PROSITE entry PS51817

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PURL: https://purl.expasy.org/prosite/signature/PS51817

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General information about the entry

Entry name [info]	PEPTIDASE_A3B
Accession [info]	PS51817
Entry type [info]	MATRIX
Date [info]	01-SEP-2016 CREATED; 13-FEB-2019 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51817
Associated ProRule [info]	PRU01160

Name and characterization of the entry

Description [info]

Peptidase family A3B domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=108;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=103;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.3854437; R2=0.0066549; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=20884.0000000; R2=0.0000000; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1145; H_SCORE=20884; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=469; H_SCORE=20884; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-49; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='E';  M= -60, -81, -31, 112, -84, -76, -53, -85, -41, -77, -73, -57, -55, -34, -51, -57, -61, -77, -80, -74;
/M: SY='T';  M= -48, -63, -63, -63, -65, -65, -69, -45, -62, -58, -56, -53, -66, -61, -67,  63,  73,  55, -86, -64;
/M: SY='K';  M= -64, -79, -57, -44, -78, -72, -56, -80,  94, -77, -65, -50, -67, -40,  72, -58, -60, -75, -73, -64;
/M: SY='I';  M= -66, -75, -86, -82, -46, -89, -80,  93, -79,  46, -33, -78, -77, -74, -80, -75, -60, -24, -73, -55;
/M: SY='W';  M= -53, -72, -67, -64, -58, -62, -72, -68, -61, -71, -68, -56, -66, -59, -67,  67,  66, -66, 131, -49;
/M: SY='F';  M= -73, -71, -87, -81, 106, -84, -68, -42, -79,  48, -42, -79, -85, -82, -76, -75, -66, -49, -48, -27;
/M: SY='N';  M= -55, -67, -53, -62, -61, -58, -54, -57, -58,  43, -52,  82, -73, -55, -63,  62, -47, -59, -83, -64;
/M: SY='N';  M= -54, -66, -41, -57, -76, -50, -47, -75, -51, -82, -70, 108, -70, -49, -58,  63, -43, -74, -91, -70;
/M: SY='N';  M= -61, -72, -33,  69, -79, -58, -46, -79, -45, -81, -71, 106, -66, -43, -54, -48, -51, -78, -90, -73;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='N';  M= -58, -67, -53, -64,  75, -58, -54, -65, -59, -63, -63,  82, -73, -59, -63,  60, -48, -65, -67, -46;
/M: SY='R';  M= -63, -77, -66, -56, -65, -78, -64,  61,  62, -56, -52, -58, -69, -50,  63, -60,  18, -46, -75, -61;
/M: SY='I';  M= -65, -78,  72, -59, -59, -80, -72,  87, -69, -44, -47, -58, -72, -67, -75, -66, -57,  10, -82, -61;
/M: SY='T';  M= -56, -67, -66, -68, -60, -75, -74,  66, -64, -49, -49, -55, -64, -66, -71, -46,  96, -36, -82, -62;
/M: SY='T';  M= -55, -64, -64, -64, -61, -70, -63, -49, -60, -48,  98, -53, -62, -60, -65, -44,  98, -48, -83, -60;
/M: SY='A';  M=  99, -61, -68, -60, -76, -49, -69, -65, -63, -67, -61, -62, -66, -59, -67, -41, -52, -52, -76, -71;
