Home  |  Contact
Entry: PS51870

General information about the entry

Entry name [info] APP_E2
Accession [info] PS51870
Entry type [info] MATRIX
Date [info] 10-OCT-2018 CREATED;
26-FEB-2020 DATA UPDATE;
26-FEB-2020 INFO UPDATE.
PROSITE Doc. [info] PDOC00204
Associated ProRule [info] PRU01218

Name and characterization of the entry

Description [info] Amyloid precursor protein (APP) E2 domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=199;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=194;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2405782; R2=0.0084607; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=22663.1796875; R2=16.1209831; PRIORITY=1; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=1036; H_SCORE=39365; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=504; H_SCORE=30788; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-36; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='Y';  M= -21, -74,  -1,  17, -60,  33,  23, -69,  17, -15, -61,  22, -68,   5, -57,   9,  18, -68, -67,  54;
/M: SY='Q';  M= -61, -74,  42, -55,  36, -71, -60,  -2, -11,   5, -53,  -2, -73,  47,  -9,  15, -56,  29, -70,  14;
/M: SY='D';  M= -63, -77,  97, -39, -75, -63, -52, -77, -52, -24, -71,  29, -69,  28,   4,  16, -55, -75, -87,   5;
/M: SY='P';  M= -60, -79, -66, -58, -70,  -9,  47,  23, -61, -24,  22, -61,  81,  46, -65,   8,  -3,  -8, -79, -64;
/M: SY='Y';  M= -22, -81, -68, -66, -29, -16, -42, -14, -59, -56, -52, -67, -79,  39,  -4, -62, -64, -61, -36, 120;
/M: SY='F';  M= -68, -72, -70,  -3,  89,   5, -62, -51, -10,  32, -49,  24, -79, -69, -67, -66, -63, -56, -54,  13;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='E';  M= -19, -75, -53,  58,   6, -13, -60, -65,  12, -29, -63, -58,  23, -48,  36,  32, -55,   6, -75, -63;
/M: SY='H';  M= -21, -74, -61,  19, -62, -21,  50,  28,  17,  11,  40,  -1,  11, -55,  -9,  -5,  -5, -10, -79, -60;
/M: SY='P';  M=  31, -73, -56,  24,  22,  11, -60, -70, -58, -70, -65,  32,  54,   8, -64,  11,   1, -67, -70,  12;
/M: SY='D';  M=  20, -73,  69,  -1, -81,  35, -59, -78,   0, -78, -71,  11, -65,   5, -60,  17,  14, -71, -84, -70;
/I:         I=-28; MD=-71;
/M: SY='P';  M=   4, -80,  46, -56,  22, -71, -61, -66,   8,   1, -61, -61,  64, -61,  -3, -17, -61, -67, -68,  42; D=-28;
/I:         I=-28; MI=-71; MD=-71; IM=-71; DM=-71;
/M: SY='N';  M=  14, -75,  34,  20,   0,  27,  16, -78,  29, -76, -70,  35, -69, -54,   0, -53,   6, -73, -81, -66; D=-28;
/I:         I=-28; DM=-71;
/M: SY='N';  M= -19,  46,   5, -11, -76,  -2, -51, -75, -51, -78, -69,  98, -70, -53,  -7,  10,  20, -72, -91, -71;
/I:         I=-28; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='E';  M= -60, -80,  22, 104, -80, -74, -54, -80, -44, -27, -70, -55, -57, -37, -53, -13, -59, -74, -81, -72;
/M: SY='H';  M= -23, -80, -54, -52, -69, -70, 140, -84,   3, -69, -55, -44, -70, -46,  16, -58, -66, -82, -96, -41;
/M: SY='E';  M=  35, -73,  -2,  70, -79, -63,  24, -77,  36, -74, -67, -52, -61,  15, -49,  27, -54, -69, -79, -67;
/M: SY='H';  M=  16, -73, -53,  23, -66, -65,  68, -68,  36,  -3,  12,  48, -68, -48,  18,  -5, -56, -66, -77,   6;
/M: SY='Y';  M= -74, -76, -79, -79,  97, -80, -50, -52, -72, -46, -50, -75, -85, -74, -69, -70, -66, -57, -34, 103;
