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Entry: PS51845

General information about the entry

Entry name [info] PDEASE_I_2
Accession [info] PS51845
Entry type [info] MATRIX
Date [info] 20-DEC-2017 CREATED;
20-DEC-2017 DATA UPDATE;
31-JUL-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC00116
Associated ProRule [info] PRU01192

Name and characterization of the entry

Description [info] 3'5'-cyclic nucleotide phosphodiesterase domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=324;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=319;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1944997; R2=0.0084625; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=923; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=509; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-32; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='T';  M= -15,  -3, -35,  22, -77, -70, -25, -63, -64, -29, -64, -16,  15, -64,   6,  15,  38,  24, -93, -76;
/M: SY='N';  M= -41, -82,  12,  26, -80, -15, -63, -42,  12, -38, -66,  31, -26,  25,  19, -16,  14, -28, -86, -25;
/M: SY='R';  M= -11, -18,  32,  21, -76, -59, -22,   9, -27, -34, -18,  13,   5, -57,  43, -61,  18, -28, -88, -71;
/M: SY='E';  M= -32, -82,  53,  66, -82, -74, -61, -42, -53, -21, -71, -55, -12,  15,  -9,   5,   6, -73, -88, -73;
/M: SY='Y';  M= -66, -80, -29,  -2,  14, -81, -33, -16, -63,  14, -54,  -7,  -7,  14,   9, -68, -15,  26,  40,  55;
/M: SY='P';  M= -28, -81,  -7,  42, -78, -29, -63, -49, -58, -22,  28,   6,  60,  47, -64, -10, -15, -11, -83, -72;
/M: SY='S';  M=  10, -75,  14,  11, -79,  15, -16, -63,  20, -44, -69,  13,  27, -56, -42,  28,  14, -33, -85, -73;
/M: SY='I';  M= -13, -32,  -1, -23,  20, -78, -13,  34,   1,  28, -49, -11, -78,  24,  -7, -37, -63,  -6, -73,  -1;
/M: SY='M';  M=  15,  12, -80, -72, -57, -78, -72,  16, -25,  45,  51, -74,   5, -20, -72, -62,  -4,  22, -79, -63;
/M: SY='Q';  M=  39, -76,  16, -24, -78, -43,  18, -24,  37, -48, -63, -56, -70,  51,  19,   1, -59, -18, -81, -67;
/M: SY='D';  M=  10,  26,  41,   8,  -4, -24,  -2, -36,   8, -14, -64,   3, -16,  -8,   3, -15,   0, -39, -79,   0;
/M: SY='T';  M=   1,   0,   3,  31, -63, -23, -66,   7, -63,   7,  30,  10,  -6, -61, -69, -57,  34,  16, -81,  -8;
/M: SY='L';  M= -67, -74, -79, -34,   1, -84, -70,  48, -74,  59,  27,  -1, -30, -70, -40, -73, -62,   7, -72,  -7;
/I:         I=-7; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='P';  M= -13, -80,  23,  47, -29, -45, -61, -34,  12, -74, -68,  -2,  66,  18, -58,  10, -57, -24, -79, -20;
/M: SY='N';  M= -44, -77,  54,  28, -79, -38, -57, -73,  21, -39, -70,  54,  35, -15, -15,  12, -55, -20, -87, -71;
/M: SY='V';  M=  19, -72, -10,  20,  -4, -73, -68, -15, -62,  20,   5,   2,   1, -61,   0, -33,  -8,  41, -79, -62;
/M: SY='D';  M=  -5,   4,  36,  14, -73, -13, -59, -44, -39,  -7, -63,  34, -70,  25,  21,  10,  26, -22, -85, -68;
/M: SY='C';  M= -14,  46,  30,  -3, -71, -68, -15,  10,  27, -42, -24,  10, -69,   6, -25,  14,  41, -33, -83, -26;
/M: SY='W';  M= -25, -86, -77,  13,  -6, -76, -77,  -9, -12,   5, -60, -22, -27, -64, -37, -72, -72, -17, 145,  17;
/M: SY='D';  M=   1,   0,  57,  28, -81,  35, -59, -80,  15, -80, -73,  35, -67, -52, -11,   3, -33, -43, -85, -72;
/M: SY='F';  M= -68, -73, -83, -80,  82, -82, -71,  53, -77,  34, -42, -75, -42, -77, -77,   5, -61, -41, -57,  -6;
/M: SY='D';  M= -66, -78,  70,  17,  -2, -67,  34, -76, -28, -74, -69,  40,  21, -11,   5, -34,  11, -75, -78,  30;
/M: SY='I';  M= -61, -74,  26, -10,   2, -44, -69,  50,   1,  12, -49, -63, -33, -64, -67,   8,   4,  27, -75,  -3;
/M: SY='F';  M= -19, -75, -86, -79, 107, -80, -71,   3, -76, -22, -52, -77,  11, -24, -76, -72, -67, -54,  53, -27;
/M: SY='H';  M= -12, -17,  -2,  34, -74, -64,  65, -74,   6, -23, -63,  30, -67,  15,   5,  39,  13, -70, -85, -62;
/M: SY='F';  M= -40, -71, -87, -81,  95, -84, -71,  10, -79,  35,  -7, -79, -84, -81, -77, -74, -64,  16, -54, -33;
/I:         I=-23; MD=-58;
/M: SY='D';  M=   0, -73,  62,  14, -78, -42, -60, -71, -56, -37, -44,  29, -69, -55,  -5,  42,  22, -19, -90, -71; D=-23;
/I:         I=-23; MD=-58;
/M: SY='D';  M= -26, -80,  59,  56, -73, -22, -37,  -1, -27, -70, -68, -54, -68, -23,  13,   7, -59,  -2, -81,  10; D=-23;
/I:         I=-23; MD=-58;
/M: SY='W';  M=   6, -74, -77, -73,  57,  -6, -70,   2,   0,  15,  -3, -26, -77, -70, -69, -32,  12, -14,  63,  14; D=-23;
/I:         I=-23; MD=-58;
/M: SY='P';  M= -15, -75, -40,  30, -71, -67,   9, -36, -31, -29,   2, -58,  49, -55, -26,  47,  39, -65,  31, -19; D=-23;
/I:         I=-23; MD=-58;
/M: SY='W';  M= -66, -11,  35, -37,  28,  20,  24, -43, -17,  22, -58,   5, -31, -32,  -5, -20, -64, -34,  59, -16; D=-23;
/I:         I=-23; MD=-58;
/M: SY='S';  M= -82,-100, -21,  17, -22, -93, -90, -96, -39, -99, -96, -81, -30, -79, -38,  37,  -1, -32,-109, -92; D=-23;
/I:         I=-23; MI=0; MD=-58; IM=0; DM=-58;
/M: SY='E';  M= -22, -77,  49,  51, -77,  27,  -6, -75,  -9, -46, -12,  35,  -1, -18, -60, -26, -16, -30, -83, -23;
/M: SY='H';  M= -38, -76,  55, -22, -73, -66,  68, -73, -48,   1, -62,  58, -72,   9,  44, -15, -30, -73, -89, -61;
/M: SY='P';  M=  15, -76,  39,  42, -74, -44,  -6,   0, -56, -40,  33, -15,  50, -54, -12,  13, -56, -22, -83, -69;
/M: SY='L';  M= -21, -70, -77, -32, -18, -79, -70, -40, -71,  64,  38, -73, -77, -68, -73, -64,  42,   4,  63, -54;
/M: SY='P';  M=  13,  14, -70, -65, -24, -70,  -8,  33,  10,  -7,  -9, -63,  33, -62, -25,  28,  19,  16, -79, -63;
/M: SY='Y';  M= -14,  11, -66, -25, -10,   5,  -5, -62,   3,  -9,  21, -60,  -2,  22,  11,  18,  17, -27,  33,  44;
/M: SY='C';  M=  22,  85, -80, -76, -57, -76, -76,  40, -74,  27,  17, -21, -80, -73, -77, -64, -58,  37, -82, -64;
/M: SY='M';  M=   1, -14, -73, -73,  20,  39, -69,  14, -70,   9,  47, -63, -72, -68, -73,   0,  31,   5, -72, -12;
