ProRule logo

General rule information [?]

Accession PRU01218
Dates 2-AUG-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51870; APP_E2
Name Amyloid precursor protein (APP) E2 domain
Function The E2 domain forms an antiparallel dimer. E2 dimerization is a dynamic and reversible process and heparin binding to E2 shifts the association-dissociation equilibrium in favor of dimer.

Propagated annotation [?]

Comments [?]

Similarity Belongs to the APP family.

Gene Ontology [?]

GO:0008201; Molecular function: heparin binding.

Features [?]

From: PS51870
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       E2 #        

Additional information [?]

Size range 185-210 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P12023 (A4_MOUSE)
Eukaryota; Metazoa
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]