/M: SY='K';  M=  -7, -73, -64, -53, -63, -73,  19, -56,  56,  35, -50, -57, -70,  33,  37, -57,  23, -16, -76, -60;
/M: SY='N';  M=  22, -73,  37,  43, -76, -64, -56, -73,  27, -23, -65,  47, -66, -47,  34, -51,  14, -68, -82, -68;
/M: SY='A';  M=  95, -63, -67, -57, -77, -50, -67, -66, -60, -67, -61, -61, -66,  27, -64, -41, -53, -53, -75, -70;
/M: SY='Q';  M= -62, -80, -52,  43, -77, -72, -53, -72,  58,  -4, -59, -53, -66,  82,  39, -56, -61, -71, -74, -64;
/M: SY='Q';  M= -19, -75,  28,  -2, -76, -67, -55, -68,  57, -65,  60, -49, -65,  75, -43,   3,  14, -66, -77, -63;
/M: SY='R';  M=  27, -76,  15,  -3, -76, -19, -58, -67,   1, -69, -62, -55, -70,  39,  79, -55, -60,   9, -78, -65;
/M: SY='M';  M= -65, -69, -84, -75, -44, -83, -64, -32, -74,  76,  93, -79, -80, -67, -72, -75, -62, -11, -72, -52;
/M: SY='E';  M= -59, -79,   1,  91, -82, -71, -54, -81,  23, -76, -70, -53, -59,  35,   2,   2,  -3, -74, -79, -70;
/M: SY='E';  M= -60, -77,  19,  68, -79, -72, -56, -73,  51, -72, -66, -51, -61,  52,  -3, -53,  27, -17, -79, -67;
/M: SY='R';  M= -60, -76, -59, -51, -74, -18,  21, -67,  36, -69, -61,  15, -70,  39,  77,  -6,   1,  13, -79, -62;
/M: SY='H';  M= -67, -82, -51,  28, -68, -72, 131, -83, -51, -69, -56, -47, -68,  43,   6, -58, -66, -82, -87,  11;
/M: SY='R';  M= -64, -80, -62, -50, -74, -75,  51, -68,  26, -68, -59, -55, -73,  44,  93, -59, -62,  14, -78, -59;
/M: SY='N';  M= -16, -74,  27,  55, -76, -62,  35, -76, -48, -30, -67,  57,   3, -46,  21,  36, -53, -72, -85, -67;
/M: SY='K';  M= -63, -79, -55,   4, -79, -71, -55, -80,  92, -77, -65, -50, -65,  33,  53, -57, -59, -75, -73, -65;
/M: SY='M';  M= -58, -70, -77, -75,  -3, -80, -73,  58, -71, -37,  77,   3, -74, -70, -73, -64,  13,  62, -78, -56;
/M: SY='T';  M=  32, -65,  20, -56, -74, -59, -62, -66, -57, -71, -65,  44,  22, -58, -65,  17,  79, -59, -86, -69;
/M: SY='K';  M=  -1, -78, -59,   1, -73, -70, -60, -72,  85, -73, -64, -54, -66,   5,  43, -57, -60, -14,  69, -61;
/M: SY='V';  M= -15, -68, -77, -14, -53, -81, -76,  21, -71,  21,  48, -74, -76, -70, -73, -65,  -8,  78, -81, -59;
/M: SY='M';  M= -61, -70, -81, -71, -52, -77, -59,  19,  10,  -3, 130, -69, -71, -59, -61, -70, -59,   8, -74, -52;
/M: SY='K';  M= -63, -78,  17, -41, -80, -68, -55, -79,  92, -78, -66,  10, -65,  46,  27, -55, -58, -76, -75, -65;
/M: SY='E';  M= -60, -81,  24, 100, -82, -74, -54, -76, -43, -74, -70, -54, -58,  39, -52, -56, -60, -14, -81, -71;
/M: SY='W';  M= -75, -99,-102, -80, -40, -74,-101, -71, -72, -27, -71, -96, -79, -72, -76, -82, -87, -85, 177, -28;
/M: SY='S';  M=  29, -70,  17,  14, -77, -57, -57, -72,  -4, -30, -65,   8, -65,  58, -54,  66, -48, -66, -80, -66;
/M: SY='E';  M=  24, -77,  37,  95, -82, -68, -55, -81, -46, -76, -72,   7, -59, -40, -55, -53, -58, -73, -82, -73;
/M: SY='A';  M=  80, -64, -73, -65, -60, -59, -69, -50, -67,  49, -46, -69, -72, -63, -70, -51, -56, -47, -74, -64;
/M: SY='E';  M= -63, -82,  49,  76, -76, -73, -51, -81, -39, -75, -69, -52, -64,  41,  59, -57, -62, -77, -76,  14;
/M: SY='E';  M= -14, -77,  55,  59, -79, -10,  22, -78, -47, -29, -68,  38, -65,  29,  15,  -7, -57, -74, -85, -67;
/M: SY='R';  M= -66, -82, -59, -47, -76, -73,  83, -82,  22, -73, -61, -51, -71,  60,  89, -58, -65, -78, -79, -56;