/M: SY='L';  M= -62, -66, -74, -71, -47, -79, -68, -39, -70,  75, -36, -68, -74, -68, -72, -59,  68, -43, -76, -57;
/M: SY='I';  M= -66, -75, -86, -82, -46, -89, -79,  92, -79,  48, -33, -78, -77, -74, -80, -75, -60, -24, -73, -55;
/M: SY='D';  M= -68, -81, 119, -31, -88, -64, -53, -86, -55, -85, -84, -35, -67, -54, -63, -56, -57, -83,-103, -70;
/M: SY='S';  M= -44, -63, -56, -58, -72, -55, -62, -68, -57, -72, -67, -45, -62, -52, -63,  92,  70, -60, -84, -66;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/M: SY='C';  M= -47, 106, -62, -63, -73, -56, -65, -75, -62, -74, -70, -50, -71, -57, -67,  92, -42, -66, -88, -71;
/M: SY='T';  M= -52, -61, -57, -61, -67, -68, -68, -58, -57, -63, -60, -47, -59, -62, -66, -35, 115, -50, -88, -65;
/M: SY='H';  M= -63, -73, -54, -56, -68, -70, 132, -75, -58, -67, -56, -44, -66, -51, -56, -50,  68, -71, -98, -44;
/M: SY='N';  M= -54, -66, -41, -57, -76, -50, -47, -75, -51, -82, -70, 108, -70, -49, -58,  63, -43, -74, -91, -70;
/M: SY='M';  M= -64, -75, -85, -80, -49, -85, -73,  92, -74, -31,  99, -74, -73, -69, -76, -73, -59, -25, -74, -54;
/M: SY='I';  M= -65, -78, -86, -85, -49, -91, -86, 108, -79, -32, -35, -76, -74, -76, -83, -74, -58, -19, -73, -56;
/M: SY='C';  M= -53, 137, -71, -72, -72, -66, -72, -77, -69, -72, -70, -58, -80, -69, -75,  62, -51, -66, -94, -76;
/M: SY='P';  M= -68, -88, -68, -60, -51, -71, -56, -67, -64, -72, -62, -73, 111, -64, -71, -64, -61, -73, -55,  87;
/M: SY='T';  M=  53, -63, -61, -63, -64, -61, -65, -55, -61,  26, -53,  35, -67, -61, -67, -44,  73, -51, -81, -65;
/M: SY='L';  M= -67, -69, -85, -77, -40, -86, -68, -32, -78,  92, -28, -84, -84, -71, -75, -77, -63, -39, -71, -53;
/M: SY='I';  M= -61, -74, -85, -82, -50, -89, -86,  93, -78, -34, -37, -77, -75, -76, -81, -71, -56,  58, -78, -58;
/M: SY='P';  M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83;
/M: SY='E';  M=  57, -73, -41,  93, -81, -64, -58, -76, -48, -73, -68, -59, -59, -41, -56, -50, -57, -66, -78, -73;
/M: SY='S';  M= -54, -72, -63, -57, -66, -66, -65,  59,  63, -58, -55, -53, -66, -51, -49,  66, -48, -47, -76, -63;
/M: SY='W';  M= -74, -94, -90, -78, -32, -75, -69, -67, -70, -64, -64, -87, -81, -68, -71, -76, -79, -78, 162,  88;
/M: SY='I';  M= -62, -72, -85, -80, -47, -88, -79,  75, -78,  48, -34, -79, -78, -74, -79, -73, -58,  47, -76, -57;
/M: SY='N';  M= -63, -74, -53, -58, -66, -66, -58,  61,  61, -58, -54,  82, -70, -53, -48, -56, -53, -48, -80, -64;
/M: SY='S';  M= -50, -71, -57, -56, -77, -56, -61, -73, -58, -79, -70,  23,  80, -55, -65,  82,  13, -69, -83, -71;
/M: SY='T';  M= -61, -67, -73, -71, -49, -79, -70,  23, -69,  65, -38, -66, -72, -68, -72, -57,  73, -40, -77, -58;
/M: SY='H';  M= -57, -72,  31, -52, -73, -58, 106, -80, -55, -76, -65,  59, -68, -49, -57,  62, -50, -77, -94, -54;
/M: SY='Y';  M= -68, -78, -71, -65, -40, -80, -50, -53, -47,  44, -46, -68, -81, -54,  74, -67, -65, -57, -52,  87;
/M: SY='Q';  M= -62, -82,  71,  71, -87, -69, -51, -82, -44, -77, -70, -47, -62,  85, -50, -53, -60, -79, -83, -68;
/M: SY='I';  M= -60, -74, -85, -82, -50, -89, -86,  92, -78, -34, -37, -77, -75, -76, -81, -71, -56,  60, -78, -58;
/M: SY='I';  M= -61, -71, -85, -79, -47, -87, -79,  68, -77,  48, -35, -79, -79, -74, -78, -72, -57,  57, -77, -57;
/M: SY='M';  M= -58, -66, -73, -68, -55, -73, -58, -42, -63, -37, 129, -61, -66, -59, -64, -56,  68, -45, -78, -54;
/M: SY='F';  M= -64, -71, -68, -64,  79, -76, -62, -61, -48, -56, -57, -59, -73, -60,  69, -55,  66, -59, -62, -42;
/M: SY='T';  M=  58, -62, -60, -59, -72, -54, -65, -65, -59, -69, -63, -51, -63, -56, -65,  63,  67, -56, -81, -68;
/M: SY='V';  M= -56, -69, -84, -79, -52, -86, -86,  62, -76, -37, -40, -78, -77, -77, -78, -68, -53,  88, -83, -60;
/M: SY='D';  M= -65, -81, 103,  67, -87, -68, -53, -86, -50, -82, -80, -41, -63, -46, -59, -56, -58, -81, -94, -71;
/M: SY='N';  M= -61, -67, -37, -57, -76, -52, -45, -74, -49, -81, -69, 120, -71, -51, -57, -43,  28, -74, -95, -71;
/M: SY='S';  M= -47, -68, -55, -51, -76, -55, -59, -75,  63, -78, -69, -45, -63, -45, -45,  92, -41, -69, -79, -66;
/M: SY='K';  M= -66, -75, -63, -51,  75, -74, -61, -67,  93, -62, -60, -55, -69, -50, -35, -62, -60, -67, -59, -44;
/M: SY='Y';  M= -69, -81, -75, -77, -26, -82, -48,  62, -69, -45, -44, -73, -80, -65, -68, -68, -63, -43, -37, 118;
/M: SY='N';  M= -51, -64, -47, -58, -73, -55, -55, -69, -53, -74, -66,  83, -65, -53, -61,  61,  69, -64, -89, -68;
/M: SY='L';  M= -66, -72, -85, -79, -43, -88, -73,  63, -78,  76, -30, -81, -81, -72, -77, -76, -62, -31, -72, -54;
/M: SY='N';  M= -59, -65, -41, -58, -73, -55, -49, -70, -51, -76, -66, 108, -68, -53, -59, -41,  69, -67, -93, -70;
/M: SY='Q';  M= -61, -84, -57, -38, -85, -70, -49, -78, -34, -72, -59, -52, -69, 116,  68, -52, -63, -77, -73, -61;
/M: SY='E';  M= -57, -78, -47,  70, -82,  54, -60, -84,  63, -80, -71, -52, -61, -44, -45, -54, -62, -78, -75, -72;
/M: SY='L';  M= -67, -69, -85, -77, -40, -86, -68, -32, -78,  92, -28, -84, -84, -71, -75, -77, -63, -39, -71, -53;
/I:         I=-30; MD=-77;
/M: SY='H';  M= -84, -97, -85, -85, -74, -98,  98,  65, -85, -62, -60, -75, -89, -77, -83, -83, -80, -55,-102, -63; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='D';  M= -65, -81, 103,  67, -87, -68, -53, -86, -50, -82, -80, -41, -63, -46, -59, -56, -58, -81, -94, -71;
/M: SY='D';  M= -65, -84,  84,  54, -86, -68, -58, -81, -53, -82, -76, -50,  80, -51, -63, -58, -59, -80, -88, -75;
/M: SY='I';  M= -60, -74, -73, -64, -58, -81, -75,  67,  63, -45, -46, -65, -71, -61, -53, -65, -55,  56, -77, -61;
/M: SY='K';  M=  53, -71, -59, -46, -78, -62, -61, -74,  93, -74, -64, -52, -64, -45, -34, -51, -55, -66, -73, -67;
/M: SY='I';  M= -66, -75, -86, -82, -46, -89, -79,  90, -79,  52, -32, -79, -77, -74, -80, -75, -60, -25, -73, -55;
/M: SY='Q';  M= -59, -85, -54, -34, -90, -67, -47, -76, -39, -71, -57, -50, -66, 131, -40, -48, -62, -77, -72, -61;
/M: SY='F';  M= -76, -71, -88, -84, 122, -83, -68, -49, -79, -40, -51, -77, -86, -90, -76, -74, -67, -54, -40, -19;
/M: SY='Q';  M= -63, -82, -57, -41, -81, -71, -52, -79,  63, -74, -62, -51, -68,  89,  71, -55, -62, -76, -73, -63;
/M: SY='E';  M= -62, -81,  74,  95, -85, -72, -53, -85, -45, -79, -76, -48, -59, -39, -55, -56, -59, -79, -87, -72;
/M: SY='V';  M= -58, -68, -85, -79,  75, -84, -79, -26, -76, -40, -45, -78, -81, -81, -76, -69, -55,  87, -66, -42;
/M: SY='D';  M= -57, -75, 103, -38, -83, -59, -55, -82, -55, -82, -79, -38, -66, -52, -63,  62, -49, -77, -95, -69;
/M: SY='E';  M= -56, -80, -39,  95, -83,  56, -58, -87, -49, -79, -74, -54, -59, -42, -58, -54, -63, -79, -78, -75;
/M: SY='T';  M= -52, -68, -59, -56, -72, -64, -59, -70, -43, -71, -64, -49, -65, -50,  70,  60,  73, -62, -82, -65;
/M: SY='F';  M= -76, -71, -88, -84, 122, -83, -68, -49, -79, -40, -51, -77, -86, -90, -76, -74, -67, -54, -40, -19;
/M: SY='G';  M= -50, -71, -62, -70, -77,  87, -70, -77, -65, -77, -70, -49, -65, -65, -73, -44,  68, -70, -78, -73;
/M: SY='I';  M= -60, -72, -74, -75, -54, -82, -79,  92, -71, -40, -42, -64, -68, -71, -76, -57,  68, -27, -78, -59;
/M: SY='K';  M= -64, -79, -57, -44, -78, -72, -56, -80,  94, -77, -65, -50, -67, -40,  72, -58, -60, -75, -73, -64;
/M: SY='Y';  M= -71, -82, -70, -74, -19, -78, -37, -56, -65, -53, -50, -72, -83, -61, -62, -66, -65, -62, -27, 135;
/M: SY='D';  M= -58, -74,  73, -41, -80, -61, -55, -80,  68, -80, -72,  23, -65, -47, -44,  49, -50, -75, -85, -68;
/M: SY='L';  M= -67, -69, -85, -77, -40, -86, -68, -32, -78,  92, -28, -84, -84, -71, -75, -77, -63, -39, -71, -53;
/M: SY='G';  M= -54, -81, -65, -68, -84,  87, -71, -84, -67, -86, -74, -56,  80, -67, -77, -53, -65, -82, -75, -80;
/M: SY='Q';  M= -57, -76, -55, -41, -81, -68, -53, -69, -44, -68, -58, -49, -64, 114, -47, -44,  68, -67, -77, -62;
/M: SY='T';  M= -56, -66, -65, -67, -60, -74, -73,  62, -63, -50, -50, -54, -63, -66, -71, -45,  98, -37, -83, -62;
/M: SY='Y';  M= -71, -82, -64, -66, -29, -75, 102, -64, -63, -58, -51, -60, -78, -56, -59, -64, -66, -68, -41, 118;
/M: SY='V';  M= -52, -66, -83, -77, -54, -84, -86, -19, -75, -39, -42, -78, -79, -77, -76, -66, -50, 103, -88, -62;
/M: SY='A';  M=  83, -62, -63, -59, -75, -49, -66, -68, -61, -70, -64, -55, -65, -55, -65,  63, -46, -56, -78, -70;
/M: SY='P';  M= -66, -92, -67, -55, -86, -68, -70, -74, -63, -84, -70, -73, 128, -66, -75, -64, -59, -79, -79, -83;
/M: SY='Q';  M= -61, -80, -55, -38, -83, -69, -53, -78,  89, -75, -62, -49, -64,  93, -29, -53, -59, -76, -72, -63;
/M: SY='P';  M= -61, -79, -63, -57, -79, -68, -69, -68, -61, -76, -67, -63, 111, -65, -72, -52,  68, -67, -82, -77;
/M: SY='T';  M= -56, -66, -65, -67, -60, -74, -73,  62, -63, -50, -50, -54, -63, -66, -71, -45,  98, -37, -83, -62;
/M: SY='T';  M= -54, -71, -58, -56, -76,  54, -65, -74,  67, -75, -66, -48, -63, -54, -47, -47,  68, -67, -77, -69;
/M: SY='T';  M= -48, -62, -57, -59, -69, -61, -65, -63, -57, -67, -63, -46, -60, -57, -64,  63,  99, -55, -86, -66;
/I:         I=-28; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='F';  M= -76, -71, -88, -84, 122, -83, -68, -49, -79, -40, -51, -77, -86, -90, -76, -74, -67, -54, -40, -19;
/M: SY='I';  M= -66, -75, -86, -82, -46, -89, -79,  92, -79,  48, -33, -78, -77, -74, -80, -75, -60, -24, -73, -55;
/M: SY='I';  M= -66, -75, -86, -82, -46, -89, -79,  92, -79,  48, -33, -78, -77, -74, -80, -75, -60, -24, -73, -55;
/M: SY='G';  M= -49, -77, -64, -76, -83, 103, -71, -91, -70, -86, -75, -50, -68, -67, -77, -49, -68, -84, -74, -78;
/M: SY='H';  M= -69, -77, -61, -60, -57, -75, 132, -60, -64,  46, -44, -52, -74, -54, -58, -64, -66, -65, -90, -41;
/M: SY='R';  M= -65, -77, -52, -53, -76, -66, -49, -80, -30, -78, -66,  78, -75, -43, 100, -55, -58, -77, -81, -65;
/M: SY='F';  M= -84, -79, -96, -92, 114, -91, -76, -57, -87, -48, -59, -85, -94, -98, -84, -82, -75, -62, -49, -27;
/M: SY='M';  M= -72, -81, -93, -86, -55, -91, -76,  62, -82,  28,  96, -83, -83, -75, -81, -82, -68, -39, -81, -61;
/M: SY='T';  M= -64, -72, -55, -67, -79, -68, -64, -73, -61, -78, -72,  78, -72, -65, -70, -47,  86, -68, -99, -76;
/M: SY='S';  M= -53, -73, -58, -65, -83, -58, -63, -82, -63, -87, -79,  56, -74, -57, -68,  89, -46, -77, -93, -76;
/M: SY='E';  M= -69, -83, -41,  82, -89, -72, -57, -89, -52, -87, -80,  78, -70, -47, -61, -59, -63, -86, -94, -81;
/M: SY='H';  M= -68, -77, -58, -65, -78, -72,  99, -79, -63, -77, -68,  56, -74, -61, -66, -53,  68, -75,-103, -62;
/M: SY='G';  M= -57, -85, -72, -84, -91,  95, -79, -99, -78, -94, -83, -58, -76, -75, -85, -57, -76, -92, -82, -86;
/M: SY='S';  M= -52, -77, -67, -71, -86,  57, -71, -88, -70, -89, -81, -54, -73, -63, -75,  79, -54, -80, -87, -78;
/M: SY='I';  M= -70, -83, -94, -91, -58, -97, -94,  90, -86, -42, -45, -85, -83, -84, -89, -80, -65,  40, -85, -66;
/M: SY='T';  M= -65, -72, -74, -74, -63, -83, -76, -54, -72,  45, -53, -66, -75, -73, -77, -56,  86, -54, -89, -68;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	1
Number of true positive hits	1
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Peptidase A3B
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

1 sequence

POL_RTBVP   (P27502)

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment