ProRule PRU01218

General rule information [?]

Accession PRU01218
Dates 2-AUG-2018 (Created)
22-NOV-2019 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51870; APP_E2
Name Amyloid precursor protein (APP) E2 domain
Function The E2 domain forms an antiparallel dimer. E2 dimerization is a dynamic and reversible process and heparin binding to E2 shifts the association-dissociation equilibrium in favor of dimer.
Scope(s) Eukaryota
Example(s) P12023 (A4_MOUSE);

Propagated annotation [?]

Comments [?]

SIMILARITYBelongs to the APP family.

Gene Ontology [?]

GO:0008201; Molecular function:heparin binding

Features [?]

From: PS51870
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="E2 #"

Additional information [?]

Size range 185-210 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]