PROSITE entry PS51776

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General information about the entry

Entry name [info]	RH1
Accession [info]	PS51776
Entry type [info]	MATRIX
Date [info]	01-OCT-2015 CREATED; 13-FEB-2019 DATA UPDATE; 08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC51776
Associated ProRule [info]	PRU01112

Name and characterization of the entry

Description [info]

RH1 domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=89;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=84;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6321311; R2=0.0054875; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=12700.2861328; R2=4.7751842; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1434; H_SCORE=19548; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=705; H_SCORE=16067; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-33; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='S';  M= -46, -34, -31,  18, -24,  -8, -91, -34, -30, -19,  10, -18,   6, -18,  17,  19, -25, -40,-106, -38;
/M: SY='W';  M=  22,-100,  11,  16, -28,  -5, -17, -42, -48, -40,   6,   1, -18, -34, -55,   5, -26, -26,  44, -42;
/M: SY='M';  M=  -1, -15, -45,  22, -28,  10,  -1, -25, -42, -35,  30, -19,  -6, -10,   4, -15, -26, -11,   0, -12;
/M: SY='S';  M= -35, -98,   0,  14,  -9,  14, -88, -36, -82, -44, -89, -15,  -2, -35,   4,  40,   7, -11,-103, -38;
/M: SY='C';  M=  10,  38,   0,  -8, -21, -38, -91, -81, -54,   8,  23, -85,  -2, -40, -93,  35, -11,  -2,-105, -89;
/M: SY='W';  M= -20, -97,  18,   5,   4,  -4,  -5, -28, -86,  19,  38, -85, -50, -84, -10,  13, -45,  -5,  41, -80;
/M: SY='D';  M= -62,   4,  54,  42, -96, -23, -24, -90, -47, -67,  45,   6, -39, -12, -10,  22,  -9, -24,-107, -43;
/M: SY='D';  M=   6, -94,  48, -22, -39, -54, -26, -94,  31, -96, -90,   7, -13, -74,  10,  31,  22, -43,-104, -34;
/M: SY='P';  M=  -9,  28,  27, -15, -50,  -5,   3, -21, -47, -89,  15,  -8,  45, -79, -19,  23,  15, -41, -99,  15;
/M: SY='S';  M=   4, -22,  12,  -2,  15,  14, -82, -20,  -9, -65,   5,  22,  30, -77, -28,  31, -21, -27, -95, -23;
/M: SY='S';  M=  -4,   9, -53,  26, -17,  -7, -30, -37, -35,   5, -28, -15, -23, -42, -28,  55,  10, -29,   7, -83;
/M: SY='H';  M=  14, -23,  22,  29, -14,   2,  45, -29, -51, -61, -29,  24, -11,  35, -26,  -3,   5, -51,-100, -82;
/M: SY='L';  M= -53, -23, -23,   5, -41, -61, -86,  16, -86,  52,  38, -89,  12, -11, -41, -43,   4,  11, -94, -20;
/M: SY='T';  M= -14, -87, -36, -34, -80, -50, -16, -25, -35,  -3,  55,  10, -87, -77, -44,  38,  63,  -3, -98,   1;
/M: SY='V';  M=  -3, -87, -10, -49, -85, -84, -88, -62, -82, -30, -75,   9,  14, -81, -33,  56, -17,  64,-105, -85;
/M: SY='E';  M= -28, -94,  33,  66, -91, -34, -80, -51, -40, -44,  16, -11,  17, -15, -80, -22,  -1,  31,-102, -43;
/M: SY='D';  M= -86, -98,  89, -18, -31, -43,  15, -30,   4, -15, -30,  15, -90, -71,  42, -78, -79, -91,-107, -83;
/M: SY='V';  M= -73, -86,-103, -97, -73,-104,-105,  -6, -95, -31, -62, -98, -99, -97, -96, -87, -71, 102,-107, -81;
/M: SY='Y';  M= -56,-100, -85, -35, -19, -92,   6, -16, -77, -78, -73, -83, -96,  53, -13,   8, -48, -82,  15, 113;
/M: SY='D';  M=   1, -96,  69,  45, -53,  -1,  24,-100, -31, -98, -91,  42, -85,  10,  -4, -21, -48, -95,-106, -87;
/M: SY='L';  M= -40, -91,-101, -46, -29,-103, -89,  60, -93,  63,  57, -96, -97, -51, -93, -91, -34, -27, -17, -30;
/M: SY='A';  M=  93, -81, -86, -79, -30, -70, -88, -83, -82, -86, -81, -79, -86, -78, -86,  23, -28, -40, -95, -88;
/M: SY='S';  M=  16, -90, -28, -29, -86,  32,   6, -86,   4, -34, -81,   8, -87,  29, -78,  45,   8, -21, -92,  23;
/M: SY='D';  M=  11,  19,  38,  26, -86, -35,  -9,   0, -48,   0, -76,   3, -88, -36, -38,  26, -23,  22,-103, -85;
/M: SY='I';  M= -82, -92,-104,-100,   3,-107, -98,  83, -97,  26,  27, -97, -96, -94, -98, -92, -77,  43, -92, -73;
