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PROSITE entry PS51665


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General information about the entry

Entry name [info] ENKURIN
Accession [info] PS51665
Entry type [info] MATRIX
Date [info] 01-FEB-2013 CREATED;
10-MAY-2017 DATA UPDATE;
27-MAR-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51665
Associated ProRule [info] PRU01000

Name and characterization of the entry

Description [info] Enkurin domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=93;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=88;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.8593566; R2=0.0047969; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=15482.0000000; R2=0.0000000; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1489; H_SCORE=15482; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=759; H_SCORE=15482; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-36; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='K';  M= -36, -60, -51,  38,-105, -53, -15, -12,  58, -24, -58,  -3,  -8,  58,  19, -11, -48, -33,-108, -96;
/M: SY='R';  M= -55, -63, -16,  28, -53, -88,   1, -46,  -7, -40,  -9, -40, -42, -31,  79,  -5, -24,  -5, -60,  41;
/M: SY='K';  M=   2, -61, -64,  -3,-102, -98, -15, -28,  58, -11, -46,  40, -26,  32,  36, -13, -27, -38,-108, -42;
/M: SY='E';  M=  12,-105,  14,  58, -69, -49,  -7,   4,  26, -15,  -8, -19, -65,  11, -19, -13,  13, -75,-110, -68;
/M: SY='E';  M=  -3,-108,  -7,  72, -62, -77,   2, -38,  22, -22, -28,  -2, -95,  54,  -1, -19, -89, -46,-109, -71;
/M: SY='W';  M=  -8,-107, -94,  28, -93,-103, -42,   8,  17,  -9,   5, -26, -61,  30,  16,  -4, -27,  25,  87, -61;
/M: SY='K';  M=   8, -27, -16,  40,-105, -75, -59, -26,  48, -40, -17, -47, -30,  15,  46,   5, -24, -22, -54, -97;
/M: SY='R';  M=  14,-107, -22,  47, -43, -71, -87, -63,  44, -54, -36, -25, -48,  25,  55, -20, -50, -54,-104,   6;
/M: SY='E';  M=  45,-104,  11,  58,-101, -51, -56, -16,   7, -33, -50, -12, -51,  -5,  -1, -26, -16, -36,-107,   1;
/M: SY='Q';  M=   8,-107, -47,  46, -20, -75, -42,  17, -14,  -4,  -1,  14, -40,  69,  -2, -59, -24, -65, -21, -20;
/M: SY='E';  M=  10,-107, -23,  77, -56, -71, -22,   1,  19, -26, -53, -29, -63,  15,  -8, -58, -15, -28,-107, -20;
/M: SY='E';  M=  17,-106,  -9,  64, -36, -73,  -1, -59,  17, -41,  26, -23, -96,  33,  14,  -1, -43, -26, -51, -49;
/M: SY='R';  M=  -4,-108, -18,  22, -20, -60, -61, -25,   3, -33, -21,   2, -12,  28,  56, -27, -35, -22, -97,  54;
/M: SY='E';  M=  -6, -20,  32,  38, -32, -75,   6,   0,  16,  -5, -18, -12, -46,  35,  28, -34, -16, -44,-109, -46;
/M: SY='Q';  M=  17,-106, -29,  44, -59, -98,  19, -20,   0, -28,   0,  17, -98,  47,  47,  -8, -47, -49, -50, -66;
/M: SY='Q';  M=   7,-105,   3,  17,   7, -71, -72, -61,  -1, -22,  -2,  42,-101,  51, -12,  12, -28, -49, -43,  47;
/M: SY='Q';  M=  -7,-103, -25,  22, -59, -34, -27,   8,   3,   9,   6, -25, -41,  30,   8,  11,   0,  24,-109, -93;
/M: SY='Q';  M= -11,-110,  -8,  44, -62, -61, -56, -21,  31, -24,  -8, -60,  48,  55,  32, -59, -65, -46,-107, -69;
/M: SY='E';  M=   0,-108,  60,  61, -77, -45, -10, -34,  -1, -39, -65, -31,  -1,  27,  -6, -25, -26, -49,-113, -58;
