ProRule PRU01208

General rule information [?]

Accession PRU01208
Dates 19-APR-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51861; OXYTX_ICK
Name Oxytoxin-type inhibitor cystine knot (ICK) domain
Function Oxytoxins are disulphide-rich polypeptides that contain five disulfide bridges and block L-, N- and P/Q-type voltage-sensitive calcium ion channels (VSCCs) .
Scope(s) Eukaryota
Example(s) P86716 (SPN1A_OXYTA);

Propagated annotation [?]

Comments [?]

TISSUE SPECIFICITYExpressed by the venom gland.
DOMAINThe presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

GO:0005576; Cellular component:extracellular region
GO:0090729; Molecular function:toxin activity

Features [?]

From: PS51861
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Oxytoxin-type inhibitor cystine knot (ICK) #"
DISULFID 4 18 disulf C-x*-C
DISULFID 11 23 disulf C-x*-C
DISULFID 15 50 disulf C-x*-C
DISULFID 17 39 disulf C-x*-C
DISULFID 25 37 disulf C-x*-C

Additional information [?]

Size range 50-70 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]