/M: SY='Y';  M= -16,   5, -29, -90, -36,  75, -74, -92, -84, -89, -83,  -3, -92, -82, -36, -37, -83, -91, -72,  89;
/M: SY='K';  M=  21,   5, -25, -69, -39, -16,  19, -48,  50, -90, -82,  -8, -85,  43,  31,  14,  28, -85, -96, -82;
/M: SY='E';  M= -79, -99,  42, 102,-103, -26, -72,-102, -63, -96, -92, -71, -77,  19, -72, -74, -34, -96,-101, -91;
/M: SY='F';  M= -88,  12,-105, -99,  93,-103, -88,  -9, -97,  56, -19, -98,-103, -98, -95, -93, -83, -10, -74, -53;
/M: SY='E';  M= -79, -98, -11,  97, -98, -92, -72, -95,   2, -27, -24, -74, -78,  46, -14, -36, -31, -91, -97, -88;
/M: SY='R';  M=  -9, -94, -41,  -3, -92, -35, -78, -25,  62, -46, -80, -72, -29, -19,  63,  18, -13, -15, -95, -84;
/M: SY='L';  M= -50, -89,-103, -96, -64,-103, -90,  57, -95,  67,  58, -98, -98, -89, -94, -92, -79,  14, -92, -73;
/M: SY='I';  M=  -6, -91, -96, -93, -73, -58, -96,  84, -88, -26,   2, -87, -91, -87, -16,   9,   7,  33, -96, -78;
/M: SY='D';  M=   9, -94,  69,  28,-100,  16,   5,-100, -29, -97, -90,  33, -85,  -8,  33,   5, -75, -94,-104, -87;
/M: SY='R';  M=  15, -20,   9,   9, -90, -31, -21, -20,  16, -29, -12,  -9, -87,  25,  52, -19,  13,   0, -98, -83;
/I:         I=-18; MD=-45;
/M: SY='Y';  M= -60,   1, -90, -91,  68, -32,  67, -81, -87, -75, -74, -24, -33, -29, -85, -52, -86, -84, -63, 101; D=-18;
/I:         I=-18; MD=-45;
/M: SY='G';  M= -72, -97, -12, -43,-101,  93, -88,-107, -84, -68, -93, -14, -89, -83,  -3, -31, -17,-101, -97, -96; D=-18;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='P';  M= -20,  10, -42,  36, -94,  -9, -12,  -1,  18, -59, -27,  27,  50,   3, -10,   5, -15, -30,-100, -89; D=-18;
/I:         I=-18; DM=-45;
/M: SY='D';  M=  -7, -96,  71,  66, -40,  21, -76, -99, -47, -64, -91, -41,  -2,  -9, -79,  -2, -77, -94,-101, -46;
/M: SY='A';  M=  56,  -2, -83, -20, -11, -46, -85,   1, -40, -45, -76,  -8,  21, -19, -45,  33, -21,  18, -95, -35;
/M: SY='V';  M=  11, -87,-100, -94,  28, -98, -97,  34, -93,   1, -61, -95, -36, -93, -94, -84, -73,  80, -93, -23;
/M: SY='Q';  M=   8, -22,  21,  23, -92, -20,  26, -26,   5, -25, -79,   0, -85,  43, -10,  25,  23, -25,-100, -83;
/M: SY='G';  M= -45, -93,  23,  30, -97,  60, -77, -99, -47, -97, -88,  21, -17,   0,  38,   7,  15, -93, -98, -89;
/M: SY='L';  M= -50, -88, -34, -93, -25,-102, -89,  23, -94,  83, -50, -98, -99, -89, -93, -92, -79,  10,  27, -70;
/M: SY='M';  M= -46, -87, -96, -87, -72, -37, -81,  18, -84, -10, 115, -87, -90,  32, -84, -83, -21,  52, -95, -73;
/M: SY='P';  M= -49,-100, -35, -32,  28, -58, -32, -88, -34, -92, -84, -33, 111, -42, -87,  16,  -7, -90, -91, -35;
/M: SY='K';  M= -81, -93,  -8, -71,  -4, -92,   0,  14,  69,  34, -21, -41,  13,  12,   1, -40, -36, -46, -90, -75;
/M: SY='V';  M= -74, -86, -99, -95, -30,-101, -97,  53, -92,   3,  25, -30, -95, -92, -94, -85, -18,  84, -98, -76;
/M: SY='V';  M= -33, -88, -98, -38, -71, -39,-101,  66, -92, -27, -58, -93, -94, -92, -95, -84, -71,  85, -99, -78;
/M: SY='R';  M= -33, -92, -27, -31, -44,  -7,   2, -92,   7, -65, -82,  46, -88, -18,  79,  23,   8, -57,   9, -30;
/M: SY='V';  M=  47, -17, -93, -88, -76, -88, -95,  30, -87, -21,  -7, -87, -90, -87, -91, -73,  27,  72, -99, -81;
/M: SY='L';  M= -84, -87,-101, -94, -19, -40, -85, -51, -95,  91,   8, -99, -28, -88, -92, -93, -81, -59, -88, -70;
/M: SY='E';  M= -41, -97, -11, 111,-101, -91, -70,-101, -60, -94, -90,   3, -74, -21, -69, -73, -77, -94, -99, -91;
/M: SY='M';  M= -77,   2, -77,  24, -76, -49,  30, -32, -22,  43,  54,  22, -88,  32, -77,  17,  15, -72, -94, -16;
/M: SY='L';  M= -84, -87, -26, -92, -25,-102, -85, -50, -94,  90,  33, -98,-100, -87, -92, -93, -80, -16, -89, -70;
/M: SY='E';  M= -47, -97,  70,  94, -99, -89,   4, -97, -64, -51, -89, -67, -78, -27, -73, -27, -76, -44,-103, -87;
/M: SY='S';  M=  37, -87, -11,  29, -44, -22, -80,   1,  -8, -27, -20, -17, -83,  24, -39,  45,  10, -13, -96, -83;
