PROSITE documentation PDOC51781SH3b domain profile
Src homology 3 (SH3) domains (see <PDOC50002>) are widespread among metazoan intracellular signalling proteins and typically bind proline-rich polypeptides. The SH3b domain is a prokaryotic homologue. The SH3b domain might have two possible functions: (1) promoting survival of a pathogen within the invaded cell by modulating pathways controlled by SH3 domains; or (2) promoting invasion by binding to receptors on eukaryotic cells [1,2].
Some proteins known to contain a SH3b domain are listed below:
- Listeria invasion-associated protein p60, a probable endopeptidase.
- Staphylococcus simulans lysostaphin.
- Bacillus subtilis β-N-acetylglucosaminidase lytD.
- Bacillus subtilis uncharacterized protein YfhK.
- Synechocystis sp. serine/threonine-protein kinase D (spkD).
The profile we developed covers the entire SH3b domain.
Last update:October 2017 / Profile revised.
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PROSITE method (with tools and information) covered by this documentation:
| 1 | Authors | Whisstock J.C. Lesk A.M. |
| Title | SH3 domains in prokaryotes. | |
| Source | Trends Biochem. Sci. 24:132-133(1999). | |
| PubMed ID | 10322416 |
| 2 | Authors | Ponting C.P. Aravind L. Schultz J. Bork P. Koonin E.V. |
| Title | Eukaryotic signalling domain homologues in archaea and bacteria. Ancient ancestry and horizontal gene transfer. | |
| Source | J. Mol. Biol. 289:729-745(1999). | |
| PubMed ID | 10369758 | |
| DOI | 10.1006/jmbi.1999.2827 |
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