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Entry: PS51728

General information about the entry

Entry name [info] RTT109_HAT
Accession [info] PS51728
Entry type [info] MATRIX
Date [info] 01-JUL-2014 CREATED;
13-FEB-2019 DATA UPDATE;
12-AUG-2020 INFO UPDATE.
PROSITE Doc. [info] PDOC51728
Associated ProRule [info] PRU01064

Name and characterization of the entry

Description [info] Rtt109-type histone acetyltransferase (HAT) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=373;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=368;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2920060; R2=0.0058039; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=63463.1445312; R2=15.7928858; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1673; H_SCORE=89885; N_SCORE=12.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=726; H_SCORE=74929; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-43; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='S';  M= -30,-106,  38, -29,-105, -10,  -7, -55, -87, -20, -32,  14,  -8,  14,  13,  52,  22, -66,-115, -21;
/M: SY='L';  M= -22,-103,-109, -53,   9, -63,  31,  -9, -20,  74,   4,-105,-111, -39,-101, -43, -30, -46,-104, -84;
/M: SY='L';  M= -31, -25,   7,  17, -49, -44, -96, -13, -10,  31,  -7, -11,   3, -15,  20,  -7,  -5,  15,-111, -95;
/M: SY='E';  M= -16,   6,  42,  60,-104, -58, -35, -38, -10, -10, -96, -20, -98,  17, -17,  32, -29, -99,-112, -17;
/M: SY='R';  M=  20, -29, -94,  -1, -26, -59,  14, -25,  -2,  25, -86,   9,-104,  11,  28,  25, -20, -54,-106,  -5;
/M: SY='L';  M= -43,-103, -40, -23, -82,-110,  12,   9, -21,  70, -71,-102,-109, -96,-101,  18, -29, -19,  27, -88;
/M: SY='S';  M=  46,-101, -49, -20, -45, -28, -97, -52,  11,  24, -88, -91,   5,   4, -93,  47, -14, -89,-109, -97;
/M: SY='A';  M=  38,-105,  13,  37, -48, -94, -32,-106,  31, -72, -99, -23,  23,  21, -51,  36, -43,-100,-110, -39;
/M: SY='V';  M=  35, -11, -45, -20, -46, -58, -28, -11, -15, -35, -87,  -1,   4, -48,  -3,  -7,   9,  48,-111, -13;
/M: SY='L';  M= -96,-103,-112, -41, -40,-115,-102,  23, -54,  79, -66,-109, -48,-101,-105,  -3, -45, -13,-105, -88;
/M: SY='P';  M=   7,-116, -34, -51,-111, -51,-102, -13, -96, -48, -97,-102, 113, -97, -56, -22, -90, -36,-112,-110;
/M: SY='K';  M= -28,-108, -42,  47, -63,  31, -24,-105,  51, -53, -98, -13, -20,  18, -29, -14,  14, -30,-110,-100;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='D';  M= -13,-106,  61, -47,-110,  52, -94,-106, -10, -38,-102,  25, -15, -90, -97,  12,  18, -40,-116,-104;
/I:         I=-42; MD=-106;
/M: SY='H';  M= -24, -20,  -3,   9, -57,   6,  60, -34, -32, -13, -24, -24,   5, -32,  33, -21,  -9,  25,-114, -46; D=-42;
/I:         I=-42; MD=-106;
/M: SY='T';  M= -22,  -9,  -4,  26, -48, -27,  -4, -44,  37,-105, -98,  26,  -7,  24, -18,  29,  38,-100,-113, -99; D=-42;
/I:         I=-42; MI=-106; IM=-106; DM=-106;
/M: SY='F';  M=-100, -37,-110, -22,  90,-113, -96, -30,-105,  34,  -6,-106, -50,-106,-104, -55,  -4,  -7, -83,  46;
/M: SY='Q';  M= -27,-107,  19,  40, -31, -56,  26, -66,  24,-104, -97,  -4, -97,  41,  34,   8,  34, -62,-112, -95;
/M: SY='V';  M=   9, -18,-109,-104, -17, -67,-103,  41,-102,  39, -74, -22, -45, -23, -32, -52, -32,  48,-105,   1;
/M: SY='Y';  M= -99, -12, -28,-100,  34, -62,  67,  15, -52,  28, -78, -97,-110, -42,   4, -56, -23, -21, -89,  76;
/M: SY='H';  M= -25, -24, -36, -36, -92,-101, 119, -96, -52, -63, -87,  -3,-103,   5, -89,  -1,   0,  16,-112,  43;
/M: SY='L';  M= -96,-103,-111, -55, -18,-116,-103,  39,-107,  71, -67, -12,-112,-103,-107,-103, -14,  21, -10, -18;
/M: SY='Q';  M=  -5,  -1, -44, -30,  -1, -58,  33, -94, -10, -71, -91, -33,-102,  75,  16,  44, -47,  18,-108, -33;
/M: SY='S';  M= -51, -31, -28, -36,-103, -89, -94, -98, -89, -67, -97, -12, -43, -86, -95,  85,  73, -39,-117, -99;
/M: SY='P';  M=  -5,-107, -19, -31,-102, -98,  -1,   0,  10, -13, -90,  24,  63,  27, -36,  14,  -5,   0,  21, -97;
/M: SY='P';  M= -11,-114,-100, -49,  -7,-101, -25, -94, -96, -22,  -9,-103, 112, -98,-105, -38, -10, -15,  -4,-102;
/M: SY='T';  M=  -5, -33, -94, -29,   7,-100, -95, -58,  24, -43, -92, -87,   3, -20,  42,  17,  65, -13,-108, -34;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='K';  M= -42,-110, -17,  33,-109,-103,  -3, -66,  65,-105, -97, -24,  28, -13,  56, -22, -38, -16,-110, -98;
/M: SY='C';  M= -37,  89, -27, -23,-100, -98,  15, -99, -20, -46, -95, -42,-101, -91, -15,  46,  69, -60,-116,  -9;
/I:         I=-29; MD=-75;
/M: SY='H';  M= -44,-112,  15, -20, -56,-103,  78, -34,  17, -11, -95, -26,  52,  -3, -24,   9,   7,-102,-119, -95; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='P';  M=  42,-109,  -3, -37, -49, -37,-102,   6, -52, -41, -97,  16,  58,  -4, -53, -39,  11, -56,-116,-106; D=-29;
/I:         I=-29; DM=-75;
/M: SY='L';  M= -63, -31, -51,-106, -41, -67,  52,  16, -38,  60, -75,  -9,-115, -23,-105,-104, -34,  -5,-111, -13; D=-29;
/I:         I=-29; DM=-75;
/M: SY='F';  M= -54,-107,-116,-113,  84,-116,-103,  28,-109,  -4, -81, -30,-116, -41,-109,-103, -14,  26,   2,  34; D=-29;
/I:         I=-29; DM=-75;
/M: SY='H';  M= -16,   3, -22, -11,  -8, -23,  56,-100, -62, -43, -94, -20,  45,  -2, -48,  52,  22, -41,-108,  12;
/M: SY='P';  M=  13,-111, -33, -46, -17, -59,   0,-101,  25, -36, -96, -47,  90,   6, -92,  12, -89, -58,  27,  -1;
/M: SY='P';  M=  25,-106, -94, -48,  19, -96,  25, -98,  19,  -8, -31,   8,  63, -21,   2,  29, -50, -96,-105, -36;
/M: SY='P';  M=  20,-106,  -3, -25,-104, -69,   7,   0,   1, -32, -93,   3,  68, -20, -16,  26,   6, -40,-111, -40;
/M: SY='Q';  M= -18,-109,   3,  -1, -46,  24,  -6,  11,  29, -39, -22,   8,  14,  50, -23, -12, -33, -95,-106,   2;
/M: SY='Q';  M=  34,  22,  25,  20,-109, -95,  27, -60,   9, -76, -97,  -8,  21,  34, -12,  21, -19, -38,-114, -99;
/M: SY='K';  M= -92, -32,  16,  -8, -52, -45,  47, -54,  55, -26, -93, -12,  13, -21,  20,  23,   1, -14,-113, -94;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='P';  M= -26,-121, -18,   1,-122, -62,  -4, -60, -16,-120,-110, -10,  69,  -7,  -3,  26,  -9,-114,-124,-114; D=-19;
/I:         I=-19; DM=-47;
/M: SY='P';  M= -21,  16,   3,  35,-111, -53,  -2, -36, -22, -23, -99,   6,  74, -17, -50, -46, -21, -28,-119,-107; D=-19;
/I:         I=-19; DM=-47;
/M: SY='R';  M= -31,-107,  31, -82,-104,-100,  -7, -67,  41, -22,  10,  -1,  18,  21,  49,   1,  15, -33,-111, -37;
/M: SY='T';  M= -34,   6, -21, -93, -47,-100,   9, -29, -38, -94, -91, -82, -41, -93, -49,   2, 101,   1,-118, -96;
/M: SY='Y';  M= -48,-106,-106,-102,  35, -45, -24,  39, -35, -28, -19, -99, -44, -15,  -7, -33,  19,  27,  25,  69;
