We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01208
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01208
General rule information
[?]
| Accession | PRU01208 |
| Dates | 19-APR-2018 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51861; OXYTX_ICK |
Name | Oxytoxin-type inhibitor cystine knot (ICK) domain |
| Function | Oxytoxins are disulphide-rich polypeptides that contain five disulfide bridges and block L-, N- and P/Q-type voltage-sensitive calcium ion channels (VSCCs) . |
| Scope(s) |
Eukaryota Oxyopes |
| Example(s) | P86716; |
Propagated annotation
[?]
Comments
[?]
| SUBCELLULAR LOCATION | Secreted. |
| TISSUE SPECIFICITY | Expressed by the venom gland. |
| DOMAIN | The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. |
Keywords
[?]
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
| Knottin | |
| Secreted | |
| Toxin | |
Gene Ontology
[?]
| GO:0005576; Cellular component:extracellular region |
| GO:0090729; Molecular function:toxin activity |
Features
[?]
| From: PS51861 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Oxytoxin-type inhibitor cystine knot (ICK) #" | |||||||||
| DISULFID | 4 | 18 | disulf | C-x*-C | ||||||||
| DISULFID | 11 | 23 | disulf | C-x*-C | ||||||||
| DISULFID | 15 | 50 | disulf | C-x*-C | ||||||||
| DISULFID | 17 | 39 | disulf | C-x*-C | ||||||||
| DISULFID | 25 | 37 | disulf | C-x*-C | ||||||||
Additional information
[?]
| Size range | 50-70 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Eukaryota [7] All [ 7 ]
- Retrieve set of proteins with 3D structure for this domain