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Entry: PS51936

General information about the entry

Entry name [info] POU_4
Accession [info] PS51936
Entry type [info] MATRIX
Date [info] 02-DEC-2020 CREATED;
02-DEC-2020 DATA UPDATE;
02-DEC-2020 INFO UPDATE.
PROSITE Doc. [info] PDOC00035
Associated ProRule [info] PRU01285

Name and characterization of the entry

Description [info] POU-specific (POUs) atypical domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=97;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=92;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1392422; R2=0.0075682; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1237; N_SCORE=11.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=577; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-21; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='R';  M=  9,-73,-58, -7,-67, -3,-58,-36, 15,-21, -5, 34, 28,-15, 34, 23,-11,-12,-74, 11;
/M: SY='S';  M=-30,-72,-25, 20,  1,-30, 19,-28,  6, -2,-58,-23, 12,-12, 22, 40, 31,-33,-75,-16;
/M: SY='P';  M=-22,-75, -7,  5,-12,-18, -7,-63,-14, -4, 13,-18, 41, 12, 28, 16, 18,-31,-70, 31;
/M: SY='S';  M=-56,-73, -3,-32, 10,  4, -9, -7,-10,-19,-60,  1, 36,-10,-29, 51, 11,-18, 17, 10;
/M: SY='P';  M= -6,-75, 35,-18, -5,-24,-59,-14,  4,-16,-62, 36, 54,-14, -7, 20,-23,-37,-76, -4;
/M: SY='E';  M=-37,-74, 25, 34,-10,  1,-61,  3,-10, 13,  3,  0,-28,-54, -3, 28,-56, -4, 13,-13;
/M: SY='H';  M=  4, 19,-21,-20,-15, 13, 34,-17,  7, 11, 22, 28, -4, -7, -8, -2,-58,-28,-74,  9;
/M: SY='S';  M= -8,-72, 10, 32, 29,-66, 18,-35,-58,-22,-60,-56, 35,-18,-27, 46, 14,  3,-76,-58;
/M: SY='E';  M=-20, 23, 15, 44,-16,-39,-60, -1,-25, 21,-56,  3, 15,  0,-62, 29,-13,-58,-76,-12;
/M: SY='E';  M=-19, -1, 30, 66,-23,-69,-57,-13, -7,-18,-63,  7,-21,-16,  9, 12,  6,-64,-78,-11;
/M: SY='D';  M= 12,-73, 59, 24,-29,-27,-58, -7,-29,-69,-66,  6,  4,-11,-28, 30, 15,-33,-79,  4;
/M: SY='W';  M= 22,-74,-37, 18,-24,-68, 32,-58,-57, 21,-54,-21, 37,-15, 10,  6, -3,-16, 56,  8;
/M: SY='D';  M=-38,-78, 56, 40,-77, 15,  5,-34,  5,-35,-65,  7, 20, 19, -1,-29,-26, -6,-83,-68;
/M: SY='P';  M=  2,-74, 12, -9,-23,-72,-66, 33,-62, 25,-49,-10, 45,  9,-22, -9, -3,  6,-76,-17;
/M: SY='P';  M= -4,-75, 27, 26,-28,-14, -4, -3,-31,-41, 23, 15, 31, 14, 20, 24, -5,-63,-80,-65;