/M: SY='Y';  M=  28, -74, -73, -72, -32, -73, -50,  -4, -67, -51, -49, -72, -79, -64, -66, -61, -59,  38, -42, 111;
/M: SY='Q';  M= -60, -76, -49,  37, -77, -67, -53, -70,  56, -28, -61,  43, -66,  74,   4,  -7, -56, -14, -77, -65;
/M: SY='E';  M= -60, -76,   4,  81, -79, -70,  29, -79,  37, -75, -68,  27, -60,  15, -47, -52,  28, -73, -82, -67;
/M: SY='M';  M= -63, -69, -84, -75, -46, -81, -63, -32, -72,  63, 109, -77, -78, -65, -70, -73, -60,  16, -74, -52;
/I:         I=-22; MD=-57;
/M: SY='K';  M= -72, -88, -69, -57, -86, -81, -67, -86,  80, -82,  21, -61, -77, -52,  48, -10, -68, -82, -84, -74; D=-22;
/I:         I=-22; MD=-57;
/M: SY='K';  M=  15, -84, -66,  29, -85, -77, -75,   8,  31, -77, -73,  25, -79, -63, -65,   5, -66,  -6, -93, -81; D=-22;
/I:         I=-22; MI=0; MD=-57; IM=0; DM=-57;
/M: SY='K';  M= -75, -88,  31, -58, -90, -79, -69, -21,  57, -86, -78,  31, -79,  26, -55, -64,  24, -80, -95, -80; D=-22;
/I:         I=-22; DM=-57;
/M: SY='D';  M= -77, -90,  89,  -3, -11, -77, -65, -12,  -9, -84, -82,  15, -78,   1, -69, -67, -68, -82, -99, -75; D=-22;
/I:         I=-22; DM=-57;
/M: SY='P';  M= -65, -87, -63, -55, -83, -68,  15, -74, -13, -82, -69,   6, 117, -61,  -6, -60,  -3, -77, -81, -77;
/M: SY='K';  M=  23, -72, -52,  26, -76, -19, -58, -73,  79, -26, -64,  26, -64, -45, -39,   9, -54, -68, -76, -68;
/M: SY='A';  M=  76, -66, -65, -61, -67,  31, -64, -67, -62, -68, -62, -58, -67,  10, -66, -44,  27, -58, -69,  34;
/M: SY='A';  M=  81, -67,  52,  35, -79, -55, -63, -71, -57, -71, -66, -55, -65, -53, -64, -46, -54, -60, -81, -71;
/I:         I=-22; MD=-57;
/M: SY='E';  M= -69, -88,  -2,  82, -86, -82, -63, -81,  -3, -26,  21, -65,   3,  33, -59, -66, -69, -79, -87, -77; D=-22;
/I:         I=-22; MD=-57;
/M: SY='K';  M= -19, -89, -71,   9, -89, -86, -75, -80,  52, -35, -75, -69, -80,  32,  -8, -68,  23, -22, -92, -81; D=-22;
/I:         I=-22; MI=0; MD=-57; IM=0; DM=-57;
/M: SY='M';  M= -72, -80, -85, -76,  59, -85, -68, -52,   6,  14,  80, -77, -84,   0, -69, -14, -68, -12, -67,  17; D=-22;
/I:         I=-22; DM=-57;
/M: SY='K';  M=   9, -75, -55,  -3, -75, -66, -54, -73,  67, -70,  39,  42, -68, -43,  65, -55, -58, -69, -77, -65;
/M: SY='Q';  M= -60, -78, -53,   0, -81, -21, -55, -73,  82, -73, -62,   0, -65,  83, -33, -54, -58, -16, -74, -65;
/M: SY='E';  M=  -1, -78,  26,  82, -80, -71, -55, -79, -40, -74, -69, -53, -61,  10,  52, -53,  18, -72, -81, -69;
/M: SY='M';  M= -63, -70, -82, -76,   3, -81, -65,  51, -71,  35, 108, -72, -74, -66, -71, -69,  13, -36, -72, -51;
/M: SY='T';  M= -54, -65, -58, -62, -64, -65, -62, -52,  -9,  -5,  42,  41, -66, -58, -62,  28,  81,  10, -85, -63;
/M: SY='E';  M=  22, -75, -47,  69, -77,  14,  16, -19,  -8, -27, -63,  -1, -63,  52, -54, -10, -58, -67, -78, -67;
/M: SY='R';  M= -64, -79, -61, -52, -73, -74,  75, -72,  36, -70, -60, -53, -72, -43,  92, -12, -62,   0, -80, -57;
/M: SY='F';  M= -74, -73, -85, -81, 111, -82, -61, -48, -76, -16,  21, -76, -85, -81, -73, -73, -67, -54, -40,  58;
/M: SY='Q';  M= -60, -81, -49,  46, -84, -69, -50, -77,   0, -73, -62,   7, -65, 105,  35, -51,  -5, -75, -76, -64;
/M: SY='K';  M=   6, -71, -53,   6, -76, -62, -57, -70,  63, -73, -64,  32, -65,  29,   3,  39,  15, -22, -79, -66;
