PROSITE documentation PDOC51781
SH3b domain profile


Src homology 3 (SH3) domains (see <PDOC50002>) are widespread among metazoan intracellular signalling proteins and typically bind proline-rich polypeptides. The SH3b domain is a prokaryotic homologue. The SH3b domain might have two possible functions: (1) promoting survival of a pathogen within the invaded cell by modulating pathways controlled by SH3 domains; or (2) promoting invasion by binding to receptors on eukaryotic cells [1,2].

Some proteins known to contain a SH3b domain are listed below:

  • Listeria invasion-associated protein p60, a probable endopeptidase.
  • Staphylococcus simulans lysostaphin.
  • Bacillus subtilis β-N-acetylglucosaminidase lytD.
  • Bacillus subtilis uncharacterized protein YfhK.
  • Synechocystis sp. serine/threonine-protein kinase D (spkD).

The profile we developed covers the entire SH3b domain.

Last update:

October 2017 / Profile revised.


Technical section

PROSITE method (with tools and information) covered by this documentation:

SH3B, PS51781; SH3b domain profile  (MATRIX)


1AuthorsWhisstock J.C. Lesk A.M.
TitleSH3 domains in prokaryotes.
SourceTrends Biochem. Sci. 24:132-133(1999).
PubMed ID10322416

2AuthorsPonting C.P. Aravind L. Schultz J. Bork P. Koonin E.V.
TitleEukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer.
SourceJ. Mol. Biol. 289:729-745(1999).
PubMed ID10369758

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