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Entry: PS51781

General information about the entry

Entry name [info] SH3B
Accession [info] PS51781
Entry type [info] MATRIX
Date [info] 01-NOV-2015 CREATED;
22-NOV-2017 DATA UPDATE;
13-NOV-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC51781
Associated ProRule [info] PRU01117

Name and characterization of the entry

Description [info] SH3b domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=66;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=66;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1614432; R2=0.0073224; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1139; N_SCORE=10.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=593; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-27; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='E';  M=  25, -74, -55,  45, -18,  -6, -60, -31,  21, -71, -65, -56, -10,  29, -55,  32,   6, -65, -72,  20;
/M: SY='T';  M=   5, -72,  40,  34, -76,   4, -59, -70,  28, -71,   4,  13,  -9,   3, -54, -17,  49, -34, -83, -69;
/M: SY='T';  M= -20, -67, -54,  18, -67, -29, -60, -19,  -4, -65,   2,  28, -64, -53, -60,  50,  67,  -4, -80,  -6;
/M: SY='A';  M=  51, -70, -61, -22, -61,  -1, -57, -66,  37, -29, -60, -21, -68,  22,  -7,  21, -55, -36, -65,  51;
/M: SY='T';  M= -57, -70, -61, -20,  -6, -69,  13,  23, -13, -32,   4,  23, -69, -16,  -2,  23,  57,   6, -71,  37;
/M: SY='V';  M= -55, -70, -77, -73,  19, -77, -75,  53, -19, -43, -45, -69, -75, -69, -71,  30, -51,  71, -74,   4;
/M: SY='T';  M= -27, -67, -60, -61, -66,   4, -63,   2,  16, -62,  -1,   9, -66, -56, -16,  50,  60,  11, -79, -14;
/I:         I=-26; MD=-65;
/M: SY='A';  M=  34, -73,   4, -21, -66,  34, -68,   5, -67, -33, -60, -12,  13, -65, -72,  -3, -21,  23, -76,  19; D=-26;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='D';  M=  -7, -71,  54,  26, -73,   4, -59, -68, -54, -12,   4,  11, -24,  -5, -13,  11,  52, -64, -84, -67;
/M: SY='W';  M=  -9, -75,  20,  -1,  34,  25, -62, -68, -22, -68,   4,  33,  42, -59, -65,  22, -57, -33,  67,  -8;
/M: SY='L';  M=  38, -68, -73, -17, -53, -72, -70,  28, -27,  54,   4, -70, -73, -64, -69, -59,  20,   1, -75, -60;
/M: SY='N';  M= -63, -73,  16,  16, -14, -61, -50,   6, -51, -70, -64,  94, -13, -52,   3, -21, -15, -67,  41,  20;
/M: SY='V';  M= -58, -69, -81, -77,  -3,  -3, -75,  31, -74,  40,  43, -74, -77, -72, -75, -67,  -4,  62, -76, -56;
/M: SY='R';  M= -67, -82, -64, -53, -66, -77, -52, -75,  15, -31,   9, -58, -75, -42, 107, -62, -65, -71, -70,  24;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='S';  M=   6, -68,  25,  31, -75, -60,  -2, -69, -19, -72, -66, -48, -63,   2, -15,  65,  48, -27, -84, -66;
/M: SY='G';  M= -10, -76, -18,  34, -78,  72, -65, -22,  35, -75, -68, -52, -65, -54, -18, -26, -23, -29, -76, -72;
/M: SY='P';  M=  34, -81, -15, -54, -83, -10, -67, -73, -16, -79, -68, -12, 106,   0, -68, -55, -57, -72, -79, -78;
/M: SY='G';  M= -54, -72,  31,  11,  15,  58, -61, -75, -16, -32, -68,  31, -67, -57, -64,  35,   7, -71, -77, -64;