/M: SY='F';  M=  23,  36, -92, -45,  49, -90, -83, -62, -87,  47,  25, -87, -94,  -7, -87,   3, -10,  10, -84,   5;
/M: SY='Y';  M=  46,  36, -86, -39, -38, -85,  45, -17, -42, -12, -69, -81, -90, -80, -32, -11,  15,  43, -89,  46;
/M: SY='S';  M=  16,  18, -31,  -5, -89,   3, -79, -50,  31, -34, -27,  32, -85, -10, -12,  45,  -4,  14, -98, -85;
/M: SY='R';  M= -44, -97,  26,  52, -91,  -6, -21, -55,  20, -22, -81, -46, -10,  46,  56, -25, -78, -89, -93,  -6;
/I:         I=-19; MD=-47;
/M: SY='N';  M= -22, -18, -26, -77, -55, -53, -13, -13,  11, -25, -82,  75, -35, -13,  48,  10, -75, -35,-102, -32; D=-19;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='E';  M= -21, -98,  47,  52,-100, -21,   1, -47, -41, -55, -87,  12,   7,  45,  20,   4, -78, -57,-103, -88; D=-19;
/I:         I=-19; DM=-47;
/M: SY='E';  M=  -5, -25,  10,  50, -95,  -3,  24, -34,   0, -93, -85, -25, -43,  22,  45,  22, -21, -89, -98, -34; D=-19;
/I:         I=-19; DM=-47;
/M: SY='L';  M=  -6,   7, -24,  41, -72, -57,  -6,   8, -25,  52, -64, -35, -17,   9, -27,  -8, -77, -69, -89,  22;
/M: SY='Q';  M= -25, -28,  21,  21, -89, -25,  12, -30,  20,   1, -77,  38, -43,  47,  19,   9,   2, -50, -98, -82;
/M: SY='C';  M=   4,  40,   1,  23, -83, -35, -82,  -9, -25,   3,   0,   6, -39,  18, -31, -14,  34,  31,-100, -83;
/M: SY='E';  M= -21, -93,  17,  87, -94, -87,  10, -91,   0, -21, -83, -26, -78,   3, -40,  -4,  30, -86, -99, -85;
/M: SY='L';  M=  -5, -89, -89,  -1,  -5, -95, -84,  24, -78,  47,  15, -33, -93,  -4,  28, -45, -76,  40, -91, -29;
/M: SY='E';  M= -34, -31,  39,  72, -48, -32, -10, -41,  -1, -63,   6,  15, -35,  26,  -9, -14,   5, -48, -99, -84;
/M: SY='E';  M= -38, -94,   5,  58, -87, -46, -74, -53, -33,  19,  13, -18, -29,  55,  44, -26, -12, -54, -95, -82;
/M: SY='L';  M= -31, -25, -93, -12,  -9, -97, -21, -18, -42,  81, -52, -92, -97, -23, -87,  -4, -77, -19, -89, -72;
/M: SY='R';  M= -32, -94, -16, -16, -89, -89, -74, -16,  55,  -3, -75, -72, -87,  49,  70,  -1, -22, -42, -93, -80;
/M: SY='E';  M=  36, -90,  27,  37,   2, -36,  36, -49,   7,  -8,   9,   9, -85,  -1,   4, -45, -18, -26, -95, -78;
/M: SY='E';  M=  -6, -94,  60,  67, -25, -85, -73, -44,   6, -61, -85,  15, -81,  26,  -7, -33,   3, -58,   2, -83;
/M: SY='N';  M= -52, -90, -80, -27, -45, -26,  34,  32,  16,  18, -67,  41, -90,   1,  28, -19, -35,  30, -97, -77;
/M: SY='E';  M=   3, -93,  19,  57, -36, -53,  -7, -88,  18, -20, -21,  16, -83,  42,  17, -19,  -1, -61,  -6, -14;
/M: SY='Q';  M= -38,  -6, -10, -10, -91, -54,  52, -56, -21, -14,  10,  -6, -37,  80,  56,   8, -20, -86, -96, -77;
/M: SY='L';  M= -14, -88, -47, -90, -62, -51, -86,   4, -91,  84,  -6, -95, -98, -14, -59, -50, -79, -31,  10, -72;
/M: SY='E';  M= -22, -19, -73,  52, -15, -89, -25, -18,  11,  12, -28, -76, -29,  43,  21,  18,  -3, -18, -91, -18;
/M: SY='R';  M=   6, -23, -14,  26, -15, -37, -31, -32,  -9,   0,  -3,   7, -86,  -3,  34,  34,  19, -45,   1, -10;
/M: SY='Q';  M= -55, -99,  38,  68, -99, -88,   6, -95,   6, -63, -38, -38, -15,  80,   4, -24, -78, -62,  -3, -83;
/M: SY='Y';  M= -82,   2, -82, -54,   3, -39, -18, -57,  52,  11, -11,  -2,  -2,  -8,  21, -18,  -6, -42, -78,  68;
/M: SY='E';  M= -51, -14,   0,  69, -92, -22, -29, -32,   7, -29,   7, -17,  19,  25, -14,   0,   6, -29, -97, -44;
/M: SY='R';  M= -10, -95, -20,  46, -38, -44, -25,   5,  41, -34, -78, -28, -85,  24,  59, -74,   2, -81, -92, -21;
/M: SY='E';  M= -19, -95, -13,  67, -92, -54,   0, -89,  44,  -7, -27, -73,  -2,   6,  36, -12, -43, -48, -96, -84;
/M: SY='K';  M=  26, -92, -42, -11, -90,  -5,  -6, -27,  57, -29, -79, -20, -15, -66,  55, -17, -11, -46, -94, -40;
/M: SY='Q';  M=  37, -91,   9,  43, -96, -35, -28, -90,  25, -63, -82,   7, -16,  48,  12, -17,   4, -40, -97, -86;
/M: SY='E';  M=   2, -93,  19,  51, -14,  -7,   3, -32,  -9,  22, -74, -34, -24,  41, -14,  -3, -77, -55, -93, -37;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.