/M: SY='Y';  M= -37,  -1, -75, -15,  40, -81, -12,  25, -69,  26,  31, -73, -79,  14, -69, -69, -62,  17, -56,  70;
/M: SY='R';  M= -39, -75, -26,  20, -25, -70,  48, -69,   6, -39,   0,  -3, -69,  -1,  55,  22,  27, -35, -75,  23;
/M: SY='M';  M= -64, -71, -85, -77, -17, -82, -64,  25, -73,  47, 108, -76, -77, -67, -71, -73, -38,  10, -72, -10;
/M: SY='F';  M= -27, -72, -86, -81, 101, -82, -67,  -6, -77,  18,  -1, -78, -84, -81, -75, -73, -65,  -6, -48,  32;
/M: SY='Q';  M= -29, -75, -57,  20,  -4, -70,  55, -43, -17, -15,  37,   7, -69,  58, -15,   3,  31, -35,  14,  -1;
/M: SY='D';  M= -64, -81,  61,  47, -80, -38,  15, -81,   1, -42, -69,  -1, -68,  22,  60, -24, -38, -77, -85, -67;
/M: SY='H';  M= -40,  14, -72, -68,  22, -74,  49, -21, -62,  38,  35, -64, -77, -61,  19,  25,  -1, -17,  15,  22;
/M: SY='G';  M= -21,  39,  37, -18, -80,  62, -60, -82,  -6, -48, -72,  60, -71, -20, -55, -13, -59, -78, -84, -74;
/M: SY='L';  M= -64, -70, -81, -75,  48,  -7, -69, -21, -25,  68,  22, -76, -81, -71, -72, -45, -62,  19, -66, -47;
/M: SY='V';  M=  -9,  38, -19, -72,  24, -78, -74,  46, -72,   9, -11, -70,  11, -72, -75, -32,   8,  48, -73,  -8;
/M: SY='E';  M= -14, -76,  15,  53, -77, -64,  15, -77,  21, -74,  -9,  17, -64,  46,  15,  35, -32, -73,  38, -63;
/M: SY='K';  M= -37,  39,  16, -21,  -2, -69,  -1,  -7,  49, -42, -61,  38, -69,   1,  28, -34,  29, -36, -77,  -8;
/M: SY='F';  M= -73, -71, -86, -81, 111, -83, -65, -45, -78,  18, -46, -77, -85, -83, -75, -74, -66, -20, -43,  31;
/M: SY='K';  M= -60, -77, -53,  13, -11,  -7,  45, -75,  69, -36, -19,  14, -66,  54,   2,   0, -58, -73, -75, -59;
/M: SY='I';  M= -24,  58, -84, -80, -17, -84, -78,  83, -77,  23,  40, -75, -77, -74, -79, -71, -59,   5, -75, -57;
/I:         I=-42; MD=-106;
/M: SY='P';  M= -18, -81,  49, -52, -84, -35, -22, -79,   6, -84, -74,  13,  82, -58, -29,  37, -40, -78, -87, -76; D=-42;
/I:         I=-42; MI=-106; MD=-106; IM=-106; DM=-106;
/M: SY='H';  M= -26,  26,  12,  12, -65, -75,  39,  -1, -10, -45,  23, -60,  25,  28, -63, -34,  21,   9, -77,  30; D=-42;
/I:         I=-42; DM=-106;
/M: SY='E';  M= -58, -76,  45,  67, -76, -45, -58, -25, -31, -68, -20,   6,   5,  12,  -7,  11,  -4,  14, -84, -69;
/M: SY='T';  M= -16,  19, -23,   5,   1, -71, -67, -32,  39, -38, -56, -56, -66, -19, -56, -21,  68,  39, -80, -62;
/M: SY='L';  M= -25,  -8, -84, -77,  36, -83, -69, -13, -77,  82, -12, -81, -83, -72, -75, -75, -63, -41, -67, -48;
/M: SY='C';  M=  -7,  88, -70, -22, -28, -74,  19,   6, -13,   9,  50, -63, -76,  14,  33, -31, -20,  -1, -80, -61;
/M: SY='R';  M=  -6, -74, -55, -26, -71, -65, -53, -74,  -5, -36, -54,  54, -71, -46,  85,  12,  13, -69, -78, -17;
/M: SY='W';  M= -75, -81, -89, -80,  89, -79, -70, -56, -74, -14, -56, -82, -83, -77, -74, -76, -73, -64, 135,  56;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='L';  M= -39,  26, -84, -78,  25, -84, -72,  48, -76,  55,  52, -78, -80, -73, -76, -72, -60,  25, -71, -51;
/M: SY='M';  M= -12, -72, -33,   2,  20, -75,  25, -45, -62,  50,  57, -67, -75,   7,  -3,  -7, -60,  -8, -67,  22;
/M: SY='M';  M=  34,  20, -63, -29, -68, -61, -63, -13, -28, -59,  58, -30, -66,   4, -13,  50,  48, -18, -80, -64;
/M: SY='V';  M= -58,  21, -84, -78, -49, -85, -80,  33, -76,  44, -37, -79, -80, -75, -77, -70, -55,  77, -81, -59;
/M: SY='E';  M= -31, -79, -44,  77, -77, -71,  18, -81,  46, -75, -67, -21, -62,  15,  41,  -4, -59, -75, -76, -17;
/M: SY='K';  M=  11, -72,  25,   6, -76, -31, -20, -37,  72, -72, -65,  17, -65, -47, -18,  13,  -1, -15, -79, -67;
/M: SY='N';  M= -51, -73,   4, -59, -76,  56,  69, -81, -27, -51, -68,  83, -70, -54, -28,  -1, -56, -79, -87, -65;
/M: SY='Y';  M= -71, -82, -70, -74, -19, -78, -37, -56, -65, -53, -50, -72, -83, -61, -62, -66, -65, -62, -27, 135;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='R';  M=  -8, -78, -61, -52, -67, -48,  13, -77,  29, -73, -63, -19, -71,  -1,  87,  26, -58, -72,  10,  28;
/M: SY='N';  M= -46, -75,  46,  -9, -78, -35, -19, -73,  14, -75,   3,  64,  31,   4,  39,   5, -24, -29, -85, -68;
/M: SY='N';  M= -58, -69, -55, -66, -63, -66, -61,  22, -61, -54, -53,  90,   3, -63, -67, -55, -50,  66, -89, -66;
/M: SY='P';  M=  29, -79, -65, -56, -79, -65, -24, -69,   3, -38, -65, -65, 105, -61, -31, -55,  26, -67, -79, -75;
/M: SY='Y';  M= -72, -81, -72, -75,  44, -78, -40, -55, -67, -51, -50, -73, -84, -64, -64, -67, -66, -61, -28, 129;
/M: SY='H';  M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37;
/M: SY='N';  M= -62, -67, -35, -57, -77, -50, -43, -76, -48, -84, -70, 124, -73, -50, -56, -18, -46, -78, -96, -72;
/M: SY='W';  M=   9, -78, -77, -68,  53, -67, -72, -64, -62, -31, -63, -13, -75,   8,   6,  30, -63, -44, 136, -38;
/M: SY='R';  M= -34, -74, -69, -63, -58, -76, -62,  44,   5,  -7,  34, -17, -72, -55,  66, -30,  22,   7, -73,   6;
/M: SY='H';  M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37;
/M: SY='A';  M=  90,  37, -68, -63, -75,   6, -71, -64, -64, -67, -62, -62, -68, -61, -69, -26, -53, -15, -77, -72;
/M: SY='F';  M=  58, -67, -76, -71,  75, -66, -72,  -1, -70, -23, -52, -69, -74, -71, -72, -55,   9,  20,  21, -44;
/M: SY='D';  M= -17,  36,  94, -42, -81, -60, -54, -79, -55, -80, -75,  61, -68, -55, -63,   6,   9, -75, -97, -71;
/M: SY='V';  M= -52, -66, -80, -75, -55, -83, -84, -21, -73, -41, -43, -75, -77, -76, -75, -63,  12, 100, -88, -62;
/M: SY='T';  M=  52,  43, -69, -66, -62, -18, -68, -53, -65,  26,  32, -61, -69, -63, -69,  -5,  55, -24, -79, -65;
/M: SY='Q';  M= -62, -84, -54, -38, -82, -68,  96, -78, -44, -70, -56, -48, -67, 117, -43, -51, -64, -80, -79, -52;
/M: SY='C';  M=  40,  73, -66, -66,  13,  -9, -67, -62, -64, -41,  39, -19, -69, -63, -69,  21,  61, -55, -79, -62;
