PROSITE entry PS51936
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General information about the entry
| Entry name [info] | POU_4 |
| Accession [info] | PS51936 |
| Entry type [info] | MATRIX |
| Date [info] |
02-DEC-2020 CREATED;
02-DEC-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00035 |
| Associated ProRule [info] | PRU01285 |
Name and characterization of the entry
| Description [info] | POU-specific (POUs) atypical domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=97; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=92; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1392422; R2=0.0075682; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1237; N_SCORE=11.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=577; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-21; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='R'; M= 9,-73,-58, -7,-67, -3,-58,-36, 15,-21, -5, 34, 28,-15, 34, 23,-11,-12,-74, 11; /M: SY='S'; M=-30,-72,-25, 20, 1,-30, 19,-28, 6, -2,-58,-23, 12,-12, 22, 40, 31,-33,-75,-16; /M: SY='P'; M=-22,-75, -7, 5,-12,-18, -7,-63,-14, -4, 13,-18, 41, 12, 28, 16, 18,-31,-70, 31; /M: SY='S'; M=-56,-73, -3,-32, 10, 4, -9, -7,-10,-19,-60, 1, 36,-10,-29, 51, 11,-18, 17, 10; /M: SY='P'; M= -6,-75, 35,-18, -5,-24,-59,-14, 4,-16,-62, 36, 54,-14, -7, 20,-23,-37,-76, -4; /M: SY='E'; M=-37,-74, 25, 34,-10, 1,-61, 3,-10, 13, 3, 0,-28,-54, -3, 28,-56, -4, 13,-13; /M: SY='H'; M= 4, 19,-21,-20,-15, 13, 34,-17, 7, 11, 22, 28, -4, -7, -8, -2,-58,-28,-74, 9; /M: SY='S'; M= -8,-72, 10, 32, 29,-66, 18,-35,-58,-22,-60,-56, 35,-18,-27, 46, 14, 3,-76,-58; /M: SY='E'; M=-20, 23, 15, 44,-16,-39,-60, -1,-25, 21,-56, 3, 15, 0,-62, 29,-13,-58,-76,-12; /M: SY='E'; M=-19, -1, 30, 66,-23,-69,-57,-13, -7,-18,-63, 7,-21,-16, 9, 12, 6,-64,-78,-11; /M: SY='D'; M= 12,-73, 59, 24,-29,-27,-58, -7,-29,-69,-66, 6, 4,-11,-28, 30, 15,-33,-79, 4; /M: SY='W'; M= 22,-74,-37, 18,-24,-68, 32,-58,-57, 21,-54,-21, 37,-15, 10, 6, -3,-16, 56, 8; /M: SY='D'; M=-38,-78, 56, 40,-77, 15, 5,-34, 5,-35,-65, 7, 20, 19, -1,-29,-26, -6,-83,-68; /M: SY='P'; M= 2,-74, 12, -9,-23,-72,-66, 33,-62, 25,-49,-10, 45, 9,-22, -9, -3, 6,-76,-17; /M: SY='P'; M= -4,-75, 27, 26,-28,-14, -4, -3,-31,-41, 23, 15, 31, 14, 20, 24, -5,-63,-80,-65; /M: SY='E'; M= 19,-74, 32, 53,-70, -5,-58,-17, 5,-25,-63,-23,-17, 2,-24, 11, 5,-64,-75, 13; /M: SY='E'; M= 12,-74,-31, 62, 19,-70,-58,-63, 38,-11, -9,-58,-65, 0,-21, 3,-22,-17,-69, 10; /M: SY='V'; M=-34, 7,-27, 4,-57,-22,-70, 9,-44, 33, -7, 2, 2,-64,-70, 1, -4, 52,-81,-63; /M: SY='E'; M=-15,-76, 26, 66,-72,-69,-57,-66, -7, -6,-62,-23, 4, 31, 9, 12,-29, -6,-78,-15; /M: SY='E'; M=-17,-76,-16, 78,-21,-71,-56,-19, 7,-25,-63,-57,-63, -7, 27, 13,-26,-34,-73, 7; /M: SY='F'; M=-65, -4,-12,-20, 57,-20, 24, -7, 1, 38, 35,-66,-23, -9,-64,-14,-61,-26,-63, 20; /M: SY='M'; M=-30, -2,-25, 13, 12,-38,-62,-46,-10, 45, 78,-68, 2,-10,-64,-36, -9,-22, 15,-14; /M: SY='R'; M=-30,-76, -6, 0,-25, -7,-57,-67, 34,-10, 30, 2,-13, 7, 64, 16,-57,-33,-76,-62; /M: SY='R'; M=-29, -9, -6, 25, -2,-37,-56,-66, 43, 6, 21,-57,-13, 46, 47,-29,-61,-66,-72,-17; /M: SY='D'; M=-61, 6, 83, 31,-25, 38, 4,-83,-54,-80,-75, 34,-67,-11,-23,-31,-59,-80,-87,-68; /M: SY='P'; M=-34,-75, 10, 49,-76,-64, -7,-19,-51,-71,-14, 20, 52, 19, -6, 42, -1,-19,-82,-68; /M: SY='W'; M= 14,-74, 30, 28,-21,-37, -5,-66,-29,-25, 38, 10, 0,-12,-62, 6, 26,-64, 85,-13; /M: SY='K'; M= 13, -8, 19, 14,-20,-29, -3,-60, 30, 2, 10, 8,-17,-14, 21, 0,-56, 2,-77,-22; /M: SY='V'; M= 3, 24, -8,-33,-20,-76,-70, 32, -8, 11, 17,-68,-75,-64, 9,-28,-56, 56,-77,-11; /M: SY='K'; M= 23,-73,-22, 3, -3,-35, 20, 1, 52,-13, 15,-57,-68, 16, 4,-11,-57, 0,-73,-19; /M: SY='E'; M= 3,-76, 1, 70,-72,-35,-56,-27, 24,-11, -3, -1,-64, 10, 18,-30,-20,-65,-76,-19; /M: SY='E'; M= -2,-77, 28, 79,-73,-41,-57, 1, 21,-37, 54,-56,-62, -9,-53,-58,-59,-35,-79,-67; /M: SY='I'; M=-63,-75,-30,-27,-21,-41,-78, 89,-73, 4, 23,-72,-74,-71,-34,-70,-23, 22,-75,-57; /M: SY='R'; M=-30,-77, 11, 7,-76,-69,-56,-75, 67,-47,-65,-21,-67,-43, 72, 13,-57,-31,-77,-65; /M: SY='D'; M= 14,-73, 40, 31,-75,-30,-59,-36, 30,-47,-66, 13,-18, 21, -3, -5, 34,-66, 20,-66; /M: SY='F'; M=-72,-75,-78,-30,102,-80,-59,-27,-34,-26,-51,-72,-82, 22,-31,-69,-66,-29, 19, 61; /M: SY='M'; M=-62,-71,-80,-33, 9,-45,-69, 22,-72, 47, 81,-74, 1,-68,-72,-69, -5, 31, 22,-52; /M: SY='Q'; M= 6,-71,-19, 6,-19,-22, 32,-30,-11,-35, 13, 28,-67, 54,-22, 39, 12,-35,-76, -6; /M: SY='Q'; M= 13, -8,-53, 22,-76,-65, -5,-69, 6,-24, -6, 39,-68, 78, 35,-38, 1,-40,-78,-64; /I: I=-42; MD=-106; /M: SY='H'; M=-36, -5,-58, -6,-19,-71, 69,-70, -8,-27, -5, 51,-76,-52, 47,-29,-62,-42, 14, 59; D=-42; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='N'; M=-36,-73,-12, -2,-74,-21, 33,-75,-18,-44,-10, 77,-24, 16, 48, 20,-18,-73, 18,-63; /M: SY='I'; M=-35,-75, -1,-31, 8,-82,-75, 81,-31, 19,-41,-70,-74,-69,-33,-15,-58, 13, 13,-54; /M: SY='S'; M=-26,-73,-61,-54,-73,-62,-61,-66, 26,-72,-64,-54, 61, 7, 25, 67,-15, 4,-78,-19; /M: SY='Q'; M=-62,-83,-16,-16,-76,-70, 5,-71,-42, -4,-56,-54,-17,111, 34,-54,-63,-73, 54,-58; /M: SY='R'; M= 32,-72,-59, -5,-72, 6, 33,-69, -8,-45,-62, 16,-68, 17, 52, 3, 17,-17, 26,-63; /M: SY='Q'; M= -1,-73, 4, 30,-29,-41, -7, 17,-56,-13, -1,-59,-23, 49, -8,-30, 26, 26,-77,-11; /M: SY='V'; M=-11,-70,-80,-75,-53,-79,-80, 60,-73, -5, 3,-73,-27,-72,-76, -1,-24, 70, 19,-59; /M: SY='A'; M= 70,-66,-23,-31,-20, 18,-67,-61, -5,-40,-61,-58,-68,-58,-24, 27,-52, 7,-76,-67; /M: SY='Q'; M=-25,-77, 15, 53,-72,-70,-55,-65, -8, 14, 19,-11,-18, 66, 17, 3,-30,-65,-78,-64; /I: I=-45; MD=-115; /M: SY='M'; M= 16,-68, -7,-67,-57,-71,-65,-21,-34, -9, 95,-23,-24,-63,-67, 0,-18, 51,-79,-18; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='T'; M= 5, 2,-60,-58,-69,-67, -3,-29, 7,-63, -6,-50,-21,-16, -6,-20, 96,-38,-84,-65; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='G'; M= -3,-76,-59, 15,-80, 73, -6,-83,-12,-80,-70,-52, 3,-54, 36, 16,-38,-76,-76,-72; /M: SY='I'; M=-38,-73,-76,-71,-50,-81,-70, 73,-69, 26, 0,-22,-22, 22,-72,-64, 18, 16,-71, 16; /M: SY='S'; M=-50, 23,-57,-59, 1,-57, 23,-68,-20,-41, 24, 34,-15,-52, -3, 82, -3,-65,-80,-60; /M: SY='Q'; M=-60,-80,-59,-15, 1,-36, 24,-66,-48,-11,-55,-54, 6,109,-49,-29, 9,-32, 24,-56; /M: SY='S'; M= 13, -1,-60,-58,-20,-29, 38,-11,-59,-70,-64,-13, 39, -7,-64, 78,-14,-63,-78,-15; /M: SY='Y'; M=-37, 43,-19, -7,-40,-74, 66,-62,-56, -8, 20,-61,-76,-55, 27,-24,-25,-63,-52, 97; /M: SY='I'; M=-30,-71,-74,-73,-54,-77,-74, 67,-69, 20,-42, 18, 5,-69,-35,-10, -4, 44,-79,-60; /M: SY='S'; M=-22,-67,-17,-24,-72,-56,-59,-68, 5,-21, -6,-48,-24, 27,-56, 89, 11,-64,-80,-65; /I: I=-17; MD=-44; /M: SY='Q'; M=-40,-83,-63,-49,-26,-73, 65,-75, 29,-47, -2,-56, 8, 78, 45,-58,-22,-76, 65,-55; D=-17; /I: I=-17; MD=-44; /M: SY='W'; M=-71,-82,-78,-71, 71,-14, 45,-62,-32,-40,-59,-70,-29, 11,-21,-68, -9,-30,116, 36; D=-17; /I: I=-17; MD=-44; /M: SY='L'; M=-69,-73,-81,-75, 33,-84,-67, -4,-34, 73, 3,-20,-21,-70, -4,-75,-65,-45,-68,-17; D=-17; /I: I=-17; MD=-44; /M: SY='N'; M= -7,-73,-55, 35,-66,-70,-60,-59,-30, 35,-54, 51, 2,-12, 21, -9, 4,-28,-81,-66; D=-17; /I: I=-17; MD=-44; /M: SY='Q'; M=-31,-82,-20,-56,-84, 52, 39,-42, -9,-78,-68,-55,-14, 72, 17,-27,-22,-39,-81,-69; D=-17; /I: I=-17; MD=-44; /M: SY='Q'; M=-75,-89, 23, 16,-87,-78, 9,-40,-63,-11,-73, 54,-82, 60,-68,-32,-28,-82,-97,-77; D=-17; /I: I=-17; MI=0; MD=-44; IM=0; DM=-44; /M: SY='G'; M= -7,-74,-66,-71, 33, 75, 19,-12,-25,-66, -6,-18,-26,-65,-70,-11,-13,-40,-67, 8; /M: SY='T'; M=-19,-71, 2, 0,-66,-40,-60,-31, 31, 11,-57,-14,-66, 31, 1, 34, 46,-33,-77,-18; /M: SY='D'; M=-14,-79, 62, 48,-82, 9,-59,-77,-25,-78,-71,-51, 56, 11,-26, -2, -6,-42,-84,-72; /M: SY='M'; M=-60,-70,-77,-10,-51,-78,-63, 7,-32, 34,110,-71,-18,-61,-67,-28,-28, 27,-76,-55; /M: SY='S'; M=-27, 4,-59,-57,-29,-13, -5,-70, 35,-24,-64, 7, 19,-52,-25, 72, 9,-66, 13,-14; /M: SY='D'; M=-21,-76, 61, 42,-76,-38,-56,-67, -6,-47, 23, 32, 17, 11, 5,-54, 7, -4,-85,-68; /M: SY='Q'; M=-19,-78, 10,-15,-76,-67, -1, 3, 0,-45,-12,-13, 6, 74, 53, 29,-56,-65,-78,-63; /M: SY='K'; M=-60, 65,-60,-20,-73,-71,-63,-61, 78,-66, 0,-11, 4, 12,-18,-33, 3, 22,-79,-67; /M: SY='R'; M=-35,-78,-61,-49,-74,-34,-57,-28, 69,-39, -4,-54,-69,-12, 83,-58, -6,-68,-74,-63; /M: SY='R'; M= 13,-74,-60,-54, 1,-38,-57,-70, 2,-42,-62, 25, 2, 14, 79, -7, 17,-37,-75,-61; /M: SY='A'; M= 63,-68,-64, -6,-65,-29,-67, 40,-12, -3,-53, 13,-69,-58,-21, 