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annotation rule: PRU01192

General rule information [?]

Accession PRU01192
Dates 31-OCT-2017 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51845; PDEASE_I_2
Name 3'5'-cyclic nucleotide phosphodiesterase (PDEase) domain
Function 3'5'-cyclic nucleotide phosphodiesterases (EC (PDEases) contain a catalytic domain of approximately 270 amino acids at the carboxyl terminus.

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
Cofactor a divalent metal cation
Note: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions
end case

Similarity Belongs to the cyclic nucleotide phosphodiesterase family.

Cross-references [?]


Gene Ontology [?]

case <FTGroup:1>
GO:0046872; Molecular function: metal ion binding.

Keywords [?]

end case

case <FTTag:act_site> and <FTGroup:1>
end case

Features [?]

From: PS51845
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       PDEase #        
ACT_SITE     77     77       Proton donor   act_site   H  
METAL     81     81       Divalent metal cation 1     H   1
METAL     117     117       Divalent metal cation 1     H   1
METAL     118     118       Divalent metal cation 1     D   1
METAL     118     118       Divalent metal cation 2     D   1
METAL     229     229       Divalent metal cation 1     D   1

Additional information [?]

Size range 300-450 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P16586 (PDE6C_BOVIN)
Comments None


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UniProtKB rule member sequences [?]