We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE documentation PDOC51893A kinase-anchoring proteins AKAP-5 and AKAP-12 calmodulin (CaM)-binding motif profile
View entry in original PROSITE document format
View entry in raw text format (no links)
PURL: https://purl.expasy.org/prosite/documentation/PDOC51893
Description
The A kinase-anchoring proteins AKAP-5 and AKAP-12 (Gravin) bind calmodulin (CaM), a Ca(2+)-sensing protein that is expressed in all eukaryotic cells and mediates many essential processes driven by Ca(2+), including long-term changes in synaptic connections in the brain, apoptosis, and immune responses. The AKAP CaM-binding motif contains hydrophobic amino acids in a 1-4-7-8 pattern within an helix (see <PDB:5NIN>) [1].
The profile we developed covers the entire AKAP CaM-binding motif.
Last update:April 2019 / First entry.
-------------------------------------------------------------------------------
Technical section
PROSITE method (with tools and information) covered by this documentation:
Reference
| 1 | Authors | Patel N. Stengel F. Aebersold R. Gold M.G. |
| Title | Molecular basis of AKAP79 regulation by calmodulin. | |
| Source | Nat. Commun. 8:1681-1681(2017). | |
| PubMed ID | 29162807 | |
| DOI | 10.1038/s41467-017-01715-w |
Copyright
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.