/M: SY='T';  M= -57, -66, -62, -65, -61, -72, -68,  38, -59,   6, -51,   7, -65, -63,  -6, -45,  95, -43, -83, -62;
/M: SY='Y';  M= -62, -72, -77, -17,   6, -83, -63,  26, -72,  31, -41, -76, -80, -69, -72, -69, -58,  60, -58,  76;
/M: SY='Q';  M=  44, -73,  -5,  14, -80,  -3, -57, -74,  32, -73, -64,  22, -65,  68,   4, -48,   4, -68, -77, -68;
/M: SY='A';  M=  71, -62, -58, -59, -74, -52, -63, -66, -58, -70, -63,  37, -65, -56, -64,  42,  46, -56, -81, -69;
/M: SY='L';  M= -65, -70, -81, -75, -40, -82, -63,   3, -74,  77,  36, -78, -81, -68, -72, -12, -61, -10, -65,  43;
/M: SY='E';  M= -59, -81, -34, 106, -84, -15, -54, -84,  -7, -77, -72, -56, -57,  15, -50, -56, -61, -77, -79, -73;
/M: SY='Q';  M= -20, -79,  26,  74, -84, -68, -52, -78,  -4, -74, -66,   8, -61,  83, -48, -51,   6, -74, -80, -68;
/M: SY='E';  M= -60, -82, -33, 106, -84, -75, -52, -83, -41, -76, -71, -56, -57,  49, -50, -55, -61, -77, -79, -72;
/M: SY='N';  M= -15, -70,   3,   9, -67,  32, -53, -69, -55, -74, -67,  81, -69, -54, -62,  24,   0, -12, -77,  30;
/M: SY='K';  M=  27, -70,   7,  -9, -71, -63, -60,  -9,  54, -21, -60,  26, -67,   3,  -3,  15,   8, -11, -79, -66;
/M: SY='E';  M=  40, -71,  -3,  53, -74,  33,  21, -66, -57, -22, -63, -55, -65, -52, -63,  25, -55,   2, -80, -68;
/M: SY='E';  M= -60, -81, -34, 105, -81, -76, -54, -11, -42, -72, -68, -57, -57,  38, -51, -56, -61, -71, -79, -71;
/M: SY='K';  M= -63, -78, -57, -45, -77, -72, -57, -79,  91, -76, -65, -50, -66, -41,  69, -56,   6, -73, -74, -64;
/M: SY='Q';  M= -63, -81,  18,  38, -76, -72,  46, -12,  42, -27, -60, -51, -66,  68,  49, -57, -61, -70, -78, -61;
/M: SY='Q';  M= -60, -83, -53,  27, -86,   1, -50, -79, -38, -73, -61, -52, -67, 112,  47, -51, -63, -78, -74, -63;
/M: SY='L';  M= -67, -72, -83, -76, -44, -85, -72,  49, -77,  77, -32, -81,  20, -71, -77, -75, -62, -36, -72, -56;
/M: SY='E';  M=   7, -74, -56,  57, -67,   0, -64,  31, -52, -25, -56, -61, -67, -51,  36,   8, -56,  26, -78, -66;
/M: SY='A';  M=  57, -70,  -2,  52, -79,  18, -61, -74, -52, -73, -67, -54, -63,   3,   1,  18,   1, -64, -78, -71;
/M: SY='V';  M=  21, -67, -69,   8, -56, -74, -70,   0, -66,  28,  45, -67, -71, -64, -69, -56,  44,  51, -80, -61;
/M: SY='H';  M= -69, -81, -53, -53, -68, -71, 149, -86, -58, -68, -54, -43, -70, -47, -52, -59, -68, -86,-103, -37;
/M: SY='Q';  M=   0, -80,  -5,  35, -79, -68, -53, -69, -46,   0, -57, -55,  22, 107, -49, -52, -61, -70, -75, -64;
/M: SY='Q';  M=  -1, -79,  18,  34, -83, -20, -52, -70, -45, -70, -61,  10, -66, 106, -48, -50, -59,  -6, -77, -65;
/M: SY='R';  M= -67,  45, -63, -53, -74, -76,  75, -83, -31, -73, -62, -54, -76, -43, 104, -61, -66, -77, -81, -58;
/M: SY='V';  M= -56, -69, -84, -79, -52, -86, -85,  55, -76,  -6, -40, -78, -78, -77, -78, -68, -53,  88, -83, -60;
/M: SY='Q';  M=  -4, -74, -56,  31, -67, -70, -56, -53,   0,  18,  45,  24, -69,  82, -52, -56, -58,  12, -76, -62;
/M: SY='A';  M=  66, -62, -61, -60, -72, -55, -66, -60, -60, -66, -61,  11, -65, -58, -65,  45,  54,   1, -81, -68;
/M: SY='H';  M=  -7, -74,  -1,  19, -68, -65,  79,  32, -55, -59,  45,  58, -68,  31, -58,   5, -55, -57, -85, -57;
/M: SY='L';  M= -67, -72, -85, -79,  34, -86, -72,  56, -78,  69,  25, -80, -81, -73, -76, -76, -62, -34, -67, -48;
