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annotation rule: PRU01285 |
Accession | PRU01285 |
Dates | 17-AUG-2020 (Created) 17-AUG-2020 (Last updated, Version 1) |
Data class | Domain |
Predictors | PROSITE; PS51936; POU_4 |
Name | POU-specific (POUs) atypical domain |
Function | HNF1alpha (MODY3 gene product, the most commonly mutated MODY protein) and HNF1beta (hepatocyte nuclear factor 1beta; also known as vHNF1 or TCF2) (MODY5 gene product) are atypical members of the POU transcription factors. Their atypical POUs domains have at least one additional alpha-helix at the N-terminus, and the second helix and adjacent loop of their POUh domains are much longer, creating a more extensive interface between the POUs and POUh domains. |
From: PS51936 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | POU-specific atypical # |
Size range | 90-100 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | P27889 (HNF1B_MOUSE) |
Scope | Eukaryota; Metazoa |
Comments | None |
Eukaryota | [18] |