/M: SY='M';  M= -46,  50, -75, -71, -56, -75, -65,   4, -67, -14, 109, -65, -71, -64, -69, -36,  53,  28, -81, -58;
/M: SY='H';  M= -20, -78, -69, -68,  72, -42,  94, -64, -66, -56, -55,  -7, -78, -63, -64, -34, -66, -67,  81,  70;
/M: SY='Y';  M=  47,  53, -70, -67,   6, -65, -62, -53, -64,   0, -54, -63, -73, -63, -18,  14,  24,  10, -64,  58;
/M: SY='M';  M=  -4, -17, -81, -76,  54, -79, -65,  32, -73,  50,  58, -74, -78, -70, -73, -68,  -7, -41, -60,  27;
/M: SY='L';  M= -64,  10, -80, -75, -43, -83, -68,  -4, -75,  77,  -1, -77, -81, -70, -74, -40,   8,   8, -70,  12;
/M: SY='K';  M= -18, -17, -27, -26, -62, -31, -59, -61,  45,  -2,  38, -28, -67,  21,  -4,  21,  41, -40,  43,  16;
/M: SY='T';  M=  12, -69, -53,  -3, -69, -64,  13, -68,  16, -28, -61,  47, -66,  25,  27,  -3,  59, -63, -79,  -4;
/M: SY='P';  M=   4,  19, -12, -18, -31,  38, -66, -67, -62,  -2, -62,  15,  65, -62, -70,  -9,  37, -65, -79, -70;
/I:         I=-14; MD=-34;
/M: SY='K';  M=   8, -80, -62,  -7, -82,  26, -67, -28,  53, -79, -71,  29, -74, -23,   6,  -8, -63, -16, -84, -75; D=-14;
/I:         I=-14; MI=0; MD=-34; IM=0; DM=-34;
/M: SY='L';  M= -25, -75, -89, -82,   6, -88, -76,  40, -81,  60,  44, -84, -84, -76, -80, -78, -66,   6,   5, -56; D=-14;
/I:         I=-14; DM=-34;
/M: SY='Q';  M=  13, -74, -17,  16, -21, -25,  34, -63,  29, -40,  43, -37,  -7,  56, -22, -26,  12, -13,   5, -14;
/M: SY='N';  M=  -5, -72,  15,  42, -76, -24,  37, -74,   5, -56, -66,  65, -66,   4,  11,  16,   2, -40, -85, -66;
/M: SY='W';  M= -19,  27, -68, -64,  26, -72,  34,   8,  31,  -7, -52,   0, -74, -22, -23,  -2,  -9,  14,  49,  48;
/I:         I=-9; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='L';  M= -70, -72, -86, -80,  63, -86, -68,  -1, -79,  66,  29, -82, -85, -76, -76, -77, -65,  -7, -61,  13; D=-9;
/I:         I=-9; DM=-23;
/M: SY='T';  M= -53, -67,  10,  -6, -73, -12, -65, -67, -58, -71, -66, -17,   6, -59, -66,  34,  93, -60, -88, -69; D=-9;
/I:         I=-9; DM=-23;
/M: SY='D';  M= -16, -81,  87,  42, -85, -67,  -8, -81, -24, -80, -74, -46,  54,  17, -16, -56, -30, -78, -88, -71;
/M: SY='L';  M= -64, -71, -83, -77, -44, -84, -71,  42, -76,  73,  31, -79, -80, -70, -75, -38, -21,   3,  26, -54;
/M: SY='E';  M= -61, -81,  45, 102, -84, -74,  -5, -85, -43, -77, -73, -52, -57,   2, -53, -56, -60, -78, -83, -71;
/M: SY='I';  M=   8,  61, -73,   0, -57, -78, -74,  70, -27,  10, -45, -69, -74, -64,  16, -63, -12,   6, -78, -62;
/M: SY='L';  M= -41, -70, -80, -72,  52, -52, -66, -38,  16,  65,  47, -74, -80, -67, -65, -71, -62,   1, -64, -11;
/M: SY='A';  M=  79, -64, -69, -64, -69,  17, -70,  -7, -65,  -5, -56, -62, -68, -61, -69,   5, -26,  -7, -76, -68;
/M: SY='L';  M=  35, -68, -78, -72, -50, -36, -68,  16, -72,  64,  51, -73, -76, -66, -72, -15, -58, -14, -73, -58;
/M: SY='L';  M= -24,  10, -83, -78,  16, -83, -69,  46, -76,  63,  20, -78, -80, -71, -75, -72, -61,   2, -65,  27;
/M: SY='I';  M= -31, -71, -82, -78,  60, -83, -76,  69, -75,   1,  10, -73, -76, -76, -77, -66,  18,  36, -66, -46;
/M: SY='A';  M=  88, -62, -65, -60, -76,  -2, -68, -67, -62, -69, -63, -58, -66, -58, -67,  27,  -5, -55, -77, -71;
/M: SY='C';  M=  80, 100, -70, -65, -75, -22, -72, -70, -66, -69, -64, -62, -72, -64, -71,   1, -54, -57, -82, -74;
/M: SY='L';  M=  51, -16, -77, -71,  -1, -70, -70,  30, -71,  52,  36, -71, -74, -67, -72, -59,  -5, -29, -72, -57;
/M: SY='C';  M= -18, 114, -77, -76, -62, -29, -76,  45, -72, -38,  33, -66, -78, -73, -77,   5,   6,  15, -86, -68;
/M: SY='H';  M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37;
/M: SY='D';  M= -68, -81, 119, -31, -88, -64, -53, -86, -55, -85, -83, -20, -67, -54, -63, -55, -57, -83,-103, -70;
/M: SY='L';  M= -63, -71, -82, -77, -13, -84, -65,  15, -75,  62, -36, -79, -82, -71, -73, -72, -60,  47, -62,  61;
/M: SY='D';  M= -66,  15, 109,  27, -86, -26, -54, -85, -26, -83, -81, -13, -66, -52, -61, -56, -58, -81, -98, -71;
/M: SY='H';  M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37;
/M: SY='P';  M= -64, -83, -65, -55, -78, -71, -62, -72, -45, -74,  15, -63,  98, -55,  71, -59,  26, -72, -79, -71;
/M: SY='G';  M= -25, -76, -64, -76, -83, 102, -71, -90, -69, -86, -75, -50, -68, -67, -77, -49, -68, -83, -74, -78;
/M: SY='T';  M= -59, -69, -67, -64,  25, -76, -16, -47, -24, -11, -52, -60, -71, -61,  47, -53,  70,  41, -71,  22;
/M: SY='N';  M= -54, -65, -45, -58, -73, -30, -52, -70, -52, -75, -67,  95, -66, -53, -60,  39,  68, -66, -90, -69;
/M: SY='N';  M= -62, -68, -36, -55, -77, -51, -43, -76, -47, -83, -69, 122, -73,  14, -55, -23, -47, -78, -94, -71;
/M: SY='S';  M=  41, -68, -59, -55, -73, -57,  -3, -32, -55, -16, -60,  15,   8,  50, -20,  60,   8, -60, -79, -65;
/M: SY='F';  M= -74, -74, -82, -80, 107, -82, -57, -50, -75, -20, -49, -76, -85, -79, -72, -72, -67, -55, -37,  81;
/M: SY='Q';  M= -64, -76, -67, -54, -54, -76,  59, -17, -58,  57,   4, -62, -75,  87, -56, -62, -63, -54, -71,  10;
/M: SY='I';  M=  -2,  57, -78, -72, -56, -79, -75,  71, -30, -13,  46, -70, -74,  18, -71, -64,  -9,  34, -78, -60;
/M: SY='N';  M=  19, -71, -48, -48, -78, -59, -51, -74,  58, -75, -18,  82, -68,  52, -10, -48, -19, -71, -80, -67;
/M: SY='T';  M=  25,  15, -62, -62, -12, -60, -66, -58, -60, -62,  24, -52, -64, -59, -66,  57,  76,  -4, -81, -63;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='N';  M= -45, -75,  13,  32, -80,   6, -53, -79,  40, -78, -68,  56, -66,  42,  33,   9, -26, -76, -80, -68;
/M: SY='S';  M=  -3, -67,  18, -54, -74, -55,  55, -73, -56, -74, -67,  16, -65, -13, -60,  82,  35, -66, -86, -62;
/M: SY='P';  M= -12, -81,  -7,  65, -77, -69,   1, -71, -28, -74, -67, -61,  84,  -3, -24,  -7, -58, -13, -78,  -8;
/M: SY='L';  M= -64,  30, -80, -72, -21, -83, -69, -12, -38,  78, -34, -77, -35,  11, -71, -72, -34,  13, -73, -55;
/M: SY='A';  M=  93, -62, -66, -60, -76, -10, -68, -67, -62, -69, -62, -60, -66, -58, -67,  18, -51, -54, -76, -71;
