -47, 7, 18, 41, 10, -36, 41,-207, -42; /M: SY='W'; M= -54, -13, 23, 4, 9, -39, -27, 6, 5, -55, -23,-188, 37, -16, -23, -28, 53, -3, 64, 8; /I: I=-6; MI=0; MD=-15; IM=0; DM=-15; /M: SY='D'; M= -70,-237, 60, 31,-238,-225, 10, -66,-208,-233, -31, 8, -21,-207, -24,-213, -57,-232,-249,-226; D=-6; /I: I=-6; DM=-15; /M: SY='S'; M= -72,-222,-213,-214, -53, -40,-216,-221, -36, -33,-217, -8,-221,-208, -20, 60, 28,-217, 0,-217; D=-6; /I: I=-6; DM=-15; /M: SY='F'; M= 18,-222,-222,-217, 55, -77, 12, -36,-212, -80,-203,-216, 16,-214, -4, -65,-209, -19,-205, 44; D=-6; /I: I=-6; DM=-15; /M: SY='L'; M=-209,-216,-222, -35,-194,-229,-216, 10, -63, 60, 5,-220,-223,-213, -59,-214, 13, 1,-221,-203; D=-6; /I: I=-6; DM=-15; /M: SY='M'; M= -36,-214,-214, -67,-197,-217, 31, -36, -7, 26, 80,-208, -1,-200, 12, -52, -54, 12, 13,-197; D=-6; /I: I=-6; DM=-15; /M: SY='N'; M= -14,-213, -49, -59, -58, -45, 44, -58, 37, -13,-200, 54,-210, -39, -6, 4, -4, -59,-222,-202; D=-6; /I: I=-6; DM=-15; /M: SY='P'; M= 33, -39, 9, -60, 17, -8,-201, -66, -28, -73,-202, 0, 36, -8, -5, 10,-195, -58,-210, 1; D=-6; /I: I=-6; DM=-15; /M: SY='D'; M= -5,-209, 43, -15, -54, -14,-203, -29, 4, -2, -26,-194,-208, -50, -57, 14, -57, 39,-218, -52; D=-6; /I: I=-6; DM=-15; /M: SY='P'; M= -2, -28, 14, -55, -14, -1,-202, -71, 19, -51,-201, -3, 60,-196, -67, 19, -23, -6, 1,-203; D=-6; /I: I=-6; DM=-15; /M: SY='R'; M= 12, -22, -54, -3, -8, 1, 28, 16, 28, -47,-192,-191, -42, -42, 31, 8, -3, -22, 0,-194; D=-6; /I: I=-6; MI=0; MD=-15; IM=0; DM=-15; /M: SY='H'; M=-204, 51,-210,-212, -65, 23, 75, -53, -55, -40,-203,-199,-216,-209,-212,-198, 56, -11,-232,-205; D=-6; /I: I=-6; MI=0; MD=-15; IM=0; DM=-15; /M: SY='P'; M= 1,-214,-196, 27,-218,-204,-202,-212, 8,-213, -18,-195, 52, 0, 4, 35, 34,-207,-220,-210; D=-6; /I: I=-6; DM=-15; /M: SY='C'; M= 18, 75,-203,-206, 48, 61,-202, -62, -26,-201,-199, -42, -44,-202,-205, 3,-195,-200,-201, 12; D=-6; /I: I=-6; MI=0; MD=-15; IM=0; DM=-15; /M: SY='K'; M= -16, -27, 42, -15,-205, -47, 9, -52, 52, -43, -27, 43, 19, 31, 28, -15, -21, -67,-211,-196; /M: SY='R'; M= -79,-201, -54, -17, -6,-205,-195, 26, -51, 11, -23, 2,-202,-189, 48, -15, 45, 42, 14, -12; /M: SY='L'; M= -18,-198, -51,-202, 18, -65,-201, 17,-201, 55, 5, -47,-206,-199,-203, -6, 15, 54,-204,-184; /M: SY='I'; M= -61,-203,-209,-204, 38,-212, 28, 63, -56, 38,-169,-203,-208, -9,-201,-199, -59, 41, -11, 38; /M: SY='I'; M=-193, -21, -58,-205, 54,-214,-204, 59,-203, 42, -32,-205, -42, -29, -46,-200, -45, 51,-199,-178; /M: SY='D'; M=-197,-210, 123, -54,-214, -60, 9, -58,-184, -82,-208,-167,-197,-183, -20,-185, -44,-208,-229,-198; /M: SY='E'; M= -61, -17, 32, 110,-212,-201, -16,-213,-174,-207,-203, -42, -9,-168,-184, -11,-188,-206,-213,-202; /M: SY='Y'; M= 37, 36,-204,-202, -20, -16,-190, 12,-198, -31, -15,-199, -40,-197,-200,-189, -23, 41, 8, 93; /M: SY='T'; M= -16, -23, -43, -51, 40, 32, -17, -32,-193, 17,-184,-187, -58, 15, -60, 30, 52, -79,-197, 20; /M: SY='M'; M= -44,-201,-197, -29,-183, -68,-189, -66, 46, 52, 82, -40, -36, -29, -9, -20, 10,-181,-200, 18; /M: SY='L'; M= -23, 36, -53, -61, 18, -26,-195, -13, -51, 46, 42,-197,-205, -7,-198, -2, 8, 30,-199, 26; /I: I=-36; MD=-90; /M: SY='H'; M= -39,-214, 10, -64,-207, -69, 102,-208,-191,-208,-196, -12, 98, -12,-195,-188, 14,-208,-217, -27; D=-36; /I: I=-36; MI=0; MD=-90; IM=0; DM=-90; /M: SY='P'; M= 44,-203,-190, -18, -1, -38, -23, -35, -33, -31, -26, 36, 68, -10, 22, -5, -14,-192, 8, -38; /M: SY='G'; M= -45, 12,-192, -58, -44, 83, 43,-205,-192,-205,-197, 6, 22,-192, -6, -30, -20, -21,-203, 19; /M: SY='Y'; M= -27, 23, -54, 35, -4,-206, -23, 7, -64, 18, -3,-197, -53, 4, -49, -66, -27, -4, 31, 89; /M: SY='L'; M= -24, -20, 