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PROSITE entry PS51948


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS51948
Entry name [info] COV_NSP12_RDRP
Accession [info] PS51948
Entry type [info] MATRIX
Date [info] 07-APR-2021 CREATED;
07-APR-2021 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51948
Associated ProRule [info] PRU01293

Name and characterization of the entry

Description [info] Coronavirus Nsp12 RNA-dependent RNA polymerase (RdRp) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=568;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=563;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.7770711; R2=0.0119955; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=2187; N_SCORE=28.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=394; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_01 which contains 572'970 sequence entries.


Total number of hits 32 in 32 different sequences
Number of true positive hits 32 in 32 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotic viruses
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] Nsp12 RNA-dependent RNA polymerase
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
32 sequences

R1AB_BC133  (P0C6W1), R1AB_BC279  (P0C6V9), R1AB_BC512  (P0C6W0), 
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PDB
[Detailed view]
17 PDB

6M71; 6NUR; 6NUS; 6YYT; 7BTF; 7BV1; 7BV2; 7BZF; 7C2K; 7CYQ; 7L1F; 7O7Y;
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