 |
|
| annotation rule: PRU01192 |
General rule information
[?]
| Accession | PRU01192 |
| Dates | 31-OCT-2017 (Created) 22-NOV-2019 (Last updated, Version 2) |
| Data class | Domain |
| Predictors | PROSITE; PS51845; PDEASE_I_2 |
| Name | 3'5'-cyclic nucleotide phosphodiesterase (PDEase) domain |
| Function | 3'5'-cyclic nucleotide phosphodiesterases (EC 3.1.4.17) (PDEases) contain a catalytic domain of approximately 270 amino acids at the carboxyl terminus. |
Propagated annotation
[?]
Comments
[?]
case <FTGroup:1>
| Cofactor | a divalent metal cation Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions |
end case
| Similarity | Belongs to the cyclic nucleotide phosphodiesterase family. |
Cross-references
[?]
| PROSITE | PS00126; PDEASE_I_1; 1; |
Gene Ontology
[?]
case <FTGroup:1>
GO:0046872; Molecular function: metal ion binding.
Keywords
[?]
end case
case <FTTag:act_site> and <FTGroup:1>
end case
Features
[?]
| From: PS51845 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | PDEase # | |||||||||
| ACT_SITE | 77 | 77 | Proton donor | act_site | H | |||||||
| METAL | 81 | 81 | Divalent metal cation 1 | H | 1 | |||||||
| METAL | 117 | 117 | Divalent metal cation 1 | H | 1 | |||||||
| METAL | 118 | 118 | Divalent metal cation 1 | D | 1 | |||||||
| METAL | 118 | 118 | Divalent metal cation 2 | D | 1 | |||||||
| METAL | 229 | 229 | Divalent metal cation 1 | D | 1 | |||||||
Additional information
[?]
| Size range | 300-450 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P16586 (PDE6C_BOVIN) |
| Scope | Eukaryota |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]