We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS51861
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PURL: https://purl.expasy.org/prosite/signature/PS51861
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General information about the entry
| Entry name [info] | OXYTX_ICK |
| Accession [info] | PS51861 |
| Entry type [info] | MATRIX |
| Date [info] |
20-JUN-2018 CREATED;
26-FEB-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51861 |
| Associated ProRule [info] | PRU01208 |
Name and characterization of the entry
| Description [info] | Oxytoxin-type inhibitor cystine knot (ICK) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=54; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=49; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1349561; R2=0.0033110; TEXT='-LogE'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=7789.5083008; R2=4.2398958; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1923; H_SCORE=15943; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=1319; H_SCORE=13382; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-7; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='N'; M= 9, 34,-21, 33, -2,-25, -3,-15,-12, 0,-15, -7, 41,-19, -6,-15, 2, 4,-13,-56,-31, -5; /M: SY='W'; M=-26, -7,-15,-16,-10, 1, 5,-31,-16,-11,-20,-16, 1,-30,-10, -9,-16,-22,-25, 72, 7,-10; /M: SY='K'; M= 0, 0,-18, 3, 32,-19,-13,-14,-23, 34,-17, 11, -3, 10, 6, 4, 0,-13,-23,-17,-13, 22; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='W'; M=-29,-29, -9,-24,-10, 15, -6,-29, -4,-20, 12, -4,-44,-30,-15,-11,-25,-24, -9, 84, 39,-10; /M: SY='P'; M= 14,-11,-30, -5, 5,-31, -5, -4,-16, 5,-21,-16,-16, 53, 5,-10, -1, 5,-16,-39,-29, 0; /M: SY='I'; M= -3,-13,-16,-22,-13, 4,-13,-17, 30, -7, 17, 15, -6,-21,-16,-18,-11, -2, 18,-25, 2,-15; /M: SY='G'; M= -6, 5,-41, 9, -7,-34, 26, 25,-20,-11,-15,-10, -1, -4,-12,-15, -3,-18,-28,-19,-16, -9; /M: SY='T'; M= 10, 0,-20, -5, -9,-15, -9,-15, -5, -5,-11,-11, 5, -5, -5,-19, 31, 34, -1,-39,-15,-10; /M: SY='S'; M= 4, -6,-20, -7,-11,-14,-14,-14,-12, -1,-12, -6, -2, -6, 5, 7, 18, 18, -2,-30,-10, -7; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='D'; M= 5, 15,-27, 23, -7,-30, 9,-20,-16, -5,-11,-17, 6, -7, -9,-18, 13, 11,-12,-30,-16, -9; /M: SY='D'; M= 0, 47,-24, 65, 4,-38, -7,-17,-28, 0,-13,-21, 32,-16,-10,-13, 0, -4,-20,-49,-19, -3; /M: SY='D'; M= 0, 50,-30, 90, 10,-50,-10,-20,-40, 0,-10,-30, 10,-10,-10,-10, 0,-10,-20,-40,-10, 0; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='D'; M= 3, 28,-27, 56, -2,-31,-16,-23,-15, -6, -4,-21, 1,-19,-16,-10, -3, -4, 2,-37, -4, -9; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='P'; M= -5, -9,-21, -3, 24,-31,-12, -1,-27, 21,-23,-15,-16, 57, 4, -4, -5, -7,-32,-23,-17, 14; /M: SY='E'; M= 0, 12, -7, 6, 21,-29, 8,-10,-16, 7,-15, -9, 20, -7, 2,-15, 0,-11,-27,-24,-28, 16; /M: SY='H'; M=-18,-18,-39,-18, -2,-19,-28,107,-11,-20, 1, 20,-12, 1, -4,-12,-12,-16,-21,-43, 7, -2; /M: SY='H'; M=-20,-20,-50,-20, 0,-30,-30,140,-20,-20,-10, 20,-10, 10, 0,-10,-10,-20,-30,-50, 0, 0; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='H'; M=-20,-20,-50,-20, 0,-30,-30,140,-20,-20,-10, 20,-10, 10, 0,-10,-10,-20,-30,-50, 0, 0; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='P'; M=-10,-20,-30,-10, 10,-40,-10, 10,-30, 10,-30,-40,-30,110, 0,-10,-10, 