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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU01285


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU01285
General rule information [?]

Accession PRU01285
Dates 17-AUG-2020 (Created)
27-JUN-2022 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51936; POU_4
Name POU-specific (POUs) atypical domain
Function HNF1alpha (MODY3 gene product, the most commonly mutated MODY protein) and HNF1beta (hepatocyte nuclear factor 1beta; also known as vHNF1 or TCF2) (MODY5 gene product) are atypical members of the POU transcription factors. Their atypical POUs domains have at least one additional alpha-helix at the N-terminus, and the second helix and adjacent loop of their POUh domains are much longer, creating a more extensive interface between the POUs and POUh domains.
Scope(s) Eukaryota
Metazoa
Example(s) P27889;

Propagated annotation [?]

Keywords [?]

DNA-binding
Nucleus
Transcription
Transcription regulation

Gene Ontology [?]

GO:0045893; Biological process:positive regulation of DNA-templated transcription
GO:0005634; Cellular component:nucleus
GO:0006357; Biological process:regulation of transcription by RNA polymerase II

Features [?]

From: PS51936
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="POU-specific atypical #"

Additional information [?]

Size range 90-100 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]