2,-26,-25,-77,-66; /M: SY='F'; M=-68,-73,-80,-74, 72,-82,-67, 36,-67, 38, 39,-25, 3,-70, 19,-71,-62, -4,-61,-42; /M: SY='Y'; M=-40,-78,-73,-73, 58,-77, 1, 5,-66,-50,-50,-70,-81,-65,-23,-31,-22,-56,-36,114; /M: SY='R'; M= -4, 19,-23,-26,-67,-69, -7,-30, -6, -2, 19,-55,-69, 11, 59, 12, 52,-26,-80,-62; /M: SY='W'; M=-43, 4,-96,-78, -8,-73,-96,-33,-71,-67,-70,-87,-78,-72,-75,-42,-10,-36,170,-31; /M: SY='Y'; M=-71,-79,-27,-71, 57,-35,-44,-57,-62,-53,-52,-69,-82,-63, 10,-65,-31,-62,-34,117; /M: SY='L'; M=-14,-71,-74,-12, 1,-37,-69, 10,-36, 60,-39,-73, 8, 17,-69,-66,-15, 25,-73,-56; /M: SY='R'; M=-17,-73, 1, 15,-63,-34,-60, -8, 6, 35,-51, 14,-70, 18, 39,-32, 24,-24,-78,-62; /M: SY='C'; M=-62, 99, -1, 51,-67,-73,-11,-71, 21,-25, 20,-19,-71, 4, 0,-24,-20,-68, 19, 8; /M: SY='K'; M=-63,-79,-60,-47,-73,-73,-57, 21, 72,-44,-58,-54,-68, 52, 66,-28,-60,-62,-73,-62; /M: SY='N'; M= -3, -3,-17,-24, -7,-30, -9,-71, 35,-45, -7, 63,-25, 22, 30, 0, 20,-68,-79,-63; /M: SY='N'; M=-36, -2, 5, 24,-66,-65, -9, -7, -7,-23,-60, 59,-68, 10, 24, 17, 26,-36,-78, 16; /M: SY='P'; M=-17,-80,-69,-61,-68,-37, 1, 15,-35, 11, -9,-28, 99,-65,-32,-24,-24,-14,-78,-69; /M: SY='E'; M= 5,-74, 2, 39,-72, 38,-61,-69, -6,-27,-65,-11, 12, 11,-60, 26, -6,-17, 9,-10; /M: SY='Q'; M= 10,-30,-63,-58,-68, 26,-62, 2, 17, 11, -5, 6, -1, 44, 20,-11, 0,-33,-76,-65; /M: SY='L'; M= 11,-70,-70,-61,-14,-72, -4,-23,-11, 44, 16,-64,-29, 34, 12,-27, 32, 2,-73,-17; /M: SY='W'; M= 1,-75,-65, 6, 47,-39,-61,-60, 12, 14,-12, -8, -2, 36, -2, -5,-25,-61, 69, 14; /M: SY='S'; M= 20, -3,-24, 23,-71,-30, 3,-27,-23,-29, 9, 16, 14, 30,-30, 32, 29,-35, 18,-65; /M: SY='M'; M=-60, 24,-23, 16, 9,-40, -4,-15,-55,-26, 65, 37,-71, 27, 5, 3, -6, -3,-69, 38; /M: SY='M'; M= 34, 37,-28,-26,-71,-63,-61,-30,-21,-38, 43, 15, 27, 14, 34, 30,-53, -7,-80,-66; /M: SY='S'; M= -9,-73,-24, -9,-76, 33,-61,-73, -6,-49,-66,-10, 47, 34,-20, 48, 26,-69,-77,-23; /M: SY='H'; M= -1, 4, 15,-56,-17,-10, 60,-26, -6,-24,-59, 16, -7, 24,-18, 13, 32,-37, 13, 10; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 18 in 18 different sequences |
| Number of true positive hits | 18 in 18 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | POU-specific atypical |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
18 sequences
HMBX1_CAEEL (Q9TYT0), HMBX1_HUMAN (Q6NT76), HMBX1_MOUSE (Q8BJA3), HN1BA_DANRE (A1L1N5), HN1BB_DANRE (Q8UW00), HNF1A_CHICK (Q90867), HNF1A_HUMAN (P20823), HNF1A_MOUSE (P22361), HNF1A_RAT (P15257), HNF1A_SALSA (Q91474), HNF1B_HUMAN (P35680), HNF1B_MOUSE (P27889), HNF1B_PIG (Q03365), HNF1B_PONAB (Q5RER5), HNF1B_RAT (P23899), HNF1B_XENLA (Q91910), HNFAA_XENLA (Q05041), HNFAB_XENLA (Q91739)» more
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| PDB [Detailed view] |
6 PDB
1IC8; 2H8R; 8PI7; 8PI8; 8PI9; 8PIA |