/M: SY='I';  M=   2, -71, -73, -66,  -3, -76, -70,  51, -11,  25,  -8, -18, -74,  36, -31, -27, -17,  39, -75, -57;
/M: SY='L';  M= -65, -71, -76, -34, -47, -81, -64, -15,  -1,  76,  52, -11, -79, -62,   7, -72, -62, -28, -73, -55;
/M: SY='Y';  M= -70, -80, -69, -72,  25, -76,  37, -58, -65, -54, -51, -53, -81, -61, -62, -13, -64, -62, -32, 126;
/I:         I=-36; MD=-90;
/M: SY='N';  M= -70, -82, -55, -68, -91, -27, -61, -90,  -3, -95, -83,  93, -83, -15, -67,  30, -59, -89,-102, -84; D=-36;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='D';  M= -60,  21,  88,  10, -82,  11, -55, -81, -55, -81, -76,  50, -67, -54, -63,  12,   9, -76, -93, -71;
/M: SY='T';  M= -37, -71, -45,   1, -69,  -2,  21,   8,  14, -42,  -2,   0, -66, -52,  46,  23,  53, -22, -81, -63;
/M: SY='S';  M=   9, -64, -57, -47, -75, -15, -60, -73, -58, -76, -70, -46, -64, -50, -62, 102, -17, -65, -82, -67;
/M: SY='V';  M= -55, -68, -76, -73, -57, -81, -81,  44, -71, -43, -45, -70,  13, -73, -75, -49,  45,  80, -84, -62;
/M: SY='M';  M= -65, -69, -84, -76, -43, -83, -64, -33, -75,  80,  88, -80, -80, -67, -72, -76, -62, -40, -72, -52;
/M: SY='E';  M= -60, -81, -31, 112, -84, -76, -53, -85, -41, -77, -73, -57, -55, -34, -51, -57, -61, -77, -80, -74;
/M: SY='N';  M= -62, -73, -45, -53, -75, -59,  70, -73, -45, -75, -63,  96, -72,  42,  39,  -7, -53, -22, -89, -61;
/M: SY='H';  M= -70, -80, -55, -55, -13, -72, 145, -80, -59, -29, -52, -45, -71, -49, -53, -60, -68, -81, -94,  -5;
/M: SY='H';  M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37;
/M: SY='F';  M=  17,  57, -81, -75,  73, -76, -72,   5, -71,  30, -47, -73, -79, -74, -20, -64,   0, -10,  52, -42;
/M: SY='A';  M=  60, -67,  34,  16, -77, -55,  -5, -72, -54, -72, -13,  20, -66, -51,  -2,  50, -49, -63, -82, -68;
/M: SY='Q';  M=  -5, -73, -65, -30, -11, -69,   7,   8, -57,  18, -49, -59, -71,  80, -58,  29, -10,  19, -73,  -7;
/M: SY='C';  M=  64,  76, -68, -65, -15,  12, -71, -63, -65, -66, -62, -58, -69, -64, -70,   1,  42, -11, -80, -69;
/M: SY='F';  M= -66, -73, -82, -75,  83, -82, -71,  23,  -4,  10, -46, -75, -80,  -9, -69, -71, -62,  39,  63,   6;
/M: SY='M';  M= -15, -74, -58,  11, -31,   0, -56, -33,  38, -62,  67,   6, -67,  49,  34,   3,   6, -63, -75, -62;
/M: SY='I';  M= -66, -73, -85, -80, -44, -87, -74,  74, -78,  65,  33, -79, -79, -72, -77, -75, -61, -27, -72, -54;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='L';  M= -66, -69, -83, -75, -42, -84, -66, -33, -76,  85,  60, -80, -81, -68, -73, -74, -15, -40, -72, -53;
/M: SY='Q';  M= -16, -74, -49,   4, -80, -36, -50, -74, -26, -74, -64,  66, -68,  88,  23,  28, -29, -43, -80, -66;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='D';  M= -38, -74,  54,  53, -75, -50,  -4, -70, -28, -15, -65,  16, -65,   8,   5,  38,  -2, -23, -85, -67;
/M: SY='P';  M= -36, -80,  42,  63, -81, -68,  42, -78, -22, -78, -70, -53,  73, -21, -59,   9,   1, -75, -84, -69;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='E';  M= -33, -77, -25,  66, -79,  60, -11, -84,  -3, -80, -72,  24, -63, -23, -22,  -7, -36, -78,  32, -70;
/I:         I=-42; MD=-106;
/M: SY='C';  M= -35,  99, -65, -69,  -7, -71,  59, -36, -40, -15,  41,  50, -13, -65, -68, -13, -60, -36, -81,  21; D=-42;
/I:         I=-42; MI=-106; MD=-106; IM=-106; DM=-106;
/M: SY='N';  M= -64, -74,  47, -20, -82, -31,  -7, -80, -51, -84, -72, 102, -72,  43, -57, -25, -53, -81, -94, -71; D=-42;
/I:         I=-42; DM=-106;
/M: SY='I';  M= -66, -76, -86, -83,  34, -89, -81,  96, -79,  11, -36, -77, -76, -76, -81, -74, -59,   3, -68, -50;
/M: SY='F';  M= -71, -70, -85, -80,  98, -83, -67, -24, -77,  52, -41, -77, -84, -80, -75, -73, -13, -47, -51,  -5;
/M: SY='S';  M=   3,   4,   6,  10, -72, -44, -60,   4,  20, -21, -14, -52, -66,  50, -46,  61, -28, -28, -79, -65;
/M: SY='N';  M= -39, -70, -47, -58, -74,  22,  67, -26, -27, -75, -65,  91, -30, -26, -59,  15,  21, -71, -89, -64;
/M: SY='L';  M= -66, -70, -83, -76,  17, -71, -67,   0, -75,  80,  43, -79, -82, -69, -39, -26, -62, -29, -69, -50;
/M: SY='S';  M= -51, -70,  38,  -3, -62, -57, -58, -73, -18, -77, -70,  23,  36, -23, -60,  74,  35, -68, -85, -69;
/M: SY='R';  M= -19, -75, -24, -28, -72, -19,  24,   3,  51, -38, -61,  -3,  19, -49,  52,  27, -21, -31, -78, -64;
/M: SY='E';  M=   7, -75,  49,  54, -79, -57, -56, -74,  40, -74, -31,   5, -64, -12,  18,  12, -35, -22, -82, -68;
/I:         I=-6; MD=-14;
/M: SY='E';  M= -60, -79,  53,  71, -82, -20,  -9, -77, -49, -67,  -6, -50, -63,  58, -55,   2,   1, -40, -84, -69; D=-6;
/I:         I=-6; MI=0; MD=-14; IM=0; DM=-14;
/M: SY='Y';  M= -72, -79, -74, -71,  70, -80,  11, -59, -21, -54, -11, -69, -82, -63,  40, -68, -27, -36,  37,  93; D=-6;
/I:         I=-6; DM=-14;
/M: SY='K';  M= -34, -16, -57,  28, -73, -73, -33, -35,  58,  -4, -59, -19, -68,  52,  38, -20, -26, -16, -77, -65; D=-6;
/I:         I=-6; DM=-14;
/M: SY='Q';  M= -60, -61,  15,  42, -75, -70,  27, -73, -21, -31, -63, -17, -66,  59,  27,  12,  48, -69, -81, -18; D=-6;
/I:         I=-6; DM=-14;
/M: SY='M';  M=  -3, -70, -81, -76,  45, -80, -72,  28, -74,  42,  49, -74, -78, -72, -75, -66,  20,  28, -70, -50; D=-6;
/I:         I=-6; DM=-14;
/M: SY='R';  M= -43, -77, -68,  -5,  18, -79, -59,   2,  -8,  30,  24, -65, -76, -51,  83, -66, -63, -30, -69, -14;
/M: SY='Q';  M=  -9, -76,  18,  23,  -1, -44,  43, -76,  37, -72, -64,  28, -67,  50,  37, -11, -18, -73, -76, -20;
/M: SY='M';  M= -10, -71, -75, -69, -10,  -1, -67,  41, -66,  44,  55, -66, -73,  10, -10,  -7,  13, -27, -73, -56;
/M: SY='M';  M= -59, -71, -84, -79,   0, -85, -76,  66, -75,   6,  70, -77, -76, -73, -76, -71, -56,  63, -76, -54;
/M: SY='I';  M= -61, -77, -15,   1, -61, -16, -69,  73,  32, -24, -49, -61, -70, -56,  34,   1, -57, -10, -76, -61;
