ProRule PRU01208
General rule information
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Accession | PRU01208 |
Dates | 19-APR-2018 (Created)
22-NOV-2019 (Last updated, Version 2) |
Data class | Domain; |
Predictors |
PROSITE; PS51861; OXYTX_ICK |
Name | Oxytoxin-type inhibitor cystine knot (ICK) domain |
Function | Oxytoxins are disulphide-rich polypeptides that contain five disulfide bridges and block L-, N- and P/Q-type voltage-sensitive calcium ion channels (VSCCs) . |
Scope(s) |
Eukaryota Oxyopes |
Example(s) | P86716 (SPN1A_OXYTA); |
Propagated annotation
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Comments
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SUBCELLULAR LOCATION | Secreted. |
TISSUE SPECIFICITY | Expressed by the venom gland. |
DOMAIN | The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. |
Keywords
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case <FTTag:disulf> | |
Disulfide bond | |
end case | |
Knottin | |
Secreted | |
Toxin |
Gene Ontology
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GO:0005576; Cellular component:extracellular region |
GO:0090729; Molecular function:toxin activity |
Features
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From: PS51861 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Oxytoxin-type inhibitor cystine knot (ICK) #" | |||||||||
DISULFID | 4 | 18 | disulf | C-x*-C | ||||||||
DISULFID | 11 | 23 | disulf | C-x*-C | ||||||||
DISULFID | 15 | 50 | disulf | C-x*-C | ||||||||
DISULFID | 17 | 39 | disulf | C-x*-C | ||||||||
DISULFID | 25 | 37 | disulf | C-x*-C |
Additional information
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Size range | 50-70 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 1 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [7] All [ 7 ]
- Retrieve set of proteins with 3D structure for this domain