PRU01285

Accession	PRU01285
Dates	17-AUG-2020 (Created) 27-JUN-2022 (Last updated, Version 2)

Data class

Domain

Predictors

PROSITE; PS51936; POU_4

Name	POU-specific (POUs) atypical domain

Function

HNF1alpha (MODY3 gene product, the most commonly mutated MODY protein) and HNF1beta (hepatocyte nuclear factor 1beta; also known as vHNF1 or TCF2) (MODY5 gene product) are atypical members of the POU transcription factors. Their atypical POUs domains have at least one additional alpha-helix at the N-terminus, and the second helix and adjacent loop of their POUh domains are much longer, creating a more extensive interface between the POUs and POUh domains.

GO:0045893; Biological process: positive regulation of DNA-templated transcription.
GO:0005634; Cellular component: nucleus.
GO:0006357; Biological process: regulation of transcription by RNA polymerase II.

DNA-binding
Nucleus
Transcription
Transcription regulation

From: PS51936

Key

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To

Description

Tag

Condition

FTGroup

DOMAIN

from

to

POU-specific atypical #

Size range	90-100 amino acids
Related rules	None
Repeats	1
Topology	Undefined
Example	P27889 (HNF1B_MOUSE)
Scope	Eukaryota; Metazoa
Comments	None

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

• UniProtKB/Swiss-Prot sets
  

  Eukaryota

  [18]

  
  
• Retrieve set of proteins with 3D structure for this domain