2,-199, -16, -64,-200, 50, -30, 54, -14, -42, -2,-198,-201,-194, 8, 27,-204, -33; /M: SY='D'; M= -2, 26, 61, 16, -1, -8,-189, -31,-191, 21, -25, -10,-201, -33, -53, -35, -6, -5,-201, 42; /M: SY='F'; M= 39,-198,-200, -26, 50,-200,-197, -32, -22, 49,-176, -52, 7, -10,-197, -45, 24, -7,-198,-182; /M: SY='C'; M= 36, 48, -46, -64, 19, -35, 3, 23, -68, 27, -15, -51, -37,-196, -29, -42, -52, 26,-200, 18; /M: SY='C'; M= 31, 45,-202,-197, -40, -21, 12, 44, -59, 30, 39, -19,-204, 29,-198, -29,-187, 19,-206,-189; /M: SY='R'; M= -7,-202, -13, 0, 34, -43, 21, -28, -35, 13, 20, -17, -40, 23, 35, 26, 3, -81,-199, 9; /M: SY='M'; M= 31, 8,-196, -63, 15, -40, 35, 31, 28, -1, 38, -3,-201, -7, 20, -38, -31, -35,-202, -27; /M: SY='D'; M= 9,-200, 46,-186,-191, -61, 39, -34, -9, 36, -23, 24,-200, -43, -50, 34, 17, -39,-209, -11; /M: SY='P'; M= 0, -36, -23, -62, -17, 38, 9,-201, 7, -51,-195, 23, 77, 2, 4, -63, 19, -77,-207,-197; /I: I=-15; MI=0; MD=-37; IM=0; DM=-37; /M: SY='C'; M= 23, 50, -14,-202,-199, -65, -28, 23, -3, -16,-192, -39, 15,-201,-204, 13,-193, 19,-215, 8; D=-15; /I: I=-15; DM=-37; /M: SY='Q'; M= -40, -26, 6, 34,-212,-203, -19,-203, 34, -49,-199, -35, -36, 41, 13, 38, -57, 1,-217,-202; D=-15; /I: I=-15; DM=-37; /M: SY='Y'; M=-193,-205, -7, 24, 22, -60, -25, -7, 21, 10, 3, 3, 11, 6, 27, -21, 20,-189,-196, 42; /M: SY='V'; M= 6, -1,-204, -53, -21, -38,-201, 48,-197, 12, -20, -13, -42, 30, -56,-192,-186, 66,-205, -12; /M: SY='I'; M= -19,-202, -19,-200, 13, -66, -35, 74, -64, -21,-174, -36,-204, -44, -25, -16, 1, 39,-198, 39; /M: SY='C'; M= -2, 90,-205, -54, 12, -25,-199, 11,-201, 57, -3, -23, -14, -41,-203, -59, -57, -28,-202, -9; /M: SY='F'; M= -9, 11,-204, -59, 67,-207, 3, -2,-197, 33,-175,-198,-206, 12, -45,-191, 35, 35,-194, 6; /M: SY='G'; M= -21, -11, 0, -57, -54, 99,-199,-208,-197, -30,-199,-182,-199, -34,-204, -67,-195, -37,-205,-203; /M: SY='D'; M= -78,-210, 122, -6,-216,-194,-183,-214,-183,-213,-210, -39, -42, -3, -56, -34,-186,-211,-228,-200; /M: SY='P'; M= -26, -27,-193, -7, -53,-197, -38, -56, -57, -22,-191, -57, 98, -23, 11, 31, -14, -11,-204, 17; /M: SY='H'; M= 17, -15, -51, 32, -18, -65, 46, -77, 12, 14,-185, 32, -12, 24, 37,-186, -54, -31,-204, 0; /M: SY='Q'; M= -35,-212,-186,-167,-213,-197,-179,-202,-170, -76,-187,-181, -46, 135, 3, -54, -45, -65,-202, -38; /M: SY='I'; M= 14, 10,-201,-200,-188, 32, 10, 60,-199, 31, -27,-192, -44,-194,-202, 39, -30, -39,-206,-191; /M: SY='P'; M= -12,-206, 19, -12, -50, 20, 46, -62, -65, -81,-195, -1, 82, -29, -12, 5, 24, -32,-211,-197; /M: SY='Y'; M= -10, -25, -48,-198, 82,-202, 38, -58,-197, -31, -25, -12, 44,-197,-198, -14, -54,-189,-179, 86; /M: SY='H'; M= -66, -26, -16,-194, -5, -48, 83, 51, -40, -32,-178, 19, -19, -35, -20,-190, 7, 42,-207, 9; /M: SY='N'; M=-185, 38, 30, 24,-201, -15,-186, -28, 0, -84,-196, 58, -8, -49, -11, 55, 14, -81,-211, -2; /M: SY='R'; M= -16, -23,-195, -30, 30, -18, 17, -12, -2, 13, 4,-189, -19, -49, 65, 1, 31,-187,-201, -36; /M: SY='N'; M= -47, 6, 44, -15,-195, -71, -6, -17, -26, -6, 21, 45,-200, -36, 14, 37, -29, 29,-212, -27; /M: SY='S'; M= -51,-205, 43, 44, -17, -5, 22, -64, -19, -53, -6, -44, 40, -36, -5, 50, -12,-199, 14,-193; /M: SY='Y'; M= 5, -20, 38, 11, -46, -27, 20, -67, -51, -31,-191, 17, 10, -3, 23, 24, -26, -36, 6, 51; /M: SY='F'; M= 10, 19, -21, -14, 49, -27, 15, -21, 1, -21,-186, -3, 0, -9, 21, 6, -6, 16,-202,-184; /M: SY='Y'; M= -3,-203, 12, 9, 27, -42, -14, -4, -65, -7,-185, -24, 21, -42, -8, 23, -13, 13, 34, 42; /M: SY='L'; M= -15, 10, -44,-198, 13, -13,-192, 6, -51, 43, 35, 43, 3,-194,-198, -18, 6, -13,-199, 28; /I: I=-16; MD=-41; /M: SY='S'; M= 7, 8, -4, -32, 9, -61, 20, -29, -1, -32, -22, -55, 