ProRule PRU01285

General rule information [?]

Accession PRU01285
Dates 17-AUG-2020 (Created)
27-JUN-2022 (Last updated, Version 2)
Data class Domain;
Predictors PROSITE; PS51936; POU_4
Name POU-specific (POUs) atypical domain
Function HNF1alpha (MODY3 gene product, the most commonly mutated MODY protein) and HNF1beta (hepatocyte nuclear factor 1beta; also known as vHNF1 or TCF2) (MODY5 gene product) are atypical members of the POU transcription factors. Their atypical POUs domains have at least one additional alpha-helix at the N-terminus, and the second helix and adjacent loop of their POUh domains are much longer, creating a more extensive interface between the POUs and POUh domains.
Scope(s) Eukaryota
Example(s) P27889 (HNF1B_MOUSE);

Propagated annotation [?]

Keywords [?]

Gene Ontology [?]

GO:0045893; Biological process:positive regulation of DNA-templated transcription
GO:0005634; Cellular component:nucleus
GO:0006357; Biological process:regulation of transcription by RNA polymerase II

Features [?]

From: PS51936
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="POU-specific atypical #"

Additional information [?]

Size range 90-100 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


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UniProtKB rule member sequences [?]