PRU01218
General rule information
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| Accession | PRU01218 |
| Dates | 2-AUG-2018 (Created) 22-NOV-2019 (Last updated, Version 2) |
| Data class | Domain |
| Predictors | PROSITE; PS51870; APP_E2 |
| Name | Amyloid precursor protein (APP) E2 domain |
| Function | The E2 domain forms an antiparallel dimer. E2 dimerization is a dynamic and reversible process and heparin binding to E2 shifts the association-dissociation equilibrium in favor of dimer. |
Propagated annotation
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Comments
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| Similarity | Belongs to the APP family. |
Gene Ontology
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GO:0008201; Molecular function: heparin binding.
Features
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| From: PS51870 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | E2 # | |||||||||
Additional information
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| Size range | 185-210 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P12023 (A4_MOUSE) |
| Scope | Eukaryota; Metazoa |
| Comments | None |
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UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [25]
- Retrieve set of proteins with 3D structure for this domain