General rule information
[?]
Accession |
PRU01192 |
Dates |
31-OCT-2017 (Created) 22-NOV-2019 (Last updated, Version 2) |
Predictors |
PROSITE; PS51845; PDEASE_I_2
|
Name |
3'5'-cyclic nucleotide phosphodiesterase (PDEase) domain |
Function |
3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17) (PDEases) contain a catalytic domain of approximately 270 amino acids at the carboxyl terminus. |
Propagated annotation
[?]
case <FTGroup:1>
Cofactor |
a divalent metal cation Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions |
end case
Similarity |
Belongs to the cyclic nucleotide phosphodiesterase family. |
case <FTGroup:1>
GO:0046872; Molecular function: metal ion binding.
end case
case <FTTag:act_site> and <FTGroup:1>
end case
From: PS51845 |
Key
|
|
From
|
|
To
|
|
Description
|
|
Tag
|
|
Condition
|
|
FTGroup
|
DOMAIN
|
|
from
|
|
to
|
|
PDEase #
|
|
|
|
|
|
|
ACT_SITE
|
|
77
|
|
77
|
|
Proton donor
|
|
act_site
|
|
H
|
|
|
METAL
|
|
81
|
|
81
|
|
Divalent metal cation 1
|
|
|
|
H
|
|
1
|
METAL
|
|
117
|
|
117
|
|
Divalent metal cation 1
|
|
|
|
H
|
|
1
|
METAL
|
|
118
|
|
118
|
|
Divalent metal cation 1
|
|
|
|
D
|
|
1
|
METAL
|
|
118
|
|
118
|
|
Divalent metal cation 2
|
|
|
|
D
|
|
1
|
METAL
|
|
229
|
|
229
|
|
Divalent metal cation 1
|
|
|
|
D
|
|
1
|
Additional information
[?]
Size range |
300-450 amino acids |
Related rules |
None |
Repeats |
1 |
Topology |
Undefined |
Example |
P16586 (PDE6C_BOVIN) |
Scope |
Eukaryota |
Comments |
None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see
prosite_license.html.
UniProtKB rule member sequences
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