/M: SY='E';  M= 19,-74, 32, 53,-70, -5,-58,-17,  5,-25,-63,-23,-17,  2,-24, 11,  5,-64,-75, 13;
/M: SY='E';  M= 12,-74,-31, 62, 19,-70,-58,-63, 38,-11, -9,-58,-65,  0,-21,  3,-22,-17,-69, 10;
/M: SY='V';  M=-34,  7,-27,  4,-57,-22,-70,  9,-44, 33, -7,  2,  2,-64,-70,  1, -4, 52,-81,-63;
/M: SY='E';  M=-15,-76, 26, 66,-72,-69,-57,-66, -7, -6,-62,-23,  4, 31,  9, 12,-29, -6,-78,-15;
/M: SY='E';  M=-17,-76,-16, 78,-21,-71,-56,-19,  7,-25,-63,-57,-63, -7, 27, 13,-26,-34,-73,  7;
/M: SY='F';  M=-65, -4,-12,-20, 57,-20, 24, -7,  1, 38, 35,-66,-23, -9,-64,-14,-61,-26,-63, 20;
/M: SY='M';  M=-30, -2,-25, 13, 12,-38,-62,-46,-10, 45, 78,-68,  2,-10,-64,-36, -9,-22, 15,-14;
/M: SY='R';  M=-30,-76, -6,  0,-25, -7,-57,-67, 34,-10, 30,  2,-13,  7, 64, 16,-57,-33,-76,-62;
/M: SY='R';  M=-29, -9, -6, 25, -2,-37,-56,-66, 43,  6, 21,-57,-13, 46, 47,-29,-61,-66,-72,-17;
/M: SY='D';  M=-61,  6, 83, 31,-25, 38,  4,-83,-54,-80,-75, 34,-67,-11,-23,-31,-59,-80,-87,-68;
/M: SY='P';  M=-34,-75, 10, 49,-76,-64, -7,-19,-51,-71,-14, 20, 52, 19, -6, 42, -1,-19,-82,-68;
/M: SY='W';  M= 14,-74, 30, 28,-21,-37, -5,-66,-29,-25, 38, 10,  0,-12,-62,  6, 26,-64, 85,-13;
/M: SY='K';  M= 13, -8, 19, 14,-20,-29, -3,-60, 30,  2, 10,  8,-17,-14, 21,  0,-56,  2,-77,-22;
/M: SY='V';  M=  3, 24, -8,-33,-20,-76,-70, 32, -8, 11, 17,-68,-75,-64,  9,-28,-56, 56,-77,-11;
/M: SY='K';  M= 23,-73,-22,  3, -3,-35, 20,  1, 52,-13, 15,-57,-68, 16,  4,-11,-57,  0,-73,-19;
/M: SY='E';  M=  3,-76,  1, 70,-72,-35,-56,-27, 24,-11, -3, -1,-64, 10, 18,-30,-20,-65,-76,-19;
/M: SY='E';  M= -2,-77, 28, 79,-73,-41,-57,  1, 21,-37, 54,-56,-62, -9,-53,-58,-59,-35,-79,-67;
/M: SY='I';  M=-63,-75,-30,-27,-21,-41,-78, 89,-73,  4, 23,-72,-74,-71,-34,-70,-23, 22,-75,-57;
/M: SY='R';  M=-30,-77, 11,  7,-76,-69,-56,-75, 67,-47,-65,-21,-67,-43, 72, 13,-57,-31,-77,-65;
/M: SY='D';  M= 14,-73, 40, 31,-75,-30,-59,-36, 30,-47,-66, 13,-18, 21, -3, -5, 34,-66, 20,-66;
/M: SY='F';  M=-72,-75,-78,-30,102,-80,-59,-27,-34,-26,-51,-72,-82, 22,-31,-69,-66,-29, 19, 61;
/M: SY='M';  M=-62,-71,-80,-33,  9,-45,-69, 22,-72, 47, 81,-74,  1,-68,-72,-69, -5, 31, 22,-52;
/M: SY='Q';  M=  6,-71,-19,  6,-19,-22, 32,-30,-11,-35, 13, 28,-67, 54,-22, 39, 12,-35,-76, -6;
/M: SY='Q';  M= 13, -8,-53, 22,-76,-65, -5,-69,  6,-24, -6, 39,-68, 78, 35,-38,  1,-40,-78,-64;
/I:         I=-42; MD=-106;