/M: SY='C';  M= -42,  85, -97,  -1, -22,-107,   7,  -4,  63,   7, -87, -49,-105, -11, -41, -62, -92,  -4,  14,  -7;
/M: SY='Q';  M= -31, -32, -26,  52,-101, -61, -93,  27, -30, -25, -89, -39, -97,  53, -34,  18,  41, -11,-112, -97;
/M: SY='Q';  M= -91,-109,  22,  34,-113, -97,   1,-111,  31,-109, -99,  33, -44,  64,  39,  33, -44,-107,-113, -98;
/M: SY='H';  M=-100,-112, -46, -89, -95,-105, 135,  16, -92, -35, -83, -12, -24, -11, -38, -93, -97, -16,   3, -27;
/M: SY='F';  M=-102,-104,-117,-110,  98,-116,-101,  -4,-107,  45, -19,-110, -26, -25, -45,-106, -97, -17, -85, -65;
/M: SY='F';  M= -99,-103,-116,-110,  70,-117,-104,  45, -42,  53, -70,-110,-113,-108,-107,-105, -31,  15, -94, -29;
/M: SY='T';  M=  36, -28,-102, -35, -42, -66,  -9,  12, -98,  24, -80, -96,-103, -37,-102,  10,  39,  37,-110, -34;
/M: SY='L';  M= -30,-101,-112,-107, -38, -45,-104,   0,-107,  72, -68,-108, -29,-103,-107, -99,  12,  37,-107, -89;
/M: SY='S';  M=  26,  14, -44, -52,  21, -61, -96, -34, -52,  -6, -90, -88,-102, -90, -98,  76, -17,  -6,-104,   2;
/I:         I=-6; MD=-16;
/M: SY='E';  M= -53,-125, -28,  38,-120,-121,-117,  10,-108, -74,-111,-110,-118,-104, -35,  32, -13,   2,   2,-117; D=-6;
/I:         I=-6; MD=-16;
/M: SY='W';  M= -71, -35,  15,  -1, -49,-129,-120,-138,  -5,-137,-130, -14,  21,  24, -40, -59, -68,-137,  42,-124; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='D';  M= -33,-132,  30, -11,-132, -48,-117,-129, -54, -62,-125, -37, -26,  10, -35,  16, -17, -73,  21,-123; D=-6;
/I:         I=-6; DM=-16;
/M: SY='H';  M=   9,-107,  20,   8, -61,  -2,  59, -61,   0, -43, -94,   5,   2,  48, -17,  11, -19,-101,-107,  19;
/M: SY='P';  M=  -9,-108,  38,  33,-109, -11,  19, -66, -37, -76, -98,  39,  50,  30,  -8,  13, -49, -41,-113, -35;
/M: SY='E';  M= -47,-109,  28,  57, -12,   3,   1, -51, -19,-105, -98,  26, -23,  41,  42, -16, -22,-105,-110, -96;
/M: SY='V';  M= -30,  -1,-105, -97, -89, -32,-103,  25,  25,  26, -76, -98,-105,   0, -10, -39,   7,  60,-110, -93;
/M: SY='L';  M= -23, -22,-113,-107,  43,-113,-104,  35,-107,  62, -18,-109,  23,-105,-107,-102, -36,  13,-100, -82;
/M: SY='V';  M= -14,  -5,-113,-109,  19, -65,-110,  57,-106, -10,  22,-106,-108,-105,-108, -38, -45,  72,-107, -87;
/M: SY='F';  M=   0,   8,-107,-105,  76,-106, -93, -29,-102,  33,   0, -29,-110,-101,-102,  -4,   5, -51, -85,  59;
/M: SY='A';  M=  78, -98, -97, -96,-110,  64,-101,-105, -96,-106, -98, -87, -98, -92,-102,  12, -87, -94,-107,-105;
/M: SY='I';  M= -96,-103,-117,-111, -21,-118,-106,  70,-109,  64,  37,-111,-110,-104,-108,-106, -92,   9,-104, -85;
/M: SY='E';  M= -90,  -1, -64, 112,-114,-106, -86,-115, -74,-108,-104, -88, -88, -34, -84,  -7, -90,-107,-112,-105;
/M: SY='V';  M=  44,   4,-109,-104, -87,-104,-109,  47,-103,  16, -75,-103,-106,-102,-106, -90,   1,  61,-111, -94;
/M: SY='Y';  M= -97, -25,-103,-102,  43,-107,  43,  -7, -99,  26, -78, -47,-111, -37, -98,  11, -34, -44, -79,  99;
/M: SY='V';  M= -91, -29,-105,   9, -41,-115,-106,  47, -40,  31, -73,-104,-107, -38, -24, -98, -11,  67,-110, -91;
/M: SY='Y';  M=-103,-112,-103,-106,  31,-110, -71, -87, -98, -84, -81,-103,-115, -94, -95, -97, -35, -92, -60, 134;
/I:         I=-19; MD=-47;
/M: SY='T';  M= -51,-104,-103, -56,  -2,-110,  -4,  10,-101,  18, -85, -43,-105,-101,-106, -23,  81, -15,-111,  12; D=-19;
/I:         I=-19; MD=-47;
/M: SY='T';  M=-107, -35,-114,-113,-117,-122,-118, -17,-111, -30, -12, -54,-118,  20,-117,  -2,  71, -31,-136,-116; D=-19;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='F';  M=-119,-130, -22, -11,  23, -70, -28,  16, -34, -11,-106,  -3, -60,-115, -60, -19, -53,-106,-119,  14; D=-19;
/I:         I=-19; DM=-47;
/M: SY='P';  M=-106,-125,   7,   9,-126, -41,  -5,-119,  10, -81,-114,  11,  69, -18, -51,   8,-101, -53,-128,-117; D=-19;
/I:         I=-19; DM=-47;
/M: SY='T';  M=  -7, -34,  29,  28, -57, -23,-104, -69,   0, -34,-107, -44, -22, -45,-101,  15,  41,-106,-124,-110; D=-19;
/I:         I=-19; DM=-47;
/M: SY='H';  M= -64, -26,  24, -27,-109, -54,  58,-104,  15, -52, -36, -17, -11,  15,   9,  14,  52, -34,-121, -97; D=-19;
/I:         I=-19; DM=-47;
/M: SY='S';  M=   2,-102,  -6,  -8, -97,  12,  31,   2, -15, -47, -92,   1, -47, -86, -12,  48,  29, -15,-108,  17;
/M: SY='E';  M=   1,  18,   5,  45,-101, -57, -23, -53, -12,  10, -91, -39,  -7,   6, -11,  41,  17, -35,-112, -98;
/M: SY='R';  M=  24,-102, -94, -88, -47, -59,   5, -95, -10,  -7, -89, -39,-100,  13,  64,  26,  49, -35,-110, -94;
/M: SY='T';  M= -91,-100,-103,-102, -40,-109,   1,  46,-100,  34, -28, -29,-103, -99,-103, -36,  67,  25,-105,  24;
/M: SY='I';  M= -96,-103,-117,-111,  26,-119,-108,  68,-109,  57, -66,-111,-111,-106,-109,-105, -91,  36,-102, -82;
/M: SY='F';  M=-105,-106,-109,-110, 104,-111, -84, -84,-104, -77, -82,  -8,-116,-106,-101,-101, -97, -89, -68,  97;
/M: SY='V';  M= -88,-101,-116,-111, -83,-118,-116,  68,-108, -40,   0,-109,-109,-108,-109,-100, -85,  88,-114, -91;
/M: SY='S';  M= -23, -27, -87, -32,-106, -40, -91,-105, -89,-108,-102, -77, -95, -81, -93, 108, -27, -97,-114, -98;
/M: SY='K';  M= -94,-108, -86, -73,-110,-101, -90,-110, 114,-109, -97, -79, -94, -71, -56, -88, -33,-106,-104, -97;
/M: SY='A';  M=  74,  40,-106,-100, -94, -95,-106,  -6,-100,   6, -81,-101,-105, -98,-103, -84, -85,  53,-111, -98;
/M: SY='D';  M= -99,-112, 122, -63,-119, -96, -85,-118, -37,-116,-115, -67, -98, -85, -94, -87, -89,-114,-134,-102;
/M: SY='T';  M= -78, -94, -88, -90,-102, -89, -95, -97, -89,-101, -96, -77, -93, -86, -95,  83,  92, -89,-117, -97;
/M: SY='T';  M= -53, -94, -87, -91,-101, -93, -95, -93, -37, -98, -94,  25, -93, -89, -94,  49, 102, -36,-118, -98;
/M: SY='G';  M= -81,-108, -96,-107,-113, 104,-102, -54,-101,-116,-106, -82, -27, -98,-108, -28, -98,-113,-106,-109;
/M: SY='Y';  M= -99,   7,-104,-100,  52,-109,  35, -33, -98,  23, -78,-100,-112,  27, -96, -27, -42, -88, -76, 102;
/I:         I=-6; MD=-16;
/M: SY='C';  M=   0,  55,-113,-112, -49,  18, -10, -60, -36, -16,-108, -33,-120, -13,-114,  32, -51, -44,-128,-114; D=-6;
/I:         I=-6; MD=-16;
/M: SY='P';  M=-112,-128,  30,-100,-131,-116,  -6,-125,  11, -76,-120, -14,  51, -18,-108,   8,  16,-123,-137,-121; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='H';  M= -40,  -6,-125, -66,-122,-131,  10,  -8,   3, -23,-110,-118,-130, -45,   2, -12,  -9,  -1,-139,-120; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='L';  M=-123,-133,-136,-129,-109, -72, -39,   7, -18,  23, -22,-130, -59, -32,-125,-126, -19,  -7,-131,  -1; D=-6;