/M: SY='P';  M=   5,-108,  -7,  30, -82, -85,  10, -20,   6, -11, -41,  -4,  67,  39,  -7,   1, -44, -40,-110, -76;
/M: SY='M';  M=  -7, -32,  26,  34, -66, -74, -25, -46,  34,  -4,  45,   7,  14, -24,  10,  -2, -10, -43,-110, -72;
/M: SY='C';  M=  11,  56, -62,  31, -99,  -1, -31,   5,   6, -51,  38, -65, -17,  44,   2, -14, -28, -22,-107,  -6;
/M: SY='P';  M= -24,-112, -17,  -2,-106, -83,  -7,  -1,  28, -38,   4,  -7,  86,  41,  -4, -43, -44, -42,-109,-100;
/M: SY='P';  M=  -2, -45,  12,   7, -44,   8, -21, -47,  -7, -85, -98,   2,  75,  31,   1,  18, -37, -70,-110,-101;
/M: SY='G';  M=  25,-105, -93, -35,-108,  66,   3, -55,  17, -50, -67, -53, -29,  31,  12, -16, -32, -34,-107,-100;
/M: SY='H';  M= -36,  20, -56, -14, -12, -61,  87, -21, -25,   5,  74, -44, -32,  18, -20, -64,  13, -13,-108,   1;
/M: SY='R';  M=  12, -60, -70,  -9, -77, -69, -49, -21,  31, -48, -43, -89, -21,  16,  65, -63,  31,  12,-104,  14;
/M: SY='L';  M= -47, -21, -44,  13, -30, -57,   4, -46,  15,  38,  33, -22,  11,  23,  36, -37, -68, -15,-102,   9;
/I:         I=-8; MD=-21;
/M: SY='M';  M= -63,-104, -23,   4, -83, -84,  -4,  11,-100,  53,  96,-103,-107, -19,-101, -61, -66,  -1,-107, -41; D=-8;
/I:         I=-8; MD=-21;
/M: SY='P';  M= -19, -98,  30, -10,-110, -36, -55, -44, -46, -43,-101, -79,  62, -46,  -1,  61,   5,-101,-116, -64; D=-8;
/I:         I=-8; MI=0; MD=-21; IM=0; DM=-21;
/M: SY='E';  M= -36,-113,  53,  81, -87, -45, -63, -72, -29, -64,-103, -62,  11,  26, -18, -19, -75, -78,-116, -85; D=-8;
/I:         I=-8; DM=-21;
/M: SY='E';  M=  15, -41,  35,  74, -74, -36, -15, -81, -11, -81, -98,   5, -35,  39, -49,  17, -45, -70,-111, -61;
/M: SY='E';  M= -72,-111,  19, 105, -86, -79, -84,-112, -20, -86, -53, -84, -60,  41, -55, -68, -71,-107,-111,-101;
/M: SY='R';  M= -95,-111, -93, -48,-102,-106, -16, -46,  21, -10, -89, -87,-104,  27, 104, -55, -46, -36,-106, -92;
/M: SY='Q';  M=   0, -50,  -8,  21, -56, -70, -34, -10,  19,  25,  13,  -1,-100,  69,   2, -63, -37,  -4,-106, -67;
/M: SY='E';  M=  27, -71,  -5,  66,-107, -14, -47, -46,  11, -39, -39, -20, -94,  47,   9,  -5, -24, -76, -31, -67;
/M: SY='L';  M=  -2, -98,-104, -72, -81,-107,  -2,  31,-100,  58,  17, -75,-104, -64,-102, -69,  57,   5,-106, -23;
/M: SY='L';  M= -95, -52,-111, -57, -76,-115, -99,  25, -40,  79,  14,-108,-111, -70,   8, -76, -92,   9,-104, -86;
/M: SY='Q';  M= -15, -53,  42,  44,-107, -61,  -3, -26,   9, -54, -95,  37, -65,  50,  19,   8, -10, -51,-112, -63;
/M: SY='G';  M=   6, -57,  -4,  -3,-106,  61,  -5, -52,  21, -40,   2,  28, -64,  10, -24,  -2, -40, -36,-109, -99;
/M: SY='L';  M=  14, -99, -75,-104, -76,-109, -99, -30,-105,  85,  35,-109, -71, -99,-104, -76, -60, -44,-103, -86;
/M: SY='K';  M= -41,-109, -40, -16, -62,-101,   9, -79,  85, -31, -92, -25, -65,  49,  52, -87, -65,-103,-104, -50;
/M: SY='Q';  M=  29,-104, -58,  20, -48, -89, -41, -21,  55, -39, -47,  12, -66,  59,  10, -25,  -8, -35,-106, -49;
/M: SY='N';  M= -34,-104, -41, -21,-106, -55,   9, -66,  58, -76, -51,  65, -99, -34,  61,  22, -22,-103,-111, -96;
/M: SY='W';  M=-100,-117,-105, -26, -21,-105,  28, -51,   4,  -3, -52, -38,-106,  46,   0, -99,-102,-102, 143,  53;