/M: SY='H';  M=-36, -5,-58, -6,-19,-71, 69,-70, -8,-27, -5, 51,-76,-52, 47,-29,-62,-42, 14, 59; D=-42;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='N';  M=-36,-73,-12, -2,-74,-21, 33,-75,-18,-44,-10, 77,-24, 16, 48, 20,-18,-73, 18,-63;
/M: SY='I';  M=-35,-75, -1,-31,  8,-82,-75, 81,-31, 19,-41,-70,-74,-69,-33,-15,-58, 13, 13,-54;
/M: SY='S';  M=-26,-73,-61,-54,-73,-62,-61,-66, 26,-72,-64,-54, 61,  7, 25, 67,-15,  4,-78,-19;
/M: SY='Q';  M=-62,-83,-16,-16,-76,-70,  5,-71,-42, -4,-56,-54,-17,111, 34,-54,-63,-73, 54,-58;
/M: SY='R';  M= 32,-72,-59, -5,-72,  6, 33,-69, -8,-45,-62, 16,-68, 17, 52,  3, 17,-17, 26,-63;
/M: SY='Q';  M= -1,-73,  4, 30,-29,-41, -7, 17,-56,-13, -1,-59,-23, 49, -8,-30, 26, 26,-77,-11;
/M: SY='V';  M=-11,-70,-80,-75,-53,-79,-80, 60,-73, -5,  3,-73,-27,-72,-76, -1,-24, 70, 19,-59;
/M: SY='A';  M= 70,-66,-23,-31,-20, 18,-67,-61, -5,-40,-61,-58,-68,-58,-24, 27,-52,  7,-76,-67;
/M: SY='Q';  M=-25,-77, 15, 53,-72,-70,-55,-65, -8, 14, 19,-11,-18, 66, 17,  3,-30,-65,-78,-64;
/I:         I=-45; MD=-115;
/M: SY='M';  M= 16,-68, -7,-67,-57,-71,-65,-21,-34, -9, 95,-23,-24,-63,-67,  0,-18, 51,-79,-18; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='T';  M=  5,  2,-60,-58,-69,-67, -3,-29,  7,-63, -6,-50,-21,-16, -6,-20, 96,-38,-84,-65;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='G';  M= -3,-76,-59, 15,-80, 73, -6,-83,-12,-80,-70,-52,  3,-54, 36, 16,-38,-76,-76,-72;
/M: SY='I';  M=-38,-73,-76,-71,-50,-81,-70, 73,-69, 26,  0,-22,-22, 22,-72,-64, 18, 16,-71, 16;
/M: SY='S';  M=-50, 23,-57,-59,  1,-57, 23,-68,-20,-41, 24, 34,-15,-52, -3, 82, -3,-65,-80,-60;
/M: SY='Q';  M=-60,-80,-59,-15,  1,-36, 24,-66,-48,-11,-55,-54,  6,109,-49,-29,  9,-32, 24,-56;
/M: SY='S';  M= 13, -1,-60,-58,-20,-29, 38,-11,-59,-70,-64,-13, 39, -7,-64, 78,-14,-63,-78,-15;
/M: SY='Y';  M=-37, 43,-19, -7,-40,-74, 66,-62,-56, -8, 20,-61,-76,-55, 27,-24,-25,-63,-52, 97;
/M: SY='I';  M=-30,-71,-74,-73,-54,-77,-74, 67,-69, 20,-42, 18,  5,-69,-35,-10, -4, 44,-79,-60;
/M: SY='S';  M=-22,-67,-17,-24,-72,-56,-59,-68,  5,-21, -6,-48,-24, 27,-56, 89, 11,-64,-80,-65;
/I:         I=-17; MD=-44;
/M: SY='Q';  M=-40,-83,-63,-49,-26,-73, 65,-75, 29,-47, -2,-56,  8, 78, 45,-58,-22,-76, 65,-55; D=-17;
/I:         I=-17; MD=-44;
/M: SY='W';  M=-71,-82,-78,-71, 71,-14, 45,-62,-32,-40,-59,-70,-29, 11,-21,-68, -9,-30,116, 36; D=-17;