Total number of hits	25 in 25 different sequences
Number of true positive hits	25 in 25 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Feature key [info]	DOMAIN
Feature description [info]	RH1
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

25 sequences

JIP3_DROME  (Q9GQF1), JIP3_DROPS  (Q29EP6), JIP3_HUMAN  (Q9UPT6),

JIP3_MOUSE  (Q9ESN9), JIP3_RAT(E9PSK7), JIP4_HUMAN  (O60271), 
JIP4_MOUSE  (Q58A65), JIP_CAEEL   (P34609), RILP_HUMAN  (Q96NA2), 
RILP_MOUSE  (Q5ND29), RIPL1_BOVIN (Q17QG3), RIPL1_DANRE (A0PJT0), 
RIPL1_HUMAN (Q5EBL4), RIPL1_MOUSE (Q9JJC6), RIPL1_RAT   (D3ZUQ0), 
RIPL1_XENLA (Q0IHE5), RIPL1_XENTR (A0PJP4), RIPL2_BOVIN (A4IFK7), 
RIPL2_DANRE (A4IGC3), RIPL2_HUMAN (Q969X0), RIPL2_MOUSE (Q99LE1), 
RIPL2_RAT   (Q6AYA0), RIPL2_XENLA (Q6IP02), RIPL2_XENTR (Q0P4J3), 
RIPL_DROME  (O76878)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

1 PDB

4KP3