PRU01192

General rule information [?]

Accession	PRU01192
Dates	31-OCT-2017 (Created) 19-NOV-2022 (Last updated, Version 4)

Data class

Domain

Predictors

PROSITE; PS51845; PDEASE_I_2

Name	3'5'-cyclic nucleotide phosphodiesterase (PDEase) domain

Function

3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17) (PDEases) contain a catalytic domain of approximately 270 amino acids at the carboxyl terminus.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>

Cofactor

a divalent metal cation
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions

end case

Similarity

Belongs to the cyclic nucleotide phosphodiesterase family.

Cross-references [?]

PROSITE

PS00126; PDEASE_I_1; 1;

Gene Ontology [?]

case <FTGroup:1>

GO:0046872; Molecular function: metal ion binding.

Keywords [?]

Metal-binding

end case

case <FTTag:act_site> and <FTGroup:1>

Hydrolase

end case

Features [?]

From: PS51845

Key From To Description Tag Condition FTGroup

DOMAIN from to PDEase #

ACT_SITE 77 77 Proton donor act_site H

BINDING 81 81 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1 H 1

BINDING 117 117 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1 H 1

BINDING 118 118 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1 D 1

BINDING 118 118 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2 D 1

BINDING 229 229 /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1 D 1

Additional information [?]

Size range	300-450 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P16586 (PDE6C_BOVIN)
Scope	Eukaryota
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [103]
Retrieve set of proteins with 3D structure for this domain