ProRule PRU01192
General rule information
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| Accession | PRU01192 |
| Dates | 31-OCT-2017 (Created)
19-NOV-2022 (Last updated, Version 4) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51845; PDEASE_I_2 |
Name | 3'5'-cyclic nucleotide phosphodiesterase (PDEase) domain |
| Function | 3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17) (PDEases) contain a catalytic domain of approximately 270 amino acids at the carboxyl terminus. |
| Scope(s) |
Eukaryota |
| Example(s) | P16586 (PDE6C_BOVIN); |
Propagated annotation
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Comments
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| case <FTGroup:1> | |
| COFACTOR | Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions |
| end case | |
| SIMILARITY | Belongs to the cyclic nucleotide phosphodiesterase family. |
Keywords
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| Metal-binding | |
| end case | |
| case <FTTag:act_site> and <FTGroup:1> | |
| Hydrolase | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0046872; Molecular function:metal ion binding | |
Cross-references
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| PROSITE | PS00126; PDEASE_I_1; 1; |
Features
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| From: PS51845 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="PDEase #" | |||||||||
| ACT_SITE | 77 | 77 | /note="Proton donor" | act_site | H | |||||||
| BINDING | 81 | 81 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" |
H | 1 | |||||||
| BINDING | 117 | 117 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" |
H | 1 | |||||||
| BINDING | 118 | 118 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" |
D | 1 | |||||||
| BINDING | 118 | 118 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="2" |
D | 1 | |||||||
| BINDING | 229 | 229 | /ligand="a divalent metal cation" /ligand_id="ChEBI:CHEBI:60240" /ligand_label="1" |
D | 1 | |||||||
Additional information
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| Size range | 300-450 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [103] All [ 103 ]
- Retrieve set of proteins with 3D structure for this domain