ProRule logo

General rule information [?]

Accession PRU01208
Dates 19-APR-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51861; OXYTX_ICK
Name Oxytoxin-type inhibitor cystine knot (ICK) domain
Function Oxytoxins are disulphide-rich polypeptides that contain five disulfide bridges and block L-, N- and P/Q-type voltage-sensitive calcium ion channels (VSCCs) .

Propagated annotation [?]

Comments [?]

Subcellular location Secreted.
Tissue specificity Expressed by the venom gland.
Domain The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Gene Ontology [?]

GO:0005576; Cellular component: extracellular region.
GO:0090729; Molecular function: toxin activity.

Keywords [?]

case <FTTag:disulf>
end case

Features [?]

From: PS51861
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Oxytoxin-type inhibitor cystine knot (ICK) #        
DISULFID     4     18           disulf   C-x*-C  
DISULFID     11     23           disulf   C-x*-C  
DISULFID     15     50           disulf   C-x*-C  
DISULFID     17     39           disulf   C-x*-C  
DISULFID     25     37           disulf   C-x*-C  

Additional information [?]

Size range 50-70 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P86716 (SPN1A_OXYTA)
Eukaryota; Oxyopes
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]