/I:         I=-6; DM=-16;
/M: SY='K';  M= -56,-137,-114,-110,-137,-126,  31, -71,  39,-136,-124,  25, -35, -15,  20, -38,-117,-134,-141,-123; D=-6;
/I:         I=-6; DM=-16;
/M: SY='L';  M= -60,-135, -28,  -7,-117,-139,-127, -23, -71,  20,-106,-128, -26, -24, -13,-125, -53,  -1,  -3,-121; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M= -37,-137,-120, -31,-131,-129,-121, -24,  34, -43, -39,-118,  41, -47,   3, -38, -63,-121,-135,-126; D=-6;
/I:         I=-6; DM=-16;
/M: SY='K';  M=-118,-134,-119, -41, -58, -40,-120, -48,  33, -28,-117, -51,   4, -40,  10, -16, -13, -63,-134,-123; D=-6;
/I:         I=-6; DM=-16;
/M: SY='S';  M= -73,-130, -66,-119,-127,  -3, -34, -69, -25, -29, -14, -56, -26, -20, -20,  24, -23, -14,-139,-124; D=-6;
/I:         I=-6; DM=-16;
/M: SY='T';  M= -41,-129,   8, -40, -35,  -8,  13,-124, -31, -80, -37, -25, -22, -54, -54, -23,  24, -68,-132,  -6; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M=-116,-134, -31,   1,-129,-123,  12, -73, -19, -89, -33,-112,  65, -18,  -6, -19,  -3,-124,-133, -47; D=-6;
/I:         I=-6; DM=-16;
/M: SY='K';  M= -34,-130, -19, -58,-124, -17,   7,-115,   7, -39,-115, -17, -51,  -9, -62, -31, -18,   2,-136, -25; D=-6;
/I:         I=-6; DM=-16;
/M: SY='K';  M=  -7,  -1,  -8,  -7,   0, -82,-119, -40,  12, -81,-119, -26, -13,-113,-114, -25, -64, -37,-128, -12; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='S';  M= -26, -36, -22,  -8,-129, -20, -24, -73,   7,-127,-119,   2,   7,-105, -33,  22,   3, -54,-135,-122; D=-6;
/I:         I=-6; DM=-16;
/M: SY='D';  M= -68,-126,  18, -11,-122, -14,-108,-123,  12, -43,-115, -29,  -9,   6,  -6,   5,  -4,-121,-127,  -6; D=-6;
/I:         I=-6; MI=0; MD=-16; IM=0; DM=-16;
/M: SY='H';  M=  -6,-120, -16, -32,-106, -24,  26, -29,  12,  12, -13,-106,   1, -48, -57, -22, -59, -26,-120,   2; D=-6;
/I:         I=-6; DM=-16;
/M: SY='P';  M= -29,-116, -49, -54, -62, -18,-105,  32,  -9, -64, -37,  14,  48, -36, -22,   4,   7, -41,  10, -16; D=-6;
/I:         I=-6; DM=-16;
/M: SY='S';  M= -13, -98, -38, -18,-102, -35, -33, -34, -16, -41, -95,  -9, -96, -20,  -7,  83,  40, -59,-112, -36;
/M: SY='P';  M=   5,  -3, -95,  -5, -44, -46, -98, -15,  19, -17, -93, -56,  93, -36, -23,  -3, -22, -38,-109,-102;
/M: SY='T';  M=   7,  -2, -47, -17, -26, -39, -34,  34,  -9,  -4, -22, -18, -23, -90, -15,  28,  51, -49,-106,   1;
/M: SY='T';  M=   5,-101, -91, -48, -56, -17, -92, -17,   7, -66, -92,   5, -18,   7,  42,  37,  57, -25,-110, -36;
/I:         I=-22; MD=-55;
/M: SY='T';  M= -23,-104, -44,  10,-101,-100,  12,  -2, -20, -33, -92,  25,  -6,   3, -16,  31,  51,   2,-115, -29; D=-22;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='T';  M=  14,-107,-110, -55, -27, -30,-110,   6, -22,  26, -85,-105,   3,-105,-107, -58,  34,  29,-114, -38; D=-22;
/I:         I=-22; DM=-55;
/M: SY='T';  M=  14, -12,-103, -33, -47, -38,-105,  22, -16, -31, -90, -96, -49, -28, -15,   8,  54,  17,-115, -36; D=-22;
/I:         I=-22; DM=-55;
/M: SY='R';  M=   3, -24,  19, -21, -24, -27,  -2, -58,  -3, -65, -98,  15, -40, -87,  39,  32,  27,  -6,-116, -98; D=-22;
/I:         I=-22; DM=-55;
/M: SY='A';  M=  59,   1,-100, -97,  29, -27, -99, -91, -53,  -9, -89, -92, -49, -95, -49,  23,  40, -34,  -3,   5; D=-22;
/I:         I=-22; DM=-55;
/M: SY='L';  M= -97,-101,-111,-107,  57, -57, -22,  18,-104,  66, -69,-104,-110,-103, -50, -99,  32, -26, -96, -17;
/M: SY='R';  M= -28,-104, -97,  -9, -48, -67, -96,  28,  33,  -2,  11, -18, -43, -22,  40,  10, -15,  33,-109, -93;
/M: SY='S';  M=  20,-102,  -6, -32, -13, -45,  25,  31, -21, -42, -87, -27,-101, -22,   7,  44,   7,  -5, -16,  12;
/M: SY='L';  M= -22,-104,-110,-105,  47,-111,  34,  18, -53,  57, -18,-105,-111, -99, -39, -56, -94, -15, -13,  53;
/I:         I=-45; MD=-115;
/M: SY='I';  M=  22, -22,-107,-103,   4,-104, -10,  45, -36,  33,  -9, -48,-107, -98,-102,  17, -87,  23,-101,  22; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='D';  M=   2, -22,  31,  26, -50, -99,  24, -92,   2, -21, -91,  22,-100,  14,  29,   5,  -3,  22,-114, -95;
/M: SY='R';  M= -17,-107,  14,  -5, -49, -25,  29, -56,   8, -76, -94, -40,-100,  32,  61,   1,  23, -25,  36,  10;
/M: SY='H';  M=  -8, -32, -99,  -9,  38,-105,  54, -10, -64,  37, -79, -49,  35, -14, -58, -31,   3, -23, -98,  27;
/M: SY='R';  M= -17,-108,  -7, -14,  -9, -62, -88, -16,  20, -11, -90, -21,  -3,  55,  64,  -2, -17, -95,-104, -12;
/M: SY='Q';  M=   6,-104, -15, -14, -48, -27,  10, -99,  15, -12, -91,  10, -40,  47,  39,  16,  34, -56,-109, -34;
/I:         I=-2; MD=-4;
/M: SY='R';  M= -20,-124,   3, -30,-124, -12, -32,-123, -13, -44,-112, -53, -46,  15,  55,  19,-105,-119,-126,-113; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='P';  M=  -8, -26, -22, -39, -48, -44, -34,-126, -42,-129,-123,   9,  13,   6, -57, -20, -11, -42,  -3, -43; D=-2;
/I:         I=-2; DM=-4;
/M: SY='C';  M= -36,  35,-122,-119, -37, -34, -27,-112, -53,  -1,-110, -25,  26, -19,-122,  -9,   0, -29,-132, -49; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -39,-124, -20, -28,-117, -70,  -3, -13, -39, -54,  -6, -27,  63, -21, -36,  -1, -21, -10,-126, -39; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -23,  11, -32,  -8, -47,  -7,  26,-100,  16, -21, -94,   7,  63,  35,   0, -53,  18, -29,-113, -99; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M=  18, -19,  -8,  -6,-106,  23,  -4, -11, -25, -66, -27,  52,  17,  11, -28,   7, -88,   2,-115,-101; D=-2;
/I:         I=-2; DM=-4;
/M: SY='I';  M= -28, -30, -26,   2, -33,-106, -25,  39,  -7, -18, -86, -27,  21,  36,  28,  -2, -16,   3,  18, -43; D=-2;
/I:         I=-2; DM=-4;
/M: SY='H';  M= -55,-108, -90, -16,-102,-102,  65, -10,  13, -42, -91,  20, -42,  37,  51,   8,  22, -15,-112, -20; D=-2;
/I:         I=-2; DM=-4;
/M: SY='T';  M= -42,  16,-106,-104, -31,-109, -25,  23,-102,  33, -22, -98,-106,-101,-105,   7,  57,  45,-113, -92; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M= -35,-108, -98, -49, -97,-102,  16, -34,  41, -67, -93, -27,-103, -35,  41,  28,  14,  24,  96, -88; D=-2;
/I:         I=-2; DM=-4;
/M: SY='I';  M= -93,-104,-118,-113, -82,-120,-114,  69,-110,  35, -69,-112,-111,-108,-111,-104, -89,  69,-111, -91; D=-2;
/I:         I=-2; DM=-4;
/M: SY='H';  M= -23,  87, -95, -93,   9, -97,  90,-105, -94,-101, -95, -27, -28,  13, -96,  54,   7, -59,-116, -33; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M= -58,-103,-117,-110, -36,-118,-105,  32,-110,  79, -18,-114,-114,-105,-109,-107, -49,  11,-106, -87; D=-2;
/I:         I=-2; DM=-4;
