We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU01218
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01218
General rule information
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| Accession | PRU01218 |
| Dates | 02-AUG-2018 (Created)
22-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51870; APP_E2 |
Name | Amyloid precursor protein (APP) E2 domain |
| Function | The E2 domain forms an antiparallel dimer. E2 dimerization is a dynamic and reversible process and heparin binding to E2 shifts the association-dissociation equilibrium in favor of dimer. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P12023; |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the APP family. |
Gene Ontology
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| GO:0008201; Molecular function:heparin binding |
Features
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| From: PS51870 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="E2 #" | |||||||||
Additional information
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| Size range | 185-210 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [25] All [ 25 ]
- Retrieve set of proteins with 3D structure for this domain