ProRule PRU01285
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU01285 |
| Accession | PRU01285 |
| Dates | 17-AUG-2020 (Created)
27-JUN-2022 (Last updated, Version 2) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51936; POU_4 |
Name | POU-specific (POUs) atypical domain |
| Function | HNF1alpha (MODY3 gene product, the most commonly mutated MODY protein) and HNF1beta (hepatocyte nuclear factor 1beta; also known as vHNF1 or TCF2) (MODY5 gene product) are atypical members of the POU transcription factors. Their atypical POUs domains have at least one additional alpha-helix at the N-terminus, and the second helix and adjacent loop of their POUh domains are much longer, creating a more extensive interface between the POUs and POUh domains. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P27889 (HNF1B_MOUSE); |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0045893; Biological process:positive regulation of DNA-templated transcription |
| GO:0005634; Cellular component:nucleus |
| GO:0006357; Biological process:regulation of transcription by RNA polymerase II |
Features
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| From: PS51936 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="POU-specific atypical #" | |||||||||
Additional information
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| Size range | 90-100 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [18] All [ 18 ]
- Retrieve set of proteins with 3D structure for this domain