/I:         I=-17; MD=-44;
/M: SY='L';  M=-69,-73,-81,-75, 33,-84,-67, -4,-34, 73,  3,-20,-21,-70, -4,-75,-65,-45,-68,-17; D=-17;
/I:         I=-17; MD=-44;
/M: SY='N';  M= -7,-73,-55, 35,-66,-70,-60,-59,-30, 35,-54, 51,  2,-12, 21, -9,  4,-28,-81,-66; D=-17;
/I:         I=-17; MD=-44;
/M: SY='Q';  M=-31,-82,-20,-56,-84, 52, 39,-42, -9,-78,-68,-55,-14, 72, 17,-27,-22,-39,-81,-69; D=-17;
/I:         I=-17; MD=-44;
/M: SY='Q';  M=-75,-89, 23, 16,-87,-78,  9,-40,-63,-11,-73, 54,-82, 60,-68,-32,-28,-82,-97,-77; D=-17;
/I:         I=-17; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='G';  M= -7,-74,-66,-71, 33, 75, 19,-12,-25,-66, -6,-18,-26,-65,-70,-11,-13,-40,-67,  8;
/M: SY='T';  M=-19,-71,  2,  0,-66,-40,-60,-31, 31, 11,-57,-14,-66, 31,  1, 34, 46,-33,-77,-18;
/M: SY='D';  M=-14,-79, 62, 48,-82,  9,-59,-77,-25,-78,-71,-51, 56, 11,-26, -2, -6,-42,-84,-72;
/M: SY='M';  M=-60,-70,-77,-10,-51,-78,-63,  7,-32, 34,110,-71,-18,-61,-67,-28,-28, 27,-76,-55;
/M: SY='S';  M=-27,  4,-59,-57,-29,-13, -5,-70, 35,-24,-64,  7, 19,-52,-25, 72,  9,-66, 13,-14;
/M: SY='D';  M=-21,-76, 61, 42,-76,-38,-56,-67, -6,-47, 23, 32, 17, 11,  5,-54,  7, -4,-85,-68;
/M: SY='Q';  M=-19,-78, 10,-15,-76,-67, -1,  3,  0,-45,-12,-13,  6, 74, 53, 29,-56,-65,-78,-63;
/M: SY='K';  M=-60, 65,-60,-20,-73,-71,-63,-61, 78,-66,  0,-11,  4, 12,-18,-33,  3, 22,-79,-67;
/M: SY='R';  M=-35,-78,-61,-49,-74,-34,-57,-28, 69,-39, -4,-54,-69,-12, 83,-58, -6,-68,-74,-63;
/M: SY='R';  M= 13,-74,-60,-54,  1,-38,-57,-70,  2,-42,-62, 25,  2, 14, 79, -7, 17,-37,-75,-61;
/M: SY='A';  M= 63,-68,-64, -6,-65,-29,-67, 40,-12, -3,-53, 13,-69,-58,-21,  2,-26,-25,-77,-66;
/M: SY='F';  M=-68,-73,-80,-74, 72,-82,-67, 36,-67, 38, 39,-25,  3,-70, 19,-71,-62, -4,-61,-42;
/M: SY='Y';  M=-40,-78,-73,-73, 58,-77,  1,  5,-66,-50,-50,-70,-81,-65,-23,-31,-22,-56,-36,114;
/M: SY='R';  M= -4, 19,-23,-26,-67,-69, -7,-30, -6, -2, 19,-55,-69, 11, 59, 12, 52,-26,-80,-62;
/M: SY='W';  M=-43,  4,-96,-78, -8,-73,-96,-33,-71,-67,-70,-87,-78,-72,-75,-42,-10,-36,170,-31;
/M: SY='Y';  M=-71,-79,-27,-71, 57,-35,-44,-57,-62,-53,-52,-69,-82,-63, 10,-65,-31,-62,-34,117;
/M: SY='L';  M=-14,-71,-74,-12,  1,-37,-69, 10,-36, 60,-39,-73,  8, 17,-69,-66,-15, 25,-73,-56;
