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General rule information [?]

Accession PRU01285
Dates 17-AUG-2020 (Created)
27-JUN-2022 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51936; POU_4
Name POU-specific (POUs) atypical domain
Function HNF1alpha (MODY3 gene product, the most commonly mutated MODY protein) and HNF1beta (hepatocyte nuclear factor 1beta; also known as vHNF1 or TCF2) (MODY5 gene product) are atypical members of the POU transcription factors. Their atypical POUs domains have at least one additional alpha-helix at the N-terminus, and the second helix and adjacent loop of their POUh domains are much longer, creating a more extensive interface between the POUs and POUh domains.

Propagated annotation [?]

Gene Ontology [?]

GO:0045893; Biological process: positive regulation of DNA-templated transcription.
GO:0005634; Cellular component: nucleus.
GO:0006357; Biological process: regulation of transcription by RNA polymerase II.

Keywords [?]

Features [?]

From: PS51936
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       POU-specific atypical #        

Additional information [?]

Size range 90-100 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P27889 (HNF1B_MOUSE)
Eukaryota; Metazoa
Comments None


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]