0,-40,-30,-20, 0; /M: SY='Y'; M= 4,-11,-33, -5, -8, 4,-14,-12, 1, -7, 13, 6,-17,-17, -3, -9, -6, 2, 10,-13, 15, -8; /M: SY='R'; M= 1, -4,-27, -4, 0,-14, 8,-17,-17, 12,-20, -4, -4, -4, 0, 13, 10, -7,-17,-13,-15, -4; /I: I=-7; MI=0; MD=-15; IM=0; DM=-15; /M: SY='K'; M= 3, 9,-23, 2, 8,-10, -5,-15,-13, 20,-20, 4, 17, -4, -5, -2, 11, 3,-17,-34,-19, 0; /M: SY='W'; M=-21,-34,-20,-38,-16, 0, -3,-25, 7,-11, 1, 2,-33,-32,-13, -9,-22,-24, -2, 79, 18,-16; /M: SY='P'; M= -4,-10,-15,-10, -7,-10,-17, -7, -1, -8, 7, -4,-15, 22, -8,-20, -6, 14, -5,-32, 3, -7; /M: SY='P'; M=-10, -1,-30, 10, -4, -3,-16,-11,-25, 1,-10,-31,-12, 30,-12,-10, -7, -9,-20,-22, -3,-11; /M: SY='G'; M= 21, 0,-35, -5, -9,-25, 38,-25, -5, -5,-15, -4, 0,-10, -4,-15, 5, -4, -9,-22,-35, -9; /M: SY='L'; M= -8,-12, -4,-17,-14, 16,-18,-12, 29,-20, 36, 18,-16,-30,-20,-22,-18, 0, 17,-22, 21,-14; /M: SY='F'; M= -6,-14,-21,-23,-12, 20,-16,-20, 15, 0, 12, 10, -6,-20,-16,-12, -9, -7, 9,-17, 6,-15; /M: SY='R'; M=-10,-20,-23,-10, -4,-19,-17, -4,-30, 10,-23,-11,-23, 24, 21, 54,-10,-21,-19, -9, -6, 0; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='S'; M= 10, 0,-20, -2, -4,-12, -4,-12, -8, -2,-16,-16, 2, -8, -8,-14, 36, 26, -6,-34,-18,-10; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='Q'; M= 10,-10,-20,-10, 20,-30,-20, 0,-20, 0,-20,-10,-10, 0, 80, 30,-10, 0,-30,-10,-10, 40; /M: SY='R'; M= 4,-16,-20,-13,-17, -1,-20,-19, 7, -6, -6, -4,-16,-24, -7, 18, 1, 0, 18,-21, 0,-16; /I: I=-14; MD=-29; /M: SY='N'; M= 5, 12,-13, -2,-13,-13, -9,-13, 0, -5, -6, 0, 29, -9, -3,-20, 9, 27, -1,-45,-17, -8; D=-14; /I: I=-14; MI=0; MD=-29; IM=0; DM=-29; /M: SY='E'; M= 0, 0,-11, 5, 39,-24,-15,-11,-25, 31,-15, 6, -5, 10, 9, 1, 0,-15,-25,-15,-15, 29; /M: SY='D'; M= 5, 26,-25, 47, 5,-31, -5,-15,-26, 0,-15,-25, 5,-10,-10,-10, 19, 4,-15,-35,-15, -5; /M: SY='D'; M= 0, 35,-33, 59, 1,-44, 18,-23,-31, -3,-13,-27, 7,-10,-13,-13, 0,-13,-23,-25,-16, -6; /M: SY='K'; M= -4, -4,-34, -4, 16,-14,-14, 15,-20, 27,-18, 20, -2, 10, 0, 6, -2,-12,-22,-27, -8, 8; /M: SY='I'; M= 5,-20,-20,-31,-30, 5,-19,-25, 51,-20, 15, 5, -9,-35,-25,-21,-10, 5, 45,-30, -1,-30; /M: SY='N'; M= 0, 40,-10, 10,-10,-10, 0,-10, 0, 0,-20, 0, 80,-30,-10,-20, 0, 10,-20,-70,-40,-10; /M: SY='T'; M= 5, 0,-25, -5, -1,-15,-15,-20, -9, 14, -9, 9, 5, 5, 0,-11, 11, 22, -4,-36,-10, -1; /M: SY='C'; M=-30,-20,170,-30, 10,-30,-40,-50,-20,-30, 0,-20,-10,-30,-20,-20,-20,-20,-20,-20,-60, 0; /M: SY='P'; M= -7, 2,-30, 21, 10,-43,-10, 1,-33, 7,-24,-37,-18, 73, -3,-10, -7, -3,-34,-33,-17, 0; /M: SY='P'; M= -5, -9,-30, -5, 15,-24,-10, -6,-25, 26,-25, -8,-14, 57, 0, 1, -5, -5,-29,-25,-15, 5; /M: SY='Y'; M= -2,-16,-46, -5,-11, 6,-16, -9, -5, -5, 11, -1,-21,-15, -1, -5, -6, -1, 10, 3, 29,-11; /M: SY='E'; M= 0, 0,-11, 5, 39,-24,-15,-11,-25, 31,-15, 6, -5, 10, 9, 1, 0,-15,-25,-15,-15, 29; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 7 in 7 different sequences |
| Number of true positive hits | 7 in 7 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | Oxytoxin-type inhibitor cystine knot (ICK) |
| Version [info] | 3 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
7 sequences
SPN1A_OXYTA (P86716), SPN1B_OXYTA (P86717), SPN2A_OXYTA (P86718), SPN2B_OXYTA (P86719), TOX1_OXYLI (P0C8M0), TOX1_OXYTA (P83288), TOX2_OXYLI (P84756)» more
|
| PDB [Detailed view] |
1 PDB
pdb_00002n86 |