/M: SY='F';  M=-108,-104,-120,-115, 120,-116,-101, -81,-110,  -5, -82,-110,-119,-120, -50,-107,-100, -86, -76, -54; D=-2;
/I:         I=-2; DM=-4;
/M: SY='A';  M=  84, -94, -97, -93,-106, -87,-102, -96, -94, -99, -94, -89, -97, -93,-100, -25,  69, -85,-112,-102; D=-2;
/I:         I=-2; DM=-4;
/M: SY='R';  M= -59,-115, -97, -85,-107,-110, -87, -20,   5, -55, -94, -90,-108, -75, 113, -94, -98,-103,-108, -95; D=-2;
/I:         I=-2; DM=-4;
/M: SY='A';  M=  71, -99, -95, -37,-110, -86, -99,-102, -92,-106, -98, -90,  51, -89, -47,  60, -24, -93,-112,-104; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Q';  M=  32,-111, -85,  35,-118, -97, -24,-108, -40,-104, -94, -86, -98, 113, -79, -19, -92,-104,-108, -97; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -21,-109,  31, -18,-114,  31, -93,-111, -28,-114,-104,  36,  65, -88,  17,  29, -22,-108,-115,-106; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Q';  M=  10,-114, -49, -26, -60, -99,  -5,-106, -76, -55, -90, -85,-100, 124, -36, -82, -94,-106,-106, -94; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Y';  M=-105,-116,-104,-107, -52,-111, -71, -90, -99, -87, -83,-106,-116, -94, -96,-100, -99, -95,  26, 137; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M=-100,-103,-118,-110, -74,-119,-102,  -4,-111,  90,   4,-116,-116,-104,-108,-110, -96, -72,  22, -86; D=-2;
/I:         I=-2; DM=-4;
/M: SY='F';  M=-108,-105,-119,-115, 121,-116,-100, -36, -39, -74, -84,-109,-118,-119,-106,-107,-100, -87, -74,  -2; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M=  -2,-118, -99, -89,-116, -98,-102, -62, -94,-113,-102, -49, 119, -97, -33, -11, -21,-106,-113,-113; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M= -30,-105,  14,  18, -47,  50, -15,-109,   5, -72,-102,  74,-101, -86, -92,   5, -33, -43,-116,-103; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M= -75, -97, -89, -90, -28, -83, -92,-106, -90,-109,-103, -78, -97, -82, -95, 110, -27, -99,-114, -97; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M=  41,-101, -27,  -6,-105, -33, -25,   2, -20, -99, -95, -41,  11, -88, -96,  69, -80,   6,-113,-100; D=-2;
/I:         I=-2; DM=-4;
/M: SY='E';  M= -34,-111,  32,  76,-112,-103,  -2,-109,  54, -48,-100,  -7, -95,  11, -27, -88, -41, -47,-114,-101; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M= -96,-103, -48, -93, -26, -25,   2, -38, -85,-108, -99, 114,-107, -23, -92, -54, -84, -30,  52,  -3; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M=  -9,-110, -92,  15,-110,  25,   2, -43,  37, -57, -22, -90,  70, -87, -44,  25, -27, -45,-111,-103; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='G';  M= -62,-108, -10,  -5,-109,  53,  25,-112,  40, -51,-100,  23,-100, -35,  23,  26, -53,-108,-111, -39; D=-2;
/I:         I=-2; DM=-4;
/M: SY='K';  M= -95,-110, -89, -75,-111,-103, -92,-109, 112,-110, -98, -81, -96, -73, -57, -90, -90, -43,-106, -98; D=-2;
/I:         I=-2; DM=-4;
/M: SY='H';  M= -99,-113, -89, -85,-103, -44, 133,-115,  27,-103, -90, -79,-103, -79,  36, -43, -43, -56,-125, -78; D=-2;
/I:         I=-2; DM=-4;
/M: SY='V';  M= -90,  -1,-110,-105, -42,-114,-112,  42, -24, -39, -78, -11,  21, -40, -56, -99, -87,  83,-115, -95; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M= -60, -20,-115,-108, -77, -31,-102,  10,-107,  84, -22,-112,-115, -41, -32,-107, -96, -50,-105, -88; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M= -42,-104,  70,  -7,-112,   5, -89,-111, -88,-113,-107,  48, -50, -85, -95,  63,   8,-106,-122,-103; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M= -93,-113, 101, -76,-119,  64, -92,-121, -93,-118,-113, -73,-101, -92,-101, -86, -94,-117,-123,-106; D=-2;
/I:         I=-2; DM=-4;
/M: SY='R';  M=  11,-108,  17,  18,-108, -11, -91, -37, -30, -61, -25,  -3, -42,  32,  59, -11,  11, -16,-113, -99; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Q';  M=  -5,-110, -23,  -8,-115,  58, -29,-110,  14,-108, -99, -32,-100,  80, -16, -30, -31, -41,-109,-101; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M=-100,-102,-117,-110, -74, -47,-102, -66,-111,  93, -62,-116,-117,-104,-108,-110, -96, -73,-104, -87; D=-2;
/I:         I=-2; DM=-4;
/M: SY='C';  M= -95,  61,-116,-111, -83,-118,-110,  56,-109,  50, -29,-110,-113, -39,-110,-104, -46,  47,-112, -92; D=-2;
/I:         I=-2; DM=-4;
/M: SY='K';  M= -12,-109, -49, -45,-110, -43, -22,-109,  84, -80, -98,   5,-100,   5,  52, -10, -90, -61,-109, -98; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M=-108,-133,-136,-113, -74,-107,-136,-104,-105,-103,-106,-129,-112,-105,-109,-115,-120, -46, 179, -61; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M=-109,-134,-135,-112, -74,-107,-134,-107,-103,-104,-107,-128,-112,-104, -33,-115,-121,-121, 179, -61; D=-2;
/I:         I=-2; DM=-4;
/M: SY='C';  M= -12,  77,-106, -98, -92, -51,  10,  32,  44,  24,  25, -98,-108, -94,   3, -97, -93, -10,  17, -93; D=-2;
/I:         I=-2; DM=-4;
/M: SY='R';  M=   7,-107,  -5, -84, -16, -15,   4,-109,  48,-107, -98, -39, -22, -12,  64,  31, -17,-103,-109, -96; D=-2;
/I:         I=-2; DM=-4;
/M: SY='V';  M= -23,  36,-113,-109, -86,-114,-112,  54,-107,   2, -75,-106,-109,-107,-109, -60,  13,  70,-112, -15; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M= -65,-104,-118,-111,  31,-118,-104,  44,-110,  66,  38,-113,-114,-106,-109,-107, -94,  11,-100, -28; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M= -42,-108,  92,  20,-114, -13, -22,-112, -88, -54,-107,  26, -99, -85, -95,  37, -31,-108,-125,-102; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -63,-113,  58,  -3,-114, -14, -91,-110,  36, -74, -26,   4,  67,   2,  13,  -6, -53,-109,-115,-104; D=-2;
/I:         I=-2; DM=-4;
/M: SY='V';  M=  13,-102,-111,-107, -86, -45,-109,  48,-106,  38, -74, -55, -29,-103,-108, -20, -27,  54,-111, -93; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M=  16, -25,-107,-103, -13,-106,-103,  21, -56,  41,  13, -43,-107, -98, -12,   4,  19,  27,  -8, -90; D=-2;
/I:         I=-2; DM=-4;
/M: SY='R';  M= -38,  11,  -3, -38, -99, -18, -33,  -1,  -5, -13, -17, -49,  -8,  -3,  41,  29, -17,  32, -16, -97; D=-2;
/I:         I=-2; DM=-4;
/M: SY='E';  M=  -3,-109,  48,  52,-110, -27,  24,-109, -17, -52,-100,   3, -29,  31, -21,  12,   7,-105,-116, -37; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M= -47,  36, -21, -43,   9, -28,  38,  -5, -37, -24, -89, -51, -49,  18, -27,  -2,  11,   9,  56,  48; D=-2;
/I:         I=-2; DM=-4;