/M: SY='N';  M=  20, -67, -40, -57, -77, -51, -46, -75, -47, -80, -68, 115, -72, -50,  10, -45, -48, -74, -91, -71;
/M: SY='E';  M= -61, -77,  49,  72, -79, -68, -53, -71,  11, -71,  13,  40, -63,  36, -51, -53,  -1, -15, -84, -69;
/M: SY='R';  M= -63, -79,  17, -45, -77, -70, -54, -77,  69, -73,  13, -50, -68,  29,  78,  -4, -59, -74, -76, -64;
/M: SY='K';  M= -62, -77, -59, -46, -73, -73, -60,  -1,  95, -69, -61, -52, -66, -43,  42, -59, -58,   1, -74, -64;
/M: SY='R';  M= -67, -81, -62, -53, -72, -75, -53, -75,   0, -10, -60,  15, -75, -42, 108, -61, -64, -72, -76, -62;
/M: SY='E';  M=  11, -71,  18,  44, -71, -67, -60,  -9,  -3, -61,  23,  27, -65,  29, -57, -11,  31,  24, -83, -66;
/M: SY='A';  M=  85, -62, -66, -61, -69, -53, -67, -60, -63,   9, -56,   4, -68, -59, -67,   5,   0, -52, -77, -68;
/M: SY='M';  M= -21, -70, -77, -73, -49,   0, -60,  -1, -68,  36, 111, -68, -73, -62, -68, -64,  20, -44, -69,  23;
/M: SY='H';  M=  17, -75,  52,  46, -77, -67,  83, -78,  40, -74, -66, -47, -63, -46, -49, -52,  16, -72, -86, -60;
/M: SY='C';  M= -13,  79,  32,  19, -75,  27,  17, -76,  34, -29, -67,   4, -69, -55, -57,   2,   1, -70, -84, -69;
/M: SY='Y';  M= -72, -79, -74, -76,  62, -79, -43, -53, -69, -14, -48, -74, -84, -66, -66, -68, -66, -59, -31, 121;
/M: SY='M';  M= -63, -72, -70, -62, -54, -77, -59,  -3, -50,  36,  66, -63, -73,  14,  60, -59,  46, -50, -72,  14;
/M: SY='Q';  M=  30, -73,  17,  -1, -73, -63, -59,  27,  22, -65, -60,  22, -67,  48,  20,  16,  -6, -57, -79, -65;
/M: SY='A';  M=  73, -64, -64, -11, -66, -55, -65, -58, -61, -22, -58, -59, -67, -57, -66,  42,   9,   4, -74,  12;
/M: SY='L';  M= -66, -70, -84, -77, -40, -86, -68,  15, -77,  83, -30, -82, -83, -71, -75, -76, -62,   4, -69,  12;
/I:         I=-15; MI=0; MD=-39; IM=0; DM=-39;
/M: SY='Q';  M= -64, -82,  42,  12, -79, -24,  27, -72, -52, -10, -65, -55, -73,  61,  35,  11,  -6, -20, -86, -67; D=-15;
/I:         I=-15; DM=-39;
/M: SY='E';  M=  -1, -76,   1,  47,  16, -76, -67, -56, -58, -23, -62,   2, -73, -58,  18, -13,   0,  36, -82, -64; D=-15;
/I:         I=-15; DM=-39;
/M: SY='D';  M= -58, -76,  48,  37, -78, -18, -59, -67,  10, -72, -67,  -2,  46,  35, -56,  14,  19,   7, -84, -70;
/M: SY='P';  M= -60, -79, -62, -52, -70, -68, -62,  -9,  58, -25, -60, -59,  79,  28, -49,  27, -55, -14, -73,   5;
/M: SY='P';  M=  -1, -82,   1, -56, -76,  -8, -66, -15, -62,  -2, -62,  -2, 105,   9, -71, -60, -59, -67, -79, -74;
/M: SY='N';  M= -61, -74,  31,  -5, -81, -59,  17, -78,  35, -79, -67,  86, -68,  69, -46,  -6, -53, -78, -85, -66;
/M: SY='P';  M=  35, -71, -65, -58, -74, -11, -67, -58,  28, -68, -62, -59,  64, -57,  -6,  32,  -7,  27, -79, -70;
/M: SY='H';  M=   8, -78,   8,  48, -76, -69, 104, -81,  33, -73, -63, -49,   0, -44,  24, -56, -62, -76, -85, -55;
/M: SY='R';  M= -16, -79, -53,  22, -78, -70, -53, -80,  57, -76, -65,  24, -68,  30,  81, -56, -60, -75, -76, -65;
/M: SY='I';  M= -59, -72, -85, -81, -50, -88, -84,  82, -77,   4, -37, -78, -77, -76, -79, -71, -55,  67, -79, -58;
/M: SY='L';  M= -64, -72, -69,  29, -48, -83, -65,   4, -66,  75, -35, -74, -76,  31, -67, -70, -62,  -4, -73, -57;
/M: SY='K';  M= -63, -80, -54,   1, -79, -71,  55, -80,  79, -75, -63, -49, -66,  60,  51, -56, -61, -77, -76, -60;
/M: SY='C';  M=  69,  79, -67, -64, -67, -58, -68, -65, -63, -66, -62, -58, -69, -63, -69,  -8,  56, -55, -77,  17;