/M: SY='T';  M=  32, -69,  -8, -19, -62, -66,  25,   0, -58,  15, -53,  27, -70, -58,  14, -13,  40,   3,  40, -60;
/M: SY='S';  M=   6, -71,  41,   7, -73, -58,  38, -73, -54, -37, -65,  26,  -4,  36, -58,  61, -13, -69, -82, -10;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='Y';  M=  21,   9, -64, -28,  -9,  -3, -23,  -2, -15, -60,  19,  -3, -71, -58, -63,  43,   0, -58,  37,  72;
/M: SY='P';  M= -34, -78,  27,  12, -81,   5, -60, -77,  37, -79, -70,   7,  75,  -9,  -7,   7,  11, -74, -81, -72;
/M: SY='I';  M= -58, -73, -67,   0, -60,  -9, -70,  58,  12,  -5, -47,  -8, -71,  25, -21, -26, -10,  45, -78, -62;
/M: SY='I';  M= -10, -71, -77, -73, -55, -31, -75,  62, -67,  12,   7, -69, -74, -67,   3,   8, -20,  53, -78, -60;
/M: SY='G';  M=  11, -71,   4, -26, -60,  55,  -3, -19, -63, -35, -61, -54, -68, -62, -69, -16,  52, -20, -69,  48;
/I:         I=-30; MD=-77;
/M: SY='T';  M= -58, -74, -62,  -1, -76, -71, -65,  -7,  22, -69, -64, -55, -69,  46,   3,  41,  55,   0, -85, -69; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='I';  M=   0, -70, -83, -78,  33, -36, -77,  57, -76,  35, -39, -76, -78, -74, -77, -68, -58,  52, -71, -52;
/M: SY='N';  M= -31, -75,  14,   7, -70, -66,   2, -66,  40,   1, -60,  41,  34,  19,  15,  13, -55, -24, -78,  -9;
/M: SY='K';  M=  15, -73,   5, -17,   4,  25, -61, -67,  54, -17, -61, -54, -11,   8, -21,  14, -19, -27, -71,  -4;
/M: SY='G';  M= -51, -78, -65, -26, -78,  98, -71, -89, -67, -84, -75, -53, -69, -65, -29, -51, -69, -84,  67, -71;
/M: SY='D';  M= -57, -74,  60,  45, -76,  -3, -57, -19, -52, -44,   4, -10, -64,  39, -59,  33,  31, -66, -84, -67;
/M: SY='K';  M=  -8, -74, -58,  17,  -9,  -5,   4,  20,  47, -64, -59, -16, -10, -16,  19,   6,  22, -30, -73,  -5;
/M: SY='F';  M= -37,   9, -81, -77,  57, -81, -73,  45, -74,  10, -43, -74, -78, -75, -75, -18, -11,  56, -65,  16;
/M: SY='T';  M= -59, -73,   6, -11, -71, -66,  24, -70,  44, -71,  -2,  29,  41,  -3, -15,  -2,  61, -66, -79,   0;
/M: SY='I';  M= -61, -73, -72, -70, -49, -79, -67,  61,  19,   4, -43,  17, -75, -65, -29, -64,  -9,  49, -70,  40;
/M: SY='I';  M= -60, -73,  25,   6, -12,  -2, -66,  37, -28,  37, -46, -63, -73, -63, -68,  -2,   2,  14, -71,  21;
/M: SY='W';  M= -22,  36,  56,  22, -16,  39, -63, -75, -24, -74, -70, -17, -68,   3, -19,  11, -25, -23,  72, -63;
/M: SY='F';  M= -44, -72, -16,  24,  37, -70, -61, -19,  31, -59, -58, -57, -69, -10,   1,  36,  14,  28, -68,  21;
/M: SY='D';  M= -28, -73,  60,  10, -72,  -6, -58, -27,  30, -33,  38,  24, -67,  -3, -55,  18, -21,   7, -84, -66;
/M: SY='N';  M=   1, -70, -57, -20,  16,  37, -60, -66,  28, -35, -62,  41, -68, -57, -58,  19,  31, -20, -70,  19;
/I:         I=-14; MD=-37;
/M: SY='N';  M= -78, -94,   2, -24,-101,  17, -75, -99, -19,-100, -90,  56, -88,  23, -77, -26,   4, -96,-105, -91; D=-14;
/I:         I=-14; MI=0; MD=-37; IM=0; DM=-37;
/M: SY='H';  M=  11, -94, -81, -83, -94, -35,  51, -35,  -5, -48, -82,  27, -93, -80, -82, -74,   8, -38,-109, -85; D=-14;
/I:         I=-14; DM=-37;
/M: SY='D';  M= -58, -76,  53,   0, -71,  41, -61,  -2,  24, -69, -64,  19,  -6,  -5, -59, -23, -11,  11, -78,   2;
/M: SY='W';  M= -74, -96, -94, -76, -39, -75, -85, -24, -70, -33, -66, -89, -79,  -1, -72, -78, -82, -77, 169,  44;
/M: SY='Y';  M=  34, -71, -20, -68,  -9, -69,  -4,  36, -66, -26, -50,  18, -74, -65, -69, -57,   8,  32,  37,  62;
/M: SY='Q';  M= -24, -77, -56,  35,  16,   0,  -3, -66,  54,   6, -57, -56, -68,  59, -13, -58, -61, -67, -66,  22;
/M: SY='V';  M= -58, -71, -82, -79, -49, -85, -79,  70, -75, -38, -40, -76, -76, -75, -77, -67, -12,  76, -74,  28;
/M: SY='Q';  M= -58, -75,  16,  29, -72, -68,   7, -22,  34, -68,   4,   5, -65,  58,   8,  14,  34, -33, -78,  -8;
/M: SY='Y';  M= -65, -75,  23, -64,   9, -35,   5, -56, -62,  20, -52,  11, -76, -61, -15, -12,  24, -32,  59,  85;
/M: SY='N';  M=  -4, -73,   2,   2, -75,  33,  17, -77,  37, -77, -68,  38,  14, -51, -24,  33,   6, -72, -78, -10;
/I:         I=-19; MD=-47;
/M: SY='N';  M= -39, -84,  24, -24, -78, -32, -67, -84,  15, -39, -78,  45, -80, -63, -67,  38, -14, -82,  22,  16; D=-19;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='G';  M= -23, -80, -65, -30, -87,  84, -72, -91, -31, -88, -78,  11, -73, -67, -21, -28,  -3, -84, -82, -81; D=-19;
/I:         I=-19; DM=-47;
/M: SY='E';  M= -13, -73, -52,  52, -71, -68, -58, -28,  46, -42, -61, -54, -64,  29,  13,  23,  24,  -6, -75,  -5;
/M: SY='T';  M= -57, -71, -58,   2, -68,  -6, -62,  11,  45, -65, -60, -11, -65, -52,  36, -16,  70, -27, -77, -10;
/M: SY='G';  M=  17, -75, -15, -19, -72,  85, -66, -34, -66, -76, -68, -53, -68, -13, -71, -26, -63, -39, -70,  23;
/M: SY='W';  M= -71, -85, -81, -77,  19, -77, -56, -17, -69, -55, -55, -80, -82, -67, -69, -72, -71,  -7, 132, 106;
/M: SY='V';  M= -58,  35, -83, -78, -52, -85, -80,  62, -73,  11,  16, -76, -78, -74, -21, -69, -55,  72, -81, -59;
/M: SY='P';  M=  26, -71, -19, -54, -18, -60,  14, -68,   3, -36, -63,  40,  47,  19,   8,  40,  -8, -32, -79, -64;
/I:         I=-30; MD=-77;
/M: SY='T';  M=  -8, -84, -76, -76, -86,  11, -79, -31, -73, -34, -77, -12, -20,  -9, -22,  32,  44, -75, -96, -83; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='K';  M= -56, -75, -16, -27, -76,  44,  54, -27,  55, -74, -64,  24, -67,  24, -48,  24, -56, -18, -79, -64;
/M: SY='W';  M= -70, -82,  46, -59,  52, -30, -55, -66, -59, -61, -61, -17, -77,  20,  12, -65, -67, -70, 105,  81;
/M: SY='L';  M= -61, -70, -76, -71, -14, -29,  48,  23, -18,  53, -39, -69, -77, -68, -69, -66,  12,  47, -77, -54;
/M: SY='W';  M= -54, -71, -60,  11, -61, -30,  39,  -7, -23, -18,   4, -55, -67,   1, -62,  50,  48,   3,  68,   4;
/M: SY='N';  M= -60, -72,  32, -53, -15, -63, -56, -27,  20, -34,  37,  66,  28, -10, -20,   5,  32, -20, -83, -64;
/M: SY='T';  M=  16, -70,  22,   1,  39, -14, -65,  -1,  19,   7, -55, -56, -68, -59, -11, -26,  47, -54, -72, -55;
/M: SY='S';  M=  -2, -78,  20, -24, -73, -39, -65, -21,  29, -74, -68,  14,  17, -11, -60,  30,   5,  -5, -81,  19;
/I:         E1=0; IE=-255; DE=-255;
» more