/M: SY='D';  M=  -5, -55,  60,  43, -68, -22, -85,-107,  -1, -84, -53,  36, -96,  35,   2,  19,  -3, -67,-113, -46;
/M: SY='E';  M= -26,-108,  28,  73, -80, -69, -29, -68,  22, -22, -53, -47, -94,  56, -16,  -5, -25, -33,-109, -57;
/M: SY='L';  M= -30,  -6,-109, -46, -77, -77, -99,  18, -32,  70,  18, -51,-110, -98, -56, -81, -37,  31,-103,  -1;
/M: SY='N';  M= -50,-103, -73,   5, -59, -73,  55,  29, -61,  -5,  13,  73,-102,  19, -44, -16, -10,   8,-110,   1;
/M: SY='K';  M=  20,   6, -11,  13, -67, -52,  32,-102,  53, -56, -36,  24, -98, -21,  27,  14, -18, -48,   2,  -5;
/M: SY='E';  M= -24,-110,  10,  88,-112,-102, -84, -78,   3, -73, -61, -49, -92,  64,  17, -29, -54, -81,-110, -99;
/M: SY='Y';  M=-102,-108,-109,-107,  36,-113, -25, -30,-102,  49, -18,-107,-115, -98, -59,-102, -58, -83,  -1, 107;
/M: SY='Q';  M= -29, -35, -39, -44, -49, -41, -14, -58, -79,  -8, -43,  65,-102,  97,   1, -36, -28, -15,-110, -94;
/M: SY='K';  M= -45,  -1, -80, -75,-103,   9,  45,-102,  51, -11,  16, -50,-100,  12,  42,  38,  -9, -94,-110, -93;
/M: SY='M';  M= -75,-103,-114,-106, -11, -73, -97,  23, -56,  69,  82,-108,-110, -38, -39,-104, -39, -51,-101,  -4;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='P';  M= -62,-112, -95, -88,-113, -32, -99,-105, -42,-113,-102, -44, 111, -93,-102,  45,  14,-105,-113,-109;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='F';  M= -27, -35,-112,-107,  51,-112,  49,  26,-105,  33,  45,-104,-110,-103,-104, -64, -56,  49,-102, -78;
/M: SY='S';  M= -25, -94, -99, -69, -34,  -5, -48,  25,  -1,   1, -18, -58,-102, -90,  29,  41,  27,  25,-110, -93;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='M';  M=  12,  -6, -54, -36, -10, -93, -45,  43, -15,   4,  43, -10, -83, -30, -54,  -5,  32,  11,-107, -14;
/M: SY='D';  M= -76,-112, 102,  26, -65,  -7, -87,-114, -38,-113, -52,   0, -17,  23, -92, -87, -71, -78,-124,-102;
/M: SY='T';  M= -67, -95, -89, -93,-100, -97, -62, -72, -90, -58, -93,  -2, -94, -92, -66,  37, 106, -59, -14, -97;
/M: SY='L';  M= -12, -67, -76, -28, -15,-110, -49,  15, -98,  50,  33,-105,  46,   5, -16, -98, -36,   8,-104, -13;
/M: SY='R';  M=  -7,-108, -94, -89, -78,  21, -30, -74, -21, -54, -63, -10,  46,  -5,  62,  44, -35, -44,-109, -46;
/M: SY='K';  M=  -2,-105, -98, -55, -46, -60, -28,   6,  64,   5,  -4, -92,-102,  46, -35, -44, -31,  28,-107, -49;
/M: SY='R';  M= -26, -77, -96, -83,-102,-106, -57,   9,  59, -22,  18, -70,-103,  49,  71, -91, -69, -30,-107, -94;
/M: SY='N';  M=   4,-106, -58, -24, -88, -56, -29, -28,  34, -34, -32,  57,-102,  34,  51,  16, -39, -52,-111, -59;
/M: SY='R';  M= -59, -82, -94, -85, -81,-107,  63,-105,  34, -19, -91, -44,-105, -23,  94, -69, -47, -43,-109, -20;
/M: SY='K';  M= -49,-111, -89, -59,-111,-103, -11,-111, 100,-109, -97, -82, -98, -10,  52, -90, -91, -85,-106, -97;
/M: SY='E';  M=  35,-105, -31,  67,-106, -47, -31,  -9, -16, -57,  21, -14, -96,   5,   9,  -3,  -8, -54, -14, -99;
/M: SY='E';  M=   8, -15,   9,  60, -82, -54,  -9, -84,  19, -57, -21,   2, -51,  49,  17, -33, -27,-103,  23, -30;
/M: SY='L';  M= -98,  26,-115,-109, -14,-116, -34,  43,-108,  67,  49,-110,-113, -48,-106, -75, -94, -21,-100,  20;
