PROSITE entry PS51893

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General information about the entry

Entry name [info]	AKAP_CAM_BD
Accession [info]	PS51893
Entry type [info]	MATRIX
Date [info]	05-JUN-2019 CREATED; 05-JUN-2019 DATA UPDATE; 08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC51893
Associated ProRule [info]	PRU01241

Name and characterization of the entry

Description [info]

A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding motif profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=21;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=19;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6058626; R2=0.0075913; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=975; N_SCORE=10.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=513; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-66; D=-20; I=-20; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E';  M= -29,-127,  53,  58,-105,  28,-111,   3,  16, -83,-114,-102,-115,  -7, -14, -64, -42,   7,-131,-119;
/M: SY='S';  M= -99,-121, -77,  44,-127,  59,-112, -54, -52, -91, -32,-100, -91,-102, -65,  71,   1, -75,-129,-120;
/M: SY='T';  M=  68,-112,-110,-107,-120, -76, -53,-109,-108,-115,-109, -59,  33,-107,-114,  38,  70, -17,-129,-117;
/M: SY='W';  M=-123,-148,-150,-128, -88,-122,-150, -17,-120,-116,-119,-143,-127,-120,-124,-130,-134,-129, 183, -75;
/M: SY='A';  M=  72,-114,   5,  10, -62, -36,-114,-102,   6, -81,-107, -51,-115, -38, -55,  -4, -17,  41,-127,-115;
/M: SY='S';  M=  24,-112,-105,-105,-121,-100,-110,-117,-105,-121,-115, -95,   9,-100,-111,  99,  47,-109,-130,-115;
/M: SY='F';  M=-117,-120,-134,-129,  95,-133,-120,  64,-126,  43, -87,-126,-129,-127,-125,-122,-111, -60,-103, -83;
/M: SY='K';  M=-111,-126,-104, -90,-126,-118,-104,-127, 109,-125,-113, -97,-112, -20,  50,-105,-106,-123,-120,-112;
/M: SY='K';  M=-111, -25,-104, -95,-125, -60, -17,-128,  85,-125,-113,  28,-116, -89,  84, -40,-106,-123,-124,-112;
/M: SY='L';  M=-115,-117,-132,-124,  40,-132,-114, -42,-122,  86,  58,-128,-130,-118, -33,-123,-111, -89,-114, -95;
/M: SY='V';  M= -17,-115,-129,-123,-101,-128,-126,  37,-120, -42,  59,-122,-123,-120,-122,-112, -10,  92,-131,-107;
/M: SY='T';  M= -76,-116,-109,-107,-117,-117,-113, -56, -58,-110,  45, -77,  61,-107,  25, -71, 102,-103,-131,-114;
/M: SY='P';  M= -68, -42,-112,-105,-129,  36,  46,-126,-102,-116,-116,-109, 106, -78,  44, -18,-108,-126,-127,-120;
/M: SY='R';  M=-114,-130,-108, -96,-128,-122,-104,-101,  77,-126,-114, -35,-119,  26,  91, -54, -76,-125,-124,-114;
/M: SY='R';  M=-114,-128,-107, -97,-127,-121,-105,-130,  84,-127,-115,   6,-118, -91,  87, -55, -39,-125,-125,-114;
/M: SY='K';  M=-115,-129,-108, -97,-126,-122,  50,-106,  83, -80,-113, -70, -76, -80,  83, -56, -73,-125,-126,-111;
/M: SY='S';  M=  27,-120, -66,-103,-122, -95, -43, -58,  45, -51, -29, -23,  17,  37, -34,  51, -33,  19,-128,-116;
/M: SY='K';  M=-113,-128,   6, -17,-129, -69, -21,-130,  99,-128,-117, -44,-115, -91,  49, -65, -92,-126,-125,-115;
/M: SY='S';  M=  -8,-119,  -2, -74, -91, -77, -62, -98, -38, -54, -54, -31,  10, -77,  44,  83,  19,-115,-131,-116;
/M: SY='S';  M= -23, -47,  53,  47,-104, -74, -73,-124, -12, -47,-120, -64,  22, -86, -33,  70, -72, -68,-134,-119;
/M: SY='S';  M= -34,-122,  15,  38, -61,  32,-110, -93,  25, -30, -16, -86, -89, -38, -45,  65,-102, -67,-129,-118;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.

Total number of hits	13 in 7 different sequences
Number of true positive hits	13 in 7 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	3
Feature key [info]	MOTIF
Feature description [info]	AKAP CaM-binding
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

7 sequences

AKA12_HUMAN (Q02952), AKA12_MOUSE (Q9WTQ5), AKA12_RAT   (Q5QD51),

AKAP5_BOVIN (P24275), AKAP5_HUMAN (P24588), AKAP5_MOUSE (D3YVF0), 
AKAP5_RAT   (P24587)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

1 PDB

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