/M: SY='R';  M=-17,-73,  1, 15,-63,-34,-60, -8,  6, 35,-51, 14,-70, 18, 39,-32, 24,-24,-78,-62;
/M: SY='C';  M=-62, 99, -1, 51,-67,-73,-11,-71, 21,-25, 20,-19,-71,  4,  0,-24,-20,-68, 19,  8;
/M: SY='K';  M=-63,-79,-60,-47,-73,-73,-57, 21, 72,-44,-58,-54,-68, 52, 66,-28,-60,-62,-73,-62;
/M: SY='N';  M= -3, -3,-17,-24, -7,-30, -9,-71, 35,-45, -7, 63,-25, 22, 30,  0, 20,-68,-79,-63;
/M: SY='N';  M=-36, -2,  5, 24,-66,-65, -9, -7, -7,-23,-60, 59,-68, 10, 24, 17, 26,-36,-78, 16;
/M: SY='P';  M=-17,-80,-69,-61,-68,-37,  1, 15,-35, 11, -9,-28, 99,-65,-32,-24,-24,-14,-78,-69;
/M: SY='E';  M=  5,-74,  2, 39,-72, 38,-61,-69, -6,-27,-65,-11, 12, 11,-60, 26, -6,-17,  9,-10;
/M: SY='Q';  M= 10,-30,-63,-58,-68, 26,-62,  2, 17, 11, -5,  6, -1, 44, 20,-11,  0,-33,-76,-65;
/M: SY='L';  M= 11,-70,-70,-61,-14,-72, -4,-23,-11, 44, 16,-64,-29, 34, 12,-27, 32,  2,-73,-17;
/M: SY='W';  M=  1,-75,-65,  6, 47,-39,-61,-60, 12, 14,-12, -8, -2, 36, -2, -5,-25,-61, 69, 14;
/M: SY='S';  M= 20, -3,-24, 23,-71,-30,  3,-27,-23,-29,  9, 16, 14, 30,-30, 32, 29,-35, 18,-65;
/M: SY='M';  M=-60, 24,-23, 16,  9,-40, -4,-15,-55,-26, 65, 37,-71, 27,  5,  3, -6, -3,-69, 38;
/M: SY='M';  M= 34, 37,-28,-26,-71,-63,-61,-30,-21,-38, 43, 15, 27, 14, 34, 30,-53, -7,-80,-66;
/M: SY='S';  M= -9,-73,-24, -9,-76, 33,-61,-73, -6,-49,-66,-10, 47, 34,-20, 48, 26,-69,-77,-23;
/M: SY='H';  M= -1,  4, 15,-56,-17,-10, 60,-26, -6,-24,-59, 16, -7, 24,-18, 13, 32,-37, 13, 10;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2020_06 which contains 563'972 sequence entries.


Total number of hits 18 in 18 different sequences
Number of true positive hits 18 in 18 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] POU-specific atypical
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
18 sequences

HMBX1_CAEEL (Q9TYT0    ), HMBX1_HUMAN (Q6NT76    ), HMBX1_MOUSE (Q8BJA3    ), 
HN1BA_DANRE (A1L1N5    ), HN1BB_DANRE (Q8UW00    ), HNF1A_CHICK (Q90867    ), 
HNF1A_HUMAN (P20823    ), HNF1A_MOUSE (P22361    ), HNF1A_RAT   (P15257    ), 
HNF1A_SALSA (Q91474    ), HNF1B_HUMAN (P35680    ), HNF1B_MOUSE (P27889    ), 
HNF1B_PIG   (Q03365    ), HNF1B_PONAB (Q5RER5    ), HNF1B_RAT   (P23899    ), 
HNF1B_XENLA (Q91910    ), HNFAA_XENLA (Q05041    ), HNFAB_XENLA (Q91739    )
» more

PDB
[Detailed view]
2 PDB

1IC8; 2H8R

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