/M: SY='E';  M= -92,-113,  24, 108,-116, -31, -87,-117, -76,-110,-106, -63, -89, -69, -86, -58, -59,-110,-114,-106;
/M: SY='K';  M=  -2,  -7, -35,   8, -79, -62,   2,-107,  63, -58, -96,  -2, -99,  47,  47,  -5, -15, -72,-110, -97;
/M: SY='Q';  M= -67, -36,  -4,  70,-114, -58, -86, -81,  34,-107, -99, -44, -95,  74,  30, -38, -24,-107,-109, -56;
/M: SY='L';  M= -72, -34,-115, -78, -76,-116,-100,  17,-108,  82,  58, -60,-113,-101,-106, -55, -94, -41,-105, -87;
/M: SY='K';  M=  25,-104,  41, -21, -65, -48, -92, -30,  41, -62, -60,  26, -52,   7,   7,  -1,   5,  -5,-113, -51;
/M: SY='Q';  M= -13,-112,  -8,  56, -62, -62, -37, -20, -25, -60, -93, -20, -98,  95, -19, -50, -61, -30,  14, -96;
/M: SY='I';  M= -96,-104,-116,-111, -79,-119,-108,  64, -79,  60, -36, -56,-112,-106,-109,-105, -52,  39,-107, -31;
/M: SY='E';  M= -95,-114,  54, 103,-117,-106, -87, -84, -59,-111,-108, -47, -91, -35, -87, -61, -93,-110,-117,-106;
/M: SY='K';  M= -12,-110,   3,  47, -21, -76,  -2, -79,  56, -85, -98,   1, -52,  24,  17, -10, -57, -53,-105,  15;
/M: SY='D';  M=  52,-105,  90, -13,-112, -27, -92,-109, -90, -88,-105, -18,-100, -88, -68,  -9, -34, -81,-120, -32;
/M: SY='I';  M= -98,-110,-115, -49, -83,-121, -38,  98, -55,  10,  31,-108,-108, -34, -48,-106, -93, -38,-107, -89;
/M: SY='K';  M=  11, -39, -21,  28,-108, -32, -22,-105,  54, -26, -96,  18,-100,  26,  27,   2, -38, -57, -44, -67;
/M: SY='K';  M= -67,-106,-102, -55, -68,-111, -41,  41,  52,  18,  43, -38,-104, -29, -10, -95,  16,  17,-107, -22;
/M: SY='F';  M= -73,-105,-117,-112,  79,-117,-101,  25, -79,  55, -22,-111,-116,-109,-108, -76, -58, -20, -89,  18;
/M: SY='S';  M= -71,-106,  13,  66,-113, -56, -25,-112, -24,-111,-104,  21, -95,  10, -88,  72, -41,-106,-117,-102;
/M: SY='R';  M= -42,-111, -91, -60,-109, -40, -49,-109,  67, -39, -96,   3,-102,  28,  72, -17,  -8,-105,-110, -98;
/M: SY='P';  M=  -2, -36,   6, -46, -17, -29,  60,-107,  -1, -67, -98,  12,  66,  16,   3,  -3,  -6,-106,-112, -21;
/M: SY='K';  M= -24,-111, -26, -49, -67, -30,  42, -46,  65, -75, -78,  10,  37,   3,   6, -49,   0, -45,-108,   9;
/M: SY='V';  M= -67, -38, -37, -47, -31,-114,   3,  26, -82, -29,  -4, -38, -47, -50, -65, -56, -12,  78,-110,  22;
/M: SY='F';  M= -90,-110, -27, -74,  72,-117, -14,  44, -65,   8, -41, -73,-115, -50, -78, -69, -97, -12, -86,  68;
/M: SY='Y';  M= -96,-108,-114, -75,  -1,-118, -20,  40, -65, -18,   2,-110,-114,-105, -79, -60, -93,  64, -12,  72;
/M: SY='K';  M= -28,-109,   4, -18, -35, -91, -70,  17,  42, -40, -19, -26,  -9, -14, -11, -19, -38,  33,-106,  32;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_02 which contains 571'282 sequence entries.


Total number of hits 7 in 7 different sequences
Number of true positive hits 7 in 7 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] enkurin
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
7 sequences

ENKD1_BOVIN (Q3T078), ENKD1_HUMAN (Q9H0I2), ENKD1_MOUSE (Q7TSV9), 
ENKUR_BOVIN (E1B836), ENKUR_HUMAN (Q8TC29), ENKUR_MOUSE (Q6SP97), 
ENKUR_PIG   (A0A4X1TZW7)
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PDB
[Detailed view]
8 PDB

7RRO; 7UNG; 8I7O; 8I7R; 8IYJ; 8J07; 8OTZ; 8TO0