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ProRule PRU01192


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PURL: https://purl.expasy.org/prosite/rule/PRU01192
General rule information [?]

Accession PRU01192
Dates 31-OCT-2017 (Created)
19-NOV-2022 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS51845; PDEASE_I_2
Name 3'5'-cyclic nucleotide phosphodiesterase (PDEase) domain
Function 3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17) (PDEases) contain a catalytic domain of approximately 270 amino acids at the carboxyl terminus.
Scope(s) Eukaryota
Example(s) P16586;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
COFACTOR Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions
end case
SIMILARITYBelongs to the cyclic nucleotide phosphodiesterase family.

Keywords [?]

Metal-binding
end case
case <FTTag:act_site> and <FTGroup:1>
Hydrolase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0046872; Molecular function:metal ion binding

Cross-references [?]

PROSITE PS00126; PDEASE_I_1; 1;

Features [?]

From: PS51845
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PDEase #"
ACT_SITE 77 77 /note="Proton donor" act_site H
BINDING 81 81 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
/ligand_label="1"		 H 1
BINDING 117 117 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
/ligand_label="1"		 H 1
BINDING 118 118 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
/ligand_label="1"		 D 1
BINDING 118 118 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
/ligand_label="2"		 D 1
BINDING 229 229 /ligand="a divalent metal cation"
/ligand_id="ChEBI:CHEBI:60240"
/ligand_label="1"		 D 1

Additional information [?]

Size range 300-450 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]