/M: SY='L';  M= -15, -68, -83, -75, -43, -83, -69, -32, -76,  84,  23, -81, -82, -70, -74, -73, -61,   8, -72, -54;
/M: SY='K';  M= -64, -80, -56,   0, -77, -73,  28, -12,  76, -72, -62, -51, -67,  49,  65, -57, -61, -71, -75, -62;
/M: SY='R';  M=  45, -73, -62, -53, -74,  -7,  48, -17,  53, -71, -62, -54, -68, -48,  59,  -6, -58, -64, -77, -63;
/M: SY='Y';  M= -70,  30, -76, -76,  42, -80, -47, -50, -70,  31, -45, -75, -84, -67, -67, -69, -65, -55, -37, 113;
/M: SY='I';  M= -63, -73, -85, -81,   1, -88, -80,  80, -78,  40, -35, -79, -78, -75, -79, -73, -58,  41, -73, -54;
/M: SY='R';  M= -13, -81, -61, -49, -76, -73,  53, -81,  23, -74, -62, -54, -72,  30, 100, -58, -64, -75, -77, -59;
/M: SY='A';  M=  81, -63, -69, -63, -69, -54, -69, -10, -64, -59,  16, -62, -68, -60, -68,  29, -50,  22, -78, -67;
/M: SY='E';  M= -61,  46, -42,  95, -69, -79, -59,  -1, -50,  21, -58, -62, -62, -43, -58, -61, -61, -61, -79, -69;
/M: SY='Q';  M= -14, -80, -40,  83, -83, -68,  23, -80, -43, -74, -65,  25, -61,  84, -48, -52, -59, -76, -79, -66;
/M: SY='K';  M= -15, -76, -55, -44, -77, -68,  43, -79,  98, -77, -65,   7, -65, -41,  21, -56, -58, -74, -75, -63;
/M: SY='D';  M=  -8, -79, 110,  23, -86, -63, -54, -84, -53, -82, -80,   6, -66, -52, -62, -54, -57, -79, -98, -71;
/M: SY='R';  M= -66, -83, -62, -49, -77, -76, -52, -82,   5, -75, -63, -55, -74,  29, 111, -60, -65, -76, -75, -62;
/M: SY='M';  M= -16, -69, -71, -64, -54, -73,  16, -42, -59,  23,  78, -63, -72,  19,  13,  -7,  32,  32, -74,  16;
/M: SY='H';  M= -68, -81, -54, -54, -68, -13, 147, -86, -59, -69, -55, -43, -70, -48, -53, -58, -68, -86,-101, -38;
/M: SY='T';  M=  23, -64, -64, -63, -59, -63, -61, -55, -61,  -1,  61, -55, -66, -58, -65,  45,  72, -52, -74,  22;
/M: SY='L';  M= -63, -71, -85, -78, -45, -86, -73,  59, -77,  62,  47, -79, -79, -72, -76, -74, -59,  30, -74, -55;
/M: SY='N';  M=   4, -72, -50, -54, -75, -61,  18, -76,  17, -76, -65,  79, -71, -46,  72,  -7,   7, -72, -83, -65;
/M: SY='H';  M= -16, -80, -55, -53, -69, -70, 142, -85, -53, -69, -55, -45, -70, -47,  22, -58, -67, -82, -98, -40;
/M: SY='Y';  M= -73, -80, -76, -76,  68, -79, -45, -55, -69, -50, -51, -74, -84, -67, -66, -69, -67, -61,  56, 119;
/M: SY='R';  M= -62, -81, -49,  58, -81, -73, -53, -81,  58, -75, -65, -53, -64,  61,  64, -56, -61, -76, -75, -66;
/M: SY='H';  M= -69, -81, -54, -53, -68, -71, 147, -86, -55, -69, -54, -43, -70, -47,   1, -59, -68, -85,-101, -38;
/M: SY='L';  M= -14, -68, -81, -75, -47, -82, -74,   6, -75,  68, -35, -78, -79, -72, -75, -68,  -3,  54, -77, -57;
/M: SY='L';  M= -15, -72, -70, -62, -55, -75,  53, -49,   0,  57, -43, -63, -76, -55,  55,   6, -60, -10, -76, -56;
/M: SY='N';  M=  16, -74,  23,  15, -66, -14,  24, -75,   5, -73, -65,  49, -69, -49,  45,  -3,  -4, -70, -72,  41;
/M: SY='T';  M= -52, -66, -60, -59, -66, -65, -63, -53, -56,  -1, -56,   7, -66,  27,  -2,  49,  75,  19, -83, -64;
/M: SY='D';  M= -63, -77, 101, -40,  -9,  10, -54, -79, -54, -77,   9,  25, -68, -55,  -4,  -1, -56, -77, -90, -66;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='P';  M= -64, -84, -63,  10, -68, -12, -63, -12,  -6, -26, -62, -66, 100, -58,  19, -61,  -9, -68, -71,  28;
/M: SY='E';  M= -16, -77,   0,  64, -74, -70, -54, -72,  38,   1, -62,  33, -65,  29,  37, -56, -59, -70, -78, -67;
/M: SY='K';  M=  29, -75,   2,  62, -79, -20, -58, -75,  67, -72,  14, -53, -62,   7, -42, -53, -58, -69, -76, -68;
/M: SY='A';  M=  97, -61, -67, -60, -75, -50, -69, -65, -62, -67, -61, -62, -66, -59, -67, -41,  -8, -52, -76, -71;
/M: SY='E';  M=  46, -71,  29,  60, -75, -62, -58, -70,  -5,  -5, -63,   7, -64,  15, -56,  15, -54, -64, -80, -69;
/M: SY='Q';  M=  28, -72,  -7, -49, -76, -62,  28, -69,  20, -71, -62,  27, -68,  61,  39,  16,  15, -18, -80, -63;
/M: SY='M';  M= -63, -74,  -8,  29,  22, -77,  35,  34, -64,  15,  78, -65, -72, -59, -66, -11, -59,  -6, -66,  38;
/M: SY='R';  M= -65, -80, -56,  17, -72, -74, -54, -80,  73, -75, -65, -53, -68, -40,  85, -59, -62, -75, -71,  11;
/M: SY='P';  M= -15, -77,  35,  -3,  15,   3, -62, -75,  11, -76, -69, -54,  74, -55,   7,  40, -54, -72, -76, -65;
/M: SY='Q';  M= -20, -76,   0,  30,  10, -68,  52,   7, -49, -16, -57, -53, -68,  67,  22,  36, -56, -62, -75, -56;
/M: SY='L';  M= -13, -68, -78, -74, -50, -80, -73,  32, -72,  54,  26, -72, -75, -70, -74, -63,  37,  44, -77, -58;
/M: SY='L';  M=   5, -71, -76, -67, -47, -77, -64,  16,  -8,  59,  23, -72, -77,  32, -65, -66, -60,  19, -68,  29;
/M: SY='H';  M= -59, -75,  37,  34, -77, -68,  80, -75,  -8, -71, -63, -46, -63,  65, -52,  -5,  55, -71, -86, -59;
/M: SY='H';  M= -66, -80, -54, -51, -72, -19, 128, -84,  23, -72, -58,  11, -70,   8,  36, -57, -65, -82, -91, -46;
/M: SY='L';  M= -67, -69, -85, -77, -40, -86, -68, -32, -78,  92, -28, -84, -84, -71, -75, -77, -63, -39, -71, -53;
/M: SY='H';  M= -61, -76,   1, -49, -72, -69,  60, -70,  57, -24, -60,   8, -69,  14,  57,  13,  -8, -17, -80, -60;
/M: SY='D';  M= -62, -73,  68,  -4, -55, -74, -59, -48, -61,  18, -53, -55, -72,  10, -65, -59,  24,  40, -72,  50;
/M: SY='I';  M= -14, -73, -80, -77, -50, -81, -78,  85, -75,  34, -37, -72, -74, -71, -77,  -4,  -1,   1, -75, -58;
/M: SY='D';  M= -63, -78,  94,  53, -82, -64, -53, -20, -51, -78, -75,  42, -65, -48, -60,  -6, -55, -75, -93, -70;
/M: SY='E';  M= -63, -78, -54,  56, -65, -77, -56, -60,  25,  41, -51, -60, -68,  52,  47, -61, -62, -62, -74, -62;
/M: SY='R';  M=   6, -76, -63,   4, -69, -72,  18, -63, -36, -24,  40, -59, -72, -46,  92, -12, -60,   2, -78, -61;
/M: SY='M';  M= -20, -71, -75,  10, -53, -81, -73,  65, -69,   8,  70, -72, -72, -66, -72, -66,  -9,  47, -78, -58;
/M: SY='N';  M=  -7, -70,  10, -53,  -6, -55, -47, -75,  -3, -78, -67, 107, -72,  13,  20, -47, -51, -75, -86, -66;
/M: SY='Q';  M= -15, -82, -54,  28, -82, -11, -52, -77, -40, -73, -62, -53, -67, 107,  38, -11, -61, -76,  44, -61;
/M: SY='S';  M=  25, -63, -59, -59, -71, -54, -62, -66, -58, -68,  22, -48, -63, -53, -63,  85,  55, -58, -82, -66;
/M: SY='M';  M= -64, -72, -81, -15, -47, -85, -70,  62, -74,  56,  73, -77, -76, -67, -74, -73, -60,   6, -74, -55;
/M: SY='A';  M=  55, -70,  42,  34, -71, -59, -59, -65, -56, -29, -63, -54, -66,  27, -61,  32, -52, -13, -77,   6;
/M: SY='M';  M= -63, -70, -82, -72, -47, -77, -61, -38, -67,  56, 113, -73, -76, -61,  -9, -10, -61, -44,  51, -51;
/M: SY='L';  M= -67, -69, -83, -75, -41, -86, -67, -33, -74,  90, -29, -82, -84, -69, -10, -77, -63, -40, -71, -54;
