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| annotation rule: PRU01285 |
General rule information
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| Accession | PRU01285 |
| Dates | 17-AUG-2020 (Created) 17-AUG-2020 (Last updated, Version 1) |
| Data class | Domain |
| Predictors | PROSITE; PS51936; POU_4 |
| Name | POU-specific (POUs) atypical domain |
| Function | HNF1alpha (MODY3 gene product, the most commonly mutated MODY protein) and HNF1beta (hepatocyte nuclear factor 1beta; also known as vHNF1 or TCF2) (MODY5 gene product) are atypical members of the POU transcription factors. Their atypical POUs domains have at least one additional alpha-helix at the N-terminus, and the second helix and adjacent loop of their POUh domains are much longer, creating a more extensive interface between the POUs and POUh domains. |
Propagated annotation
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Gene Ontology
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GO:0045893; Biological process: positive regulation of transcription, DNA-templated.
GO:0005634; Cellular component: nucleus.
GO:0006357; Biological process: regulation of transcription by RNA polymerase II.
GO:0005634; Cellular component: nucleus.
GO:0006357; Biological process: regulation of transcription by RNA polymerase II.
Keywords
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Features
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| From: PS51936 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | POU-specific atypical # | |||||||||
Additional information
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| Size range | 90-100 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | P27889 (HNF1B_MOUSE) |
| Scope | Eukaryota; Metazoa |
| Comments | None |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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UniProtKB/Swiss-Prot sets
Eukaryota [18]
- Retrieve set of proteins with 3D structure for this domain