15, -7, 13, 27, -59, -38,-211, -6; D=-16; /I: I=-16; MD=-41; /M: SY='H'; M= 18, 10, -24, -56, 5, -36, 41,-208, 13, -14,-199, -14, 2, -41, 27, -43,-201,-206, 35, 10; D=-16; /I: I=-16; MI=0; MD=-41; IM=0; DM=-41; /M: SY='Q'; M= 13,-217, -54, 13, 1,-210, -33,-207, -1, -34,-203, 17,-214, 46, -49, -8, -28, -23,-216, 0; D=-16; /I: I=-16; DM=-41; /M: SY='Y'; M= -38,-215, -27, -40, -27, -67, 21, 16, -31, -39,-197, 3, 2,-201, -25, 5, 22, -11,-211, 41; D=-16; /I: I=-16; DM=-41; /M: SY='R'; M= -26, -18, 1, 12, -18, -66, 12, -33, -14, 11,-194, -43, 7, -54, 24, -19, 2, -13,-216, -28; D=-16; /I: I=-16; DM=-41; /M: SY='V'; M= -42,-211, 17, -12, 4, -6, 18, -5, 19, -22, 20, -47, -42, -18, -4, -30, -36, 23,-213, -53; D=-16; /I: I=-16; DM=-41; /M: SY='F'; M= -21, -23, -21, -53, 59, -28,-201, 1, -36, 31,-183, -41, 31, -8, -29,-199, -58, -7, -9, -11; D=-16; /I: I=-16; DM=-41; /M: SY='H'; M= 22, -24, 12, -18, -23, -15, 26, -18, 6, 17,-185, -18,-199, -39, 24, 25, 18, -18,-207, -51; /M: SY='C'; M= -23, 36, -54, -50, 5, -74,-194, 6, 30, 17,-182, 1, 33, 19, 4, 9, -30, 20,-204, -51; /M: SY='Y'; M= -62, 29, 33, 5, 0, 15, -14, -37, -31, -23, 18, -52, 23, 3, -18, -32, -4, 3, 5, 55; /M: SY='P'; M= 5, 47, -10, 17, -50, -69,-194, 20, 6, -27,-189, -23, 57, 0, -2, 37, -57, -27,-209,-197; /M: SY='H'; M= -25,-203, 35, -70, 3, -28, 76, 10, -8, -14,-184, -50, -52, -42, 38, -19, 25, 18,-210,-185; /M: SY='F'; M= -73, -30, -6, 38, 65, -41, -19, -29, -63, -70, -34, 24, -48,-186, 36, -26, -35, -11,-189, 62; /M: SY='Y'; M= -74, -19,-194, -7, -1,-204, 33, 9,-187, -54,-182, -14, 0, 19, 12, -38, 30, 2, 23, 93; /M: SY='C'; M=-191, 76, -53,-192, -15, -22,-196, 7, 27, 46,-178,-193, -42, 24, 21, 4, -22, -30, -9,-189; /M: SY='N'; M= -27, -23, -14, 10, -65, -76, 18, -2, -63, -7,-189, 67, -43, -42, 22, 36, -7, -68, 58, 22; /M: SY='W'; M= 19, 14, -55, -21, -14,-199, 10, -4, 17, -59, 6,-189,-199, 10, 7, -5, 50, 13, 70, 10; /M: SY='T'; M=-180, 47,-189,-191,-199, -22,-195, -14,-188,-195,-192, -17,-194, -39, -48, 66, 95, -43,-215,-196; /M: SY='H'; M= -62,-209, -52, -59, 42, -61, 102,-195, 5, -58,-184,-189,-205, -42, 17,-193,-196, -74, 60, 94; /M: SY='R'; M= -74,-213,-191, -16,-206,-206,-182,-212,-155,-205,-194,-186, -37, -29, 123,-190,-195,-206,-206,-193; /M: SY='C'; M=-192, 110, -58, -31, 60, -70,-196, 11,-197, 6, 1, 39, -46, -23, -56, 6,-188, -57,-203,-183; /M: SY='P'; M= -45, -11, -23, -28,-210, 48, 5, -67, -36, -70,-197, -45, 105,-192,-200, -38, -27, -51,-209,-205; /M: SY='Q'; M= 18, -12, -51, -62,-201, -44, -20,-193, 41, 3,-187,-188, 40, 64, 44, -16,-188, -10, 28,-193; /M: SY='D'; M= 11, 24, 83, 30, -3, -69,-186,-204, -51, -37,-198, 40, -52, -30, -4, 8,-185,-201, 0, -41; /M: SY='V'; M= -76, -23, -25,-200, -7, -60, -22, 49, -37, 7,-175,-196,-203,-199,-201, -31, 50, 64, 5, -30; /M: SY='C'; M= 62, 82,-198,-195, -56, -33,-200,-183, -18, -17,-186, -14, -51, -42,-197,-179, 46, 34,-211,-197; /M: SY='N'; M= 2,-203, 41, 10, -16, -43, 11, -71, 10, -53,-193, 68, -59, -42, 20, 16, -25, -74,-204, 33; /M: SY='L'; M= 14, 9, -44, -27, 38,-204, -21, -4, -20, 53, 2, -49, -26, -46, -24, -66, 3, -18, 2, 5; /M: SY='L'; M= -74, 24, -44, -30, 35,-211, -14, 39,-203, 66, -20,-204, -9,-200,-204, -63, -52, 15, -3,-181; /M: SY='N'; M= -12, 16, -13, 4, -48, 33,-188, -29, 5, -82,-195, 54,-198, 34, 20, 42, -15, -73,-209,-197; /M: SY='K'; M= -26,-202, -26, -28, -15, 8, -29, 5, 38, -52, -27, -13, -1, 28, -10, 8, 31, 25,-205, -32; /M: SY='Y'; M= -45, 28, -29, -59, 17, -69, 12, 12, 21, 28, 35,-195, 39, 20, -64, -63, -45, -25,-195, 50; /M: SY='Y'; M= -30, -26, -44, -33, -1, 34, -21,-191, -12, -50, -25, -14, -51, -42,-192, 29, 41, -18,-189, 83; /M: SY='F'; M= -78, 18, -7, 34, 