Post-processing [info]

COMPETES_HIT_WITH PS50002

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_10 which contains 561'356 sequence entries.


Total number of hits 53 in 43 different sequences
Number of true positive hits 53 in 43 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 96.36 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Prokaryotes (Bacteria)
Maximum number of repetitions [info] 4
Feature key [info] DOMAIN
Feature description [info] SH3b
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
43 sequences

ALE1_STACP  (O05156    ), BCN5_CLOPF  (P08696    ), BLYA_BACSU  (O31982    ), 
DPP6_LYSSH  (P39043    ), LSTP_STASI  (P10547    ), LSTP_STAST  (P10548    ), 
LYS_CLOPE   (P26836    ), LYTA_STAAU  (P24556    ), LYTD_BACSU  (P39848    ), 
LYTH_STAA3  (Q2FG95    ), LYTH_STAA8  (Q2FXU3    ), LYTH_STAAB  (Q2YT98    ), 
LYTH_STAAC  (Q5HFD1    ), LYTH_STAAM  (Q7A2R2    ), LYTH_STAAN  (Q7A588    ), 
LYTH_STAAS  (Q6G8T7    ), LYTH_STAAU  (O32421    ), LYTH_STAAW  (Q7A0Q6    ), 
LYTH_STAEQ  (Q5HNS0    ), LYTH_STAES  (Q8CP02    ), LYTH_STAHJ  (Q4L6X7    ), 
LYTH_STAS1  (Q49Y70    ), LYTO_STAA8  (Q2FX77    ), P60_LISGR   (Q01835    ), 
P60_LISIN   (Q01836    ), P60_LISIV   (Q01837    ), P60_LISMO   (P21171    ), 
P60_LISSE   (Q01838    ), P60_LISWE   (Q01839    ), SPKD_SYNY3  (P54735    ), 
TAGH_BACAN  (Q81K31    ), TAGH_BACCZ  (Q630Y3    ), Y1605_HAEIN (P44272    ), 
Y260_TREPA  (O83284    ), YFHK_BACSU  (O31579    ), YGIM_ECO57  (P0ADU0    ), 
YGIM_ECOL6  (P0ADT9    ), YGIM_ECOLI  (P0ADT8    ), YGIM_SHIFL  (P0ADU1    ), 
YRAI_BACSU  (O07909    ), YRAJ_BACSU  (O07934    ), YRVJ_BACSU  (O32041    ), 
YWSB_BACSU  (P96729    )
» more

UniProtKB/Swiss-Prot
False negative sequences
2 sequences

LYS_BPB30   (Q8HA43    ), PH_STAA8    (Q2FYD8    )

		
PDB
[Detailed view]
4 PDB

1R77; 4LXC; 5LEO; 5NMY

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