/M: SY='D';  M= -16, -78,  63,  54, -78, -69,  32,  -7,   5, -71, -66, -48, -64,  45,  -9, -10,  -8, -31, -84, -65;
/M: SY='M';  M=  51,  49, -77, -70, -27, -67, -66,  16, -69,  27,  86, -69, -73, -64, -70, -21, -57, -24, -74, -20;
/M: SY='I';  M= -60, -74, -41, -80, -51, -88, -85,  91, -77, -35, -38, -76, -75, -76, -80, -71, -56,  60, -78, -58;
/M: SY='L';  M= -66, -70, -84, -77, -42, -28, -70,  28, -78,  84,  -4, -81, -82, -71, -76, -75, -63, -37, -71, -54;
/M: SY='A';  M=  92, -62, -66, -60, -74, -34,  13, -66, -62, -47, -61, -60, -66, -58, -66,  13, -51, -54, -77, -69;
/M: SY='T';  M= -52, -62, -57, -60, -68, -68, -68, -59, -57, -63, -60, -47, -26, -62, -66, -36, 115, -51, -88, -66;
/M: SY='D';  M= -67, -81, 116,  11, -40, -65, -53, -85, -54, -83, -82, -36, -66, -53, -63, -56, -58, -82, -99, -69;
/M: SY='M';  M= -64, -70, -84, -75, -46, -81, -61,  18, -70,  56, 116, -75, -76, -63, -37, -73, -61, -39, -73, -52;
/M: SY='A';  M=  68, -64, -59, -23, -75, -53, -63, -68,   3, -71, -64, -15, -64, -18, -59,  58,  26, -58, -79, -69;
/M: SY='K';  M= -37,  37, -65, -58, -29, -42,  23, -56,  52,  44,  -6,  10, -74, -19,  39, -62, -34, -37, -76, -59;
/M: SY='H';  M= -69, -81, -58, -57, -16, -73, 130, -74, -59, -63, -53, -50, -73,  12, -54, -60, -36, -76, -65,  79;
/M: SY='F';  M= -10, -70, -76, -75,  96, -39, -64,   7, -70,  -4,  47,  16, -79, -72, -38,   1, -60, -50, -54, -33;
/M: SY='E';  M= -38, -77,  14,  62, -80,  -4, -55, -79,  38, -75, -20,   9, -63,  46,  12,  15, -12, -74, -79, -68;
/M: SY='H';  M= -21, -75, -63, -58,  16, -72,  44,  24,  23,  11, -50,  30, -73,  40,  20, -59, -12, -55, -66,  40;
/M: SY='R';  M= -63, -73, -72, -20,   3, -81, -64,   5,  -5,  39,  28, -68, -76, -16,  63, -66, -30,  32, -74, -56;
/M: SY='K';  M=  41, -69,  14,  -8, -77,  15, -61, -72,  52, -73, -15,  30, -28, -51, -50,  -5,  28, -65, -79, -69;
/M: SY='Q';  M=  -4, -75,  39,  27, -75, -67, -56, -70,  40, -27,  28, -20, -29,  42,  30,  10,   0, -68, -79, -65;
/M: SY='F';  M= -71, -71, -85, -79,  96, -83,  13,  -8, -76,  42,  47, -76, -83, -77, -74, -74, -65, -30, -53, -31;
/M: SY='K';  M= -62, -75, -19,   6,  28, -23, -57, -41,  56, -17,  24,  27, -69,  45,  15, -57, -11, -12, -72, -56;
/M: SY='E';  M=  15, -71, -14,  62, -76, -50,  25, -72,  27, -72, -66,  15, -27, -20, -52,  11,  44, -34, -82, -67;
/I:         I=-4; MD=-10;
/M: SY='M';  M=  -8, -72, -73, -66, -57, -73,  37,  26,  24,  23,  92, -64, -72, -58, -30,  15, -58, -28, -77, -56; D=-4;
/I:         I=-4; MD=-10;
/M: SY='V';  M=  19, -71, -80, -75, -21, -78, -10,  37, -74,  40,  19, -75, -78, -70, -74, -66, -26,  46, -72,  23; D=-4;
/I:         I=-4; MD=-10;
/M: SY='Q';  M= -34, -76,  30,  49, -81, -38,   0, -77, -47, -76, -60,  42, -22,  52,  14,  29,  -1, -41, -85, -68; D=-4;
/I:         I=-4; MD=-10;
/M: SY='T';  M=  -4, -72,  13,   1, -73, -39, -60, -21,  32, -25, -61,  39, -67,  40, -30, -10,  48, -13, -83, -67; D=-4;
/I:         I=-4; MD=-10;
/M: SY='G';  M= -61, -12,   3, -32,  29,  48, -65, -29,  22, -17, -64,  29,  35,  -2, -62, -19, -61, -30, -74, -62; D=-4;
/I:         I=-4; MD=-10;
/M: SY='E';  M= -53, -77,  37,  44, -28, -23, -58, -68,  26, -31, -31, -10,  -2,  24, -55,  20, -10, -11, -75,  24; D=-4;
/I:         I=-4; MD=-10;
/M: SY='F';  M= -18, -78,  -4, -35,  48, -43, -68, -56, -43,  11, -58,  -6,  -7, -37, -74,   0,  -5,  14, -69,  36; D=-4;
/I:         I=-4; MD=-10;
/M: SY='N';  M= -14, -19,  37, -17, -80, -75, -22, -42, -32, -82,  -3,  52, -26, -64,  17, -53,  21, -78, -92,   9; D=-4;
/I:         I=-4; MI=0; MD=-10; IM=0; DM=-10;
/M: SY='W';  M= -83,  14, -94, -42, -51, -94, -88, -31, -44,  42, -18, -31, -95, -29, -39, -34, -40, -70,  98, -65; D=-4;
/I:         I=-4; DM=-10;
/M: SY='N';  M= -64, -78,  42,  32, -80, -68, -19, -45, -37, -37, -10,  53, -71,  24, -34,  25,  13, -39, -92, -72; D=-4;
/I:         I=-4; DM=-10;
/M: SY='N';  M= -43,  16,  44,  -4, -35, -22, -56, -41, -18, -80, -73,  87, -75, -57,  -8, -19, -18, -32, -94, -73; D=-4;
/I:         I=-4; DM=-10;
/M: SY='P';  M= -16, -79,  -5,  40, -26, -17, -56, -73,  31, -72, -65, -56,  55,  38,  12, -24,   2, -50, -69,  35;
/M: SY='E';  M= -18, -73, -19,  55, -71, -67,  37,  15, -25, -49,   6,  17, -63,  25, -18,  26,  40, -59, -82, -63;
/M: SY='H';  M= -66, -79,  76, -20, -29, -67, 100, -82,  15, -75, -66,  11, -30,  23, -11, -37, -30, -80, -91, -54;
/M: SY='R';  M= -64, -80, -60, -49, -74, -73,  38, -38,  58, -54,   3, -53, -70,  14,  89, -15, -61, -72, -76, -60;
/M: SY='D';  M= -17, -75,  42,  29, -63, -72,  25,  33, -55,  19, -53,  -5, -14,  -3,  17, -16,   2, -53, -79, -16;
/M: SY='L';  M= -64, -72, -71, -15, -17, -80, -63,  -1,  20,  63,  27, -68, -75,  33,   8, -66,  -2, -22, -72, -56;
/M: SY='V';  M=  13, -21, -80, -75,  26, -78, -74,  29, -73,  38,  20, -74, -77, -72, -74, -64,   5,  55, -73, -54;
/M: SY='M';  M= -64,  65, -78, -69, -51, -47, -66,  18,  10,  58,  69, -71, -78, -16,   6, -70, -62, -45, -75, -58;
/M: SY='Q';  M=  28,  48, -26,  -1, -75,  12, -60, -31, -12, -68,  30, -21, -68,  53,  19,  41, -54, -64, -78, -67;
/M: SY='M';  M= -62, -70, -77, -74, -20, -77, -62,  28, -69,  48, 103,  17, -75, -64, -69, -35, -27,  -3, -74, -53;
/M: SY='M';  M= -15,  27, -82, -75, -13, -78, -65,  15, -72,  58,  94, -74, -77, -66, -71, -20, -59, -12, -73, -53;
/M: SY='M';  M= -62, -71, -84, -77, -48, -83, -68,  59, -73,  36, 104, -76, -75, -67, -73, -72, -59,  22, -75, -54;
/M: SY='H';  M= -60, -71, -55, -50, -72, -69,  88, -72,  71, -70, -60, -46, -63, -48, -42, -48,  73, -66, -84, -57;
/M: SY='C';  M=  67, 100, -72, -67, -69, -23, -72, -61, -67, -15, -13, -63, -74, -66, -72,   7, -31,  -7, -82, -71;
/M: SY='C';  M=  70, 116, -72, -68, -74,  -5, -74, -72, -68, -69, -65, -63, -75, -68, -74, -25, -56, -59, -85, -76;
/M: SY='D';  M= -50, -81, 119, -31, -88, -64, -53, -86, -55, -84, -83, -35, -67, -54, -63, -55, -57, -82,-103, -70;
/M: SY='I';  M= -64, -73, -85, -80, -46, -88, -78,  77, -78,  58, -33, -79, -79, -74, -79, -74, -59,  24, -74, -56;
/M: SY='S';  M= -28,  62, -57, -60, -74,   0, -61, -73, -59, -76, -70,  17, -67, -53, -64,  94, -41, -35, -84, -69;
/M: SY='N';  M=  45, -68,  14, -55, -76,  -9,  56, -75, -55, -76, -66,  89, -69, -53, -60,  13, -50, -70, -88, -66;
/M: SY='P';  M= -57, -80, -66,  12, -69, -73, -70,  42, -62, -58, -55, -69,  91,  21, -70,  -3, -56,  31, -79, -69;
/M: SY='T';  M=  46,  55, -63, -63, -69, -62, -69, -59, -61, -37, -59, -54, -65, -63, -68,   3,  87, -14, -85, -68;
/M: SY='K';  M= -64, -79, -57, -44, -78, -72, -56, -80,  95, -77, -65, -50, -66, -40,  69, -58, -60, -75, -73, -64;
/M: SY='P';  M= -42,  -8, -41, -29, -77,   4, -66, -31, -61, -15, -63,  -9, 102,  18, -70,  -4,  -1, -39, -79, -74;
/M: SY='W';  M= -71, -85, -92, -77,  25, -77, -81, -37, -36,  18,  40, -85, -79, -69, -22, -77, -75, -21, 154,  -8;
/M: SY='E';  M= -22, -79,  41,  62, -81, -12,  17, -79,   5, -56, -70,  12,  55,  13, -56,   3, -57, -76, -83, -70;
/M: SY='I';  M= -61, -70, -80, -76, -20, -83, -25,  54, -74,  45,   4, -26, -77, -72, -75, -68,   8,  53, -76, -21;
/M: SY='H';  M=  14,  48, -58, -31, -63, -63,  75, -71, -55, -68, -60, -20, -69,  61, -57,  38,  27, -66, -73,  44;
/M: SY='R';  M= -27, -76, -57,  11, -30, -69,  38,  -2,  38, -22, -58, -14, -68,  39,  58,  19,  -6, -64, -76, -30;
/M: SY='Q';  M= -63, -81, -56,  23, -76, -72,   2, -73,  46, -14,  -9, -19,  13,  67,  65, -57, -61, -72, -75, -63;
/M: SY='W';  M= -68, -86, -91, -78, -45, -77, -94,  28, -72, -54, -60, -84, -76, -72, -76, -72,  15,  23, 159, -36;
/M: SY='A';  M=  72, -62, -65, -62, -69, -57, -68, -56, -62, -16, -57, -32, -66, -60, -67,  16,  57,   4, -80, -67;
/I:         I=-45; MD=-115;
/M: SY='E';  M= -20, -77,  44,  60, -71, -41,  -6, -70,  20,  -9,  43,  35, -67, -24, -26, -58, -60, -69, -80,  -5; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='R';  M=  17,  20,   9, -61, -61,  -6, -63, -53, -20,  43, -13, -22, -75, -57,  60, -38, -60,  -5, -77, -62;
/M: SY='I';  M= -60, -72, -85, -80, -49, -87, -82,  76, -77,  30, -36, -78, -78, -75, -79, -72, -56,  63, -78, -58;
/M: SY='M';  M=  33,  20, -71, -68, -17, -67, -60, -48, -65,  16,  75, -64, -72, -62, -67,   9,  37,  -4, -66,  51;
/M: SY='E';  M=  19, -73,   7,  78, -77, -65, -56, -73,  -4, -22, -65,  15, -61,  19, -54,   9,   9, -67, -81, -69;
/M: SY='E';  M= -60, -81, -31, 112, -84, -76, -53, -85, -41, -77, -73, -57, -55, -34, -51, -57, -61, -77, -80, -74;
/M: SY='F';  M= -76, -74, -86, -83, 115, -83, -63, -51, -78, -43, -52, -77, -87, -85, -75, -74, -68, -56, -39,  55;
/M: SY='F';  M= -28, -77, -83, -80, 100, -78, -64, -55, -74, -49, -55, -15, -84, -78, -73, -72, -69, -61,  96,  63;
/M: SY='D';  M=  16, -76,  51,  45, -77, -67,   4, -74, -23, -34,  28, -13, -63,  24,  40,   7, -58, -70, -83, -66;
/M: SY='Q';  M= -60,   9, -54,  11, -90, -69, -49, -77, -41, -72, -60, -52, -67, 126, -43, -50, -63, -78, -74, -63;
/M: SY='G';  M=   0, -73, -64, -72, -81,  89, -70, -84, -67, -82, -73, -51, -68, -65, -74,  21,  16, -76, -77, -76;
/M: SY='D';  M= -38, -81, 111,   4, -85, -67,  -6, -83, -55, -39, -79, -39, -68, -54, -28, -57, -59, -80,-100, -70;
/M: SY='E';  M= -18, -76,   5,  45, -61, -77, -60, -22,  23,  40,  30, -63, -71, -50,  43, -64, -62, -58, -75, -18;
/M: SY='E';  M= -61, -81, -34, 108, -82, -77, -54, -80, -44, -72,  29, -59, -57, -36, -53, -59, -62, -75, -81, -73;
/M: SY='K';  M=  15, -76, -61, -49, -77, -70, -59, -76,  78, -45, -64, -54, -68,  -7,  66, -55,  -1, -70, -75, -66;
/M: SY='E';  M= -10, -75, -52,  53, -14, -69, -59, -36,  33,  -2, -61, -20, -66,  32,  14,  24,  12, -65, -77, -64;
/M: SY='R';  M= -62,  -7, -61,  34, -18, -75,  10, -54,  -9,  33,  25, -15, -73,  25,  37,   5, -60,  -1, -75,  -5;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='G';  M= -55, -77, -11, -26, -82,  83,  24, -87, -18, -84, -73,  43, -70,  11, -15, -51, -64, -83, -79, -73;
/M: SY='L';  M= -65, -73, -77, -70, -49, -81, -66,  22, -30,  63,  48, -19, -10,  22, -69, -69, -11,   3, -74, -15;
/M: SY='P';  M= -63, -85,   3,  49, -85, -29, -60, -78, -24, -80, -70, -28,  89,  54, -20, -57,  -3, -78, -81, -75;
/M: SY='P';  M= -63, -79, -77, -69,  14, -79, -76,  44, -71, -28, -50, -76,  81,  -6, -76, -68, -58,  53, -75, -23;
/I:         I=-45; MI=0; MD=-115; IM=0; DM=-115;
/M: SY='S';  M= -11, -68, -14, -65, -62, -66, -66,  39, -65,  -9,  59, -57, -68, -60, -69,  62,  39, -13, -81, -62;
/M: SY='P';  M=   4,  10,   1,  11, -85, -68, -69, -76, -62, -82, -71, -69, 114, -63, -73, -61, -60, -76, -82, -82;
/M: SY='M';  M= -65, -71, -85, -78,  59, -24, -63,  -1, -73,  26, 108, -75, -78, -69, -72, -72, -63,   3, -64, -12;
/M: SY='M';  M= -58,  88, -84, -78,  56, -29, -63, -47, -72, -40, 118, -71, -78, -69, -72, -70, -63, -51, -69, -47;
/M: SY='D';  M= -68, -81, 111,  11, -88, -65, -53, -86, -54, -85, -83,  26, -68, -53, -63, -56, -58, -83,-102, -72;
/I:         I=-42; MD=-106;
/M: SY='R';  M= -68, -85, -65, -53, -79, -78, -56, -85,  16, -78, -67, -58, -24,  -6, 106, -21, -66, -79, -79, -66; D=-42;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='N';  M= -37, -75,  35,  40, -75, -26,  53, -78,   9, -76, -68,  58, -66,  19, -54,  -1,  24, -74, -84,  -3;
/M: SY='K';  M= -35, -73, -26, -49, -77, -65, -58, -75,  75, -77, -67,  39,  -3,  -9,  13,  13,  41, -70, -80, -68;
/M: SY='C';  M=  35,  49, -22,  -9, -74, -49, -66, -61,  42, -67,  -7,   7,  18, -56, -20, -13,  19,  16, -82, -70;
/M: SY='D';  M= -19, -51,  52,  -8, -67, -63,  15, -65, -57, -29,   7,  27, -69,  21, -62,  47,  18,  -9, -80,  24;
/M: SY='E';  M= -61, -75, -14,  47, -61, -81, -69,  41,  26,   9,   4, -66, -70, -56, -28, -65, -25,  44, -80, -63;
/M: SY='P';  M=  46, -73, -65,  25, -66, -67,  -1,   3, -64,  20, -53, -68,  59, -60, -69, -19, -25,  -1, -79, -68;
/M: SY='P';  M= -63, -81, -31,   5, -80, -37, -62, -38,  56, -43, -66,   4,  81,  16,  -6, -26,   5, -72, -79, -72;
/M: SY='S';  M= -17,  -4, -63, -58, -68, -10, -63,   2,  27,   6, -15, -54, -69,  32, -27,  65,  -3, -32, -79, -65;
/M: SY='Q';  M= -37, -80, -60, -10, -75,  -5, -53, -63, -48,   0,  63, -56, -69, 111, -49, -54, -63, -66, -74, -61;
/M: SY='Q';  M= -38,  -8,  -3,  -5, -64, -79, -68,  69, -60, -48, -47, -64, -72,  80, -63, -62, -59,  30, -78, -62;
/M: SY='G';  M= -53, -17,  -9, -68, -68,  57, -70, -54, -67,   9, -58, -20,  -6, -65, -31,  39, -56,  37, -81, -69;
/M: SY='F';  M= -67, -74, -75,  -2, 103,  46, -68, -60, -73, -52, -58, -32, -79, -77, -75, -66, -68, -63, -51, -32;
/M: SY='I';  M= -68, -76, -86, -82,  68, -85, -76,  79, -77,  -5,  50, -76, -78, -76, -78, -26, -62, -33,  32, -42;
/M: SY='D';  M= -41, -78,  73,  17, -24, -39, -61,  49, -13, -59,  -5, -17, -69, -58, -65, -20,   8, -52, -77,  23;
/M: SY='Y';  M= -70, -78,  54, -56,  59, -73,  57, -33, -10, -38,  -9,  16, -76,  -6, -25, -63, -63, -66, -58,  69;
/M: SY='I';  M=  17, -72, -79, -77,  58, -27, -76,  63, -74, -24, -46, -13, -77, -74, -77, -20, -58,  34, -68, -49;
/M: SY='V';  M=  23, -70, -82, -76, -55, -42, -81,  55, -75,   2, -43, -75, -77, -50, -77, -64, -55,  71, -81, -62;
/M: SY='C';  M=  11,  91, -64,  29, -68,  -4,  47,   6, -63,  -7,  21, -61, -73, -16, -31, -17,  -5, -32, -85, -65;
/M: SY='P';  M= -47, -82,   7, -29, -71, -73, -69,   1, -33,   6,  15, -68, 102, -65, -72, -63,   7, -25, -80, -72;
/M: SY='P';  M= -38, -74, -72, -66,  28, -75, -66,   5, -66,  36,  52, -12,  53,  23, -69, -15,  24, -28, -72, -56;
/M: SY='F';  M= -44,  69, -85, -80,  78, -81, -68, -29, -76,  16,  22, -78, -85, -78, -75, -72, -65,   9,  72,  43;
/M: SY='Y';  M= -38, -78,  19,  40, -51, -47,   9, -69,  -6, -67, -62,  -3, -69,  31,  -5, -11,  17, -45, -58,  83;
/M: SY='T';  M=   9, -70,  14,  34, -68, -69, -64, -30,  10,   8, -58, -55, -66, -18, -12,  14,  52,  -2, -82, -66;
/M: SY='W';  M=   9, -17, -77,  -3, -19, -75, -73, -10, -69,  32,  24, -75, -12, -66, -72, -65,  12,   3, 115,  14;
/M: SY='D';  M=  30, -71,  33, -31,  16, -23,  13, -27, -63,  27, -53, -25, -72,  23, -66, -16,  27, -15, -77, -58;
/M: SY='D';  M=  12,  14,  63,  10, -78, -36,  10, -73,   0, -74, -69, -11, -67,   2,  -9,  23,  35, -28, -88, -68;
/M: SY='H';  M=  -5, -11, -14, -63,  44, -75,  49, -17, -21,  40,   6, -24, -77,  20,  15, -35, -34, -12, -71, -49;
/M: SY='F';  M=  -8,  -3, -79, -76,  56,  -7, -76,  30, -74,  11, -47, -71, -77, -75, -76, -26,  18,  48, -69, -50;
/I:         I=-6; MD=-15;
/M: SY='H';  M= -67, -81, -38,   5,  17, -37,  65, -66,  -8,  15, -59,   1,  62, -23, -65,  11, -62, -45, -79, -28; D=-6;
/I:         I=-6; MD=-15;
/M: SY='P';  M= -54, -90,  -3,  37, -85, -66, -10, -62,  13, -20,  20, -21,  65,   4, -66, -69, -24, -51, -90, -79; D=-6;
/I:         I=-6; MI=0; MD=-15; IM=0; DM=-15;
/M: SY='D';  M= -65, -81,  57,  11,   5,  -3, -67,   5,  28, -11, -65, -57,  15, -60, -62,  -2, -62, -19,  36, -64; D=-6;
/I:         I=-6; DM=-15;
/M: SY='C';  M=  20,  43, -69, -13, -14, -38, -67,  26, -20,  21,  30, -21, -14, -18, -26,   3,  23, -49, -76, -17;
/M: SY='Q';  M=  -6,  26, -19,  51,  11, -39, -59, -72,   3, -42, -64, -22,  15,  66, -23, -13,  18, -69, -76, -63;
/M: SY='P';  M= -40, -81,  28,  31,  -1, -69, -62, -28, -26, -45, -66,  11,  77,  31, -63, -45,  21, -70,  43, -65;
/M: SY='M';  M= -66,  -7, -83, -75, -13, -82, -69,  23, -73,  60,  79, -77,  -7, -20, -73, -72,  -9, -43,  63, -52;
/M: SY='L';  M= -63, -71, -79, -74, -10, -80, -65,   3, -71,  60,  47, -74, -79, -67, -29,   2,  -6,  22, -68,  32;
/M: SY='D';  M= -63, -80,  75,  37, -82, -21,  36, -22,  26, -76, -69, -25, -66,  50, -32, -32, -16, -75, -87, -66;
/M: SY='H';  M=   3, -18, -61, -61, -35,  29,  67, -38, -54, -43, -23,  25,  13,  -4,  37, -29,  22, -26, -79,  -7;
/M: SY='C';  M= -62,  76, -83, -77, -51, -84, -76,  35, -76,  53,  15, -76, -81, -22, -77, -70, -13,  38, -80, -61;
/M: SY='R';  M=  10, -78,   1,  35, -73, -31,  -5, -31,  -1, -20, -62,  -8, -69,  48,  52, -30,  -7, -45,  42, -63;
/M: SY='D';  M= -18, -77,  48,  47, -74, -67,  18,   7,  27, -39, -64,  21, -66,  18, -53,  19, -41, -65, -81, -15;
/M: SY='N';  M= -36, -68, -39, -58, -76, -52, -45, -74, -50, -35, -68, 118, -74, -14, -58,  -8, -48, -76, -94, -72;
/M: SY='R';  M= -37, -81, -64, -54, -17, -76,  46, -72,  41,  -5, -58, -57, -74, -11,  88, -62, -65, -71, -71,  17;
/M: SY='E';  M=  10, -76,   5,  61, -79, -43, -57, -73,  27, -45, -26,  -9, -65,  44,  20,   9, -57, -22, -80, -68;
/M: SY='W';  M= -65,  -6, -60,   2, -61, -72,  55,   0,  45, -29,  -8,   8, -71,  52,   8, -24, -62, -67,  70,  37;
/M: SY='W';  M= -76, -97, -95, -80, -36, -76, -80, -69, -72, -42, -68, -91, -81, -71, -74, -80, -83, -81, 167,  67;
/M: SY='Q';  M= -22, -78, -52,  42, -79, -70, -41, -43,  64, -70,   5, -53, -64,  73,  -5, -23,  -3, -38, -76, -46;
/M: SY='E';  M=  33, -74,   3,  48, -81,  -9, -62, -76,  39, -76, -70, -14, -66, -13,  -5,  22, -19, -39, -81, -72;
/M: SY='L';  M= -50, -74, -76, -69, -52, -82,   7, -11,  -5,  56,  26, -20, -80,  11,   8, -69, -33,  27, -75,   3;
/M: SY='A';  M=  50, -73,  23, -60, -69, -32, -11,  39,   4, -12,  -9, -21, -72,   8, -65, -10, -27, -26, -81, -67;
/M: SY='E';  M= -12, -83,  36,  61, -85, -43,  14, -83,  -7, -80, -73, -56,  29,  13,  31,  -4, -62, -51, -86, -72;
/M: SY='Q';  M= -38, -36, -62,  35, -80,  -1, -66, -28,  31, -12, -18, -36,   2,  55, -31,  -9, -37, -33, -83, -73;
/M: SY='Q';  M= -63, -88,   3,  33, -31, -19, -65, -75, -15, -77, -72, -65, -77,  63,   7,  -3, -52,   0,  14,  17;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_07 which contains 560'537 sequence entries.


Total number of hits 99 in 99 different sequences
Number of true positive hits 99 in 99 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] PDEase
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
99 sequences

PDE10_HUMAN (Q9Y233    ), PDE10_MOUSE (Q8CA95    ), PDE10_RAT   (Q9QYJ6    ), 
PDE11_DROME (Q9VJ79    ), PDE11_HUMAN (Q9HCR9    ), PDE11_MOUSE (P0C1Q2    ), 
PDE11_RAT   (Q8VID6    ), PDE11_TAKRU (Q1KKS3    ), PDE1A_BOVIN (P14100    ), 
PDE1A_HUMAN (P54750    ), PDE1A_MOUSE (Q61481    ), PDE1B_BOVIN (Q01061    ), 
PDE1B_CRIGR (Q64395    ), PDE1B_HUMAN (Q01064    ), PDE1B_MOUSE (Q01065    ), 
PDE1B_RAT   (Q01066    ), PDE1C_HUMAN (Q14123    ), PDE1C_MOUSE (Q64338    ), 
PDE1C_RAT   (Q63421    ), PDE1_CAEEL  (O18696    ), PDE1_DROME  (B7YZV4    ), 
PDE2A_BOVIN (P14099    ), PDE2A_HUMAN (O00408    ), PDE2A_MOUSE (Q922S4    ), 
PDE2A_RAT   (Q01062    ), PDE2_CAEEL  (P30645    ), PDE2_DICDI  (Q23917    ), 
PDE2_YEAST  (P06776    ), PDE3A_HUMAN (Q14432    ), PDE3A_MOUSE (Q9Z0X4    ), 
PDE3A_RAT   (Q62865    ), PDE3B_HUMAN (Q13370    ), PDE3B_MOUSE (Q61409    ), 
PDE3B_RAT   (Q63085    ), PDE3_CAEEL  (Q8I0P7    ), PDE3_DICDI  (B0G0Y8    ), 
PDE4A_DROME (Q9W4T4    ), PDE4A_HUMAN (P27815    ), PDE4A_MOUSE (O89084    ), 
PDE4A_RAT   (P54748    ), PDE4B_DROME (P12252    ), PDE4B_HUMAN (Q07343    ), 
PDE4B_RAT   (P14646    ), PDE4C_DROME (Q9W4S9    ), PDE4C_HUMAN (Q08493    ), 
PDE4C_MOUSE (Q3UEI1    ), PDE4C_RAT   (P14644    ), PDE4D_HUMAN (Q08499    ), 
PDE4D_MOUSE (Q01063    ), PDE4D_RAT   (P14270    ), PDE4E_DROME (Q8IRU4    ), 
PDE4_CAEEL  (Q22000    ), PDE4_DICDI  (Q86H13    ), PDE5A_BOVIN (Q28156    ), 
PDE5A_CANLF (O77746    ), PDE5A_HUMAN (O76074    ), PDE5A_MOUSE (Q8CG03    ), 
PDE5A_RAT   (O54735    ), PDE5_CAEEL  (P91119    ), PDE6A_BOVIN (P11541    ), 
PDE6A_CANLF (Q28263    ), PDE6A_HUMAN (P16499    ), PDE6A_MOUSE (P27664    ), 
PDE6B_BOVIN (P23439    ), PDE6B_CANLF (P33726    ), PDE6B_HUMAN (P35913    ), 
PDE6B_MOUSE (P23440    ), PDE6C_BOVIN (P16586    ), PDE6C_CHICK (P52731    ), 
PDE6C_HUMAN (P51160    ), PDE6C_MOUSE (Q91ZQ1    ), PDE6_CAEEL  (Q9N2V9    ), 
PDE6_DROAN  (B3LVW5    ), PDE6_DROER  (B3P3K2    ), PDE6_DROGR  (B4JXX2    ), 
PDE6_DROME  (Q9VFI9    ), PDE6_DROMO  (B4K9L4    ), PDE6_DROPE  (B4G4E5    ), 
PDE6_DROPS  (Q298P4    ), PDE6_DROSE  (B4HEM4    ), PDE6_DROSI  (B4QZU1    ), 
PDE6_DROVI  (B4LVU6    ), PDE6_DROWI  (B4NAL6    ), PDE6_DROYA  (B4PSS5    ), 
PDE7A_HUMAN (Q13946    ), PDE7A_MOUSE (P70453    ), PDE7A_RAT   (O08593    ), 
PDE7B_HUMAN (Q9NP56    ), PDE7B_MOUSE (Q9QXQ1    ), PDE8A_HUMAN (O60658    ), 
PDE8A_MOUSE (O88502    ), PDE8B_HUMAN (O95263    ), PDE8B_MOUSE (E9Q4S1    ), 
PDE8_DROME  (Q6NNF2    ), PDE9A_DROME (Q9I7S6    ), PDE9A_HUMAN (O76083    ), 
PDE9A_MOUSE (O70628    ), PDE9A_PANTR (H2QL32    ), PDE9A_RAT   (Q8QZV1    )
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PDB
[Detailed view]
319 PDB

1F0J; 1MKD; 1OYN; 1PTW; 1Q9M; 1RKP; 1RO6; 1RO9; 1ROR; 1SO2; 1SOJ; 1T9R; 1T9S; 1TAZ; 1TB5; 1TB7; 1TBB; 1TBF; 1UDT; 1UDU; 1UHO; 1XLX; 1XLZ; 1XM4; 1XM6; 1XMU; 1XMY; 1XN0; 1XOM; 1XON; 1XOQ; 1XOR; 1XOS; 1XOT; 1XOZ; 1XP0; 1Y2B; 1Y2C; 1Y2D; 1Y2E; 1Y2H; 1Y2J; 1Y2K; 1Z1L; 1ZKL; 1ZKN; 2CHM; 2FM0; 2FM5; 2H40; 2H42; 2H44; 2HD1; 2O8H; 2OUN; 2OUP; 2OUQ; 2OUR; 2OUS; 2OUU; 2OUV; 2OUY; 2OVV; 2OVY; 2PW3; 2QYK; 2QYL; 2QYM; 2QYN; 2WEY; 2Y0J; 2YY2; 3B2R; 3BJC; 3D3P; 3DY8; 3DYL; 3DYN; 3DYQ; 3DYS; 3ECM; 3ECN; 3FRG; 3G3N; 3G45; 3G4G; 3G4I; 3G4K; 3G4L; 3G58; 3GWT; 3HC8; 3HDZ; 3HMV; 3HQW; 3HQY; 3HQZ; 3HR1; 3I8V; 3IAD; 3IAK; 3IBJ; 3ITM; 3ITU; 3JAB; 3JBQ; 3JSI; 3JSW; 3JWQ; 3JWR; 3K3E; 3K3H; 3K4S; 3KKT; 3LXG; 3LY2; 3N3Z; 3O0J; 3O56; 3O57; 3QI3; 3QI4; 3QPN; 3QPO; 3QPP; 3SHY; 3SHZ; 3SIE; 3SL3; 3SL4; 3SL5; 3SL6; 3SL8; 3SN7; 3SNI; 3SNL; 3TGE; 3TGG; 3TVX; 3UI7; 3UUO; 3V9B; 3W5E; 3WD9; 3WI2; 3WS8; 3WS9; 3WYK; 3WYL; 3WYM; 4AEL; 4AJD; 4AJF; 4AJG; 4AJM; 4BBX; 4C1I; 4D08; 4D09; 4DDL; 4DFF; 4E90; 4FCB; 4FCD; 4G2J; 4G2L; 4G2W; 4G2Y; 4GH6; 4HEU; 4HF4; 4HTX; 4HTZ; 4I9Z; 4IA0; 4JIB; 4KP6; 4LKQ; 4LLJ; 4LLK; 4LLP; 4LLX; 4LM0; 4LM1; 4LM2; 4LM3; 4LM4; 4MD6; 4MRW; 4MRZ; 4MS0; 4MSA; 4MSC; 4MSE; 4MSH; 4MSN; 4MUW; 4MVH; 4MYQ; 4NPV; 4NPW; 4NW7; 4OEW; 4OEX; 4OGB; 4P0N; 4P1R; 4PHW; 4PM0; 4QGE; 4TPM; 4TPP; 4W1O; 4WCU; 4WN1; 4WZI; 4X0F; 4XY2; 4Y2B; 4Y86; 4Y87; 4Y8C; 4YQH; 4YS7; 4ZO5; 5AXP; 5AXQ; 5B25; 5B4K; 5B4L; 5C1W; 5C28; 5C29; 5C2A; 5C2E; 5C2H; 5DH4; 5DH5; 5EDE; 5EDG; 5EDH; 5EDI; 5I2R; 5JO3; 5K1I; 5K32; 5K6J; 5K9R; 5LAQ; 5LBO; 5OHJ; 5TKB; 5TZ3; 5TZA; 5TZC; 5TZH; 5TZW; 5TZX; 5TZZ; 5U00; 5U7D; 5U7I; 5U7J; 5U7K; 5U7L; 5UOY; 5UP0; 5UWF; 5VP0; 5VP1; 5W6E; 5WH5; 5WH6; 5WQA; 5XKM; 5XUI; 5XUJ; 5ZNL; 5ZZ2; 6A3N; 6ACB; 6B96; 6B97; 6B98; 6BLF; 6BOJ; 6C7D; 6C7E; 6C7F; 6C7G; 6C7I; 6C7J; 6CYB; 6CYC; 6CYD; 6F6U; 6F8R; 6F8T; 6F8U; 6F8V; 6F8W; 6F8X; 6FDC; 6FDI; 6FE7; 6FEB; 6FET; 6FT0; 6FTA; 6FTW; 6FW3; 6IJH; 6IJI; 6MSA; 6MSC; 6MZB; 6NJH; 6NJI; 6NJJ
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