/M: SY='F';  M=  13, -23, -16,  32,  45,  -4,  10,-105, -36, -61,-100, -97, -58, -42,  21, -33,  -1, -59,  -4,  -3; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M=   3,  -1,  45,   8, -51,-104,-100, -68,   0, -65,-108,  -6,  31, -17,  -8,  20,  -7,-109,-123,-109; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M=  -7,-116,  10,  25,-120, -44,  -4,-115, -60, -55,-109,  22,   3,   9, -29,  28,   8, -60,-127,-111; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M=  -8,-118, -12,   0,-121,  15,-105, -37,  -5,-119,-112,  27, -31,   1, -36,  15,   7, -74,-126, -58; D=-2;
/I:         I=-2; DM=-4;
/M: SY='H';  M= -19,-128, -20, -13,-128, -38,  34,-121, -12, -45, -42, -11, -20,  31, -58,  -6, -15, -46,-136,-117; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='W';  M=  21,-104, -47,-100, -44, -67,  -4, -10,-100, -23, -20, -96,  22, -99,-104,   4,  55,  32,  65, -16; D=-2;
/I:         I=-2; DM=-4;
/M: SY='K';  M= -93, -26,   4,  17,-110, -61,   9, -61,  60,-104, -25, -41, -98,  51,  36, -20,  31, -44,-112, -97; D=-2;
/I:         I=-2; DM=-4;
/M: SY='A';  M=  65,  49,-102, -97, -47,  26,  -2, -96, -12,   3,  22, -94,-104, -37,  -5, -33, -91, -91,-109, -99; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M= -50, -30,-103, -97,  54, -59,  26, -95,  41, -47,  -4, -97,-108, -92,  -3, -47, -10, -97,  84,  81; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Y';  M= -61,-107,-113,-109, -32, -46, -92,  -1,-106,  58,  12,-111,-114,-101,-104,-104, -97,   3,  61,  84; D=-2;
/I:         I=-2; DM=-4;
/M: SY='I';  M= -42,-105, -50,-100,   8,-112, -28,  40, -95,  38, -75, -26,-109,  19,  23, -45,  -5,  28,-104,   0; D=-2;
/I:         I=-2; DM=-4;
/M: SY='I';  M= -92,-104,-117,-112, -83,-119,-114,  71,-110,  26, -70,-110,-111,-108,-111, -38, -88,  69,-112, -91; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -45,-124,-100, -89,-119,-101,-103,-107, -96,-117,-103,-106, 128, -99,-108, -96, -92,-111,-112,-116; D=-2;
/I:         I=-2; DM=-4;
/M: SY='G';  M= -58,-109, -97,-109,-116, 104,-104,-123,-103,-119,-108, -83,-101,-100,-110, -42,-100,-116,-107,-111; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Y';  M=  -2,  40, -94,  42,  37,-105, -23, -23, -95,   7, -23, -98,-106, -46, -98,  20, -52, -90, -89,  74; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M= -47,-108,  87,  39,-115, -95, -88,-113, -86,-113,-108,  11,  -3, -22, -93,  45, -12,-108,-124,-103; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M= -42,-108,  17,  16, -49, -44, -90,-107,  31,-108,-100,  20,  34,  20,  28,  35,  14, -60,-112, -42; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Q';  M=   0,-109, -99,  13,  -4, -33,  21,  15, -24,  19, -32, -55,-107,  22,  -3,   0, -30, -18,-104,  22; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='E';  M= -27,-111,  -1,  81, -49,-105, -92, -64, -36, -62,-101, -16, -98,  -3,  12,  12,  -2, -16,-116,-103; D=-2;
/I:         I=-2; DM=-4;
/M: SY='T';  M=  24, -98, -99, -97, -49, -97,-100,  33, -60,  -9,  35, -40, -99, -93,-100,  48,  59,  -1,-111, -94; D=-2;
/I:         I=-2; DM=-4;
/M: SY='R';  M= -15,-107, -92,   5, -97,-104,  45, -52,  19,   8, -26, -36,-102,  -2,  77, -23,  -7, -15,-108, -19; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M=  25,-103, -46, -45,-106, -14,  30,-103,  34, -60, -95,   1,  14, -11,  39,  41,  12, -46,-111, -97; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Y';  M= -99,-106,-108,-106,  74, -56,  -6,   5, -57,  13,  13,-102,-111,-100, -15, -34,  -5, -33,  24,  82; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M= -54,-102,-112, -46,  51,-115,  -4,  44,-106,  61, -29,-107,-110,-104,-106,-102,  -6,  13, -99, -78; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -64,-114, -29, -14,-106, -20, -26, -47,   4, -52, -97, -25, 101, -40,  28,  -3, -46, -69,-107,  -3; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -11,-105,   3, -30,-103,  13, -92, -15,  16,  -4, -93,  35,  41, -34,  26,  35, -49, -56,-111, -99; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M=  17, -28, -27, -28, -45, -28,  14, -89, -89,   0, -35,   0,  32, -19,  11,  35,  30,  10,-111, -35; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M=   5,-104, -14,  -7,   0, -37, -24, -59,  24, -39, -94,  22,  35,  22,  16,  39,   2, -44,-108, -95; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Y';  M=  -1, -31,  13,  -1,   2, -60,  -3,-109,  -2, -52,-102,  24, -18,  -3,  14,  14, -10,-106,   8,  27; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M=  -7,-114,   9, -55, -33, -16,-103,-108, -32, -28, -29, -45,  44,  13, -42,  47,  -3, -61,-120,-107; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M= -48,-128,  30, -56,-126, -41, -30, -35, -24, -40,-116, -34, -22,  15,-114,  18, -21, -29,  -6,-119; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='P';  M=  -7,-128,-122,-121,-122, -55, -29, -19, -76, -12,-110,  -2,  19,-118, -23, -15,   1, -13,-138,-123; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M=   2,-109,   8, -90, -56, -11,  -5, -62,  -3, -29, -99,  73, -10,  15,  29,  -4, -90, -64,-119,-102; D=-2;
/I:         I=-2; DM=-4;
/M: SY='W';  M=-107,-132, -34,-110, -73,-105,-133,-105,-103,-103,-106,-125,-110,-103,-107,-113,-119,-120, 181, -59; D=-2;
/I:         I=-2; DM=-4;
/M: SY='T';  M= -46,-102, -92,  13, -11, -66, -11,  31,   7, -22, -85, -23, -99,  14,   2,  25,  52,  11,-108, -34; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Y';  M= -49, -23, -26, -53, -46,-107,  28,  23, -96, -17, -21,  14, -28,  11, -97, -51, -91,  33,  24,  93; D=-2;
/I:         I=-2; DM=-4;
/M: SY='G';  M= -80,-105, -44,-102,-111,  95, -99,-117, -98,-114,-105, -41, -99, -95,-105,  32,  -6,-110,-107, -43; D=-2;
/I:         I=-2; DM=-4;
/M: SY='H';  M= -99,-111,  50, -83, -95,-100, 123,-111, -90,-103, -92,  13, -13, -84, -90, -18,   5,-110,-115,  45; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -40,-115,-104, -96,-102,-105,-106,  56,-100, -91, -32,-104, 105,-101,-109, -23, -29,  -2,-111,-104; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Y';  M=-104,-107,-111,-109,  83,-114,  15, -47,-104,  28, -29,-107,-116,-103, -54,-103, -98, -38, -75,  92; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M= -38,-110,  25,  20,-111,   4,  28, -51, -21, -40,-103,  -7,-104, -35, -18,  52,  -4, -46,-120, -46; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='Q';  M=  -4,-113,   6,  16,-111,   6, -98, -60, -20, -14,-100,   7, -43,  48, -24,  17, -13, -47,  21,-104; D=-2;
/I:         I=-2; DM=-4;
/M: SY='I';  M= -29,-112,   8, -12,-103,-106,  14,  33, -18,  -3, -30,  24,  31, -38, -32,  16,  -6, -41,-119,-101; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M= -14,  23,  34,  -6,-106,  25, -93,-102, -32, -23, -97,   2,  23,  12, -94,  55,   4, -40,-114,-101; D=-2;
/I:         I=-2; DM=-4;
/M: SY='H';  M= -11,-103,  33,   3, -40, -40,  51, -19, -22, -66,  -9,  48, -12, -47, -20,  50,  -4, -30,-116, -94; D=-2;
/I:         I=-2; DM=-4;
/M: SY='S';  M=   1,-105,  45, -23,-101,  19,   6, -59, -17, -68, -99,   2,  40, -86, -48,  52, -31,-101,-107,  31; D=-2;
/I:         I=-2; DM=-4;
/M: SY='L';  M= -36,  36,  -4, -52,  14,-104, -97,   4,   1,  40, -81, -41,  35,  -8, -11,  10,  16, -51,-105, -46; D=-2;
/I:         I=-2; DM=-4;
/M: SY='A';  M=  70, -99, -17, -48,-107, -29,  -3,-102,  -5,-104, -96, -25,  32, -86,  -7,  42, -18, -93,-110, -48; D=-2;
/I:         I=-2; DM=-4;
/M: SY='V';  M=  24,   2,  13, -20, -44,-103,  -3,  19, -97,   6, -81, -96,  20, -96, -32, -25,  -2,  55,-113, -94; D=-2;
/I:         I=-2; DM=-4;
/M: SY='Y';  M= -94, -36, -12,   0,  33,  -4,   4, -59,  -5, -65, -92,  20,  52,   4, -16,   0,  -2, -66, -93,  64; D=-2;
/I:         I=-2; DM=-4;
/M: SY='N';  M= -33, -25,  23,   0,-107, -45,  -5,-100,  10, -46, -25,  48,  35,  26,  27,  14,  14, -19,-114, -98; D=-2;
/I:         I=-2; DM=-4;
/M: SY='R';  M=-114,  13, -56,-115,-116, -42, -42, -35,-108,  -5, -35, -31,  -9,  -4,  26,  -2, -35, -13,  10, -44; D=-2;
/I:         I=-2; MI=0; MD=-4; IM=0; DM=-4;
/M: SY='I';  M= -95,-107,-117,-114, -80,-120,-113, 101,-109,  -1,  33,-108,-107,-106,-112,-104, -89,  22,-106, -88; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -48,-123, -98, -87,-117, -99,-101,-105, -94,-115,-102,-105, 130, -98,-107, -94, -90,-110,-111,-115; D=-2;
/I:         I=-2; DM=-4;
/M: SY='H';  M= -30, -25, -98, -93, -89, -28,  65, -34, -36,  38, -28, -91,-105, -28,  58,  19,  -7, -19,-107,   4; D=-2;
/I:         I=-2; DM=-4;
/M: SY='F';  M=-106,-103,-117,-113, 116,-114, -95, -78,-109,  12, -79,-109,-117,-115,-106,-105, -98, -84, -73,  40; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -95,  -7,  21,  12,-116, -98, -97,-107, -91,-114,-103, -40, 118, -92,-102,  -4, -89,-110,-113,-111; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M= -99,-113, 123, -62,-120, -96, -85,-118, -86,-116,-115, -67, -98, -86, -95, -87, -89,-115,-135,-102; D=-2;
/I:         I=-2; DM=-4;
/M: SY='D';  M= -99,-113, 123, -62,-120, -96, -85,-118, -86,-116,-115, -67, -98, -86, -95, -87, -89,-115,-135,-102; D=-2;
/I:         I=-2; DM=-4;
/M: SY='P';  M= -15,-121, -98, -87,-117, -98,-101,-105, -94,-115,-101,-104, 128, -98,-107, -93, -90,-109,-111,-114; D=-2;
/I:         I=-2; DM=-4;
/M: SY='K';  M= -94,-108, -87, -73,-110,-102, -90,-108, 113,-108, -97, -80, -95, -72, -56, -89, -89, -42,-104, -97; D=-2;
/I:         I=-2; DM=-4;
/M: SY='A';  M=  62, -22, -92, -92,-105,  40, -97, -99, -92,-102, -95, -82, -95, -88, -97,  57,  46, -56,-109,-100;
/M: SY='R';  M= -97,-113, -93, -81,-106,-107, -82,-113, -20,-105, -94, -86,-105, -70, 121, -91, -95,-106,-106, -92;
/M: SY='F';  M= -45,-102,-116,-112, 122,-111, -95, -80,-107, -45, -81,-106,-115,-115,-105,-103, -97, -85,  19,  32;
/M: SY='L';  M= -95,   0,-113,-105, -38,-114, -98,  26,-101,  79,  58,-109,-111, -98,  -1,-104, -92, -11,-102, -84;
/M: SY='D';  M= -58, -25,  85,  56,-108, -20,  45, -62, -10, -41, -99, -10, -95,  11,  -1, -58, -89,-106,-116, -34;
/M: SY='E';  M= -91,-109,  40,  85, -47,-100,  80,-110, -50,-102,  -4, -79, -92,  39, -82,   8, -89,-106,-113, -36;
/M: SY='L';  M= -96, -99,-112,-106, -73,-115, -99,  20,-106,  88,  18, -38,-112,-100,-105,-104, -39, -20,-102, -84;
/M: SY='D';  M=  32,  -9,  56,  14, -51, -26, -94,  11, -89, -55, -26, -12, -99,  39, -94, -37, -28,  41,-113, -95;
/M: SY='E';  M= -55,-104,  34,  57, -96, -18,  -3, -60, -82, -41, -92, -15, -97,  -2,  14,  40, -84,  29,-106,  27;
/M: SY='E';  M= -60, -20,  46,  87,-111, -28, -86,-108, -78,-105,-101, -25, -90,  25, -86,  18,  29, -66,-114,-100;
/M: SY='N';  M=  25, -99,   3, -22, -20,  17, -19,  -3, -51, -29, -89,  60, -99, -88, -27, -10,  38,   6,-109, -19;
/M: SY='R';  M= -46,-106,  11,  16, -55,  -6,  45, -38, -75,-100,  10, -19,  14, -78,  70,  45, -25, -42,  -6, -92;
/I:         I=-5; MD=-12;
/M: SY='Y';  M=  15,-110,   8,  27, -97, -31,  -5,  19,   7, -28, -94,   9, -43, -44, -29, -27,   4, -64,-107,  37; D=-5;
/I:         I=-5; MI=0; MD=-12; IM=0; DM=-12;
/M: SY='K';  M= -26,-111,  -6,  12, -50,  -1,  39,-106,  39, -30, -32, -47,  29,  20, -30,   7,  10, -68,-112, -24; D=-5;
/I:         I=-5; DM=-12;
/M: SY='N';  M=  -9,-103,  39,  17,-107,   7, -90, -62,  32, -52, -97,  39, -38,  -6, -48,  33,  13, -15,-114,-100; D=-5;
/I:         I=-5; DM=-12;
/M: SY='M';  M= -33, -21, -37, -60, -33,  24,  14,  22,   4, -40,  44, -14,  -8, -94, -49, -51,  37,  42,-111, -93; D=-5;
/I:         I=-5; DM=-12;
/M: SY='W';  M= -53,-130, -13, -37,-118, -24, -33,-121, -12, -14, -44,  12,   0, -33,   3, -24, -24,-121,  59, -41; D=-5;
/I:         I=-5; DM=-12;
/M: SY='S';  M= -39,-129, -36, -57,-128, -71, -33, -16,  14,-127,-120, -33,  31, -53,-111,  42, -55,-119,  20,-120; D=-5;
/I:         I=-5; DM=-12;
/M: SY='P';  M= -82,-134,-118, -58,-131,  10,-122, -75,  14, -76, -44, -12,  37,-113, -18, -45,   0, -69,  16,-125; D=-5;
/I:         I=-5; MI=0; MD=-12; IM=0; DM=-12;
/M: SY='S';  M= -34,-127, -13, -46,-133,  -3, -23,-129,-117, -78,-126,  10,-126,-113,-123,  49, -33, -46,-143,-127; D=-5;
/I:         I=-5; DM=-12;
/M: SY='V';  M=-115,-131, -50, -50,-123,-131,-124, -43,  23,-112,   8,-119,  23, -38, -16, -34,-111,  38,-137,-122; D=-5;
/I:         I=-5; DM=-12;
/M: SY='R';  M=-113,-127,-120,-112,-120, -33,-118, -30,  28, -48, -14,-112, -50, -52,  34,-111,  12,  19,-132,-117; D=-5;
/I:         I=-5; DM=-12;
/M: SY='S';  M= -80,  -1,  22, -85,-103,  -6, -89,-100, -16,-104, -98,  28, -17, -31, -53,  80,  50, -41,-113, -36;
/M: SY='L';  M=  -9,-100,-107,-102, -81,-109,-102,  37,-101,  55,  27, -29,  13, -38, -53, -95,   7,  45,-107, -89;
/M: SY='D';  M= -23,-105,  77,  54,-110, -95,  15,-108,  29, -60,-100, -37, -93,  -5, -50,  28,   5,-103,-116, -97;
/M: SY='Q';  M= -15,-107,  13,  66,-110, -98, -25,-105,   6,-102,  -6, -14, -93,  81,   9, -14,  25,-101,-109, -96;
/M: SY='F';  M= -25,-101,-116,-111, 122,-110, -98, -79,-107, -72, -82,-105,-114,-115,-105, -41, -96, -36,  25,  -8;
/M: SY='W';  M= -27,-125,-127,-108, -71,-102,-121,-100,-101, -97,  13,-120,-108,-100,-104,-107, -35,-111, 176,  18;
/M: SY='E';  M= -46,-107,  12,  97,-106,-102, -86,  -4, -45, -65,  -3,  -6, -90, -11, -85, -17,   5, -27,-111, -99;
/M: SY='M';  M= -59,-106, -84,  68, -15,-105, -87,  -1, -76, -17,  80, -91, -26,  -8,  54, -35,   4, -47,-106, -90;
/M: SY='M';  M= -48, -99,-111,-104, -77,-108, -90, -16,-100,  60, 123, -25,-105, -93, -99,-101, -33, -71,-103, -82;
