ProRule PRU01218
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01218 |
| Accession | PRU01218 |
| Dates | 2-AUG-2018 (Created)
22-NOV-2019 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51870; APP_E2 |
Name | Amyloid precursor protein (APP) E2 domain |
| Function | The E2 domain forms an antiparallel dimer. E2 dimerization is a dynamic and reversible process and heparin binding to E2 shifts the association-dissociation equilibrium in favor of dimer. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P12023 (A4_MOUSE); |
Propagated annotation
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Comments
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| SIMILARITY | Belongs to the APP family. |
Gene Ontology
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| GO:0008201; Molecular function:heparin binding |
Features
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| From: PS51870 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="E2 #" | |||||||||
Additional information
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| Size range | 185-210 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [25] All [ 25 ]
- Retrieve set of proteins with 3D structure for this domain