44, -3,-191, -14, -4, -29, -23, -51, 16, -34, 2, -21, 29, -17, 23, 30; /M: SY='Y'; M= -27, -24, 48, 16,-194, -18,-184, -65, 37,-200, -36, 23, 7, -36, 15, 6, 10, -57,-200, 57; /M: SY='P'; M= -36, 17, 26, -6, 2, 7, 7, 4, 13, -31, 21, 0, 29, -17, 13, 0, 6, -30,-206, -40; /M: SY='V'; M= -75, -29, -44, 22, -49, 26, -18, -10, 13, 5, -20, -24, 21, -51, -8, -21, 23, 30, -7, -33; /M: SY='M'; M= 6, -19, -27, 21, -3, 8,-194, 4, -5, -85, 40, -19, 24, -49, -41, 30, 21, 8, 14,-192; /M: SY='T'; M= -25, -31, -1, -13,-199, 34, -20, 9, -3, -27,-189, -36, -1, -40, 32, 26, 39, -2,-210,-196; /M: SY='T'; M= -20, 9, -15, -15, -33, 4, 14, 24, 26, -27, 27, -53, -20, -11, 16, 6, 30, -5,-207, -51; /M: SY='V'; M= -57, -24, -8, 3, -16, 5, 26, 1, -3, -38,-185, -6, -16, -29, -1, 11, 23, 47,-207, -4; /M: SY='E'; M= -9,-201, 12, 37,-198, -47,-189, -33, -34, 3,-189, 33, 26, 8, -18, 37, 29, -16,-210, -40; /M: SY='Y'; M= -80, -34, 3, 32, 23, -11, 4, -32, 18, -40, -33, -20, 0, 21, -19, 4, 24, -13,-197, 44; /M: SY='S'; M= 0, 30, 9, 24, -53, 5,-190,-192, 13, -35,-191, 17,-198, 10, 9, 33, 9, 18,-209, -30; /I: I=-20; MD=-51; /M: SY='S'; M= -29,-200, -27, -16, 10, -77, 8, -33, -3, 5,-185, 30,-200, 30, 7, 40, 26, 20,-207, -49; D=-20; /I: I=-20; MD=-51; /M: SY='V'; M= -25,-202, -43, 20, -43, -12, 18, 23, 8, -10, -38, -21,-200, -21, -58, 20, 21, 36, 34, -32; D=-20; /I: I=-20; MD=-51; /M: SY='S'; M= -22, 9, 16, 0, 22, -41, -4, -12, -15, 6,-188, -23, 14, 10, -11, 28, -29, 0, 10, -36; D=-20; /I: I=-20; MD=-51; /M: SY='F'; M=-192, 23, 9, -37, 27, -6, 18, 17, -20, -28, -27, 24, 0,-194, -36, 19, -12, 18, 21, -15; D=-20; /I: I=-20; MD=-51; /M: SY='D'; M= -12, -36, 26, -27, 25, -12,-203, -59, -1, -27,-201, -46, 11, 7, -46, 6, 22, -40, 2,-198; D=-20; /I: I=-20; MD=-51; /M: SY='Y'; M= -83, -28, 8, 15, 3, 13,-202, -40, -9, -90, -1, -23,-214, -42,-205, 11, -21, -41, 5, 43; D=-20; /I: I=-20; MD=-51; /M: SY='K'; M= -67,-231, -18, 11, -52, -46,-220, -53, 20, -30, 0,-215, 8, -52,-211, -34, -26, -8, -10,-219; D=-20; /I: I=-20; MI=0; MD=-51; IM=0; DM=-51; /M: SY='P'; M= -53,-204, 48, -30, -55,-194, -21, 1, -21, -24, -38,-184, 66, -38,-194, 60, 8, -22, 4, -6; /M: SY='I'; M= -71,-204, -14, 11, -53, -6,-194, 45, -13, 31, 28, -55, -40, 13, -18,-193, -21, 27,-201, 25; /M: SY='S'; M= -30, -27, 3, 9, -45, 17, -23, -42, -32, 3,-188, 12, -1, 8, 4, 46, -33, 8,-205, 11; /M: SY='H'; M= -1,-202,-193, 4,-191, 13, 33, -13, -1, -5,-184,-189, 22, 11, -28, -3, 32, 28, -2, 23; /M: SY='H'; M= -48,-203, -5, -62, 20, -3, 66, -31, 26, -25, -36, -5, -25,-187, 35, -67, 7, 45,-207,-185; /M: SY='L'; M= -85, 1, -34, 8, -49, 15,-193, -17, -36, 44, -23,-192, 35, 38,-194, 31,-187, -3,-203, -1; /M: SY='V'; M= 10, -21,-200, -13,-189,-204,-202, 58, -23, -34, 3,-195,-201, 21, -52, 4, 10, 62,-209,-191; /M: SY='P'; M= 18, 3,-191, 20, 31, 9, -21, 4, -60, -6, -17, 10, 47, -13, -58, -11, 21, -47,-203,-189; /I: I=-5; MD=-12; /M: SY='S'; M=-187,-204,-193, -9,-207, -63,-197, -53, 5, -29,-199, -17,-202, -42, 11, 79, 44, -67,-218,-202; D=-5; /I: I=-5; MD=-12; /M: SY='P'; M= -31,-221, 21, -59, -41, -11,-206, -57, -77, -87, -15, -1, 45, 24, 16, -56, 5, -16,-225,-212; D=-5; /I: I=-5; MD=-12; /M: SY='E'; M= -48,-230, -1, 49, -53, -71, -38,-224,-200, -83,-216, 12, -53, 0, 8, -41,-211, -73,-221, 35; D=-5; /I: I=-5; MD=-12; /M: SY='H'; M= -77, -37, 32, 14,-234,-226, 45,-232,-209, -62,-222, -49,-224, 19, -25, -36, 21,-228,-246,-220; D=-5; /I: I=-5; MI=0; MD=-12; IM=0; DM=-12; /M: SY='N'; M= -87,-229,-210, -62,-232,-221,-214,-230, 24, -76,-223, 42,-225,-207, 19, 0, 31,-225,-241,-225; D=-5; /I: I=-5; MI=0; MD=-12; IM=0; DM=-12; /M: SY='M'; M= -28,-226,-225,-216, -21,-228, 22,-201, 18, 19, 63,-218,-227, -6,-209, -56,-214, -38,-223, -7; D=-5; /I: I=-5; DM=-12; /M: SY='K'; M= -50,-218,-201, -14, -62, -53,-204, 1, 56,-208,-203, -17,-210, 26, 27, -57, 18, -15,-220,-207; D=-5; /I: I=-5; DM=-12; /M: SY='D'; M= 9,-217, 71, -13, -52, -47,-202,-212, -77,-214, 0,-191, 46,-197, -23, -26, 16, -59, -1,-209; D=-5; /I: I=-5; DM=-12; /M: SY='H'; M= -33, 71, -48, -29,-194, -36, 78, -20, -5, 13, 2,-194,-208,-192, 30, -55,-194, 27, 4, -27; D=-5; /I: I=-5; DM=-12; /M: SY='L'; M= -18,-230, -24, -60, -53,-230, -26, 2, -19, 23, -24, -28, -40, -35,-221, -65, -21,-206, 1,-215; D=-5; /I: I=-5; MI=0; MD=-12; IM=0; DM=-12; /M: SY='G'; M= -87,-213, -65, -20,-218, 81,-199,-222, -64,-219,-208, 7,-205, -7, 36, 14,-198,-216,-213,-209; D=-5; /I: I=-5; DM=-12; /M: SY='H'; M= 14, 25, -32, -24,-192, -69, 73, 5, -30, -10,-186, 18, -58, -15, -21, -35,-191, 30,-210, 32; D=-5; /I: I=-5; DM=-12; /M: SY='H'; M= -81,-211, -1, 59, -44, 27, 65,-213, 33,-209,-200, -3, 39,-179, 20, -28,-192,-210,-212,-196; D=-5; /I: I=-5; MI=0; MD=-12; IM=0; DM=-12; /M: SY='V'; M= 48, 28,-202,-198, 33,-197, 10, 11, -57,-182,-182,-195, -10,-196,-199, 14, -12, 58, 2, 12; /M: SY='M'; M= -47, -32,-197, -27, 31,-202, -33, 10, 21, 16, 62, -12,-202, -12, -30, 23, 8, 14,-197, 25; /M: SY='T'; M=-184, 41, -47, -49, -55,-199,-196,-188, -9, -4,-187,-180, -44,-190, -51, -17, 111,-183,-214,-194; /M: SY='Y'; M= -10,-203,-206,-201, -1,-207,-198, 49,-200, -50,-176,-202, 51,-200,-203,-193, 4, 65,-194, 67; /M: SY='H'; M= 26, 59, 40, -49,-203, 0, 101, -36,-188, -75,-192, -45,-199, -12, -23, 29, -3,-197,-218,-188; /M: SY='E'; M= -3,-205, 8, 90,-211, 9, -21,-210,-178,-206,-200,-181,-190, 41,-185, 48, -54,-203,-210,-199; /M: SY='S'; M= 55, 65,-197,-195, -17,-189,-199, -6,-194, -77,-188, -41, -38,-191,-199, 66, -11, 35,-210,-195; /M: SY='Q'; M=-189,-211,-188,-171,-207,-200, -25, 1,-172, -42,-184,-182,-197, 128, 15,-180, 18, -57, 6,-189; /M: SY='G'; M= -62,-206,-194,-205,-212, 111,-201,-220,-199,-215,-205,-180,-198,-197,-207,-179,-197,-213,-203,-207; /M: SY='L'; M= -9, 22,-193, 24,-189, -71,-192, 10, 42, 47, 20,-191,-200, 4, -4, 22, -45,-182,-204, -32; /M: SY='T'; M=-183,-195, -49, 40,-201,-197,-192,-194,-182,-197,-192, -39,-189, 14, -46, 13, 110,-187,-215,-196; /M: SY='F'; M= 12,-203,-209, -72, 100,-206,-190, -21, -70, -87,-181,-203,-210,-202, -53,-196, -46, -19, 68, 80; /I: I=-45; MD=-115; /M: SY='P'; M= -5, -32, 67, 34,-213, -69, -23,-209, 18,-210, -15, 10, 68, -32, -33, -3, -66,-206,-216,-203; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='H'; M= -85, -21, 43, 15,-198, -85, 62, -67, 30,-197,-192, 29, -50, -47, -2, 16, 28, 23,-211, 10; /M: SY='V'; M= -42, 10,-207,-203,-188, -18, -14, -32,-200, -87,-176,-201, 0,-203, -58,-190, 17, 99,-216,-193; /M: SY='T'; M= -10, 7,-194,-193,-190,-200,-196, 23, -64, -46,-182, 9,-198, 29,-195, -17, 83, 43,-209, 9; /M: SY='I'; M= -69,-201,-210,-205, 33,-213, 5, 64,-203, 51, -26,-203,-207, -39,-204,-198, 8, 33,-198, 3; /M: SY='V'; M=-191, 4,-210,-206, 34,-212, 8, 33,-203, 20, 25,-205, -42,-202,-203,-198, -56, 71, 9, 50; /M: SY='R'; M= -28, -24,-200,-194, -21,-205, 16, 16,-182, 33,-177,-193,-204, -41, 67, 2, 25, 22,-202, 19; /M: SY='D'; M= 16,-199, 49, -33, -17, -18, -28, -61,-191, 44,-182, -43, -46,-189, -28, 28, 46, -80,-209,-191; /M: SY='K'; M= 6, -16, 29, 29,-203, -21, 22,-201, 42, -49,-194, 16, 20, -40, -8, 13, 31, -67,-210, -30; /M: SY='N'; M= -43,-204, 43, 18, -52, -69, 0, -60, 1, -71, -27, 49, 47, -11, 7, 22, 24, -32,-211, -33; /M: SY='T'; M= 3,-198, 6, -64, -5, -68, 20, 19, -35, -19,-187, 21, 0, -41,-194, 34, 72,-183, 2, -47; /M: SY='E'; M= -12,-205, 33, 46, -55, -72, -23, -25, 5, -19,-192, 4, 43, 24, 8, 18, 17,-195,-210,-196; /M: SY='N'; M= -75, 26, 23, 37, 7, -51, 4, -70, 5, 8, -31, 50, 20, -42, 28, -7, -60, -29,-209,-191; /M: SY='C'; M= 12, 59, 23, 18, -49, -78,-195, 8, -62, 16,-184,-189, 0, -5, -36, 31, 4, 2, -7, -36; /I: I=-26; MD=-67; /M: SY='L'; M= -44,-229,-237,-230, -50,-237,-230, 28, -59, 39,-195,-232, -16,-226,-230, -52, -54, -24, 4,-212; D=-26; /I: I=-26; MI=0; MD=-67; IM=0; DM=-67; /M: SY='R'; M= -14, 5, -47, -5,-223, -21, 8,-219, 5, -52, -21, -17, -37, -11, 22, -8, 6, -66,-230,-215; D=-26; /I: I=-26; DM=-67; /M: SY='D'; M= -44,-200, 57, -11, -51, 4,-188,-199, 2, -27,-195, 46, -39, -5,-189, 52, 39, -44,-214,-196; /M: SY='R'; M= -5,-206, 33, 22, -63, -75, -39, -3, 15, -54, -18, -60, 29, 2, 63, 23, -51, -34,-209,-195; /M: SY='H'; M= 26, 27, -23, 25, -54,-194, 61,-200, -32,-201,-193, 46, 55, 11, 29, -31, -20, -16,-212,-194; /M: SY='H'; M= -14,-204, 6, -55,-188, -37, 87,-187,-183, 22, -19, -3,-203, 8, 47, -12, -37, 11,-204, 39; /M: SY='W'; M= 27, 4,-204, -74, 41, -30, -28, 17,-192, 16, 36, -16,-205,-195, 28, -77, -57, 35, 55,-181; /M: SY='Y'; M= -73,-203,-204,-204, 35,-208,-186, 32,-200, 43, 21, 15,-209,-197,-199, -61, -33, -22, 10, 93; /M: SY='V'; M= -70,-197,-203,-199,-187, -65,-206, 25,-198, -75,-175, -11,-203, 22,-201,-188, 42, 93,-214,-192; /M: SY='A'; M= 95, 56,-198,-193,-204, 15,-199,-197,-194, -50,-192,-190,-198,-191,-199, -1,-183,-186,-207,-201; /M: SY='L'; M= -40, 16,-213,-207, -25,-214,-201, 52,-206, 83, 0,-208,-210,-201,-206,-202, -33, -68,-201,-184; /M: SY='T'; M=-178,-192,-186,-188,-200,-190, -18,-194,-186,-198,-193,-175,-191,-185, -46, 77, 105,-186,-216,-195; /M: SY='R'; M=-197,-213,-193,-181,-206,-207,-182,-212,-153,-205,-193,-186,-205, -33, 126,-191,-195,-206,-205,-192; /M: SY='H'; M= 48,-201, -50,-186, 2, -69, 130,-205,-189,-197,-188,-178,-198,-182,-188, 42, -52,-199,-215,-177; /M: SY='T'; M=-186,-200,-189, -56,-199,-198,-189,-195, 39, -84,-191,-181,-196,-179, 75, 32, 79, -17,-208, -32; /M: SY='N'; M=-188,-203, 20, 35, -2, 6, 23,-202, 35,-202,-196, 50,-196, 0, 28, 23, 12, -27,-209,-192; /M: SY='S'; M= 10,-201, -46, 14,-202, 17, 28,-200, 27, -30,-193, -36,-196, -5, 34, 55, 13, -57,-208, -44; /M: SY='L'; M=-195, 7,-213,-208, 52, -72,-202, 53,-206, 69, 4,-207,-210,-204,-206,-202, -21, -6,-196,-177; /M: SY='H'; M=-190, 13, -56, -33, -26, -71, 85, -66, -19, -2, -26, -13,-203, -49, 2, -19, 32, 43,-202, 54; /M: SY='Y'; M=-196, -23,-212,-209, 63,-214,-195, 65,-205, 14,-171,-206,-210,-204,-204,-201,-191, 35, 6, 77; /I: I=-29; MD=-75; /M: SY='Y'; M= -21, 34,-203, -45, 8,-208, 21, 31, -31, 11, 25,-198,-207,-191, 46, -63, -70, 32,-195, 56; D=-29; /I: I=-29; MI=0; MD=-75; IM=0; DM=-75; /M: SY='C'; M= -25, 70, 24, -58, 23, 19, -3,-195,-192, -52, 0, 14, -3, -42,-197, 14, 58, -69,-204, 21; /M: SY='P'; M= 12, 28, 39, -8,-199, -69,-196, -20, -18, 3, -17, 11, 59,-190, -14, -8,-186, 25,-214,-199; /M: SY='P'; M= 19,-206, 36, -58,-207, 12, 23, -77, -30, -51, -33, -21, 45, 14, -57, 21, 18, -17, 5,-199; /M: SY='E'; M= 17,-205, -7, 42, -2, 8, 2,-200, -16, -56, 6, -3, -1, -16, -58, 12, 38, -61,-210, -46; /M: SY='D'; M= -28,-207, 70, -66,-202, -27, 27, -38, 15, -15, 7,-183, 6,-188, 5, 5, 27, -42,-215, -14; /M: SY='Y'; M= 2,-207, 6, -17, 18, -26,-193, -59, -19, -17, -27, -42, 15, -15, 17, 31, -18, -27, 37, 43; /M: SY='F'; M= -66,-205, 14, 1, 24, -52,-195, -33, 9, 19, -24, -19, -18, -7, -32, 22, 22, 1, 6, -17; /M: SY='W'; M= -5, -19, 20, 3, 1, -5, 31, -33, -64, -1, -38, 2, 24, 10, -12, 7, -28, -76, 53, -10; /M: SY='A'; M= 23,-207, -25, 1, 18, -72, -3, -39, 5, 9,-191, -20,-206, 17, -52, 18, 15, -23,-211,-194; /M: SY='I'; M= -4,-216, 12, -41, -26, -51,-206, 24, 24, -52, 19, -22, 11, 9,-200, -42, -31, -8, 7, -36; /M: SY='I'; M= -31,-214,-213,-211, 7, 5,-209, 34, -29, 20, -23, -15, -37, -54, -27, -7, -9, -18,-213, -42; /M: SY='H'; M= -6, 4, 6, -10,-211, -43, 23, -53, 6, -34, -27, 12,-210, -18, 10, 21, 2, -70, -3, -39; /M: SY='S'; M= 5, 15, 22, -6, -19, -66, -31,-206, -21, -23, 12, -22, -23, -42,-203, 42, -9, -80,-217, 1; /M: SY='T'; M= 4, 4,-208, -36, -65,-212,-207, -4, -52, 10, 20, -37, 1, -15, -27, -40, 52, -21,-219, -46; /M: SY='P'; M= -21,-219, -58, 4, -49, -8,-206, -22, 21, -37, 14, -52, 62, -2, -60, -16, -70, -37, 13,-207; /M: SY='Y'; M= -12, -36, 13, -55, 16, -41, -14,-201, -4, -6,-199, -20, -8,-202, 4, -15, -34, -13,-209, 38; /M: SY='S'; M= -26,-215, -24, 11, -65, -3, -36, -19, -33, 8,-197, -27, -15, -43,-208, 17, -22, 10,-219, -8; /M: SY='K'; M= -9, -30, -14, -59,-212, -75, 6, -67, 42, -47, -3, -6, -37, -39, -23, 30, -16, -35, 37, -52; /M: SY='T'; M= -3, -11, -53, -7, -25, -69, 9, -38, -12, -52, -21, -26, 12, 17, -58, 8, 19, -1,-220, -34; /M: SY='F'; M= -20, -23, -25, -32, 45, -72,-206, -21, -24, 3, -39, -52, -46, -6, -45, -24, 28, -41,-209, 6; /M: SY='L'; M= -35,-215, -25, -56, 0,-217, -27, 6, -40, 29, -32, -23, -48, 5, -21, -4, -12, 0,-216, -28; /M: SY='L'; M= -48, -11, 9, -39, -44, -16, -23, 11,-204, 21,-195, -7, -43, 16, -23, -10, -12, -61, -5, -28; /M: SY='C'; M= -19, 60, 24, 0, -16, -34, -20, -60, -61, -5, -39,-201, -18, -42, -34, 4, -1, -43, -7,-206; /M: SY='K'; M= -40,-217, -47, -64,-206, 3, -29, -36, 21, -16, 12, -55, -23,-200, 19, -38, 14, 7,-218, 6; /M: SY='R'; M= -66, -24, -56, -18, 2, -41, -3, -38, 4, -45, -15, -61, 18, -45, 42, -58, 21, -76,-213, 16; /M: SY='E'; M= 13, -23, 3, 46, -67, -42,-206, -10, -70, -5,-201,-204, -55, -16, 5, -41,-203, -18, 6, -42; /M: SY='D'; M=-205, 23, 29, 20, -53, -47, -4, -7, -52, -32, -4,-201, -2, -49, 1, -16, -13, -10,-220, 9; /M: SY='H'; M= 12, -23, 1, 21, -24, -41, 43, -30, -6, -70, -3, -39, 14, -30, -71, -9, -14, -70,-224,-205; /M: SY='M'; M= -10,-218, -16, 10,-208, -40,-204, -23, -17, -40, 18, -50, -37, 6, 3, 12, -12, -12,-218, 12; /M: SY='D'; M= -9,-219, 10, -38,-213, 5, -21, -20, -60, -10, -15, -22, 6, -18, -3, 0, 5, -68,-224, -47; /M: SY='F'; M=-207, -24, -26, 20, 29, -81, -29, -14,-206, -48, -20,-208, 24, 15, -59, -20, 7, 12,-220,-202; /M: SY='N'; M= -22,-220, 2, 5, -24, -26,-204, -31, 9, -39,-208, 34, 9, -49, -49, -30, -9, -71,-220, 5; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 198 in 198 different sequences |
| Number of true positive hits | 198 in 198 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotic viruses |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | (+)RNA virus helicase ATP-binding |
| Feature key [info] | DOMAIN |
| Feature description [info] | (+)RNA virus helicase C-terminal |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
198 sequences
194K_TRVSY (P05080), 1A_AMVLE(P03589), 1A_BBMV (Q00020), 1A_BMV (P03588), 1A_CCMV (P27752), 1A_CMVFN(P17769), 1A_CMVII(Q83270), 1A_CMVIX(Q66121), 1A_CMVNT(O40976), 1A_CMVO (P20122), 1A_CMVQ (P06011), 1A_CMVY (Q83264), 1A_OLV2I(Q83943), 1A_PSVJ (P28726), 1A_PZSVT(Q9DUT3), 1A_TAV (P28931), 1A_TOBSV(P89680), ALPHA_BSMV (P17595), POLG_ASGVK (Q6PLS1), POLG_ASGVP (P36309), POLG_CILVC (Q1KZ59), POLG_MRFVC (Q91TW9), POLN_AHEV (Q6QLN1), POLN_AURAV (Q86924), POLN_BFV(P87515), POLN_CHIK3 (Q5XXP4), POLN_CHIKS (Q8JUX6), POLN_EEEV1 (Q306W6), POLN_EEEV8 (Q306W8), POLN_EEEVF (Q4QXJ8), POLN_EEVV3 (P36327), POLN_EEVVC (Q8V294), POLN_EEVVM (Q9WJC7), POLN_EEVVP (P36328), POLN_EEVVT (P27282), POLN_ELV(P35928), POLN_EPMV (P20126), POLN_GETV (Q5Y389), POLN_GFKVM (Q8UZB6), POLN_HEVBU (P29324), POLN_HEVCH (Q81862), POLN_HEVCT (Q9IVZ9), POLN_HEVHY (Q9WC28), POLN_HEVME (Q03495), POLN_HEVMG (Q6J8G2), POLN_HEVMY (Q04610), POLN_HEVPA (P33424), POLN_HEVUS (Q9YLR1), POLN_KYMVJ (P36304), POLN_MAYAB (Q8QZ73), POLN_ONNVG (P13886), POLN_ONNVI (O90370), POLN_ONNVS (O90368), POLN_OYMV (P20127), POLN_RRVN (P13887), POLN_RUBVB (Q6X2U4), POLN_RUBVC (Q6X2U2), POLN_RUBVD (Q9J6K9), POLN_RUBVM (Q86500), POLN_RUBVN (Q8BCR0), POLN_RUBVO (Q99IE7), POLN_RUBVR (O40955), POLN_RUBVT (P13889), POLN_RUBVV (Q99IE5), POLN_SAGV (Q9JGL0), POLN_SFV(P08411), POLN_SINDO (P27283), POLN_SINDV (P03317), POLN_SLDV (Q8QL53), POLN_SPDV (Q8JJX1), POLN_TYMV (P10358), POLN_TYMVA (P20128), POLN_TYMVC (P28477), POLN_WEEV (P13896), R1AB_BC133 (P0C6W1), R1AB_BC279 (P0C6V9), R1AB_BC512 (P0C6W0), R1AB_BCHK3 (P0C6W2), R1AB_BCHK4 (P0C6W3), R1AB_BCHK5 (P0C6W4), R1AB_BCHK9 (P0C6W5), R1AB_BCRP3 (P0C6W6), R1AB_BEV(P0C6V7), R1AB_BRV1 (P0C6V8), R1AB_BYVU (Q08534), R1AB_CVBEN (P0C6W7), R1AB_CVBLU (P0C6W8), R1AB_CVBM (P0C6W9), R1AB_CVBQ (P0C6X0), R1AB_CVH22 (P0C6X1), R1AB_CVHN1 (P0C6X2), R1AB_CVHN2 (P0C6X3), R1AB_CVHN5 (P0C6X4), R1AB_CVHNL (P0C6X5), R1AB_CVHOC (P0C6X6), R1AB_CVM2 (P0C6X8), R1AB_CVMA5 (P0C6X9), R1AB_CVMJH (P0C6Y0), R1AB_CVPPU (P0C6Y5), R1AB_FIPV (Q98VG9), R1AB_GLRV3 (O71189), R1AB_IBVB (P0C6Y1), R1AB_IBVBC (P0C6Y2), R1AB_IBVM (P0C6Y3), R1AB_LIYV9 (Q83045), R1AB_MERS1 (K9N7C7), R1AB_PEDV7 (P0C6Y4), R1AB_SARS (P0C6X7), R1AB_SARS2 (P0DTD1), R1AB_WBV24 (Q008X6), R1A_GLRV3 (O71188), R1A_LIYV9 (Q83044), RDRP_ACLSA (P54891), RDRP_ACLSP (P27738), RDRP_ASPVP (Q64962), RDRP_BBSCV (Q65652), RDRP_BNYVS (Q65667), RDRP_BOTVF (Q9DRA1), RDRP_BOTVX (Q6YNQ7), RDRP_CGMVS (P69514), RDRP_CLBVS (Q91QZ3), RDRP_FXMV (P22168), RDRP_GVAIS (Q67704), RDRP_HASV (Q67724), RDRP_ICRSV (Q918W3), RDRP_LOLV (B1PS76), RDRP_NCBVS (Q9YRB3), RDRP_NMV(P15095), RDRP_ORSVC (P89659), RDRP_ORSVS (Q84133), RDRP_P1AMV (Q07518), RDRP_PCV87 (Q84687), RDRP_PMMVJ (P89657), RDRP_PMMVS (P29098), RDRP_PMTVS (Q9QBU0), RDRP_PMV(P20951), RDRP_PVMR (P17965), RDRP_PVX(P09395), RDRP_PVXCP (P22591), RDRP_PVXHB (Q07630), RDRP_PVXX3 (P17779), RDRP_RBDVR (Q05983), RDRP_SBWMN (Q89249), RDRP_SHMV (P89202), RDRP_SHVX (Q04575), RDRP_SMYEA (P28897), RDRP_SSDRV (Q6YI57), RDRP_TBRFV (A0A0S2T050), RDRP_TMGMV (P18339), RDRP_TMOB (P90211), RDRP_TMV(P03586), RDRP_TMVB (Q9YQ08), RDRP_TMVKR (P30738), RDRP_TMVOM (O93058), RDRP_TMVRA (Q98745), RDRP_TOMK1 (Q9Q1T8), RDRP_TOMK2 (P89676), RDRP_TOML (P03587), RDRP_TOMS1 (Q9YKD6), RDRP_TRVPP (Q9J942), RDRP_TVCV (Q88920), RDRP_WCMVM (P09498), RDRP_WCMVO (P15402), RDRP_YOMV (Q66220), RPOA_EAVBU (P19811), RPOA_LDVC (Q06502), RPOA_LDVP (Q83017), RPOA_PRRS1 (Q9YN02), RPOA_PRRSB (Q8B912), RPOA_PRRSL (Q04561), RPOA_PRRSR (Q9WJB2), RPOA_PRRSS (A0MD28), RPOA_SHFV (Q68772), TGB1_ASPVP (Q64963), TGB1_BNYVS (Q65674), TGB1_BSMV (P04867), TGB1_CVB(P37988), TGB1_FXMV (P22169), TGB1_ICRSV (Q918W2), TGB1_LOLV (B1PS77), TGB1_LSV(P27330), TGB1_LVX(P27329), TGB1_NMV(P15096), TGB1_P1AMV (Q07517), TGB1_PCV87 (Q08317), TGB1_PMTVS (Q9IV54), TGB1_PMV(P20952), TGB1_POPMV (Q02109), TGB1_PVMR (P17526), TGB1_PVSP (P16650), TGB1_PVX(P09396), TGB1_PVXCP (P22592), TGB1_PVXHB (Q07632), TGB1_PVXX3 (P17780), TGB1_SHVX (Q04581), TGB1_SMYEA (Q00846), TGB1_WCMVM (P09499), TGB1_WCMVO (P15403)» more
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| PDB [Detailed view] |
64 PDB
3VKW; 3WRX; 3WRY; 4N0N; 4N0O; 5RL6; 5RL7; 5RL8; 5RL9; 5RLB; 5RLC; 5RLD; 5RLE; 5RLF; 5RLG; 5RLH; 5RLI; 5RLJ; 5RLK; 5RLL; 5RLM; 5RLN; 5RLO; 5RLP; 5RLQ; 5RLR; 5RLS; 5RLT; 5RLU; 5RLV; 5RLW; 5RLY; 5RLZ; 5RM0; 5RM1; 5RM2; 5RM3; 5RM4; 5RM5; 5RM6; 5RM7; 5RM8; 5RM9; 5RMA; 5RMB; 5RMC; 5RMD; 5RME; 5RMF; 5RMG; 5RMH; 5RMI; 5RMJ; 5RMK; 5RML; 5RMM; 5ROB; 6JYT; 6ZSL; 7CYQ; 7NIO; 7NN0; 7NNG; 7Y38 » more |