/M: SY='Q';  M=  49, -99, -90, -35,-109,  50, -93,-103, -88,-104, -96, -82, -41,  58, -92,  56,  -6, -63,-107,-100;
/M: SY='F';  M= -16,-104, -99,  27,  95, -18,  -4, -21, -97, -79,  -4, -24, -28, -97, -98, -95, -94, -26,   1,  62;
/M: SY='R';  M= -94,-111, -93, -83,-105,   2, -84,-110, -58, -51, -93, -86,-104, -36, 116, -45, -34,-105,-106, -93;
/M: SY='Q';  M= -88,-113, -84, -14,-117, -21, -79,-105, -71, -55, -88, -80, -96, 132, -27, -32, -91,-106,-103, -92;
/M: SY='E';  M= -90,-111, -19, 115,-114,-105, -83,-114, -31,-107,-103, -86, -86, -16, -80, -86, -90,-107,-110,-103;
/M: SY='C';  M= -95, 136,-111, -43,  81,-109,-105, -93,-106, -48, -90,-100,-118,-114,-110, -97, -93, -39,-100, -79;
/I:         I=-45; MD=-115;
/M: SY='S';  M= -22,  59, -33, -87,-103, -29, -91, -34,  21, -66, -94, -37,-101, -14,  57,  70, -80,  -7,-111, -97; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='S';  M=  41, -96, -14, -92, -91, -44, -23, -48, -94,  47,  -7, -88,-100, -35, -96,  72, -79, -83,-107, -92;
/M: SY='G';  M= -79,-105, -93, -41,-110,  99,-100,-111, -41,-111,-102, -81, -23, -94,-103,  16, -93, -20,-105,-106;
/M: SY='R';  M=  15,  14,  31, -20,-103, -98, -89, -10,  23, -97, -91,  27,-101, -38,  72, -15, -86,  19,-111, -96;
/M: SY='V';  M= -12,  28,-107,-103, -82, -50,-103,  19,-102,  51,  31,-100,-106,-100,-103, -24,  32,  52,-109, -89;
/M: SY='V';  M= -43, -95,-101, -99, -89,-105,-106, -62, -96, -42, -79, -94, -27, -99, -37, -12,  72,  85,-117, -93;
/M: SY='G';  M= -15,-104, -92, -41,-110,  96, -98,-114, -39, -53,-102, -80, -97, -92,-101,  32, -91,-107,-105,-105;
/M: SY='F';  M= -49,   0,-113, -38, 104,-112,-102,  14,-106, -11, -77,-105,-111,-110,-105, -41, -91,  41, -84, -62;
/M: SY='F';  M= -97,-104, -37, -37,  78,-114,-102,  76,-105,  19,  23,-104,-108,-104,-106, -41, -91, -31, -90, -27;
/M: SY='W';  M= -55, -25, -99,  -2, -43,  63,-106, -96, -36,-100, -97, -91,-100, -94,-100,   4,  19,  14, 127, -83;
/M: SY='C';  M= -27,  65,-109, -37, -82,-109,-105,  38,-103,  42,  33,-103,-108,-100,-105, -14, -34,  57,-110, -90;
/M: SY='V';  M=  -4, -19, -14,  31, -52, -32, -23, -20, -88, -42, -85,   0,-100, -36,   2,  39,  -9,  61,-112, -42;
/M: SY='F';  M= -34, -22,-103, -54,  63,  51,-100,  20, -56,  -2,  -5, -22,   1, -38, -53, -29, -91,  22, -96, -81;
/M: SY='D';  M= -87,-103,  41,  12, -99, -41,  34,  -7,   0, -70,   0,  20,  10,   1, -31,  40,  33, -12,-111,   0;
/I:         I=-19; MD=-49;
/M: SY='P';  M=  -7, -25,   2,  15, -23,  -2, -29, -61, -49, -30, -95,  -5,  44, -88,  12,  34,  15, -24,-107,  15; D=-19;
/I:         I=-19; MD=-49;
/M: SY='P';  M= -13,-106, -26,  11, -47, -33,   4, -45,  28, -56, -94, -39,  50,  -4,   8,  38,   4,  -4,-107,   2; D=-19;
/I:         I=-19; MD=-49;
/M: SY='Q';  M= -59,-113,  12,  24,-108, -11, -97, -27,  12, -13, -28, -17,   4,  25,   3,  16, -10, -26,-116, -37; D=-19;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='S';  M= -15,-114,  11,   0,-116, -49, -37, -27,  -5, -79,-106,  23, -26, -37,  15,  28,   8, -14,-126,-110; D=-19;
/I:         I=-19; DM=-49;
/M: SY='R';  M=  15,-108, -29, -14, -57,  15, -29, -24,  13, -35, -97, -19, -14, -88,  38,  33, -31, -43,-108,   9; D=-19;
/I:         I=-19; DM=-49;
/M: SY='P';  M=  -6,-109,  23,  43,-107, -96,  13, -24, -15, -66, -34,   6,  80,  26, -59,   5, -32, -39,-110, -41;
/M: SY='S';  M=  23,  20,  -3,  -8, -47,  17, -29, -42, -20, -23, -36,  11,  -8,   8, -92,  45,  36, -38,-110, -97;
/M: SY='T';  M=  38, -98, -45,  -7, -31, -11,  -7,   4, -35, -20, -87, -13, -25,  -2, -94,  38,  44, -10,-105,   9;
/M: SY='S';  M=  20,   0, -28,  31,  -6,  -8,   1,  -2, -13, -27, -89, -25, -13, -38,   5,  38,  17, -10,-107, -40;
/M: SY='P';  M=  -2,-107,  -7,  26,-105, -21, -92, -24,  36, -55, -12, -26,  71,  -2,  11,  12, -58,  -5,-109,-100;
/M: SY='S';  M=   9, -28,  25,  12, -99,  23,  -5, -94, -20,   4, -14,   4,  13, -21, -35,  34,  13, -28,-109, -33;
/M: SY='S';  M= -12,-102,   9,  24,-105, -12, -23, -59,  17, -49, -18,  39,  25,   7, -40,  45,  27, -38,-112, -98;
/I:         I=-12; MD=-31;
/M: SY='P';  M= -36,-127, -51, -11, -26,   0, -10,-117, -25, -27,-113, -27,  18,  14,-113, -24,   5, -42,-128, -40; D=-12;
/I:         I=-12; MI=0; MD=-31; IM=0; DM=-31;
/M: SY='Q';  M=  -3,-103,  15,  40, -47, -23, -22, -19, -14,-100, -94,   6,  -4,  42,   2,  40,  34, -43,-110, -96;
/M: SY='D';  M=   4,-106,  59,  13,-109,  26,  -7, -68,   9,-104, -25, -34,  53, -18, -17, -55,  16, -18,-113,-100;
/M: SY='T';  M= -17, -26, -33, -15, -89, -19, -27,  32, -32,  32, -22, -50, -27,  10, -97,   5,  43,  27,-109, -92;
/M: SY='V';  M= -39,-100, -46, -14,  -3, -43, -29,  26, -41,  18,  10,  33, -21,  18, -95,  13,   9,  39,-107, -39;
/M: SY='V';  M=  18,  11, -55, -29, -43, -46, -29,  25, -52,   2,  -2, -22, -42, -93, -32,  26,  35,  45,-110, -92;
/M: SY='P';  M=   7,  -4, -90, -21, -49, -36, -94,-101,   0, -74, -97, -22,  92,  -2, -49,  50,   7, -60,-109,-102;
/M: SY='S';  M=   1,-102, -17,  -6, -95, -30,   6,  14,  20, -18, -87, -19,   7,  21,  10,  33,  21,  -7,-105,   6;
/M: SY='S';  M=   9,-103,  20,   8,-107, -23, -15, -38,  45,-102, -26, -11, -30,  33,  17,  54, -48, -42,-109, -96;
/I:         I=-29; MD=-75;
/M: SY='P';  M= -19,-132, -31, -29,-129, -75, -30, -40,  10, -81,  10, -51,  28, -29,  14, -16, -65, -42,-134,-122; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='Q';  M= -41,-104,  20,  24, -98, -43, -24,  -2,  10,  -4, -88,  25, -30,  59, -35,  32,  -3,  -7,-108, -15;
/M: SY='Y';  M= -23,-104,  -3, -10,  66, -44, -22, -39,  13,  -3,   3, -45, -28,  -9, -16,  -4, -43, -36, -84,  71;
/M: SY='K';  M= -21,-104,  -9,  17,-102, -44,   0, -42,  45, -11, -90,  37,  -1,  23,  41,  -6,  15, -38,-109, -95;
/M: SY='Q';  M=   7, -29, -38,  -2, -21, -29,   7,  -2,  10, -94, -23,  16,  25,  30,  24,  19, -18,   9,-104,  15;
/M: SY='I';  M= -37,-100, -50, -59,  22, -34,-101,  50, -36,  31,  18, -46, -13, -97,-101,   6,  27,  29,-103, -85;
/M: SY='K';  M=   7,-103, -19, -87, -52, -28, -23,   8,  46,  -6,  30, -42,   3, -15,   7,  11,  18, -41,  38,  17;
/M: SY='N';  M=   9,-102,  23,  15,-104, -40,  13, -99,   7, -10, -27,  55,  34,   8, -34,  32,   0, -97,-113, -97;
/M: SY='Y';  M=   8,-102, -55, -25, -40,-100, -24, -27,  14,  33, -18,   1,   6,  15, -45,  -3,  13, -13, -94,  62;
/M: SY='I';  M= -21,-102, -31, -54,  -7, -48, -12,  56, -50,  34,  42, -98,   0, -96, -19,  -5, -10,  15,  23, -85;
/M: SY='T';  M= -43, -99, -13, -14, -31,-101, -25, -29,  33,  15,  32, -85,  17, -87, -50, -18,  81, -37,-109, -92;
/M: SY='G';  M=  26,-102, -16,   4,-107,  54, -24,-106,   8, -53, -97,   9, -13,   8,  -2,  30,   4, -99,-108,-100;
/M: SY='E';  M=  16,   5, -48,  65, -49,-100,  44, -33, -21,  -1,  -3, -44, -53,  -3,   8,  -6,  10, -13,-108, -32;
/M: SY='D';  M= -46,-107,  79,  55,-111, -95, -34, -68, -12, -68,-102,  15,  39,  -1, -88,  18,  -6,-104,-117,-100;
/M: SY='F';  M= -37,-105, -46,-100,  82, -47, -88, -27, -96, -20, -83, -97,  26, -21, -18, -16,  17, -59,   7,  79;
/M: SY='S';  M=   1,  20,  46, -45, -61, -12,  44,-105, -56,-105, -98,   3,  -8,  -1,  18,  68, -15, -56,-115, -95;
/M: SY='T';  M= -43, -98,  11, -85, -99, -61, -89, -19,  20,  -9, -89,  51, -54, -31,   1,  48,  57, -14,-113, -95;
/M: SY='E';  M=   1,-103, -17,  43, -44, -99, -94,  24,  -6,  -9,  -9, -26,  18,  19, -28,  30, -31,  16,  13, -93;
/M: SY='E';  M= -28,-104,   9,  75, -46, -23, -28, -57, -56, -14, -94,   1,  12, -36, -38,  42,   2, -38,-111, -97;
/M: SY='D';  M=  25,-103,  48, -16,-105,  39,  13, -16,  -7, -29, -94,   0, -31, -37,  22,  19, -50, -55,-111, -97;
/M: SY='A';  M=  66,   0, -99, -95, -50, -62,-102,  29, -95, -51, -83, -32, -26, -50, -57,   6,  27,  38,-109, -95;
/M: SY='S';  M=   2,-101, -51, -36, -52, -97,  14, -10,  23,   4,  -8, -20,   7,  27,  -2,  37,  23,  12,-107, -18;
/M: SY='E';  M=   7,-104, -10,  57,-104, -10, -23,-102, -22, -54, -96, -38,  11,  11,  13,  47,  10, -43,  22, -38;
/M: SY='S';  M=  52, -96, -92,  -1,  17, -34, -93, -58, -54,  14, -30, -43, -58, -44, -11,  61,  -3, -86,-104, -90;
/M: SY='T';  M=  -1, -98,  12, -91, -15, -39,  20, -25, -61, -43, -87, -16, -48, -90, -95,  30,  73,  11, -15,  47;
/M: SY='T';  M=  -5,-103, -24,  29,-100,  -3, -15, -96, -15, -12, -40,  -6,   7,  34,  25,  21,  44, -43,  -8, -16;
/M: SY='N';  M= -20,-100,  -3, -11, -47, -55, -27, -18,   5, -22, -90,  61, -31, -13,  24,  17,  55, -27,-111, -35;
/I:         I=-7; MD=-18;
/M: SY='W';  M=  -6,-114, -55, -22,  -7, -46, -34, -97, -26,   8, -31,  -2,   2,-101,  -2, -27,  25, -15,  71, -35; D=-7;
/I:         I=-7; MD=-18;
/M: SY='S';  M= -22,-118, -59,  13, -45, -72,-110, -11,  -3,  11, -99, -46,  18,-101, -40,  24, -17, -29,-123,-109; D=-7;
/I:         I=-7; MD=-18;
/M: SY='P';  M= -38,-132, -53,  -1,-136, -44, -34,-129,  -5,-131,-123,-110,  36,  26, -64,  11,  -1, -67,-136,-126; D=-7;
/I:         I=-7; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='R';  M= -73, -40,-125, -43, -37, -30, -24, -13,  -7,  -6,-111, -56, -54, -40,  13, -37, -33, -36,-133, -49; D=-7;
/I:         I=-7; DM=-18;
/M: SY='K';  M= -64, -25,  -3, -29, -62, -47,-113,  -6,  20, -21,-108,  -5,   0,   5, -35,-109,  -8, -28,-127, -25; D=-7;
/I:         I=-7; DM=-18;
/M: SY='H';  M= -31,-120,-103,   1,-119,  16,  28,  -7,  -9,-115,-108,  -8,  10, -34, -15,  13,  10, -50,-126,-112; D=-7;
/I:         I=-7; DM=-18;
/M: SY='L';  M=  -9,-101, -53, -16, -29, -33, -96,  25,  18,  39, -23,   2,  -6,  -6, -54, -17,   6,  25,-105, -33;
/M: SY='R';  M= -61,   1, -18,   1, -45,-103,  13,  11,  48,  -1, -31,  -8, -43,  -4,  52, -16,  -2,   0,  18, -90;
/M: SY='D';  M=   3,-106,  79,  -1, -45, -18,  -3, -55,   1,-105,-100,  18,  34,   5, -25,  -4,   4, -45,-116, -98;
/M: SY='Y';  M= -27,  -4, -26,   3,  43, -24, -88, -19,  30,  -3,  28, -41,   4,  -8,  -5,   2, -23, -44, -91,  55;
/M: SY='L';  M=  -8,  12, -29,  -7,  45, -44, -25, -27, -58,  51,  44, -25,-106,  -1, -50, -55,  -2,   3, -99, -40;
/M: SY='W';  M= -58, -23, -22,  -9,   8, -18, -10,  15,  -7,  27, -26, -41,  22,  -1,   6, -25, -30,  20,  46,  12;
/M: SY='R';  M= -15,-107,  10,  22,-103,  -7,   1, -39,  31, -13, -41, -37,  -6,  -2,  40,  28, -31, -41, -13, -41;
/M: SY='R';  M= -95,-111, -31, -15,-105, -65,   7, -64,  36, -60, -94,   6, -47, -19,  92, -34, -11, -26,-109, -43;
/I:         I=-12; MD=-31;
/M: SY='P';  M= -18, -25,  -6,  -9, -34, -25,-116,   4, -12, -38,   0, -50,  14, -40, -58, -21,  -9, -25,-128,-114; D=-12;
/I:         I=-12; MD=-31;
/M: SY='G';  M= -24,-133, -58, -41, -62,  19, -50, -15, -58, -76,-117, -24,  10, -42, -62,-114, -34,  -1,-135, -41; D=-12;
/I:         I=-12; MI=0; MD=-31; IM=0; DM=-31;
/M: SY='C';  M= -38,  16, -14, -13, -53, -47,-118, -33, -12,  -2, -28,   1,  10,-113, -36, -35, -35, -62,-134,-120; D=-12;
/I:         I=-12; DM=-31;
/M: SY='H';  M= -30,-106, -98, -15, -29, -43,  36,  20,   7,  16,  34, -18, -44,  13,  -7, -13, -14,   8,  27,  30;
/M: SY='N';  M=   7,-105, -31, -15, -44,  27,  36, -65,  31, -57, -96,  38,  15, -18, -22,  17, -25, -16,   3, -38;
/M: SY='V';  M=  -4,  -6, -47,  -9,  13,-105, -98, -39,   3,   4,  24, -19,   1, -33,  13, -21,  23,  45,-108, -91;
/M: SY='D';  M= -45, -19,  80,  14,-111, -15,  15, -45, -15,-109,-104,  19,  13, -42, -18,  21, -88, -25,  -1,-100;
/M: SY='Y';  M=   0,-105,  13, -54,  18, -62, -37,  30, -54,  19,  39, -42,-106,  15, -51, -93,  11,   1, -98,  41;
/M: SY='P';  M= -11, -25,   5,  30, -49, -26, -24, -31,  -7,  -2, -93,   4,  51,  27, -14,   5,   6, -44,-112, -99;
/M: SY='S';  M= -47,  10, -20,   0,-106,  -3, -94,-100,  16, -27, -35,  -6,  25,   3,  10,  50,  31, -27,-113,-100;
/M: SY='I';  M=  10,-103, -60, -60, -28, -42,-102,  44, -27,  34, -22,-101, -25, -43,-102, -10,  -8,  27,-103,  20;
/M: SY='E';  M=   5, -37,  26,  38,-104, -17, -95, -14,  16, -29, -93, -18, -25, -39,  17,  11, -10,  15,-114,-100;
/M: SY='G';  M=  15,-107, -15,  -4,-111,  59, -25,-107,  29, -56, -33, -17,  20,  -1, -29, -14, -21, -46,-110,-103;
/M: SY='T';  M=  27,   1, -27, -25,  -5, -41, -94, -97,  32, -36, -94,  10, -45,   0,  23,  -3,  35, -26,  27, -15;
/M: SY='W';  M=  -6, -32,   1,   6,-102,  11, -13, -14,  16, -60,  19,   7,-101, -13,  34,  19, -11, -19,  47, -50;
/M: SY='T';  M= -35,-104, -10,  26,-107, -29, -40, -44,  22, -58, -97,  11,  26,   4, -26,  41,  52, -59,-114,-101;
/M: SY='T';  M=   2,-105,  15,  -8, -62, -29,  -9,-102,  16, -52, -33,  -3,   0,  17,  26,  29,  40, -48,-113, -41;
/I:         E1=0; IE=-380; DE=-380;
» more

Post-processing [info]

COMPETES_HIT_WITH PS51726; PS51727

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2020_04 which contains 563'082 sequence entries.


Total number of hits 3 in 3 different sequences
Number of true positive hits 3 in 3 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] Rtt109-type HAT
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
3 sequences

RT109_CANAL (Q5AAJ8    ), RT109_SCHPO (Q9Y7Y5    ), RT109_YEAST (Q07794    )

			
		
PDB
[Detailed view]
9 PDB

2RIM; 2ZFN; 3CZ7; 3Q33; 3Q35; 3Q66; 3Q68; 3QM0; 6O22

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission