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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01064


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01064
General rule information [?]

Accession PRU01064
Dates 20-SEP-2016 (Created)
03-SEP-2024 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51728; RTT109_HAT
Name Rtt109-type histone acetyltransferase (HAT) domain
Function Rtt109, also known as KAT11, is a recently characterized fungal- specific HAT that modifies histone H3 lysine 56 (H3K56) to promote genome stability and resistance to a variety of DNA-damaging agents.
Scope(s) Eukaryota
Ascomycota
Example(s) Q5AAJ8;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=2.3.1.48;

Comments [?]

CATALYTIC ACTIVITY Reaction=L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+); Xref=Rhea:RHEA:45948, Rhea:RHEA-COMP:9752, Rhea:RHEA-COMP:10731, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:61930; EC=2.3.1.48;
SIMILARITYBelongs to the RTT109 family.

Keywords [?]

DNA damage

Features [?]

From: PS51728
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Rtt109-type HAT #"

Additional information [?]

Size range 336-413 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]