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General rule information [?]

Accession PRU01192
Dates 31-OCT-2017 (Created)
19-NOV-2022 (Last updated, Version 4)
Data class Domain
Predictors PROSITE; PS51845; PDEASE_I_2
Name 3'5'-cyclic nucleotide phosphodiesterase (PDEase) domain
Function 3'5'-cyclic nucleotide phosphodiesterases (EC (PDEases) contain a catalytic domain of approximately 270 amino acids at the carboxyl terminus.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Cofactor a divalent metal cation
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions
end case

Similarity Belongs to the cyclic nucleotide phosphodiesterase family.

Cross-references [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

case <FTTag:act_site> and <FTGroup:1>
end case

Features [?]

From: PS51845
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       PDEase #        
ACT_SITE     77     77       Proton donor   act_site   H  
BINDING     81     81       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1     H   1
BINDING     117     117       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1     H   1
BINDING     118     118       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1     D   1
BINDING     118     118       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2     D   1
BINDING     229     229       /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1     D   1

Additional information [?]

Size range 300-450 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P16586 (PDE6C_BOVIN)
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]