/M: SY='D';  M= -16, -76,  56,  -5,   3, -65, -53, -74,  18, -73, -67,  51, -69,  38,  34, -53,   3, -73,  39,  10;
/M: SY='R';  M= -64, -79,  23, -48, -69, -69,  18, -78,  41, -75, -65,  34, -71,   9,  81,  -8, -59, -75, -73,  29;
/M: SY='H';  M= -61, -71,  -2, -67,  42, -76,  46,  -8, -65,  24, -47, -63, -76, -64,  -3,   6,  16,  36, -65,  42;
/M: SY='P';  M= -65, -90, -66, -55, -84, -67,  15, -74, -62, -83, -70, -70, 124, -64, -73,  -8, -58, -78, -80, -79;
/M: SY='E';  M= -13, -77,  27,  77, -74, -67,  62, -80, -48, -74, -67,   0, -62,  34, -54,  23, -56, -75, -79,   9;
/M: SY='L';  M= -64, -71, -84, -78, -43, -87, -73,  56, -77,  65, -33, -80, -80, -73, -76, -74, -59,  37, -71,   7;
/M: SY='A';  M=  56, -70,  25,  44, -62, -60, -56, -69, -55, -69, -64, -55, -65,   4, -61,  25,  -5, -62, -67,  55;
/M: SY='E';  M=   8, -72,  19,  41, -75, -64, -58, -65,  11, -69, -64,  -1, -65,  35,  23,  36,   8,  12, -81, -67;
/M: SY='K';  M= -12, -76,  17,  24, -80, -66, -56, -77,  76, -75, -66, -48, -63,  52,   0,  14,   1, -72, -77, -66;
/M: SY='V';  M= -61, -71, -83, -77,  21, -85, -76,  56, -16,  36,  19, -77, -78, -73, -73, -71, -57,  60, -73, -53;
/M: SY='R';  M= -59, -77, -63, -55,  -5,  49, -60, -74,  55, -23,  12, -53, -69,   9,  59,  -9, -62, -72, -72, -63;
/M: SY='P';  M=  29, -76,  -4,  -6,  33, -67, -65, -14, -59, -64,  15, -63,  83,   7, -11, -55,  19, -61, -72, -61;
/M: SY='E';  M=  20, -74,   1,  45, -70, -70, -60,  12,  23,  -3, -56, -57, -66,  43,  20, -54,  13, -17, -77, -65;
/M: SY='I';  M= -20, -72, -82, -78, -52,  -1, -75,  72, -74,   4,  71, -73, -74, -71, -76, -68, -58,  44, -76, -58;
/M: SY='D';  M= -13, -77,  62,  36, -77,  27,  16, -17,  -3, -67,  16, -50, -66,  45, -57, -55, -59,   5, -83, -66;
/M: SY='E';  M=  10, -76,  60,  73, -82, -17, -56, -79,  -4, -76, -72, -49, -61,  14, -55,   9,   1, -72, -83, -71;
/M: SY='F';  M= -70, -73,  -9, -76,  87, -82, -62,   0, -74,  33, -44, -75, -83, -75, -73, -72, -64,   6, -48,  63;
/I:         E1=0; IE=-255; DE=-255;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2020_01 which contains 561'911 sequence entries.


Total number of hits 18 in 18 different sequences
Number of true positive hits 18 in 18 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 7
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] E2
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
18 sequences

A4_CAEEL    (Q10651    ), A4_CAVPO    (Q60495    ), A4_DORPE    (Q06BR2    ), 
A4_DROME    (P14599    ), A4_HUMAN    (P05067    ), A4_MACFA    (P53601    ), 
A4_MOUSE    (P12023    ), A4_PANTR    (Q5IS80    ), A4_PIG      (P79307    ), 
A4_RAT      (P08592    ), A4_SAISC    (Q95241    ), A4_TAKRU    (O93279    ), 
A4_TETFL    (O73683    ), APLP1_HUMAN (P51693    ), APLP1_MOUSE (Q03157    ), 
APLP2_HUMAN (Q06481    ), APLP2_MOUSE (Q06335    ), APLP2_RAT   (P15943    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
7 sequences

A4_BOVIN    (Q28053    ), A4_CANLF    (Q28280    ), A4_FELCA    (P86906    ), 
A4_MACMU    (P29216    ), A4_RABIT    (Q28748    ), A4_SHEEP    (Q28757    ), 
A4_URSMA    (Q29149    )
» more

PDB
[Detailed view]
17 PDB

1TKN; 3K66; 3K6B; 3NYJ; 3NYL; 3PMR; 3Q7G; 3Q7L; 3QMK; 3UMH; 3UMI; 3UMK; 4RD9; 4RDA; 4YN0; 5BUO; 5TPT
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission