PRU01208

General rule information [?]

Accession	PRU01208
Dates	19-APR-2018 (Created) 22-NOV-2019 (Last updated, Version 2)

Data class

Domain

Predictors

PROSITE; PS51861; OXYTX_ICK

Name	Oxytoxin-type inhibitor cystine knot (ICK) domain

Function

Oxytoxins are disulphide-rich polypeptides that contain five disulfide bridges and block L-, N- and P/Q-type voltage-sensitive calcium ion channels (VSCCs) .

Propagated annotation [?]

Comments [?]

Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Domain	The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.

Gene Ontology [?]

GO:0005576; Cellular component: extracellular region.
GO:0090729; Molecular function: toxin activity.

Keywords [?]

case <FTTag:disulf>

Disulfide bond

end case

Knottin
Secreted
Toxin

Features [?]

From: PS51861

Key From To Description Tag Condition FTGroup

DOMAIN from to Oxytoxin-type inhibitor cystine knot (ICK) #

DISULFID 4 18 disulf C-x*-C

DISULFID 11 23 disulf C-x*-C

DISULFID 15 50 disulf C-x*-C

DISULFID 17 39 disulf C-x*-C

DISULFID 25 37 disulf C-x*-C

Additional information [?]

Size range	50-70 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P86716 (SPN1A_OXYTA)
Scope	Eukaryota; Oxyopes
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets

Eukaryota [7]
Retrieve set of proteins with 3D structure for this domain